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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Aminophenylacetylene supplier in China

Cas:54060-30-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Official website: http://www.finerchem.com/pro01en/id/18.html Product Description Product Name 3-Aminophenylacetylene/ 3-Ethynylaniline CAS No. 54060-30-9

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1 Gram

FOB Price: $52.0

Type:Lab/Research institutions

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Nanjing Yuance Industry&Trade Co., Ltd.

Purity 99% with good quality Competitive price Fast delivery Prompt shipment Appearance:White powder Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing

3-Ethynyl aniline or (3-aminophenylacetylene)

Cas:54060-30-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good price Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:As per customer's demand Application:Biological buffer Transportation:By Sea or By Air or By Courier Port:shanghai

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

3-Aminophenylacetylene[CAS:54060-30-9] 2-Bromoethyl Methyl Ether[CAS:6482-24-2] 3-Aminophenylacetylene HCL[CAS:207726-02-6] 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline[CAS:183322-18-1] 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone[CAS:179

High purity 3-Aminophenylacetylene for Erlotinib

Cas:54060-30-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 3-Aminophenylacetylene 54060-30-9 ISO Producer

Cas:54060-30-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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EAST CHEMSOURCES LIMITED

3-ethynylaniline Appearance: light yellow to colorless liquid CAS NO.:54060-30-9 Molecular Formula: C8H7N Product technical standards: Item Melting point 27°C

3-ethynylaniline

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

Basic information Product Name: 3-Aminophenylacetylene Synonyms: M-ETHYNYLANILINE;M-AMINOPHENYL ACETYLENE;3-AMINOPHENYLACETYLENE;3-ETHYNYLBENZENEAMINE;3-ETHYNYL-PHENYLAMINE;3-ETHYNYLANILINE;3-ethynyl-benzenamin;Benzenamine, 3-ethynyl

3-ethynylaniline

Cas:54060-30-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% 5. Chi

3-Aminophenylacetylene;3-Ethynylaniline(54060-30-9)

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 3-Ethynylaniline

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

3-Aminophenylacetylene CAS NO.54060-30-9

Cas:54060-30-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

3-Aminophenylacetylene Basic information Product Name: 3-Aminophenylacetylene Synonyms: M-ETHYNYLANILINE;M-AMINOPHENYL ACETYLENE;3-AMINOPHENYLACETYLENE;3-ETHYNYLBENZENEAMINE;3-ETHYNYL-PH

54060-30-9

Cas:54060-30-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 54060-30-9 with best quality

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Information Product Name: 3-Aminophenylacetylene Appearance: Transparent slightly yellow liquid M.F.: C8H7N M.W.: 117.15 CAS NO.: 54060-30-9 EINECS NO.: 258-944-6

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

3-Aminophenylacetylene CAS NO 54060-30-9

Cas:54060-30-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Aminophenylacetylene 54060-30-9

Cas:54060-30-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

3-Aminophenylacetylene with CAS:54060-30-9

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $312.0 / 334.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

3-Aminophenylacetylene CAS:54060-30-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

3-Aminophenylacetylene CAS:54060-30-9

Cas:54060-30-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail bes

Factory price 99% 3-AMinophenylacetylene CAS:54060-30-9

Cas:54060-30-9

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Aminophenylacetylene

Cas:54060-30-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 3-Aminophenylacetylene Synonyms: 3-Ethynlaniline;1-Amino-3-ethynylbenzene;1-Ethynyl-3-aminobenzene;m-Ethnylaniline;3-Ethynylaniline ,98%;3-Ethynylaniline HC;3-AMinophenylacetylene, 98% 25GR;3-AMinophenylacetylene, 98% 5GR CAS: 54

3-Aminophenylacetylene supplier best quality

Cas:54060-30-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

3-ethynylaniline

Cas:54060-30-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-methyl-4-(3-aminophenyl)-3-butyn-2-ol
69088-96-6

