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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-(Trifluoromethyl)-4-Methylbenzoic Acid supplier in China

Cas:261952-01-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:Shanghai, Qingdao

4-Methyl-3-(trifluoromethyl)benzoic acid 261952-01-6

Cas:261952-01-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-(Trifluoromethyl)-p-toluic acid

Cas:261952-01-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Methyl-3-(trifluoromethyl)benzoic acid CAS:261952-01-6

Cas:261952-01-6

Min.Order:1 Kilogram

FOB Price: $8.0 / 15.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 261952-01-6 with fast shipping

Cas:261952-01-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoic acid,4-methyl-3-(trifluoromethyl)- 261952-01-6

Cas:261952-01-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Agrochemical Intermediates , 4-Methyl-3-(trifluoromethyl)benzoic acid CAS:261952-01-6

Cas:261952-01-6

Min.Order:1 Kilogram

FOB Price: $142.0 / 158.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

4-Methyl-3-(trifluoromethyl)benzoic acid CAS:261952-01-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

4-Methyl-3-(trifluoromethyl)benzoic acid CAS:261952-01-6

Cas:261952-01-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-Methyl-3-(trifluoromethyl)benzoic acid 261952-01-6

Cas:261952-01-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Methyl-3-(Trifluoromethyl)Benzoicacid

Cas:261952-01-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-(Trifluoromethyl)-4-Methylbenzoic Acid

Cas:261952-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzoic acid,4-methyl-3-(trifluoromethyl)-

Cas:261952-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Methyl-3-(trifluoromethyl)benzoic acid CAS NO.261952-01-6

Cas:261952-01-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

4-Methyl-3-(trifluoromethyl)benzoic acid Basic information Product Name: 4-Methyl-3-(trifluoromethyl)benzoic acid Synonyms: RARECHEM AL BO 0960;M

261952-01-6 C9H7F3O2 4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Methyl-3-(Trifluoromethyl)benzoic Acid CAS No.:261952-01-6 Molecule Formula:C9H6F3N Molecule Weight:185.15 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

High Quality 4-Methyl-3-(Trifluoromethyl)benzoic Acid on stock

Cas:261952-01-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-Methyl-3-(trifluoromethyl)benzoicacid

Cas:261952-01-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-Methyl-3-(trifluoromethyl)benzoic acid

Cas:261952-01-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Methyl-3-(trifluoromethyl)benzoic acid cas no. 261952-01-6 97%

Cas:261952-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-methyl-3-(trifluoromethyl)benzonitrile

4-methyl-3-(trifluoromethyl)benzonitrile

4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

Conditions
ConditionsYield
Stage #1: 4-methyl-3-(trifluoromethyl)benzonitrile With water; sodium hydroxide In ethanol for 6h; Reflux;
Stage #2: With hydrogenchloride In ethanol; water
para-methylbenzonitrile
104-85-8

para-methylbenzonitrile

4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: silver carbonate; sodium carbonate; dipotassium peroxodisulfate / dichloromethane / 10 h / 120 °C / Schlenk technique; Sealed tube
2: sodium hydroxide; water / ethanol / 6 h / Reflux
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-dibromomethyl-3-trifluoromethyl-benzoic acid
1303518-35-5

4-dibromomethyl-3-trifluoromethyl-benzoic acid

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrachloromethane for 1h; Reflux; UV-irradiation;100%
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane; water for 24h; Reflux;100%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

3-bromo-4-methyl-5-trifluoromethylbenzoic acid

3-bromo-4-methyl-5-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With N-Bromosuccinimide; sulfuric acid at 20℃; for 16h;100%
With N-Bromosuccinimide; sulfuric acid at 20℃; for 16h;98%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

methanol
67-56-1

methanol

4-methyl-3-(trifluoromethyl)benzoic acid methyl ester
116419-94-4

4-methyl-3-(trifluoromethyl)benzoic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid Reflux;96%
sulfuric acid for 6h; Reflux;95%
With sulfuric acid Reflux;95%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

C9H6F3NO4
1070886-95-1

C9H6F3NO4

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 100℃; for 1.5h;96%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

N-(3-ethynylphenyl)-4-methyl-3-(trifluoromethyl)benzamide

N-(3-ethynylphenyl)-4-methyl-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h; Schlenk technique; Inert atmosphere;95.2%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;95.2%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

methyl iodide
74-88-4

methyl iodide

4-methyl-3-(trifluoromethyl)benzoic acid methyl ester
116419-94-4

4-methyl-3-(trifluoromethyl)benzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 24h;95%
Stage #1: 4-methyl-3-(trifluoromethyl)benzoic acid With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 18h;
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h;
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N,4-dimethyl-3-(trifluoromethyl)benzamide
1173793-77-5

