6404-31-5Relevant articles and documents
A Next-Generation Air-Stable Palladium(I) Dimer Enables Olefin Migration and Selective C?C Coupling in Air
Kundu, Gourab,Rissanen, Kari,Schoenebeck, Franziska,Sperger, Theresa
, p. 21930 - 21934 (2020/10/02)
We report a new air-stable PdI dimer, [Pd(μ-I)(PCy2tBu)]2, which triggers E-selective olefin migration to enamides and styrene derivatives in the presence of multiple functional groups and with complete tolerance of air. The same dimer also triggers extremely rapid C?C coupling (alkylation and arylation) at room temperature in a modular and triply selective fashion of aromatic C?Br, C?OTf/OFs, and C?Cl bonds in poly(pseudo)halogenated arenes, displaying superior activity over previous PdI dimer generations for substrates that bear substituents ortho to C?OTf.
3-(trimethylsilyl) pyrrolidine-2-carboxylic acid, its intermediate, preparation and application thereof
-
Paragraph 0065; 0066, (2018/10/19)
The invention relates to 3-(trimethylsilyl) pyrrolidine-2-carboxylic acids, its intermediates , preparation and application thereof, the structural formula of the described 3-(trimethylsilyl) pyrrolidine-2-carboxylic acid is (the structural formula of the described 3-(trimethylsilyl) pyrrolidine-2-carboxylic acid is shown in the description). The preparation method uses chiral proline as raw material, and carries out C-H bond activation reaction with silanization reagent after protective group and adjuvant are introduced, then an intermediate is obtained after removing protective group; the intermediate can remove auxiliary groups under the acid action and the described 3-(trimethylsilyl) pyrrolidine-2-carboxylic acid can be obtained. 3-(trimethylsilyl) pyrrolidine-2-carboxylic acids are used in asymmetric catalytic reactions. The reaction condition of the 3-(trimethylsilyl) pyrrolidine-2-carboxylic acid is mild, with high chemical yield, which provides a new way for the synthesis of the silicon-containing structural analogue, and the prepared (2R, 3R)-3-(trimethylsilyl) pyrrolidine-2-carboxylic acid, (2S, 3S)-3-(trimethylsilyl) pyrrolidine-2-carboxylic acid can be used as chiral catalyst for asymmetric reaction, and has good application prospect.
BIPHENYL COMPOUNDS AND USES THEREOF
-
Paragraph 00191, (2015/05/19)
The present invention relates to biphenyl compounds and uses thereof in medicine. Specifically, the present invention relates to a compound of Formula (I), or a stereoisomer, a geometric isomer, a tautomer, a mesomer, a racemate, an enantiomer, a diastereoisomer, an N-oxide, a hydrate, a solvate, a metabolite, a hydrolysate, a pharmaceutically acceptable salt or a prodrug thereof. The compound disclosed herein is used as a therapeutic agent particularly a GPR40 agonist for treating diabetes and metabolic disease in a patient.