2-methyl-4-(3-aminophenyl)-3-butyn-2-ol

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With sodium hydroxide In toluene at 105 - 110℃; for 4h; Inert atmosphere;100%
With sodium hydroxide In toluene at 105 - 110℃; for 4h; Inert atmosphere;100%
With sodium hydroxide; ascorbic acid In water; toluene at 90℃; for 1h; Product distribution / selectivity;97.9%
N‐(3‐ethynylphenyl)formamide
1364394-80-8

N‐(3‐ethynylphenyl)formamide

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 70 - 75℃; for 2.5h;95%
3-nitrophenylacetylene
3034-94-4

3-nitrophenylacetylene

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With hydrogenchloride; iron In methanol; water Reflux;93.5%
With iron; ammonium chloride In ethanol; water at 85℃; for 3h; Solvent; Reagent/catalyst; Concentration;92.8%
With ammonium hydroxide; zinc for 24h; Ambient temperature;36%
N-(3-ethynylphenyl)acetamide
70933-58-3

N-(3-ethynylphenyl)acetamide

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 70℃; for 2h;90%
C18H17NO2

C18H17NO2

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With water; potassium hydroxide In ethanol at 75℃; for 3.5h;89%
2-methyl-4-(3-aminophenyl)-3-butyn-2-ol
69088-96-6

2-methyl-4-(3-aminophenyl)-3-butyn-2-ol

A

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

B

3-(4-(3-aminophenyl)buta-1,3-diynyl)benzeneamine
31661-59-3

3-(4-(3-aminophenyl)buta-1,3-diynyl)benzeneamine

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 90℃; for 1h; Product distribution / selectivity;A 87.6%
B 7.3%
2-methyl-but-3-yn-2-ol
115-19-5

2-methyl-but-3-yn-2-ol

3-bromoaniline
591-19-5

3-bromoaniline

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; N,N,N',N'-tetramethylguanidine at 60℃; for 3h; Reagent/catalyst; Schlenk technique; Inert atmosphere; Green chemistry;86%
cobalt polysulfide

cobalt polysulfide

3-nitrophenylacetylene
3034-94-4

3-nitrophenylacetylene

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
In isopropyl alcohol82%
7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
208459-84-1

7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

A

(3-Ethynyl-phenyl)-[5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine

(3-Ethynyl-phenyl)-[5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine

B

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
A 75%
B n/a
3-nitrophenylacetylene
3034-94-4

3-nitrophenylacetylene

A

1,2-bis(3-ethynylphenyl)diazene oxide
871895-82-8

1,2-bis(3-ethynylphenyl)diazene oxide

B

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With Ru/C; sodium hydroxide In tetrahydrofuran; ethanol at 60℃; for 18h; Microwave irradiation;A 50%
B 15%
1-amino,3-trimethylsilylethynylbenzene
110598-30-6

1-amino,3-trimethylsilylethynylbenzene

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With potassium hydroxide In methanol; dichloromethane at 20℃; for 3h;43.1%
With potassium carbonate In tetrahydrofuran; methanol Inert atmosphere;
3-nitrophenylacetylene
3034-94-4

3-nitrophenylacetylene

A

1,2-bis(3-ethynylphenyl)diazene
137024-35-2

1,2-bis(3-ethynylphenyl)diazene

B

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
With Ru/C; sodium hydroxide In tetrahydrofuran; ethanol at 100℃; for 24h; Microwave irradiation;A 37%
B 14%
7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
208459-84-1

7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

A

[5-(4-Chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin4-yl]-(3-ethynyl-phenyl)-amine

[5-(4-Chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin4-yl]-(3-ethynyl-phenyl)-amine

B

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
A 33%
B n/a
7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
208459-84-1

7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

m-nitrobenzene boronic acid
13331-27-6

m-nitrobenzene boronic acid

A

(3-Ethynyl-phenyl)-[5-(3-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin4-yl]-amine

(3-Ethynyl-phenyl)-[5-(3-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin4-yl]-amine

B

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
A 15%
B n/a
3-Iodoaniline
626-01-7

