261952-01-6 Usage
Description
4-Methyl-3-(trifluoromethyl)benzoic acid is an organic compound characterized by its light brown solid appearance. It features a benzoic acid structure with a methyl group at the 4th position and a trifluoromethyl group at the 3rd position, which contributes to its unique chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
4-Methyl-3-(trifluoromethyl)benzoic acid is used as an intermediate in the synthesis of Bafetinib (B109050), a substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). Bafetinib is identified as a highly potent Bcr-Abl kinase inhibitor, playing a crucial role in the development of targeted cancer therapies.
Used in COVID-19 Research:
4-Methyl-3-(trifluoromethyl)benzoic acid is also a COVID-19-related research product, indicating its potential application in the development of treatments or therapies for the novel coronavirus. Its specific role in this context may involve the synthesis of compounds that target viral proteins or pathways, contributing to the ongoing efforts to combat the pandemic.
Check Digit Verification of cas no
The CAS Registry Mumber 261952-01-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,1,9,5 and 2 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 261952-01:
(8*2)+(7*6)+(6*1)+(5*9)+(4*5)+(3*2)+(2*0)+(1*1)=136
136 % 10 = 6
So 261952-01-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H6F3N/c1-6-2-3-7(5-13)8(4-6)9(10,11)12/h2-4H,1H3
261952-01-6Relevant articles and documents
Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent
Shi, Guangfa,Shao, Changdong,Pan, Shulei,Yu, Jingxun,Zhang, Yanghui
, p. 38 - 41 (2015/07/28)
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. (Chemical Equation Presented).