6289-87-8

Basic information

• Product Name: 2-(Benzoylamino)benzyl alcohol
• Synonyms: 2-(Benzoylamino)benzyl alcohol;BENZAMIDE,N-[2-(HYDROXYMETHYL)PHENYL]-
• CAS NO: 6289-87-8
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.2585
• Mol File: 6289-87-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 322.1°Cat760mmHg
• Flash Point: 148.6°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 0.000118mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 2-(Benzoylamino)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Benzoylamino)benzyl alcohol(6289-87-8)
• EPA Substance Registry System: 2-(Benzoylamino)benzyl alcohol(6289-87-8)

Safety Data

• Hazardous Substances Data: 6289-87-8(Hazardous Substances Data)

Usage

General Description

2-(Benzoylamino)benzyl alcohol is a chemical compound with the molecular formula C14H13NO2. It is a white solid at room temperature and is commonly used as a reagent in organic synthesis. 2-(Benzoylamino)benzyl alcohol is a benzyl alcohol derivative with a benzoyl group attached to the nitrogen atom. It has potential applications in pharmaceutical and medicinal chemistry due to its structural and functional properties. The compound may also be used as a building block in the synthesis of other organic compounds. However, it is important to handle this compound with caution as it may have hazardous properties and should only be used by trained professionals in a laboratory setting.

InChI:InChI=1/C14H13NO2/c16-10-12-8-4-5-9-13(12)15-14(17)11-6-2-1-3-7-11/h1-9,16H,10H2,(H,15,17)

Upstream product

• 112222-87-4 2-(benzoylamino)benzyl benzoate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 98-88-4 benzoyl chloride 
• 100-52-7 benzaldehyde 
• 118-92-3 anthranilic acid 

Downstream Products

• 46707-86-2 2-phenyl-4H-benzo[d][1,3]oxazine 
• 31590-14-4 2-aminobenzyl benzoate 
• 1309273-01-5 1-benzyl-2-phenyl-1H-indol-3-yl benzoate 
• 1309273-02-6 1-benzyl-2-phenyl-1H-indol-3-yl 4-chlorobenzoate 
• 1309273-03-7 1-benzyl-2-phenyl-1H-indol-3-yl acetate 
• 1309273-07-1 1-allyl-2-phenyl-1H-indol-3-yl benzoate 
• 1309272-96-5 N-benzyl-N-(2-formylphenyl)benzamide 
• 1309273-00-4 N-allyl-N-(2-formylphenyl)benzamide 
• 33768-43-3 N-(2-formylphenyl)benzamide 
• 62295-27-6 N-(2-formylphenyl)-N-methylbenzamide 
• 78602-05-8 1-methyl-2-phenyl-1H-indol-3-yl benzoate 
• 181220-07-5 N-[2-(chloromethyl)phenyl]benzamide 
• 59319-59-4 N-[2-(azidomethyl)phenyl]benzamide 
• 112222-87-4 2-(benzoylamino)benzyl benzoate 

Relevant articles and documents

Designing and Accurately Developing a [6 + 2] Dipolar Cycloaddition for the Synthesis of Benzodiazocines

1,6-Dipolar cycloadditions represent a valuable strategy for the rapid construction of medium-sized rings. Herein, we describe the concept for the design of 1,6-dipoles that bypasses the regioselectivity. Through the introduction of an amino group into Morita-Baylis-Hillman (MBH) carbonates, unprecedented [6 + 2] dipolar cycloadditions were accurately developed with Cs2CO3, efficiently delivering a series of benzodiazocines in mild conditions. Computational studies bring a deeper understanding of this reaction.

Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors

A novel series of benzoxazole analogs was designed and synthesized, and their inhibitory activities against Aurora kinases were evaluated. Some of the tested compounds exhibited a promising activity with respect to the inhibition of Aurora B kinase. A structure-activity relationship study indicated that linker length, regiochemistry, and halogen substitution play important roles in kinase inhibitory potency. The binding modes between representative compounds and Aurora kinases were interpreted through a molecular docking study to explain the inhibitory activity and selectivity for Aurora A and B kinases. Compounds 13l and 13q also show an antiproliferative effect on the human tumor cell lines in a dose-dependent manner. The most potent 13q demonstrated good efficacy in the prostate cancer PC-3 tumor xenograft model.

Synthesis of 1-acyl-3,4-dihydroquinazoline-2(1H)-thiones by cyclization of N-[2-(isothiocyanatomethyl)phenyl] amides generated in situ from N-[2-(azidomethyl)phenyl] amides

An efficient method for the preparation of 1-acyl-3,4-dihydroquinazoline- 2(1H)-thiones 5 has been developed. The reaction of N-[2-(azidomethyl)phenyl] amides 3, easily prepared by a three-step sequence starting with (2-aminophenyl)methanols, with Ph