3-Iodoaniline

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / bis(triphenylphosphine)palladium(II) chloride, CuI, Et3N / 2 h / 40 °C
2: 56 percent / NaOH / toluene / 2 h
View Scheme
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / tetrahydrofuran / 20 °C
2: potassium hydroxide / methanol; dichloromethane / 3 h / 20 °C
View Scheme
3-chloro-aniline
108-42-9

3-chloro-aniline

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 48 h / 80 °C / Inert atmosphere
2: sodium hydroxide / toluene / 4 h / 105 - 110 °C / Inert atmosphere
View Scheme
3-bromoaniline
591-19-5

3-bromoaniline

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / 80 °C / Inert atmosphere
2: sodium hydroxide / toluene / 4 h / 105 - 110 °C / Inert atmosphere
View Scheme
3-Bromonitrobenzene
585-79-5

3-Bromonitrobenzene

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / palladium diacetate; XPhos / tetrahydrofuran / 80 °C / Inert atmosphere
2: hydrogen / cobalt polysulfide / isopropyl alcohol / 1.25 h / 110 °C / 52476.2 Torr / Autoclave
3: sodium hydroxide / toluene / 4 h / 105 - 110 °C / Inert atmosphere
View Scheme
2-methyl-4-(3-nitrophenyl)-3-butyn-2-ol
33432-52-9

2-methyl-4-(3-nitrophenyl)-3-butyn-2-ol

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / cobalt polysulfide / isopropyl alcohol / 1.25 h / 110 °C / 52476.2 Torr / Autoclave
2: sodium hydroxide / toluene / 4 h / 105 - 110 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / cobalt polysulfide / isopropyl alcohol / 1.25 h / 110 °C / 51716.2 Torr / Inert atmosphere
2: sodium hydroxide / toluene / 4 h / 105 - 110 °C / Inert atmosphere
View Scheme
acetophenone
98-86-2

acetophenone

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid / 0.17 h / -10 °C
2: pyridine; trichlorophosphate / toluene / 20 - 115 °C
3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 55 °C
4: iron; ammonium chloride / water; ethanol / 3 h / 85 °C
View Scheme
3-Nitroacetophenone
121-89-1

3-Nitroacetophenone

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; trichlorophosphate / toluene / 20 - 115 °C
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 55 °C
3: iron; ammonium chloride / water; ethanol / 3 h / 85 °C
View Scheme
1-chloro-1-(3-nitrophenyl)ethylene
99419-61-1

1-chloro-1-(3-nitrophenyl)ethylene

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 55 °C
2: iron; ammonium chloride / water; ethanol / 3 h / 85 °C
View Scheme
C9H8O3S

C9H8O3S

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium diacetate; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; barium carbonate / water; tert-butyl alcohol / 7 h / 110 °C / Inert atmosphere
2: sodium hydroxide; water / ethanol / 2.5 h / 70 - 75 °C
View Scheme
3-bromophenylacetylene
766-81-4

3-bromophenylacetylene

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium phosphate; palladium diacetate; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine / water; tert-butyl alcohol / 4.5 h / 110 °C / Inert atmosphere
2: sodium hydroxide; water / ethanol / 2 h / 70 °C
View Scheme
2-methyl-4-(3-chlorophenyl)-3-butyn-2-ol

2-methyl-4-(3-chlorophenyl)-3-butyn-2-ol

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium phosphate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / water / 6.5 h / 110 °C / Inert atmosphere
2: water; potassium hydroxide / ethanol / 3.5 h / 75 °C
View Scheme
nitrobenzene
98-95-3

nitrobenzene

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; copper(l) chloride / methanol; acetonitrile / 18 h / 20 °C / Inert atmosphere; Irradiation
2: sodium tetrahydroborate; water / 20 h / pH 9 / Irradiation
View Scheme
3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine; piperidine / isopropyl alcohol / Heating
2: bromine; acetic acid / dichloromethane / 20 °C
3: triethylamine / N,N-dimethyl-formamide / 0.03 h / 35 °C / Microwave irradiation
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0.17 h / 35 °C / Microwave irradiation
5: hydrazine hydrate; palladium 10% on activated carbon / ethanol / Heating
View Scheme
m-Nitrocinnamic Acid
555-68-0

m-Nitrocinnamic Acid

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: bromine; acetic acid / dichloromethane / 20 °C
2: triethylamine / N,N-dimethyl-formamide / 0.03 h / 35 °C / Microwave irradiation
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0.17 h / 35 °C / Microwave irradiation
4: hydrazine hydrate; palladium 10% on activated carbon / ethanol / Heating
View Scheme
2,3-dibromo-3-(3-nitro-phenyl)-propionic acid
18193-72-1

