6274-50-6

Basic information

• Product Name: 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester
• Synonyms: 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester;Methyl 2-(4-Methoxyphenyl)-2-Methylpropanoate
• CAS NO: 6274-50-6
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.26
• Mol File: 6274-50-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 278.3°C at 760 mmHg
• Flash Point: 111.7°C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 0.00429mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester(6274-50-6)
• EPA Substance Registry System: 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester(6274-50-6)

Safety Data

• Hazardous Substances Data: 6274-50-6(Hazardous Substances Data)

Usage

General Description

The chemical compound 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester is a methyl ester derivative of 2-(4-methoxyphenyl)-2-methylpropionic acid. It is commonly used as a building block in organic synthesis and pharmaceutical production. 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester is soluble in organic solvents and has a slightly sweet odor. It is important to handle this chemical with care, as it is a potential irritant to the skin, eyes, and respiratory system. Overall, 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester is a versatile chemical with various applications in the industrial and research fields.

InChI:InChI=1/C12H16O3/c1-12(2,11(13)15-4)9-5-7-10(14-3)8-6-9/h5-8H,1-4H3

Upstream product

• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 74-88-4 methyl iodide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 547-63-7 Methyl isobutyrate 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 67-56-1 methanol 
• 2955-46-6 2-(4-methoxyphenyl)-2-methylpropanoic acid 
• 623-12-1 4-chloromethoxybenzene 
• 50415-73-1 methyl 2-(4-methoxyphenyl)propionate 
• 696-62-8 para-iodoanisole 

Downstream Products

• 32454-29-8 2-(4-methoxy-phenyl)-2-methyl-propan-1-ol 
• 63045-26-1 2-(3-Chloro-4-methoxy-phenyl)-2-methyl-propionic acid methyl ester 
• 32454-14-1 2-(4-methoxyphenyl)-2-methylpropanal 
• 4132-48-3 1-methoxy-4-(1-methylethyl)benzene 
• 85385-44-0 4-(1-deuterio-1-methylethyl)anisole 
• 32454-31-2 2-p-Methoxyphenyl-2-methyl-1-methylthiomethoxypropan 
• 32445-98-0 2,3-bis(4-methoxyphenyl)-2,3-dimethylbutane 
• 29913-51-7 2-methyl-2-(p-hydroxyphenyl)-propionic acid 
• 1421838-11-0 N-(bis(4-fluorophenyl)methyl)-2-(4-hydroxyphenyl)-2-methylpropanamide 
• 2955-46-6 2-(4-methoxyphenyl)-2-methylpropanoic acid 
• 123342-40-5 methyl 2-(4-hydroxyphenyl)-2-methylpropanoate 
• 731015-44-4 methyl 2-(3-formyl-4-hydroxyphenyl)-2-methylpropanoate 
• 40919-14-0 2-(4-methoxy-phenyl)-2-methyl-propionyl chloride 

Relevant articles and documents

Catalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides

Nucleophilic aromatic substitution (SNAr) is a powerful strategy for incorporating a heteroatom into an aromatic ring by displacement of a leaving group with a nucleophile, but this method is limited to electron-deficient arenes. We have now established a reliable method for accessing phenols and phenyl alkyl ethers via catalytic SNAr reactions. The method is applicable to a broad array of electron-rich and neutral aryl fluorides, which are inert under classical SNAr conditions. Although the mechanism of SNAr reactions involving metal arene complexes is hypothesized to involve a stepwise pathway (addition followed by elimination), experimental data that support this hypothesis is still under exploration. Mechanistic studies and DFT calculations suggest either a stepwise or stepwise-like energy profile. Notably, we isolated a rhodium η5-cyclohexadienyl complex intermediate with an sp3-hybridized carbon bearing both a nucleophile and a leaving group.

Nickel-Catalyzed oxidative coupling of unactivated C(sp3)-H bonds in aliphatic amides with terminal alkynes

In this work, we demonstrated Ni-catalyzed oxidative coupling of unactivated C(sp3)-H bonds with terminal alkynes for construction of C(sp3)-C(sp) bonds to synthesize alkyl-substituted internal alkynes. Different amides exhibited good compatibility. Preliminary mechanistic studies were conducted to account for this alkynylation.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-reiated orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.