N-methoxy-N,4-dimethyl-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;86%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 6h;
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

(4-methyl-3-(trifluoromethyl)phenyl)methanol

(4-methyl-3-(trifluoromethyl)phenyl)methanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 25℃; for 12h;77.2%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

3-bromo-1,1,1-trifluoroacetone
431-35-6

3-bromo-1,1,1-trifluoroacetone

C12H6F6O2

C12H6F6O2

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; silver(I) acetate; XPhos In 2,2,2-trifluoroethanol at 140℃; for 24h; Sealed tube;75%
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate In 2,2,2-trifluoroethanol at 140℃; for 24h;65%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

8-methyl-2,8-diazaspiro[4.5]decane

8-methyl-2,8-diazaspiro[4.5]decane

C18H23F3N2O

C18H23F3N2O

Conditions
ConditionsYield
Stage #1: 4-methyl-3-(trifluoromethyl)benzoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 0℃; for 2.5h; Inert atmosphere;
Stage #2: 8-methyl-2,8-diazaspiro[4.5]decane In dichloromethane at 20℃; for 12h; Inert atmosphere;
69%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

C12H11F3O4

C12H11F3O4

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; copper(II) acetate monohydrate at 100℃; for 24h; Sealed tube;55%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

3-(5-amino-2-methylphenyl)-7-((3-amino-4-methylphenyl)-amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

3-(5-amino-2-methylphenyl)-7-((3-amino-4-methylphenyl)-amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

N-(3-(7-((3-amino-4-methylphenyl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-4-methyl-3-(trifluoromethyl)benzamide

N-(3-(7-((3-amino-4-methylphenyl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-4-methyl-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 14h; Inert atmosphere;52%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

3-(5-amino-2-methylphenyl)-1-methyl-7-((6-methylpyridin-3-yl)amino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

3-(5-amino-2-methylphenyl)-1-methyl-7-((6-methylpyridin-3-yl)amino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

4-methyl-N-(4-methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)-3-(trifluoromethyl)benzamide

4-methyl-N-(4-methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;48%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

5-((5-amino-2-methylbenzyl)amino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester
1616628-98-8

5-((5-amino-2-methylbenzyl)amino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester

5-[(2-methyl-5-(4-methyl-3-(trifluoromethyl)benzoylamino)benzyl)amino]-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester
1616670-12-2

5-[(2-methyl-5-(4-methyl-3-(trifluoromethyl)benzoylamino)benzyl)amino]-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 4-methyl-3-(trifluoromethyl)benzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 5-((5-amino-2-methylbenzyl)amino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester In N,N-dimethyl-formamide at 20℃;
26%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

C14H18N4O3

C14H18N4O3

(E)-N-(1-(3-hydroxypropyl)-5-(3-oxomorpholino)-1H-benzo[d]imidazol-2(3H)-ylidene)-4-methyl-3-(trifluoromethyl)benzamide

(E)-N-(1-(3-hydroxypropyl)-5-(3-oxomorpholino)-1H-benzo[d]imidazol-2(3H)-ylidene)-4-methyl-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 1h;22%
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-(bromomethyl)-3-(trifluoromethyl)benzoic acid
859213-39-1

4-(bromomethyl)-3-(trifluoromethyl)benzoic acid

Conditions
ConditionsYield
With sodium bromate; sodium hydrogensulfite In ethyl acetate
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 1.5h; Heating / reflux; irradiated with a 125 W lamp;
With sodium bromate; sodium hydrogensulfite In Isopropyl acetate; water at 30 - 60℃; Heating / reflux;
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

ethanol
64-17-5

ethanol

4-methyl-3-trifluoromethyl-benzoic acid ethyl ester
859026-99-6

4-methyl-3-trifluoromethyl-benzoic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid Heating;
With sulfuric acid for 23h; Heating / reflux;
With sulfuric acid Reflux;
With sulfuric acid Reflux; Inert atmosphere;
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-(bromomethyl)-3-(trifluoromethyl)benzoyl chloride
948553-14-8

4-(bromomethyl)-3-(trifluoromethyl)benzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBrO3; NaHSO3 / ethyl acetate
2: (COCl)2; DMF / CH2Cl2 / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogensulfite; sodium bromate / water; Isopropyl acetate / Reflux
2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 5 h / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-bromomethyl-3-trifluoromethyl-benzoic acid ethyl ester
859027-01-3