2,3-dibromo-3-(3-nitro-phenyl)-propionic acid

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / N,N-dimethyl-formamide / 0.03 h / 35 °C / Microwave irradiation
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0.17 h / 35 °C / Microwave irradiation
3: hydrazine hydrate; palladium 10% on activated carbon / ethanol / Heating
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

(3-ethynyl-phenyl)-carbamic acid tert-butyl ester
185619-66-3

(3-ethynyl-phenyl)-carbamic acid tert-butyl ester

Conditions
ConditionsYield
In tetrahydrofuran Heating;100%
Stage #1: di-tert-butyl dicarbonate; 3-acetylenephenylamine In tetrahydrofuran at 70℃;
Stage #2: With 1-amino-3-(dimethylamino)propane at 20℃; for 1h;
97%
In tetrahydrofuran for 48h;92%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

3-(4-(3-aminophenyl)buta-1,3-diynyl)benzeneamine
31661-59-3

3-(4-(3-aminophenyl)buta-1,3-diynyl)benzeneamine

Conditions
ConditionsYield
With potassium carbonate; triphenylphosphine; 5,7-diphenyl-3-iodopyrazolo[1,5-a]pyrimidine; palladium on activated charcoal; copper(l) iodide In 1,2-dimethoxyethane at 80℃; for 24h;100%
With copper(I) oxide; tetrabutylammomium bromide; oxygen; sodium hydroxide In water at 80℃; for 14h; Glaser Coupling; Green chemistry;93%
With copper(II) nitrate In dimethyl sulfoxide at 100℃; for 4h; Schlenk technique; Sealed tube;92%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

N-(3-ethynylphenyl)methanesulfonamide
1025055-55-3

N-(3-ethynylphenyl)methanesulfonamide

Conditions
ConditionsYield
With pyridine at 0 - 20℃;100%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

propionyl chloride
79-03-8

propionyl chloride

N-(3-ethynylphenyl)propionamide

N-(3-ethynylphenyl)propionamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 25℃; for 17h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 17h;100%
Methyl azidoacetate
1816-92-8

Methyl azidoacetate

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

methyl 2-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)acetate

methyl 2-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)acetate

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water at 20℃; for 1h; Inert atmosphere;100%
With copper(l) iodide; sodium L-ascorbate In water; tert-butyl alcohol at 20℃; Reagent/catalyst; Solvent;100 %Chromat.
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

benzyl chloroformate
501-53-1

benzyl chloroformate

3-benzyloxycarbonylaminophenylacetylene
371153-69-4

3-benzyloxycarbonylaminophenylacetylene

Conditions
ConditionsYield
With sodium carbonate In diethyl ether; water at 20℃; for 1h;99.6%
With sodium carbonate In tetrahydrofuran; water at 20℃; for 2h;97.9%
glutaric anhydride,
108-55-4

glutaric anhydride,

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-(3-ethynylphenylcarbamoyl)butyric acid
817638-75-8

4-(3-ethynylphenylcarbamoyl)butyric acid

Conditions
ConditionsYield
In dichloromethane at 20℃; for 6h;99%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

acetyl chloride
75-36-5

acetyl chloride

N-(3-ethynylphenyl)acetamide
70933-58-3

N-(3-ethynylphenyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 25℃;99%
With triethylamine In diethyl ether at 0 - 20℃; for 1.5h; Inert atmosphere;97%
With triethylamine In diethyl ether at 0 - 20℃;94%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6-fluoro-pyrido[3,4-d]pyrimidine
175357-98-9

