639820-88-5

Basic information

• Product Name: 1-methyl-2-(2-phenyl-[1,3]dithian-2-ylmethyl)-piperidine
• CAS NO: 639820-88-5
• Molecular Weight: 307.524
• Mol File: 639820-88-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methyl-2-(2-phenyl-[1,3]dithian-2-ylmethyl)-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-(2-phenyl-[1,3]dithian-2-ylmethyl)-piperidine(639820-88-5)
• EPA Substance Registry System: 1-methyl-2-(2-phenyl-[1,3]dithian-2-ylmethyl)-piperidine(639820-88-5)

Safety Data

• Hazardous Substances Data: 639820-88-5(Hazardous Substances Data)

Upstream product

• 20845-34-5 (1-methyl-piperidin-2-yl)-methanol 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 49665-74-9 2-(chloromethyl)-N-methyl-piperidine 

Relevant articles and documents

Rigidified acetylcholine mimics: Conformational requirements for binding to neuronal nicotinic receptors

Rigidified derivatives have been designed and synthesized assuming the g+t conformer of acetylcholine (N-C-C-O=+60°, C-C-O-C=180°) as active conformation for binding to cytisine sensitive neuronal nicotinic receptors. The SAR of the compounds evaluated, along with those of more flexible analogues, support the g+t conformer hypothesis and highlight the stringent steric limitation of this nicotinic receptor sub-type. Compound 3e has low μM affinity for cytisine sensitive nicotinic receptor binding sites while being selective with regard to the α-bungarotoxin sensitive subclass. We also report few compounds with μM affinity for the α-bungarotoxin sensitive subclass.