99839-78-8

Basic information

• Product Name: BenzenepropanaMide, 4-chloro-
• Synonyms: BenzenepropanaMide, 4-chloro-
• CAS NO: 99839-78-8
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• Mol File: 99839-78-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzenepropanaMide, 4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzenepropanaMide, 4-chloro-(99839-78-8)
• EPA Substance Registry System: BenzenepropanaMide, 4-chloro-(99839-78-8)

Safety Data

• Hazardous Substances Data: 99839-78-8(Hazardous Substances Data)

Upstream product

• 6318-37-2 5-(4-chlorobenzylidene)rhodanine 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 
• 32327-71-2 3-(4-chlorophenyl)propanenitrile 
• 18166-64-8 (E)-4-chlorocinnamamide 
• 102-93-2 3-phenylpropionamide 
• 108-90-7 chlorobenzene 
• 18166-64-8 4-chlorocinnamide 
• 1073-67-2 4-vinylbenzyl chloride 
• 201230-82-2 carbon monoxide 
• 77287-34-4 formamide 

Downstream Products

• 156-41-2 4-chlorophenylethylamine 
• 140-53-4 p-chlorobenzyl cyanide 
• 1202651-28-2 5-[2-(4-chlorophenyl)ethyl]-1,3,4-oxathiazol-2-one 
• 1202651-26-0 2-chloro-4-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-thiadiazol-5-yl}oxy)-5-methylaniline 

Relevant articles and documents

Visible-Light Decatungstate/Disulfide Dual Catalysis for the Hydro-Functionalization of Styrenes

We describe an efficient photoredox system, relying on decatungstate/disulfide catalysts, for the hydrofunctionalization of styrenes. In this methodology the use of disulfide as a cocatalyst was shown to be crucial for the reaction efficiency. This photoredox system was employed for the hydro-carbamoylation, -acylation, -alkylation, and -silylation of styrenes, giving access to a large variety of useful building blocks and high-value molecules such as amides and unsymmetrical ketones from simple starting materials.

Palladium-catalyzed regiodivergent hydroaminocarbonylation of alkenes to primary amides with ammonium chloride

Palladium-catalyzed hydroaminocarbonylation of alkenes for the synthesis of primary amides has long been an elusive aim. Here, we report an efficient catalytic system which enables inexpensive NH4Cl to be utilized as a practical alternative to gaseous ammonia for the palladium-catalyzed alkene-hydroaminocarbonylation reaction. Through appropriate choice of the palladium precursors and ligands, either branched or linear primary amides can be obtained in good yields with good to excellent regioselectivities. Primary mechanistic studies were conducted and disclosed that electrophilic acylpalladium species were capable of capturing the NH2-moiety from ammonium salts to form amides in the presence of CO with NMP as a base.

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction

The p53 pathway is inactivated in almost all types of cancer by mutations in the p53 encoding gene or overexpression of the p53 negative regulators, Mdm2 and/or Mdmx. Restoration of the p53 function by inhibition of the p53-Mdm2/Mdmx interaction opens up