632330-84-8Relevant articles and documents
Synthesis of (+),(-)-neamine and their positional isomers as potential antibiotics
Ryu, Do Hyun,Tan, Choon-Hong,Rando, Robert R.
, p. 901 - 903 (2007/10/03)
The syntheses of (+)-neamine 1, (-)-neamine ent-1 and their positional isomers 2, 3, ent-2 and ent-3 are reported as potential new scaffolds for novel aminoglycoside antibiotics. These isomers exhibit similar inhibitory activities, as shown using an in vitro translation assay. A simple model is proposed to explain this lack of stereospecific binding to the ribosomal RNA.