64099-82-7

Basic information

• Product Name: TRIBUTYLPROPYNYLSTANNANE
• Synonyms: PROPYNYLTRI-N-BUTYLTIN;Tributyl-1-propynylstannane;TRIBUTYLPROPYNYLSTANNANE;(1-PROPYNYL)TRIBUTYLSTANNANE;1-PROPYNYLTRI-N-BUTYLTIN;tech.80%;Tributyl-1-propynylstannane, tech., 80%;Tributyl-1-propynylstannane, 80%, tech.
• CAS NO: 64099-82-7
• Molecular Formula: C₁₅H₃₀Sn
• Molecular Weight: 329.11
• Product Categories: Organometallic Reagents;Organotin;Organotins;Stannanes
• Mol File: 64099-82-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 277 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.082 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000768mmHg at 25°C
• Refractive Index: n20/D 1.483(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: TRIBUTYLPROPYNYLSTANNANE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIBUTYLPROPYNYLSTANNANE(64099-82-7)
• EPA Substance Registry System: TRIBUTYLPROPYNYLSTANNANE(64099-82-7)

Safety Data

• Hazard Codes: T,N
• Statements: 21-25-36/38-48/23/25-50/53
• Safety Statements: 35-36/37/39-45-60-61
• RIDADR: UN 2788 6.1/PG 3
• WGK Germany: 3
• TSCA: No
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 64099-82-7(Hazardous Substances Data)

Usage

Description

TRIBUTYLPROPYNYLSTANNANE, also known as Tributyl(1-propynyl)tin, is an organotin compound with the chemical formula (C4H9)3SnC≡CH. It is a colorless liquid with a characteristic odor and is soluble in organic solvents. Its unique structure and reactivity make it a versatile intermediate in organic synthesis.

Uses

Used in Pharmaceutical Synthesis:
TRIBUTYLPROPYNYLSTANNANE is used as a starting material for the synthesis of phenyl-substituted pyrimidine-dione by reacting with ethyl isocyanate via cycloaddition and Stille coupling reactions. TRIBUTYLPROPYNYLSTANNANE has potential applications in the development of new pharmaceutical agents.
Used in Positron Emission Tomography (PET) Imaging:
TRIBUTYLPROPYNYLSTANNANE is used in the synthesis of 18F labeled triazolo quinoline derivative, a PET ligand used in the in vivo imaging of metabotropic glutamate receptor type 1 (mGluR1). This application aids in the visualization and study of mGluR1-related neurological disorders.
Used in the Synthesis of mGluR1 Antagonists:
TRIBUTYLPROPYNYLSTANNANE is used as a key synthetic intermediate in the synthesis of 4-(1-aryltriazol-4-yl)-tetrahydropyridines, which are potent mGluR1 antagonists. These antagonists have potential therapeutic applications in the treatment of various neurological and psychiatric disorders, such as anxiety, depression, and schizophrenia.

InChI:InChI=1/3C4H9.C3H3.Sn/c3*1-3-4-2;1-3-2;/h3*1,3-4H2,2H3;1H3;/rC15H30Sn/c1-5-9-13-16(12-8-4,14-10-6-2)15-11-7-3/h5-7,9-11,13-15H2,1-4H3

Downstream Products

• 136015-76-4 [(Z)-2-(4-Chloro-phenyl)-pent-1-en-3-ynyl]-trimethyl-silane 
• 119839-50-8 methyl 2-amino-N-(benzyloxycarbonyl)-3-pentynoate 
• 136015-74-2 Trimethyl-((Z)-2-phenyl-pent-1-en-3-ynyl)-silane 
• 142363-45-9 1-propynyl(phenyl)iodonium triflate 
• 13752-78-8 2-butynenitrile 
• 619331-51-0 1-(4-benzoylpiperazin-1-yl)-2-(4-chloro-7-prop-1-ynyl-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione 
• 524729-01-9 2-[[6-methoxy-3-pyridinyl]methyl]amino-N-[4-(1-propynyl)-3-(trifluoromethyl)phenyl]benzamide 
• 910868-09-6 1-tert-butyl-2-prop-1-ynyl-3-nitrobenzene 
• 915395-92-5 5-phenyl-3-propynylisothiazole-4-carbonitrile 
• 130826-42-5 C₆H₅CH₂C(Sn(C₄H₉)3)CHCH₃ 
• 1187367-35-6 N-[1-[4-(methoxyimino-methyl)-2-prop-1-ynyl-phenyl]-3-(6-methyl-pyridin-3-yl)-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl]-acetamide 
• 112921-88-7 1-(4-(prop-1-yn-1-yl)phenyl)ethan-1-one 
• 1257848-40-0 3-(1-propyn-1-yl)benzonitrile 
• 1439560-13-0 2-(2,6-dichloro-4-prop-1-ynyl-phenyl)-3-methoxy-5-(2-pyridylmethyl)cyclopent-2-en-1-one