62625-55-2

Basic information

• Product Name: Benzenecarbothioic acid, 4-methoxy-, hydrazide (9CI)
• Synonyms: Benzenecarbothioic acid, 4-methoxy-, hydrazide (9CI)
• CAS NO: 62625-55-2
• Molecular Formula: C₈H₁₀N₂OS
• Molecular Weight: 182.2428
• Product Categories: THIOAMIDE
• Mol File: 62625-55-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenecarbothioic acid, 4-methoxy-, hydrazide (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarbothioic acid, 4-methoxy-, hydrazide (9CI)(62625-55-2)
• EPA Substance Registry System: Benzenecarbothioic acid, 4-methoxy-, hydrazide (9CI)(62625-55-2)

Safety Data

• Hazardous Substances Data: 62625-55-2(Hazardous Substances Data)

Upstream product

• 38204-31-8 2-((4-methoxyphenylcarbonothioyl)thio)acetic acid 
• 58547-63-0 4-Methoxy-S-carboxymethyl-thiobenzoesaeure-piperidinium 
• 42285-17-6 (4-methoxyphenyl)(piperidin-1-yl)methanethione 
• 123-11-5 4-methoxy-benzaldehyde 
• 121-98-2 methyl 4-methoxybenzoate 
• 3290-99-1 4-methoxybenzoic acid hydrazide 

Downstream Products

• 14537-65-6 isopropyl-[5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amine 
• 62625-62-1 2,5-bis-(4-methoxy-phenyl)-6H-[1,3,4]thiadiazine 
• 107402-76-6 2-(4-methoxyphenyl)-8-methyl-1-thia-3,4,8-triazaspiro(4.5)dec-2-ene 
• 107402-74-4 bis-(5-(4-methoxyphenyl)-2,3-dihydro-1,3,4-thiadiazol-3-yl)methane 
• 113369-20-3 2-(2-acetylaminobenzoyl)-5-p-methoxyphenyl-1,3,4-thiadiazole 
• 113369-25-8 C₁₈H₁₅N₃O₃S 
• 78344-56-6 9-acetyl-9a-hydroxy-2-p-methoxyphenyl<1.3.4>thiadiazino<6.5-b>indole 
• 113369-22-5 N-{2-[N'-(4-Methoxy-thiobenzoyl)-hydrazinooxalyl]-phenyl}-acetamide 
• 113369-24-7 N-{2-[N'-(4-Methoxy-thiobenzoyl)-hydrazinooxalyl]-phenyl}-butyramide 
• 113369-18-9 1-butyryl-2-oxoindoline-3-spiro-2'-(5-p-methoxyphenyl-1,3,4-thiadiazole-4-ine) 
• 17453-03-1 2,5-Bis-<4-methoxy-phenyl>-1,3,4-thiadiazol 
• 126118-88-5 2-(n-propyl)-5-(p-methoxyphenyl)-1,3,4-thiadiazole 
• 1456-67-3 2-(4'-methoxyphenyl)-5-phenyl-1,3,4-thiadiazole 
• 107402-83-5 1-(4-methoxythiobenzoyl)-3-phenyl-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

2,5-Disubstituted thiadiazoles as potent β-glucuronidase inhibitors; Synthesis, in vitro and in silico studies

Twenty-five thiadiazole derivatives 1–25 were synthesized from methyl 4-methoxybenzoate via hydrazide and thio-hydrazide intermediates, and evaluated for their potential against β-glucuronidase enzyme. Most of the compounds including 1 (IC50 = 26.05 ± 0.60 μM), 2 (IC50 = 42.53 ± 0.80 μM), 4 (IC50 = 38.74 ± 0.70 μM), 5 (IC50 = 9.30 ± 0.29 μM), 6 (IC50 = 6.74 ± 0.26 μM), 7 (IC50 = 18.40 ± 0.66 μM), and 15 (IC50 = 18.10 ± 0.53 μM) exhibited superior activity potential than the standard D-saccharic acid-1,4-lactone (IC50 = 48.4 ± 1.25 μM). Molecular docking studies were conducted to correlate the in vitro results and to identify possible mode of interaction with enzyme active site.

HETEROCYCLIZATION OF DERIVATIVES OF THIONCARBOXYLIC ACIDS TO 1,3,4-THIADIAZOLES UNDER THE ACTION OF TERT-BUTYL HYPOCHLORITE

A method for synthesis of 2-alkyl-5-aryl- and 2,5-diaryl-1,3,4-thiadiazoles by successive reaction of thioamides with tert-butyl hypochlorite and benzothiohydrazides was developed.The first step in the formation of 1,3,4-thiadiazoles consists of oxidation