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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is the leading manufacture of APIs, supplements raw powder and some customization products. Located in Hubei province,China. We are one of the most professional company in medical/chemical industry for more than 10 years.

High quality Erlotinib Hydrochloride

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $220.0

Type:Trading Company

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Hangzhou Hysen Pharma co.,Ltd.

Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *W

Erlotinib hydrochloride CAS:183319-69-9

Cas:183319-69-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Erlotinib hydrochloride Manufacturer/High quality/Best price/In stock

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Off-white to white crystalline powder White powder Assay(anhydrous)

High purity Various Specifications Erlotinib hydrochloride CAS:183319-69-9

Cas:183319-69-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Erlotinib hydrochloride Synonyms N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride; 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochlor

Erlotinib hydrochloride/183319-69-9

Cas:183319-69-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Erlotinib hydrochloride Cas 183319-69-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white crystalline powder Storage:Cool dry place

Top quality Erlotinib hydrochloride Cas 183319-69-9 with competitive price

Cas:183319-69-9

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Erlotinib hydrochloride CAS No.:183319-69-9 Name: Erlotinib hydrochloride Synonyms: N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride; 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilin

High purity Erlotinib hydrochloride CAS No.:183319-69-9

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Erlotinib Hydrochloride

Cas:183319-69-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Erlotinib hydrochloride 183319-69-9 ISO Producer

Cas:183319-69-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Micafungin Verified By GMP,FDA,CEP,COS,ANDA Service 1, Professional Techincal Guidence 2, Free Sample can be supplied before commercial p

Erlotinib HCl CAS No:183319-69-9

Cas:183319-69-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

183319-69-9 Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Erlotinib HCl CAS No. 183319-69-9

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Erlotinib HCl CAS No.: 183319-69-9 Molecular Formula: C22H23N3O4.HCl Molecular Weight: 429.9 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package

Erlotinib HCl

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 183319-69-9 with best quality

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Erlotinib hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:183319-69-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Anticancer CAS 183319-69-9 Erlotinib HCl Pharmaceutical Erlotinib Hydrochloride Powder Pharmaceutical Erlotinib HCl

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less8 years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediates, herbal

Supply Erlotinib hydrochloride 183319-69-9

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Erlotinib hydrochloride 99%

Cas:183319-69-9

Min.Order:1 Kilogram

FOB Price: $75.0 / 89.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Erlotinib hydrochloride CAS:183319-69-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Erlotinib hydrochloride CAS:183319-69-9

Cas:183319-69-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Erlotinib hydrochloride/erlotinib hcl

Cas:183319-69-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Erlotinib hydrochloride CAS 183319-69-9

Cas:183319-69-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Erlotinib hydrochloride CAS: 183319-69-9 Specification Items Standard Result Appearance Off-white to white crystalline powder White powder Assay(anhydrou

Factory supply Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Erlotinib hydrochloride

Cas:183319-69-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

erlotinib
183321-74-6

erlotinib

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 0℃; for 1h; Product distribution / selectivity; Inert atmosphere;100%
With hydrogenchloride In ethanol; water at 72℃; for 0.333333h; Solvent; Temperature;99%
With hydrogenchloride In water; acetone at 10℃; for 2.5h; Solvent; Temperature;98.7%
6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline
1312937-41-9

6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline

hydrochloric salt of m-aminophenylacetylene

hydrochloric salt of m-aminophenylacetylene

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: hydrochloric salt of m-aminophenylacetylene With sec.-butyllithium In tetrahydrofuran; cyclohexane at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; cyclohexane at 20℃; for 15h;
Stage #3: With hydrogenchloride In tetrahydrofuran; cyclohexane; water at 20℃; for 1h; Product distribution / selectivity;
100%
Stage #1: hydrochloric salt of m-aminophenylacetylene With sec.-butyllithium In tetrahydrofuran; cyclohexane at 0℃; Inert atmosphere;
Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; cyclohexane at 20℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; cyclohexane; water at 20℃;
100%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol for 18h; Heating;98%
In iso-propanol (IPA) for 0.5h; Product distribution / selectivity; Heating / reflux;97%
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline In N,N-dimethyl-formamide; acetonitrile at 90℃; for 7h; Darkness;
Stage #2: With hydrogenchloride In water at 15 - 30℃; Temperature; Solvent;
97.6%
6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline
1312937-41-9

