5351-07-5

Basic information

• Product Name: 2-(4-Methoxyphenyl)-2-methylpropanenitrile
• Synonyms: 2-(4-methoxyphenyl)-2-methyl-propionitrile;Benzeneacetonitrile,4-Methoxy-a,a-diMethyl-;2-(4-Methoxyphenyl)-2-methylpropanenitrile
• CAS NO: 5351-07-5
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 5351-07-5.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 284.9 °C at 760 mmHg
• Flash Point: 119.8 °C
• Appearance: /
• Density: 1.009 g/cm³
• Vapor Pressure: 0.00289mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-Methoxyphenyl)-2-methylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxyphenyl)-2-methylpropanenitrile(5351-07-5)
• EPA Substance Registry System: 2-(4-Methoxyphenyl)-2-methylpropanenitrile(5351-07-5)

Safety Data

• Hazardous Substances Data: 5351-07-5(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxyphenyl)-2-methylpropanenitrile is a chemical compound that belongs to the class of nitriles. It is commonly used in the synthesis of various organic compounds and pharmaceuticals. The compound is identified by its molecular formula C11H13NO and has a molecular weight of 175.23 g/mol. It is a clear, colorless liquid at room temperature and is soluble in organic solvents such as ethanol and ether. The compound is known to be toxic if ingested and can cause irritation to the skin and eyes upon contact. It is important to handle and use this chemical with proper safety precautions in a well-ventilated area.

InChI:InChI=1/C11H13NO/c1-11(2,8-12)9-4-6-10(13-3)7-5-9/h4-7H,1-3H3

Upstream product

• 104-47-2 p-methoxybenzylnitrile 
• 74-88-4 methyl iodide 
• 55770-61-1 2-(4-Hydroxyphenyl)-2-methylpropionitrile 
• 77-78-1 dimethyl sulfate 
• 140-29-4 phenylacetonitrile 
• 149-73-5 trimethyl orthoformate 
• 108-24-7 acetic anhydride 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 78-82-0 Isobutyronitrile 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 623-12-1 4-chloromethoxybenzene 
• 7677-24-9 trimethylsilyl cyanide 
• 7428-99-1 2-(4-methoxyphenyl)propan-2-ol 
• 1098072-77-5 5-[1-(4-methoxyphenyl)-1-methylethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 2955-46-6 2-(4-methoxyphenyl)-2-methylpropanoic acid 
• 51558-25-9 2-methyl-2-[4-(methyloxy)phenyl]-1-propanamine 
• 96047-37-9 1,2-bis-(4-methoxy-phenyl)-2-methyl-propan-1-one 
• 32454-14-1 2-(4-methoxyphenyl)-2-methylpropanal 
• 628311-33-1 2-(3-bromo-4-methoxy-phenyl)-2-methyl-propionitrile 
• 55770-61-1 2-(4-Hydroxyphenyl)-2-methylpropionitrile 
• 949589-44-0 N-methoxy-2-(4-methoxyphenyl)-N,2-dimethylpropanamide 
• 949589-15-5 2,6-bis(4-methoxyphenyl)-2,6-dimethylhept-4-yn-3-one 
• 949589-16-6 6-(4-methoxyphenyl)-3-[1-(4-methoxyphenyl)-1-methylethyl]-6-methyl-1-(triisopropylsilyl)hepta-1,4-diyn-3-ol 
• 949589-14-4 4-(4-methoxyphenyl)-1-[1-(4-methoxyphenyl)-1-methylethyl]-4-methyl-1-[(triisopropylsilyl)ethynyl]pent-2-yn-1-yl methyl carbonate 
• 949589-17-7 {3,5-bis[1-(4-methoxyphenyl)-1-methylethyl]hepta-3,4-diene-1,6-diyne-1,7-diyl}bis(triisopropylsilane) 
• 949589-25-7 {3,5-bis[1-(4-methoxyphenyl)-1-methylethyl]-7-[triethylsilyl]hepta-3,4-diene-1,6-diyn-1-yl}(triisopropyl)silane 
• 949589-19-9 {3,5-bis[1-(4-methoxyphenyl)-1-methylethyl]hepta-3,4-diene-1,6-diyn-1-yl}(triisopropyl)silane 
• 949589-20-2 1,14-bis(triisopropylsilyl)-3,5,10,12-tetrakis[1-(4-methoxyphenyl)-1-methylethyl]tetradeca-3,4,10,11-tetraene-1,6,8,13-tetrayne 

Relevant articles and documents

Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives

Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

N2-(2-METHOXYPHENYL)PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a N2-(2-methoxyphenyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The N2-(2-methoxyphenyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.