69504-10-5

Basic information

• Product Name: N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine
• Synonyms: N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine
• CAS NO: 69504-10-5
• Molecular Weight: 757.962
• Mol File: 69504-10-5.mol
• Article Data: 2

Chemical Properties

• Density: 1.22±0.1 g/cm3(Predicted)
• CAS DataBase Reference: N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine(69504-10-5)
• EPA Substance Registry System: N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine(69504-10-5)

Safety Data

• Hazardous Substances Data: 69504-10-5(Hazardous Substances Data)

Upstream product

• 58-61-7 adenosine 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 62374-23-6 N⁶,N⁶,2',3',5'-pentabenzoyl-β-D-adenosine 
• 4546-55-8 N-benzoyladenosine 
• 69504-00-3 N⁶-Benzoyl-5'-O-(monomethoxytrityl)adenosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 132849-81-1 N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate) 
• 132849-84-4 N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate) 
• 132849-83-3 N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-(2,5-dichlorophenyl triethylammonium phosphate) 
• 75074-01-0 N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat 
• 75082-94-9 Triethylammonium-6-benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)phosphat> 
• 80727-12-4 Triethylammonium-6-benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-<2-(4-nitrophenyl)ethyl>phosphat> 
• 75074-03-2 N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat 
• 75082-93-8 Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 173169-66-9 N⁶-benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)2'-O-<2-(4-nitrophenyl)ethylsulfonyl>adenosine 
• 69504-09-2 N⁶-Benzoyl-2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 
• 121409-41-4 N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite> 
• 80727-10-2 N⁶-benzoyl-3'-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> 

Relevant articles and documents

Nucleosides, XXXVII. - Synthesis and Properties of 2'-O- and 3'-O-(tert-Butyldimethylsilyl)-5'-O-(4-methoxytrityl)- and 2',3'-Bis(O-tert-butyldimethylsilyl)ribonucleosides - Starting Materials for Oligoribonucleotide Syntheses

The synthesis of aminoacylated 5'-O-(4-methoxytrityl)ribonucleosides of adenosine (1), guanosine (9), cytidine (31), uridine (17), and 5,6-dihydrouridine (23) have been optimized and these compounds (4, 12, 33, 18 and 24) silylated by tert-butyldimethylsilyl chloride.The corresponding 2'- and 3'-mono-O- as well as 2',3'-bis-O-(tert-butyldimethylsilyl) derivatives have been isolated by combination of chromatographical methods and fractional crystallization procedures in preparative scale.The characterization of the newly synthesized compounds was achieved by UV and 13C-NMR spectra.