6388-45-0

Basic information

• Product Name: 5-bromo-6-chloro-N-[(methoxycarbonyl)methyl]anthranilic acid methyl ester
• Synonyms: 5-bromo-6-chloro-N-[(methoxycarbonyl)methyl]anthranilic acid methyl ester
• CAS NO: 6388-45-0
• Molecular Weight: 336.57
• Mol File: 6388-45-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-bromo-6-chloro-N-[(methoxycarbonyl)methyl]anthranilic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-6-chloro-N-[(methoxycarbonyl)methyl]anthranilic acid methyl ester(6388-45-0)
• EPA Substance Registry System: 5-bromo-6-chloro-N-[(methoxycarbonyl)methyl]anthranilic acid methyl ester(6388-45-0)

Safety Data

• Hazardous Substances Data: 6388-45-0(Hazardous Substances Data)

Upstream product

• 125328-80-5 N-(4-bromo-3-chloro-2-methylphenyl)acetamide 
• 627531-47-9 4-amino-2-chloro-3-methylbromobenzene 
• 67-56-1 methanol 
• 1607828-47-6 5-bromo-6-chloro-N-[(methoxycarbonyl)methyl]-isatoic anhydride 
• 943138-45-2 5-bromo-6-chloro-isatoic anhydride 
• 3030-19-1 2-amino-5-bromo-6-chlorobenzoic acid 
• 125328-77-0 N-acetyl-5-bromo-6-chloroanthranilic acid 

Downstream Products

• 1607828-63-6 (5-bromo-4-chloroindol-3-yl) (β-D-galactopyranosyl)-(1→4)-β-D-glucopyranoside 

Relevant articles and documents

Indoxylic acid esters as convenient intermediates towards indoxyl glycosides

Indoxylic acid methyl and allyl esters with varied halide-substitution patterns were obtained in excellent yields using a scalable route. Phase-transfer glycosylation of these key intermediates was carried out with various glycosyl halides. Subsequent mild silver-mediated decarboxylation followed by Zemplen deacetylation led to indoxyl glycosides in good overall yields. Indoxyl glycosides are well-established and widely used tools for enzyme screening and enzyme-activity monitoring. In the past, their synthesis has been difficult, so this new approach has led to a variety of useful structures. Indoxyl glycosides with varied halide-substitution patterns were synthesized using indoxylic acid esters as key intermediates. Glycosylation under phase-transfer conditions, ester cleavage, and mild decarboxylation led to the indoxyl glycosides in good yields. This approach enables access to a number of different indoxyl compounds. Copyright