4-bromomethyl-3-trifluoromethyl-benzoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2SO4 / Heating
2: N-bromosuccinimide / (PhCO)2O2 / CCl4 / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogensulfite; sodium bromate / ethyl acetate; water / 20 - 50 °C
2: sulfuric acid / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium bromate; sodium hydrogensulfite / water; ethyl acetate / 20 - 50 °C
2: sulfuric acid / 80 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) benzoic acid
859027-02-4

4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2SO4 / Heating
2: N-bromosuccinimide / (PhCO)2O2 / CCl4 / Heating
3: K2CO3 / tetrahydrofuran / 20 °C
4: aq. NaOH / Heating
View Scheme
Multi-step reaction with 4 steps
1: sulfuric acid / Reflux
2: N-Bromosuccinimide; Perbenzoic acid / tetrachloromethane; water / 6 h / Reflux
3: potassium carbonate / acetonitrile / Reflux; Inert atmosphere
4: lithium hydroxide; water / tetrahydrofuran / 4 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 24 h / 20 °C
2: N-Bromosuccinimide; dibenzoyl peroxide / chloroform / 18 h / Reflux
3: chloroform / 3 h / 20 °C
4: sodium hydroxide / ethanol / 3 h / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoic acid ethyl ester
859027-00-2

4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2SO4 / Heating
2: N-bromosuccinimide / (PhCO)2O2 / CCl4 / Heating
3: K2CO3 / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium bromate; sodium hydrogensulfite / water; ethyl acetate / 20 - 50 °C
2: sulfuric acid / 80 °C
3: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-(bromomethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide
859213-40-4

4-(bromomethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBrO3; NaHSO3 / ethyl acetate
2: (COCl)2; DMF / CH2Cl2 / 20 °C
3: K2CO3 / dioxane / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: H2SO4 / Heating
2: N-bromosuccinimide / (PhCO)2O2 / CCl4 / Heating
3: K2CO3 / tetrahydrofuran / 20 °C
4: aq. NaOH / Heating
5: SOCl2 / Heating
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-[3-(dimethylamino)azetidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

4-[3-(dimethylamino)azetidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBrO3; NaHSO3 / ethyl acetate
2: (COCl)2; DMF / CH2Cl2 / 20 °C
3: K2CO3 / dioxane / 20 °C
4: K2CO3 / dimethylformamide / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide
641614-88-2

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBrO3; NaHSO3 / ethyl acetate
2: (COCl)2; DMF / CH2Cl2 / 20 °C
3: K2CO3 / dioxane / 20 °C
4: K2CO3 / dimethylformamide / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: H2SO4 / Heating
2: N-bromosuccinimide / (PhCO)2O2 / CCl4 / Heating
3: K2CO3 / tetrahydrofuran / 20 °C
4: aq. NaOH / Heating
5: SOCl2 / Heating
6: pyridine / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-[(R)-3-(dimethylamino)pyrrolidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

4-[(R)-3-(dimethylamino)pyrrolidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBrO3; NaHSO3 / ethyl acetate
2: (COCl)2; DMF / CH2Cl2 / 20 °C
3: K2CO3 / dioxane / 20 °C
4: K2CO3 / dimethylformamide / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

Bafetinib

Bafetinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBrO3; NaHSO3 / ethyl acetate
2: (COCl)2; DMF / CH2Cl2 / 20 °C
3: K2CO3 / dioxane / 20 °C
4: K2CO3 / dimethylformamide / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-[(S)-3-(dimethylaminomethyl)pyrrolidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

4-[(S)-3-(dimethylaminomethyl)pyrrolidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBrO3; NaHSO3 / ethyl acetate
2: (COCl)2; DMF / CH2Cl2 / 20 °C
3: K2CO3 / dioxane / 20 °C
4: K2CO3 / dimethylformamide / 20 °C
View Scheme
4-methyl-3-(trifluoromethyl)benzoic acid
261952-01-6

4-methyl-3-(trifluoromethyl)benzoic acid

4-[(R)-3-(dimethylaminomethyl)pyrrolidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

4-[(R)-3-(dimethylaminomethyl)pyrrolidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaBrO3; NaHSO3 / ethyl acetate
2: (COCl)2; DMF / CH2Cl2 / 20 °C
3: K2CO3 / dioxane / 20 °C
4: K2CO3 / dimethylformamide / 20 °C
View Scheme

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