55770-61-1

Basic information

• Product Name: 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE
• Synonyms: 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE;2-(4-Hydroxy-phenyl)-2-Methyl-propionitrile
• CAS NO: 55770-61-1
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 55770-61-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE(55770-61-1)
• EPA Substance Registry System: 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE(55770-61-1)

Safety Data

• Hazardous Substances Data: 55770-61-1(Hazardous Substances Data)

Usage

Description

2-(4-Hydroxyphenyl)-2-methylpropanenitrile, also known as zingerone nitrile, is an organic compound with the chemical formula C10H11NO. It is a nitrile derivative of zingerone, a natural compound found in ginger. Zingerone nitrile possesses anti-inflammatory and anti-arthritic properties, making it a promising candidate for the development of new pharmaceuticals for the treatment of inflammatory diseases. Its unique chemical structure and properties make it an interesting target for further research and development in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
2-(4-Hydroxyphenyl)-2-methylpropanenitrile is used as a pharmaceutical agent for the treatment of inflammatory diseases due to its anti-inflammatory and anti-arthritic properties. It has the potential to be developed into new medications that can alleviate symptoms and improve the quality of life for patients suffering from such conditions.
Used in Medicinal Chemistry Research:
2-(4-Hydroxyphenyl)-2-methylpropanenitrile serves as a subject of interest in medicinal chemistry research. Its unique chemical structure and properties make it a valuable target for the exploration of new drug development strategies and the enhancement of existing treatments for inflammatory diseases. Further research into its mechanism of action and potential synergistic effects with other compounds could lead to breakthroughs in the field of medicinal chemistry.

Upstream product

• 5351-07-5 2-(4-methoxy-phenyl)-2-methyl-propionitrile 
• 80-05-7 BPA 
• 108-95-2 phenol 
• 210551-82-9 2-(4-tert-butyldimethylsilyloxyphenyl)-2-methylpropanenitrile 
• 104-47-2 p-methoxybenzylnitrile 
• 4286-23-1 4-isopropenylphenol 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 29913-51-7 2-methyl-2-(p-hydroxyphenyl)-propionic acid 
• 5351-07-5 2-(4-methoxy-phenyl)-2-methyl-propionitrile 
• 2955-46-6 2-(4-methoxyphenyl)-2-methylpropanoic acid 
• 51558-25-9 2-methyl-2-[4-(methyloxy)phenyl]-1-propanamine 
• 949589-60-0 2-(4-hydroxyphenyl)-2-methylpropanal 
• 1638114-23-4 C₂₀H₂₀O₅ 
• 1638114-24-5 C₂₀H₁₈N₂O₃ 
• 1638114-25-6 C₃₀H₄₂N₂O₇ 
• 1638114-42-7 C₁₇H₂₁NO₃S 
• 1638114-44-9 C₁₇H₁₇NO₄S 
• 1638114-45-0 C₁₇H₁₉NO₄S 
• 1638114-46-1 C₁₉H₂₃NO₄S₂ 
• 676493-85-9 tert-butyl 2-(4-hydroxyphenyl)-2-methylpropylcarbamate 
• 874775-94-7 C₁₀H₁₄O₂ 

Relevant articles and documents

Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes

The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the-OH and-NH2 groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.

OXAZOLOBENZIMIDAZOLE DERIVATIVES

The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorde

1,3-Diethynylallenes: Stable monomers, length-defined oligomers, asymmetric synthesis, and optical resolution

A series of differently substituted 1,3-diethynylallenes (DEAs) have been synthesized, confirming that the previously introduced construction protocols tolerate a variety of functional groups. The new DEAs bear at least one polar group to facilitate enantiomer separations on chiral stationary phases and to allow further functionalization. They are thermally and environmentally stable compounds since bulky substituents next to the cumulene moiety suppress the tendency to undergo [2+2] cyclodimerization. A series of length-defined oligomers were obtained as mixtures of stereoisomers by oxidative coupling of a monomeric DEA under Glaser-Hay conditions. The electronic absorption data indicate a lack of extended π-electron conjugation across the oligomeric backbone due to the orthogonality of the allenic π-systems. Remarkably, even complex mixtures of stereoisomers only yield one single set of NMR signals, which underlines the low stereodifferentiation in acyclic allenoacetylenic structures. Optical resolution of DEAs represents an amazing challenge, and preliminary results on the analytical level are reported. Asymmetric synthesis by Pd-mediated SN2′-type cross-coupling of an alkyne to an optically pure bispropargylic precursor opens another promising route to optically active allenes with stereoselectivities currently reaching up to 78 % ee. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.