627489-10-5

Basic information

• Product Name: 1,3-Bis-benzyloxy-2-ethynyl-5-methoxy-benzene
• Synonyms: 1,3-Bis-benzyloxy-2-ethynyl-5-methoxy-benzene
• CAS NO: 627489-10-5
• Molecular Weight: 344.41
• Mol File: 627489-10-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Bis-benzyloxy-2-ethynyl-5-methoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis-benzyloxy-2-ethynyl-5-methoxy-benzene(627489-10-5)
• EPA Substance Registry System: 1,3-Bis-benzyloxy-2-ethynyl-5-methoxy-benzene(627489-10-5)

Safety Data

• Hazardous Substances Data: 627489-10-5(Hazardous Substances Data)

Upstream product

• 1034-49-7 (bromomethyl)triphenyl phosphonium bromide 
• 91360-58-6 2,6-bis(benzyloxy)-4-methoxybenzaldehyde 

Downstream Products

• 344303-15-7 5,6-bis-benzyloxy-2-(2,6-bis-benzyloxy-4-methoxy-phenyl)-benzofuran-3-carboxylic acid methyl ester 
• 344303-12-4 4,5-bis-benzyloxy-2-(2,6-bis-benzyloxy-4-methoxy-phenylethynyl)-phenol 
• 627489-05-8 2-(2,6-dihydroxy-4-methoxy-phenyl)-5,6-dihydroxy-benzofuran-3-carboxylic acid methyl ester 
• 524-12-9 wedelolactone 
• 627489-61-6 acetic acid 4,5-bis-benzyloxy-2-(2,6-bis-benzyloxy-4-methoxy-phenylethynyl)-phenyl ester 

Relevant articles and documents

Total Synthesis of Wedelolactone

The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS-induced caspase-11 expression, using a convergent synthetic approach, is described. The key steps involved in this synthesis include the palladium-catalyzed Sonogashira reaction and the palladium-catalyzed carbonylative annulation reaction. This approach allows access to diversified analogues of wedelolactone.