21405-62-9

Basic information

• Product Name: 2-(4-methoxybenzyl)malonic acid
• Synonyms: 2-(4-methoxybenzyl)malonic acid
• CAS NO: 21405-62-9
• Molecular Weight: 224.213
• Mol File: 21405-62-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxybenzyl)malonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxybenzyl)malonic acid(21405-62-9)
• EPA Substance Registry System: 2-(4-methoxybenzyl)malonic acid(21405-62-9)

Safety Data

• Hazardous Substances Data: 21405-62-9(Hazardous Substances Data)

Usage

General Description

2-(4-methoxybenzyl)malonic acid is a chemical compound with the molecular formula C12H14O5. It consists of a malonic acid core with a 4-methoxybenzyl group attached at the 2-position. 2-(4-methoxybenzyl)malonic acid is used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and advanced materials. It can undergo reactions such as esterification, carboxylation, and oxidation to produce a range of derivatives with different properties and applications. Additionally, 2-(4-methoxybenzyl)malonic acid has the potential to be used in the development of novel drugs and bioactive compounds due to its unique chemical structure.

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 
• 100-66-3 methoxybenzene 
• 1519-55-7 2-cyano-3-(4-methoxyphenyl)acrylic acid 
• 6768-23-6 diethyl-2-(4-methoxybenzylidene)malonate 
• 6335-37-1 2-(4-methoxybenzyl)malonic acid diethyl ester 
• 5553-92-4 2-(4-methoxybenzyl)malononitrile 
• 21405-61-8 2-(4-methoxybenzylidene)malonic acid 

Downstream Products

• 82983-20-8 α-methylene-4-methoxybenzenepropanoic acid 
• 1282061-25-9 C₂₀H₂₁NO₂ 
• 19897-63-3 N-methyltyrosine 
• 52939-33-0 N,O-diMe-Tyr 
• 77517-95-4 C₁₅H₁₅N₃O₃S 
• 111510-37-3 N-<3--2-(4-methoxybenzyl)propanoyl>-S-ethyl-L-cysteine 
• 107673-24-5 N-<3-mercapto-2-(4-methoxybenzyl)propanoyl>-S-ethyl-L-cysteine 
• 111510-85-1 N-<3--2-(4-methoxybenzyl)propanoyl>-S-ethyl-L-cysteine 
• 111510-62-4 N-<3-(benzoylthio)-2-(4-methoxybenzyl)propanoyl>-S-ethyl-L-cysteine 
• 111510-52-2 3-(benzoylthio)-2-(4-methoxybenzyl)propanoyl chloride 
• 111510-39-5 3-Benzoylthio-2-(p-methoxybenzyl)propionic acid 
• 77517-86-3 bis(2,4,6-trichlorophenyl) 4-methoxybenzylmalonate 
• 861545-92-8 bromo-(4-methoxy-benzyl)-malonic acid 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 

Relevant articles and documents

Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.

Pd(II)-catalyzed intramolecular amidoarylation of alkenes with molecular oxygen as sole oxidant

Stereoselective palladium-catalyzed synthesis of structurally versatile indoline derivatives, using molecular oxygen as the sole oxidant, is described. New C-N and C-C bonds form across an alkene in an intramolecular manner. The C-N bond-forming step proceeds via a syn-amidopalladation pathway. The moderate kinetic isotope effects (intramolecular KIE = 3.56) suggest that electrophilic aromatic substitution occurs in the arylation step.

Sulfur-containing acylamino acids. II. Syntheses and angiotensin I converting enzyme-inhibitory activities of N-mercaptoalkanoyl-S-ethyl-L-cysteine

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