62806-39-7Relevant articles and documents
Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors
Vazquez, Jesus,Tautz, Lutz,Ryan, Jennifer J.,Vuori, Kristiina,Mustelin, Tomas,Pellecchia, Maurizio
, p. 2137 - 2143 (2008/02/01)
We report on the design, synthesis, and evaluation of a series of furanyl-salicyl-nitroxide derivatives as effective chemical probes for second-site screening against phosphotyrosine phosphatases (PTPs) using NMR-based techniques. The compounds have been
Synthesis of 2-arylfuro[3,2-c]pyridines and their derivatives
Krutosikova, Alzbeta,Sleziak, Robert
, p. 1627 - 1636 (2007/10/03)
A series of 2-arylfuro[3,2-c]pyridines was synthesized. 3-(5-Aryl-2-furyl)propenoic acids 1a-1h were converted to the acid azides 2a-2h, which in turn were cyclized to give 2-arylfuro[3,2-c]pyridine-4(5H)-ones 4a-4h by heating in Dowtherm. The pyridones 4a-4f were aromatized with phosphorus oxychloride to the 2-aryl-4-chlorofuro[3,2-c]pyridines 5a-5f, which were reduced with zinc and acetic acid to the title compounds 6a-6f. Reacted with phosphorus(V) sulfide, the pyridones 4a-4f yielded the corresponding thiones 7a-7f.
