63476-56-2

Basic information

• Product Name: 2-phenylcyclohexyl acetate
• Synonyms: 2-Phenylcyclohexyl acetate; Acetic acid, 2-phenylcyclohexyl ester
• CAS NO: 63476-56-2
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.2915
• Mol File: 63476-56-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 307.8°C at 760 mmHg
• Flash Point: 132.7°C
• Density: 1.05g/cm³
• Vapor Pressure: 0.000709mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: 2-phenylcyclohexyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylcyclohexyl acetate(63476-56-2)
• EPA Substance Registry System: 2-phenylcyclohexyl acetate(63476-56-2)

Safety Data

• Hazardous Substances Data: 63476-56-2(Hazardous Substances Data)

Upstream product

• 2362-61-0 cis-2-phenylcyclohexanol 
• 75-36-5 acetyl chloride 
• 127-09-3 sodium acetate 
• 36367-76-7 cis-2-Phenylcyclohexyl-p-bromobenzene sulfonate 
• 36367-76-7 trans-2-Phenylcyclohexyl-p-bromobenzene sulphonate 
• 2362-61-0 trans-2-Phenylcyclohexanol 
• 108-24-7 acetic anhydride 
• 1444-64-0 2-phenylcyclohexanol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 771-98-2 1-Phenylcyclohexene 
• 64-19-7 acetic acid 
• 1444-65-1 (RS)-2-phenylcyclohexanone 

Downstream Products

• 771-98-2 1-Phenylcyclohexene 
• 15232-96-9 3-phenyl-1-cyclohexene 
• 98919-68-7 (1R,2S)-trans-2-phenylcyclohexanol 
• 2362-61-0 trans-2-Phenylcyclohexanol 
• 144647-02-9 t-butyl dimethyl silyl ketene acetal of trans-2-phenyl cycloxexyl acetate 
• 63476-55-1 4-(2-Acetoxy-cyclohexyl)acetophenon 
• 36367-76-7 trans-2-Phenylcyclohexyl-p-bromobenzene sulphonate 
• 63476-41-5 [4-(2-Hydroxy-cyclohexyl)-phenyl]-acetic acid 
• 63476-60-8 [4-(2-Hydroxy-cyclohexyl)-phenyl]-acetic acid methyl ester 
• 220365-75-3 (1R,2S)-trans-2-phenylcyclohexyl acetate 
• 22040-54-6 cis-2-phenyl-cyclohexyl acetate 

Relevant articles and documents

Diastereoselective and enantioselective alkaline-hydrolysis of 2-aryl-1-cyclohexyl acetate: a CAL-B catalyzed deacylation/acylation tandem process

Candida antarctica lipase proved to be a particularly efficient lipase for the resolution of racemic 2-arylcyclohexyl acetate in hydrolysis reaction with Na2CO3 in an organic medium. The (1R,2S)-trans-2-arylcyclohexanols 2a–2d were obtained with high ee values (up to >99%) and the selectivity reached E > 200. The influence of the enol ester and the solvent on (±)-trans-2-arylcyclohexanol in the CAL-B catalyzed acylation was also studied and compared with the deacylation. The CAL-B exhibits a better affinity for the alkaline hydrolysis reaction compared with acylation with the enol esters in the same organic solvents. The best conditions were applied to resolve a stereoisomeric mixture cis/trans-2-phenyl-1-cyclohexanol and its corresponding acetate by acylation and deacylation. The obtained results show a highly enantio- and diastereoselectivity of the CAL-B during the acylation and the deacylation in favor of the trans-(R)-enantiomer product. The resolution of a mixture of cis/trans-2-arylcyclohexanols was an easy, convenient approach to provide only one stereoisomer of a mixture of four with high enantiomeric excess.

Direct catalytic anti-markovnikov addition of carboxylic acids to alkenes

A direct catalytic anti-Markovnikov addition of carboxylic acids to alkenes is reported. The catalyst system is comprised of the Fukuzumi acridinium photooxidant (1) and a substoichiometric quantity of a hydrogen-atom donor. Oxidizable olefins, such as styrenes, trisubstituted aliphatic alkenes, and enamides, can be employed along with a variety of carboxylic acids to afford the anti-Markovnikov addition adducts exclusively. A deuterium-labeling experiment lends insight to the potential mechanism.

One-step conversion of silyl/THP ethers into the corresponding acetates

A variety of silyl and THP ethers were directly converted into the corresponding acetates using acetic anhydride in the presence of a catalytic amount of Cu(OTf)2 in CH2Cl2. It was observed that MEM ethers could also be cl