6332-83-8

Basic information

• Product Name: 2-(4-CHLOROPHENYL)-1-PHENYLETHANONE
• Synonyms: Ethanone, 2-(4-chlorophenyl)-1-phenyl-;Nsc 38739;2-(p-Chlorophenyl)acetophenone;4-Chlorobenzyl phenyl ketone;p-Chlorobenzyl phenyl ketone
• CAS NO: 6332-83-8
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.7
• Mol File: 6332-83-8.mol
• Article Data: 64

Chemical Properties

• Melting Point: 138℃
• Boiling Point: 351℃
• Flash Point: 192℃
• Appearance: /
• Density: 1.191
• Refractive Index: 1.708
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)-1-PHENYLETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)-1-PHENYLETHANONE(6332-83-8)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)-1-PHENYLETHANONE(6332-83-8)

Safety Data

• Hazardous Substances Data: 6332-83-8(Hazardous Substances Data)

Usage

Uses

2-(4-Chlorophenyl)-1-phenylethanone is an intermediate in the synthesis of pyrrobutamine which is antihistaminic. Also used as a reagent on the synthesis of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines which display antileukemic annd antiplatelet properties.

InChI:InChI=1/C12H8ClN3O4S/c13-8-4-3-7(6-9(8)16(18)19)14-12(21)15-11(17)10-2-1-5-20-10/h1-6H,(H2,14,15,17,21)

Upstream product

• 5415-05-4 2-(4-chloro-phenyl)-3-oxo-3-phenyl-propionitrile 
• 107323-82-0 4-chlorobenzylmagnesium bromide 
• 55-21-0 benzamide 
• 60-29-7 diethyl ether 
• 925-90-6 ethylmagnesium bromide 
• 71-43-2 benzene 
• 2206-94-2 1-acetoxy-1-phenylethene 
• 106-47-8 4-chloro-aniline 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 18859-48-8 2-(4-chlorophenoxy)-1-phenylethanone 
• 39774-18-0 p-chlorobenzoin 
• 77855-62-0 p-chlorobenzyl (N-benzylbenzamido)methyl sulfide 
• 19277-54-4 p-chlorophenyldiazomethane 

Downstream Products

• 101282-57-9 2-(4-chloro-benzyl)-2-phenyl-[1,3]oxathiolane 
• 109442-91-3 4-chloro-benzil-α oxime 
• 43024-03-9 2-bromo-2-(4-chlorophenyl)-1-phenylethanone 
• 5960-20-3 5-(4-chloro-phenyl)-2,3-dimethyl-4-phenyl-thiazolium; iodide 
• 126866-18-0 1-phenyl-2-(4-chlorophenyl)-propan-1-one 
• 69643-34-1 3-(4-chloro-phenyl)-4-phenyl-[1,2,5]thiadiazole 
• 3114-53-2 2,4-bis(p-chlorophenyl)-6-phenyl-1,3,5-triazine 
• 36122-12-0 2,3-bis(4-chlorophenyl)-1,4-diphenylbutane-1,4-dione 
• 14310-22-6 4-chlorobibenzyl 
• 28150-12-1 2-(4-Chloro-phenyl)-1-phenyl-butan-1-ol 
• 5171-97-1 4-Chlorbenzyl-phenylketon-hydrazon 
• 42291-06-5 α-phenyl-β-(4-chlorophenyl)ethylamine 
• 31462-15-4 p-Chlorphenyl-benzoyl-ketazin 
• 4831-05-4 2-(4-chlorophenyl)-2-diazo-1-phenylethan-1-one 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters

Commercially available cinchona alkaloids that can catalyze the enantiodivergent fluorination of β-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable.

Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds

Azidation of alkenes is an efficient protocol to synthesize organic azides which are important structural motifs in organic synthesis. Enantioselective radical azidation, as a useful strategy to install a C-N3 bond, remains challenging due to the inherently instability and unique structure of radicals. Here, we disclose an efficient enantioselective radical carboazidation and diazidation of α,β-unsaturated ketones and amides catalyzed by chiral N,N′-dioxide/Fe(OTf)2 complexes. An array of substituted alkenes was transformed to the corresponding α-azido carbonyl derivatives in good to excellent enantioselectivities, benefiting the preparation of chiral α-amino ketones, vicinal amino alcohols, and vicinal diamines. Control experiments and mechanistic studies proved the radical pathway in the reaction process. The DFT calculations showed that the azido transferred to the radical intermediate via an intramolecular five-membered transition state with the internal nitrogen of the Fe-N3 species.