6345-43-3

Basic information

• Product Name: DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE
• Synonyms: DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE;PYRIMIDINE-4,6-DICARBOXYLIC ACID DIMETHYL ESTER;4,6-PyriMidinedicarboxylic acid, 4,6-diMethyl ester;DiMethyl 4,6-pyriMidinedicarboxylate;4,6-dimethyl pyrimidine-4,6-dicarboxylate
• CAS NO: 6345-43-3
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16
• EINECS: 929-172-3
• Mol File: 6345-43-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 78-79°C
• Boiling Point: 305.7 °C at 760 mmHg
• Flash Point: 138.7 °C
• Appearance: /
• Density: 1.293 g/cm³
• Vapor Pressure: 0.000811mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -3.53±0.17(Predicted)
• CAS DataBase Reference: DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE(6345-43-3)
• EPA Substance Registry System: DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE(6345-43-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 6345-43-3(Hazardous Substances Data)

Usage

Uses

Dimethyl 4,6-Pyrimidinedicarboxylate is a compound involved in the preparation of radiolabeled selective matrix metalloproteinase 13 (MMP-13) inhibitors.

InChI:InChI=1/C8H8N2O4/c1-13-7(11)5-3-6(8(12)14-2)10-4-9-5/h3-4H,1-2H3

Upstream product

• 67-56-1 methanol 
• 16490-02-1 pyrimidine-4,6-dicarboxylic acid 
• 1558-17-4 4,6-dimethylpyrimidine 

Downstream Products

• 135002-52-7 pyrimidine-4,6-dicarbohydrazide 
• 16490-02-1 pyrimidine-4,6-dicarboxylic acid 
• 50844-89-8 4,6-dicyanopyrimidine 
• 1605325-10-7 4-(dideutero-{[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester 
• 1605325-11-8 4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid 
• 448949-22-2 4-({[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid 
• 1605324-78-4 6-{[dideutero-(3-methoxy-phenyl)-methyl]-carbamoyl}-pyrimidine-4-carboxylic acid methyl ester 
• 1605324-79-5 6-{[dideutero-(3-methoxy-phenyl)-methyl]-carbamoyl}-pyrimidine-4-carboxylic acid 
• 1605324-80-8 4-{[(6-{[dideutero-(3-methoxy-phenyl)-methyl]-carbamoyl}-pyrimidine-4-carbonyl)-amino]-methyl}-benzoic acid methyl ester 
• 1605324-81-9 4-{[(6-{[dideutero-(3-methoxy-phenyl)-methyl]-carbamoyl}-pyrimidine-4-carbonyl)-amino]-methyl}-benzoic acid 
• 544678-85-5 N⁴,N⁶-bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide 

Relevant articles and documents

METHODS OF TREATING CANCER

The present disclosure relates to methods of treating cancer in a patient using a combination of an inhibitor of an immune checkpoint protein and an indole compound or its phosphate derivative.

Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation

The noninvasive imaging of MMP activity in vivo could have a high impact in basic research as well as in clinical applications. This approach can be established using radiolabeled MMP inhibitors (MMPIs) as tracers for the detection of activated MMPs by means of PET. However, the complexity of diseases associated with dysregulated MMP expression necessitates the imaging of distinct MMPs or MMP subgroups to distinguish their individual role in specific diseases. To this end, selective and potent MMP-13 inhibitors based on a N,N′-bis(benzyl)pyrimidine-4,6-dicarboxamide core have been synthesized and successfully radiolabeled with carbon-11, fluorine-18, and gallium-68. Selected radiolabeled candidates were evaluated in vitro and in vivo regarding their pharmacokinetic properties and metabolic stability.

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

The dynamic methylation of histone lysyl residues plays an important role in biology by regulating transcription, maintaining genomic integrity, and by contributing to epigenetic effects. Here we describe a variety of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily of histone demethylases. Combined with structural data, these chemical starting points will be useful to generate small-molecule probes to analyze the physiological roles of these enzymes in epigenetic signaling.