63498-15-7

Basic information

• Product Name: 4-Amino-3-chloro-5-(trifluoromethyl)benzoyl chloride
• Synonyms: 4-Amino-3-chloro-5-(trifluoromethyl)benzoyl chloride
• CAS NO: 63498-15-7
• Molecular Formula: C₈H₄Cl₂F₃NO
• Molecular Weight: 258.02
• Mol File: 63498-15-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 116-126 ºC
• Boiling Point: 281 ºC
• Flash Point: 124 ºC
• Appearance: /
• Density: 1.577
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: 4-Amino-3-chloro-5-(trifluoromethyl)benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-chloro-5-(trifluoromethyl)benzoyl chloride(63498-15-7)
• EPA Substance Registry System: 4-Amino-3-chloro-5-(trifluoromethyl)benzoyl chloride(63498-15-7)

Safety Data

• Hazardous Substances Data: 63498-15-7(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/C8H4Cl2F3NO/c9-5-2-3(7(10)15)1-4(6(5)14)8(11,12)13/h1-2H,14H2

Upstream product

• 95656-52-3 4-amino-3-chloro-5-(trifluoromethyl)benzoic acid 
• 400-76-0 4-amino-3-(trifluoromethyl)benzoic acid 
• 97760-97-9 4-iodo-2-(trifluoromethyl)aniline 
• 97760-98-0 N-(4-iodo-2-(trifluoromethyl)phenyl)acetamide 
• 175277-96-0 N-(4-cyano-2-(trifluoromethyl)phenyl)acetamide 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 97776-04-0 diethyl 2-(4-amino-3-chloro-5-trifluoromethyl-benzoyl)-malonate 
• 63497-89-2 4-Amino-N-benzyl-3-chloro-5-trifluoromethyl-benzoic acid amide 
• 63497-87-0 4-Amino-3-chloro-N-cyclopropyl-5-trifluoromethyl-benzoic acid amide 
• 63497-65-4 4-Amino-3-chloro-N-(2-piperidino-ethyl)-5-trifluoromethyl-benzoic acid amide 
• 63497-66-5 4-Amino-3-chloro-N-(2-pyrrolidino-ethyl)-5-trifluoromethyl-benzoic acid amide 
• 63497-63-2 4-amino-3-chloro-N-(2-morpholin-4-yl-ethyl)-5-trifluoromethyl-benzamide 
• 63497-86-9 4-Amino-N-tert.butyl-3-chloro-5-trifluoromethyl-benzoic acid amide 
• 63497-88-1 4-Amino-N-(n-butyl)-3-chloro-5-trifluoromethyl-benzoic acid amide 
• 97760-76-4 4'-amino-3'-chloro-5'-trifluoromethyl-acetophenone 
• 97760-87-7 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-bromoethanone 
• 848130-79-0 2-chloro-4-oxiran-2-yl-6-(trifluoromethyl)aniline 

Relevant articles and documents

Synthesis of deuterium-labelled trantinterol

Trantinterol, a selective β2-adrenoceptor agonist, is currently in Phase II clinical trials for the treatment of asthma and bronchitis. The synthesis of deuterium-labelled trantinterol is described. The labelled trantinterol is used as an inter

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.