6318-37-2

Basic information

• Product Name: 5-[1-(4-CHLORO-PHENYL)-METH-(Z)-YLIDENE]-2-THIOXO-THIAZOLIDIN-4-ONE
• Synonyms: 5-[1-(4-CHLORO-PHENYL)-METH-(Z)-YLIDENE]-2-THIOXO-THIAZOLIDIN-4-ONE;5-(4-Chlorobenzylidene)-2-thioxothiazolidin-4-one
• CAS NO: 6318-37-2
• Molecular Formula: C₁₀H₆ClNOS₂
• Molecular Weight: 255.74374
• Mol File: 6318-37-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 399°C at 760 mmHg
• Flash Point: 195.1°C
• Appearance: /
• Density: 1.54g/cm³
• Vapor Pressure: 1.41E-06mmHg at 25°C
• Refractive Index: 1.738
• CAS DataBase Reference: 5-[1-(4-CHLORO-PHENYL)-METH-(Z)-YLIDENE]-2-THIOXO-THIAZOLIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[1-(4-CHLORO-PHENYL)-METH-(Z)-YLIDENE]-2-THIOXO-THIAZOLIDIN-4-ONE(6318-37-2)
• EPA Substance Registry System: 5-[1-(4-CHLORO-PHENYL)-METH-(Z)-YLIDENE]-2-THIOXO-THIAZOLIDIN-4-ONE(6318-37-2)

Safety Data

• Hazardous Substances Data: 6318-37-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H6ClNOS2/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)/b8-5-

Upstream product

• 98026-85-8 5-chloromethylene-2-thioxo-thiazolidin-4-one 
• 108-90-7 chlorobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 19374-88-0 5-(1-methyl-3-oxo-butylidene)-2-thioxo-thiazolidin-4-one 
• 141-84-4 2-thioxo-4-thiazolidinone 
• 538-51-2 benzylidene phenylamine 
• 2362-79-0 N-(4-chlorobenzylidene)aniline 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 

Downstream Products

• 99839-78-8 3-(4-chlorophenyl)propionic amide 
• 65562-27-8 5-(4-chloro-benzylidene)-3-(tetra-O-acetyl-β-D-glucopyranosyl)-2-thioxo-thiazolidin-4-one 
• 104183-58-6 5-(p-Chlorobenzylidene)-3--4-oxo-thiazolidine-2-thione 
• 104183-59-7 5-(p-Chlorobenzylidene)-3--4-oxo-thiazolidine-2-thione 
• 104183-57-5 5-(p-Chlorobenzylidene)-3--4-oxo-thiazolidine-2-thione 
• 23517-83-1 5-(4-chlorophenylmethylene)-3-methyl-4-oxo-2-thioxothiazolidine 
• 76979-35-6 2-methylthio-5-p-chlorophenylmethylene-thiazolinone-4 
• 15788-48-4 5-(4-Chlorophenylmethylene)-2-piperidino-2-thiazolin-4-one 
• 36937-47-0 5-(4-Chlorophenylmethylene)-2-morpholino-4-oxo-2-thiazoline 
• 76988-00-6 5-(4-Chlorophenylmethylene)-2-imino-4-thiazolidinone 

Relevant articles and documents

Synthesis, in-vitro cytotoxicity and antimicrobial evaluations of some novel thiazole based heterocycles

Condensation of rhodanine (1) with pyrazol-3(2H)-one derivatives (2a-f) gave 5-substituted-2-thioxo-1,3- thiazolidin-4-one derivatives (3a-f). Reaction of compound (1) with 2-arylmethylidene-malononitrile (4a-d) yielded the unexpected derivatives (5a-d). The latter compounds were subjected to cyclization reactions with malononitrile under different basic conditions, hydroxylamine hydrochloride and/or thiourea to furnish the fused thiazole derivatives (6a-d) and (8-10a-d). Coupling of (1) with diazotized aromatic amines (11a-c) in pyridine afforded the arylhydrazones (12a-c). Fusion of latter compounds with malononitrile afforded the thiazolopyridazine derivatives (13a-c). The structures of the newly synthesized compounds were elucidated via spectral data and elemental analyses. The in-vitro cytotoxic activity of compounds (3a-f) against the cell line MCF-7 was evaluated. Also, the synthesized products were investigated for their antibacterial and antifungal activities against six standard organisms including the G- bacteria, Staphylococcus aureus and Bacillus subtilis, G+ bacteria, Escherichia coli and Proteus vulgaris in addition to fungi, Candida albicans and Aspergillus flavus.

Solid acid TS-1 catalyst: an efficient catalyst in Knoevenagel condensation for the synthesis of 5-arylidene-2,4-thiazolidinediones/Rhodanines in aqueous medium

Abstract: TS-1 zeolite was prepared for the synthesis of 5-arylidene-2,4-thiazolidinediones/Rhodanines in aqueous medium by incorporating titanium(IV) cations in a silicate-1 framework using hydrothermal treatment and characterized by using XRD, EDX, BET, FT-IR and SEM techniques. The catalytic activity of the catalyst was tested for Knoevenagel condensation reaction. The condensation of active ethylene 2,4-thiazolidinedione with substituted aryl aldehydes under aqueous medium at 90?°C afforded the corresponding product in excellent yield up to 92% within 30?min. The present method offers several advantages over the reported methods such as easy separation of catalyst, simple work-up procedure, and an excellent yield of desired product. Furthermore, the catalyst could be reused without significant loss in activity. Graphical abstract: [Figure not available: see fulltext.]

Combination of 4-anilinoquinazoline and rhodanine as novel epidermal growth factor receptor tyrosine kinase inhibitors

Abstract A type of novel rhodanine-based 4-anilinoquinazoline, which designed the combination between quinazoline as the backbone and various substituted biological rhodanine groups as the side chain, have been synthesized, and their antiproliferative act