4-chloro-6-fluoro-pyrido[3,4-d]pyrimidine

N-(3-ethynylphenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine
1245555-86-5

N-(3-ethynylphenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Stage #1: 3-acetylenephenylamine; 4-chloro-6-fluoro-pyrido[3,4-d]pyrimidine In ISOPROPYLAMIDE at 20℃; for 0.666667h;
Stage #2: With sodium hydrogencarbonate In ISOPROPYLAMIDE at 20℃; for 0.25h;
99%
m-iodonitrobenzene
645-00-1

m-iodonitrobenzene

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

C14H10N2O2
1263386-21-5

C14H10N2O2

Conditions
ConditionsYield
With triethylamine at 80℃; for 12h; Sonogashira coupling; Ionic liquid;99%
With triethylamine In ethanol at 75℃; for 5h; Sonogashira Cross-Coupling;65%
C10H7Cl2N3O3
1547160-88-2

C10H7Cl2N3O3

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

C18H13ClN4O3
1547160-91-7

C18H13ClN4O3

Conditions
ConditionsYield
In isopropyl alcohol at 50℃; for 2h;99%
C11H9Cl2N3O3
1547160-90-6

C11H9Cl2N3O3

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

C19H15ClN4O3
1547160-93-9

C19H15ClN4O3

Conditions
ConditionsYield
In isopropyl alcohol at 50℃; for 2h;99%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

6,7-dimethoxy-4-chloroquinazoline
13790-39-1

6,7-dimethoxy-4-chloroquinazoline

6,7-dimethoxyquinazolin-4-yl-(3-ethynylphenyl)amine hydrochloride

6,7-dimethoxyquinazolin-4-yl-(3-ethynylphenyl)amine hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol for 0.5h; Reflux;99%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

C16H14N2

C16H14N2

Conditions
ConditionsYield
With C17H37FeN3P2 In tetrahydrofuran; benzene-d6 at 20℃; for 0.5h; Inert atmosphere; Glovebox; stereoselective reaction;99%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

benzoic acid
65-85-0

benzoic acid

N-(3-ethynylphenyl)benzamide

N-(3-ethynylphenyl)benzamide

Conditions
ConditionsYield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;99%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

C10H18N4O4S

C10H18N4O4S

C19H23N5O5S

C19H23N5O5S

Conditions
ConditionsYield
Stage #1: 3-acetylenephenylamine With bis(trichloromethyl) carbonate In dichloromethane at -40℃; for 1h;
Stage #2: C10H18N4O4S With pyridine; triethylamine In dichloromethane at 45℃; for 1h;
98.24%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol for 18h; Heating;98%
In iso-propanol (IPA) for 0.5h; Product distribution / selectivity; Heating / reflux;97%
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline In N,N-dimethyl-formamide; acetonitrile at 90℃; for 7h; Darkness;
Stage #2: With hydrogenchloride In water at 15 - 30℃; Temperature; Solvent;
97.6%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

(3-ethynyl-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
186519-85-7

(3-ethynyl-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Conditions
ConditionsYield
With silver trifluoromethanesulfonate In N,N-dimethyl-formamide at 90℃;98%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

5-bromo-2-methylaniline
39478-78-9

5-bromo-2-methylaniline

5-{4-(3-aminophenyl)-[1,2,3]triazol-1-yl}-2-methylphenylamine

5-{4-(3-aminophenyl)-[1,2,3]triazol-1-yl}-2-methylphenylamine

Conditions
ConditionsYield
With sodium azide; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium L-ascorbate; copper(l) iodide In dimethyl sulfoxide at 70℃; for 12h;98%
1-benzylisatin
1217-89-6

1-benzylisatin

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

1-benzyl-3-hydroxy-3-((3-aminophenyl)ethynyl)indolin-2-one
1292358-55-4

1-benzyl-3-hydroxy-3-((3-aminophenyl)ethynyl)indolin-2-one

Conditions
ConditionsYield
With 1,3-bis(2,4,6-trimethylphenyl)imidazole-2-ylidene silver chloride; water; N-ethyl-N,N-diisopropylamine at 40℃; for 16h;98%
Propyl isocyanate
110-78-1

