63294-76-8Relevant articles and documents
A practical and scalable process to selectively monofunctionalize water-soluble α,ω-diols
Zhang, Quanxuan,Ren, Hong,Baker, Gregory L.
supporting information, p. 3384 - 3386 (2014/06/09)
A practical protocol for rapid and scalable synthesis of monofunctionalized α,ω-diols using a simple and inexpensive THP ether protection/deprotection strategy was described. Use of inexpensive DHP source and ease to remove excess water-soluble α,ω-diols
Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I
Makabe, Hidefumi,Kimura, Yuka,Higuchi, Masaharu,Konno, Hiroyuki,Murai, Masatoshi,Miyoshi, Hideto
, p. 3119 - 3130 (2007/10/03)
A convergent stereoselective synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin and squamostolide was accomplished via a Pd-catalyzed cross-coupling reaction. The inhibitory activity of these compounds was examined with bovine heart mitochondrial NADH-ubiquinone oxidoreductase. These compounds showed a remarkably weak inhibitory activity compared to ordinary acetogenins such as bullatacin. Our results indicate that to maintain potent inhibitory effect, the hydroxylated lactone cannot substitute for the hydroxylated mono- or bis-THF rings with a long alkyl chain that can be seen in ordinary acetogenins.
Synthesis and characterization of (5'-deoxyadenosin-5'-yl)cobalamin (= 'adenosylcobalamin') analogues mimicking the transition-state geometry of coenzyme-B12-dependent rearrangements
Poppe,Hull,Retey
, p. 2367 - 2383 (2007/10/02)
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