6335-37-1

Basic information

• Product Name: DIETHYL 4-METHOXYBENZYLMALONATE
• Synonyms: DIETHYL 4-METHOXYBENZYLMALONATE;Diethyl 2-(4-Methoxybenzyl)malonate
• CAS NO: 6335-37-1
• Molecular Formula: C₁₅H₂₀O₅
• Molecular Weight: 280.32
• Mol File: 6335-37-1.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 365°C at 760 mmHg
• Flash Point: 158.1°C
• Appearance: /
• Density: 1.109g/cm³
• Vapor Pressure: 1.61E-05mmHg at 25°C
• Refractive Index: 1.495
• CAS DataBase Reference: DIETHYL 4-METHOXYBENZYLMALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 4-METHOXYBENZYLMALONATE(6335-37-1)
• EPA Substance Registry System: DIETHYL 4-METHOXYBENZYLMALONATE(6335-37-1)

Safety Data

• Hazardous Substances Data: 6335-37-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H20O5/c1-4-19-14(16)13(15(17)20-5-2)10-11-6-8-12(18-3)9-7-11/h6-9,13H,4-5,10H2,1-3H3

Upstream product

• 6768-23-6 diethyl-2-(4-methoxybenzylidene)malonate 
• 996-82-7 sodium diethylmalonate 
• 824-94-2 p-methoxybenzyl chloride 
• 105-53-3 diethyl malonate 
• 22767-72-2 ethyl 3-(4-methoxyphenyl)propanoate 
• 95-92-1 oxalic acid diethyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 2746-25-0 p-Methoxybenzyl bromide 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 15542-71-9 3-(4-methoxy-phenyl)-propane-1,2,2-tricarboxylic acid triethyl ester 
• 101892-24-4 allyl-(4-methoxy-benzyl)-malonic acid diethyl ester 
• 21405-62-9 2-(4-methoxybenzyl)malonic acid 
• 16015-95-5 (4-methoxy-benzyl)-malonic acid diamide 
• 94440-02-5 2-[2-(dimethylamino)ethyl]-2-(4-methoxybenzyl)malonic acid diethyl ester 
• 38279-99-1 2-(4-Methoxy-benzyl)-2-(2-methyl-allyl)-malonic acid diethyl ester 
• 38279-96-8 2-(4-Methoxy-benzyl)-2-(2-phenyl-allyl)-malonic acid diethyl ester 
• 63559-26-2 2-(p-methoxybenzyl)propane-1,3-diol 
• 205505-50-6 3-ethoxy-2-(4-methoxybenzyl)-3-oxopropanoic acid 
• 218786-62-0 2-Benzyloxymethyl-2-(4-methoxy-benzyl)-malonic acid diethyl ester 
• 92703-15-6 <4-Methoxy-benzyl>-<2-dimethylamino-ethyl>-malonsaeure 
• 218786-79-9 4-(3-Chloro-2,2-bis-chloromethyl-propyl)-phenol 
• 218786-66-4 1-(3-Chloro-2,2-bis-chloromethyl-propyl)-4-methoxy-benzene 
• 218786-65-3 2,2-Bis-hydroxymethyl-3-(4-methoxy-phenyl)-propan-1-ol 

Relevant articles and documents

Programmed Sequential Additions to Halogenated Mucononitriles

Dihalomucononitriles were synthesized and their reactivity evaluated to assess their ability to function as linchpin reagents. Bis(2-chloroacrylonitrile) and bis(2-bromoacrylonitrile) were synthesized from 2,1,3-benzothiadiazole and undergo conjugate addition/elimination reactions with both nitrogen (40-95% yield) and carbon nucleophiles (72-93% yield). Secondary amines undergo monosubstitutions, while carbon nucleophiles are added twice. The sequence of addition of the nucleophiles could be controlled to give mixed addition products. The multicomponent coupling products could then be converted to natural product like motifs using intramolecular cyclization reactions.

Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst

An environmentally benign, practically scalable and highly selective C-arylalkylation of active methylene compounds is developed using CTAB as the inverse phase transfer catalyst in water. The methodology developed is elaborated into the one-pot synthesis of quinoline derivatives and also applicable to the regioselective N-aralkyl of 2-pyridones.

Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.