63463-43-4

Basic information

• Product Name: 1-(cyclopropylcarbonyl)piperidin-4-one
• Synonyms: 1-(cyclopropylcarbonyl)piperidin-4-one;Albb-003866;1-(cyclopropylcarbonyl)-4-piperidinone(SALTDATA: FREE);1-(cyclopropylcarbonyl)-4-piperidinone;1-(Cyclopropanecarbonyl)-4-piperidone;N-Cyclopropanecarbonyl-4-piperidone;1-(Cyclopropanecarbonyl)
• CAS NO: 63463-43-4
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.21
• Mol File: 63463-43-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 267.8°C at 760 mmHg
• Flash Point: 114.2°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 0.00799mmHg at 25°C
• Refractive Index: 1.554
• PKA: -0.78±0.20(Predicted)
• CAS DataBase Reference: 1-(cyclopropylcarbonyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(cyclopropylcarbonyl)piperidin-4-one(63463-43-4)
• EPA Substance Registry System: 1-(cyclopropylcarbonyl)piperidin-4-one(63463-43-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 63463-43-4(Hazardous Substances Data)

Usage

General Description

1-(cyclopropylcarbonyl)piperidin-4-one is a chemical compound with the molecular formula C11H15NO. It is a cyclic ketone that contains a piperidine ring and a cyclopropyl carbonyl group. This chemical is often used as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals. It is known for its potential pharmacological properties, including its ability to act as an antagonist of nicotinic acetylcholine receptors. Additionally, 1-(cyclopropylcarbonyl)piperidin-4-one has been studied for its potential applications in the treatment of neurological disorders and other medical conditions.

InChI:InChI=1/C9H13NO2/c11-8-3-5-10(6-4-8)9(12)7-1-2-7/h7H,1-6H2

Upstream product

• 130311-91-0 1-cyclopropanecarbonyl-4-hydroxypiperidine 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 79-37-8 oxalyl dichloride 
• 41661-47-6 piperidin-4-one 
• 4023-34-1 cyclopropanecarboxylic acid chloride 

Downstream Products

• 130311-92-1 2-amino-3-(2-chlorobenzoyl)-6-cyclopropanecarbonyl-4,5,6,7-tetrahydro-thieno[2,3-C]pyridine 

Relevant articles and documents

Tricyclic compound serving as PRMT5 inhibitor and application of tricyclic compound

The invention belongs to the field of medical chemistry, relates to a tricyclic compound serving as a PRMT5 inhibitor and an application of the tricyclic compound, and particularly provides a compoundshown as a formula (I) or an isomer, pharmaceutically acceptable salt, a solvate, crystal or prodrug of the compound, a preparation method thereof and pharmaceutical compositions containing the compounds and the use of these compounds or compositions for the treatment of PRMT5 mediated diseases. The compound provided by the invention shows significant inhibitory activity on PRMT5.

TRIAZOLO-1,4-DIAZEPINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS

A triazolo-1,4-di-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. STR1 in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is--OCO--,--NHCO--,--CO--or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.