Propyl isocyanate

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

1-(3-ethynylphenyl)-3-propylurea

1-(3-ethynylphenyl)-3-propylurea

Conditions
ConditionsYield
In dichloromethane Cooling with ice; Reflux;98%
In dichloromethane Cooling with ice; Reflux;
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

2-iodo-4-methyl-1-[(2-methylprop-2-enyl)oxy]benzene

2-iodo-4-methyl-1-[(2-methylprop-2-enyl)oxy]benzene

3-[3-(3,5-dimethyl-2,3-dihydro-1-benzofuran-3-yl)prop-1-ynyl]aniline

3-[3-(3,5-dimethyl-2,3-dihydro-1-benzofuran-3-yl)prop-1-ynyl]aniline

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); N-benzyl-N,N,N-triethylammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene In water at 100℃; for 0.25h; Sealed tube; Inert atmosphere; Microwave irradiation; Green chemistry;98%
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate In N,N-dimethyl-formamide at 100℃; for 0.25h; Microwave irradiation; Inert atmosphere; Sealed tube; Green chemistry;92%
4-(morpholin-4-yl)-3-(trifluoromethyl)benzoic acid
677704-58-4

4-(morpholin-4-yl)-3-(trifluoromethyl)benzoic acid

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

N-(3-ethynylphenyl)-4-morpholino-3-(trifluoromethyl)benzamide

N-(3-ethynylphenyl)-4-morpholino-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h; Schlenk technique; Inert atmosphere;97.2%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;97.2%
carbon disulfide
75-15-0

carbon disulfide

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

triethylamine
121-44-8

triethylamine

3-ethynylphenyl dithiocarbamic acid triethylammonium

3-ethynylphenyl dithiocarbamic acid triethylammonium

Conditions
ConditionsYield
In diethyl ether at 20℃; for 10h;97.1%
In ethyl acetate; Petroleum ether at 20℃;
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

1-(3-aminophenyl)ethanone
99-03-6

1-(3-aminophenyl)ethanone

Conditions
ConditionsYield
With silver hexafluoroantimonate In methanol; water at 120℃; for 24h; Sealed tube;97%
With C22H20AuN3O2P(1+)*CF3O3S(1-); water; silver trifluoromethanesulfonate; acetic acid at 100℃; for 10h;91%
With water at 200℃; for 0.333333h; microwave irradiation;90%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

benzyl azide
622-79-7

benzyl azide

1-benzyl-4-(3-aminophenyl)-1H-1,2,3-triazole
1151920-00-1

1-benzyl-4-(3-aminophenyl)-1H-1,2,3-triazole

Conditions
ConditionsYield
With carbon dioxide; copper at 50℃; under 75007.5 Torr; for 10h; Green chemistry;97%
With copper(ll) sulfate pentahydrate; betaine; sodium L-ascorbate In water at 30℃; for 24h;96%
With Cu(OAc)2-anchored mesoporous SBA-15 catalyst (CuSBA-15-PTAA) In water at 50℃; for 6h;96%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

3-ethynylphenylamino oxoacetate ethyl ester
1178671-79-8

3-ethynylphenylamino oxoacetate ethyl ester

Conditions
ConditionsYield
In tetrahydrofuran; triethylamine at 50℃; for 1.5h; Inert atmosphere;97%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.5h; Sealed tube;
4-Iodoacetophenone
13329-40-3

4-Iodoacetophenone

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

1-(4-((3-aminophenyl)ethynyl)phenyl)ethanone
1263386-20-4

1-(4-((3-aminophenyl)ethynyl)phenyl)ethanone

Conditions
ConditionsYield
With triethylamine at 80℃; for 12h; Kinetics; Reagent/catalyst; Sonogashira coupling; Ionic liquid;97%
With tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate tribasic heptahydrate In ethanol; water at 80℃; for 0.166667h; Sonogashira coupling; Under air;93%
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