641614-88-2

Basic information

• Product Name: 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide
• Synonyms: 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide
• CAS NO: 641614-88-2
• Molecular Weight: 562.597
• Mol File: 641614-88-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide(641614-88-2)
• EPA Substance Registry System: 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide(641614-88-2)

Safety Data

• Hazardous Substances Data: 641614-88-2(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 859213-40-4 4-(bromomethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide 
• 261952-01-6 4-methyl-3-(trifluoromethyl)benzoic acid 
• 948553-14-8 4-(bromomethyl)-3-(trifluoromethyl)benzoyl chloride 
• 859213-39-1 4-(bromomethyl)-3-(trifluoromethyl)benzoic acid 
• 641615-36-3 N₁-([4,5'-bipyrimidin]-2-yl)-6-methylbenzene-1,3-diamine 

Downstream Products

• 641615-24-9 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide hydrochloride 
• 641615-26-1 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide methanesulfonate 

Relevant articles and documents

Design and synthesis of 3-substituted benzamide derivatives as Bcr-Abl kinase inhibitors

A series of 3-substituted benzamide derivatives structurally related to STI-571 (imatinib mesylate), a Bcr-Abl tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML), was prepared and evaluated for antiproliferative activity against the Bc

AMIDE DERIVATIVE

The present invention provides an amide derivative represented by the following general formula (1): wherein R1 represents a saturated cyclic amino group, R2 represents alkyl, halogen or haloalkyl, R3 represents hydrogen or halogen, Het 2 represents pyridyl or pyrimidinyl, and Het 1 represents a group of the formula [6], or a salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.