6318-51-0 Usage
Description
(4-chlorophenyl) 2-pyridyl ketone, also known as 2-(4-Chlorobenzoyl)pyridine, is an organic compound with a molecular structure that features a chlorophenyl group connected to a pyridyl group through a ketone linkage. (4-chlorophenyl) 2-pyridyl ketone is characterized by its reactivity and potential applications in various chemical and pharmaceutical processes.
Uses
Used in Asymmetric Transfer Hydrogenation:
(4-chlorophenyl) 2-pyridyl ketone is used as a reactant/reagent in the asymmetric transfer hydrogenation of aryl N-heteroaryl ketones. This process is catalyzed by a bifunctional oxo-tethered ruthenium complex, which allows for the selective reduction of the ketone group, leading to the formation of chiral alcohols with high enantioselectivity. This application is particularly relevant in the synthesis of optically active compounds, which are important in the pharmaceutical industry for the development of drugs with improved efficacy and reduced side effects.
Used in Chemical Synthesis:
(4-chlorophenyl) 2-pyridyl ketone can also be utilized as an intermediate in the synthesis of various organic compounds, such as pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and reactivity make it a valuable building block for the development of new molecules with potential applications in different industries.
Used in Research and Development:
In the field of research and development, (4-chlorophenyl) 2-pyridyl ketone serves as a valuable compound for studying reaction mechanisms, exploring new catalytic systems, and developing innovative synthetic methodologies. Its use in academic and industrial research can lead to the discovery of new chemical processes and the creation of novel materials with improved properties.
Check Digit Verification of cas no
The CAS Registry Mumber 6318-51-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,1 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6318-51:
(6*6)+(5*3)+(4*1)+(3*8)+(2*5)+(1*1)=90
90 % 10 = 0
So 6318-51-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H8ClNO/c13-10-6-4-9(5-7-10)12(15)11-3-1-2-8-14-11/h1-8H
6318-51-0Relevant articles and documents
Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones
Wang, Hua,Liu, Jie,Qu, Jian-Ping,Kang, Yan-Biao
, p. 3942 - 3948 (2020/03/23)
An organocatalyzed aerobic benzylic C-H oxidation of alkyl and aryl heterocycles has been developed. This transition metal-free method is able to overcome the electron-withdrawing effect as well as product-inhibition effects in heterobenzylic radical oxidation. A variety of ketones bearing N-heterocyclic groups could be prepared under relatively mild conditions with moderate to high yields.
Iron-catalyzed oxidative functionalization of C(sp3)-H bonds under bromide-synergized mild conditions
Yu, Han,Zhao, Qixin,Wei, Zheyu,Wu, Zhikang,Li, Qi,Han, Sheng,Wei, Yongge
supporting information, p. 7840 - 7843 (2019/07/12)
An efficient oxidation and functionalization of C-H bonds with an inorganic-ligand supported iron catalyst and hydrogen peroxide to prepare the corresponding ketones was achieved using the bromide ion as a promoter. Preliminary mechanistic investigations indicated that the bromide ion can bind to FeMo6 to form a supramolecular species (FeMo6·2Br), which can effectively catalyze the reaction.
A convenient and practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with formic acid as carbon monoxide source
You, Shengyong,Yan, Chenyu,Zhang, Rongli,Cai, Mingzhong
, (2019/01/04)
A practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with arylboronic acids under carbon monoxide gas-free conditions has been developed using a bidentate phosphino-functionalized magnetic nanoparticle-immobilized palladium(II) complex as catalyst. Formic acid was utilized as the carbon monoxide source with dicyclohexylcarbodiimide as the activator, and a wide variety of biaryl ketones were generated in moderate to high yields. The new heterogeneous palladium catalyst can be prepared via a simple procedure and can easily be separated from a reaction mixture by simply applying an external magnet and recycled up to 10 times without any loss of activity.