32454-14-1

Basic information

• Product Name: 2-(4-methoxyphenyl)-2-methylpropanal
• Synonyms: 2-(4-methoxyphenyl)-2-methylpropanal
• CAS NO: 32454-14-1
• Molecular Weight: 178.231
• Mol File: 32454-14-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-2-methylpropanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-2-methylpropanal(32454-14-1)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-2-methylpropanal(32454-14-1)

Safety Data

• Hazardous Substances Data: 32454-14-1(Hazardous Substances Data)

Upstream product

• 104-47-2 p-methoxybenzylnitrile 
• 74-88-4 methyl iodide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 590-86-3 isovaleraldehyde 
• 51431-73-3 1-(but-2-en-2-yl)-4-methoxybenzene 
• 14478-14-9 1-acetyloxy-2-methylpropene 
• 5351-07-5 2-(4-methoxy-phenyl)-2-methyl-propionitrile 
• 6274-50-6 methyl 2-(4-methoxyphenyl)-2-methylpropanoate 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 60-29-7 diethyl ether 
• 860586-84-1 2-iodo-1-(4-methoxy-phenyl)-2-methyl-propan-1-ol 
• 261929-95-7 β,β-dimethyl-4-methoxystyrene oxide 
• 877-99-6 1-methoxy-4-(2-methyl-1-propenyl)benzene 

Downstream Products

• 18272-88-3 1-methoxy-4-(2-methylbut-3-en-2-yl)benzene 
• 197654-86-7 4-(1,1-Dimethyl-3,3-dibromo-2-propenyl)anisole 
• 1133-13-7 3-(4-Methoxyphenyl)-3-methylbutyronitrile 
• 1186222-24-1 2-bromo-1,1-difluoro-4-(4-methoxyphenyl)-4-methylpent-1-en-3-yl acetate 
• 1186222-34-3 1,1-difluoro-4-(4-methoxyphenyl)-4-methylpenta-1,2-diene 
• 197654-87-8 4-(1,1-Dimethyl-2-butynyl)anisole 

Relevant articles and documents

Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues

A small family of structural analogues of the antimitotic tripeptides, hemiasterlins, have been designed and synthesized as potential inhibitors of tubulin polymerization. The effectiveness of a multicomponent approach was fully demonstrated by applying complementary versions of the isocyanide-based Ugi reaction. Compounds strictly related to the lead natural products, as well as more extensively modified analogues, have been synthesized in a concise and convergent manner. In some cases, biological evaluation provided evidence for strong cytotoxic activity (six human tumor cell lines) and for potent inhibition of tubulin polymerization.

Br?nsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br?nsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

Palladium-catalyzed arylation of vinylic acetates. Phosphine ligand influenced regioselectivity

A palladium-catalyzed coupling reaction of aryl bromides with vinylic acetates in the presence of tributyltin methoxide h as been described. The α-arylation aldehyde product and the aryl ketone were obtained in the presence of P(t-Bu)3 and P(o-