6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: 3-acetylenephenylamine With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; n-heptane; ethylbenzene at 20℃; for 15h;
Stage #3: With hydrogenchloride In tetrahydrofuran; n-heptane; ethylbenzene; water at 20℃; for 3h; Product distribution / selectivity;
97%
Stage #1: 3-acetylenephenylamine With lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at 0℃; Inert atmosphere;
Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; n-heptane; ethylbenzene at 20℃; for 15h;
Stage #3: With hydrogenchloride In tetrahydrofuran; n-heptane; ethylbenzene; water at 20℃; Product distribution / selectivity;
97%
N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine
938185-06-9

N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine

2-iodo-1-methoxyethane
4296-15-5

2-iodo-1-methoxyethane

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine; 2-iodo-1-methoxyethane With pyridine; tetrapropylammonium iodide In 1-methyl-pyrrolidin-2-one at 20℃; for 1h;
Stage #2: With hydrogenchloride In water
95.29%
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
for 3h; Temperature; Reflux; Large scale;95.1%
4-(methylthio)-6,7-bis(2-methoxyethoxy)quinazoline
958669-57-3

4-(methylthio)-6,7-bis(2-methoxyethoxy)quinazoline

hydrochloric salt of m-aminophenylacetylene

hydrochloric salt of m-aminophenylacetylene

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
With 3-ethynylaniline In isopropyl alcohol for 15h; Heating;90%
N-(3-trimethylsilyl-ethynyl)-6,7-bis(2-methoxyethoxy)-4-quinolyl-amine
766497-25-0

N-(3-trimethylsilyl-ethynyl)-6,7-bis(2-methoxyethoxy)-4-quinolyl-amine

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃; for 1h;90%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: 6,7-dimethoxy quinazolin-4-one With triethylamine; trichlorophosphate In toluene at 70 - 80℃; for 3h;
Stage #2: 3-acetylenephenylamine In toluene; acetonitrile at 20 - 80℃; for 2h;
88%
3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride
299912-59-7

3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: 3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride With sodium hydroxide In water; butan-1-ol pH=10 - 12; Inert atmosphere;
Stage #2: With sodium hydroxide In butan-1-ol at 115 - 120℃; for 24h;
Stage #3: With hydrogenchloride In water; butan-1-ol at 20 - 25℃;
74%
2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile
950596-58-4

2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-(dimethoxymethylene)morpholine

4-(dimethoxymethylene)morpholine

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: 3-acetylenephenylamine; 4-(dimethoxymethylene)morpholine With acetic acid In toluene Reflux;
Stage #2: 2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile In toluene Reflux;
Stage #3: With hydrogenchloride In water; toluene at 15 - 20℃;
63%
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 95 percent / P2S5 / pyridine / 24 h / Heating
2.1: aq. NaOH / methanol / 0.5 h / 20 °C
2.2: 86 percent / methanol; H2O / 5 h / 25 °C
3.1: 90 percent / 3-ethynylaniline / propan-2-ol / 15 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
2: 80 percent / dimethylformamide / 1 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
2: pyridine / propan-2-ol
View Scheme
6,7-bis(2-methoxyethoxy)quinazoline-4(3H)-thione
958669-56-2

6,7-bis(2-methoxyethoxy)quinazoline-4(3H)-thione

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aq. NaOH / methanol / 0.5 h / 20 °C
1.2: 86 percent / methanol; H2O / 5 h / 25 °C
2.1: 90 percent / 3-ethynylaniline / propan-2-ol / 15 h / Heating
View Scheme
C13H19NO5
1006377-63-4

C13H19NO5

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic anhydride / 110 °C
2.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
3.2: 81 percent / HCl / H2O / 90 - 130 °C
4.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
5.1: 80 percent / dimethylformamide / 1 h / 80 °C
View Scheme
3,4-bis(2-methoxyethoxy) benzonitrile
80407-68-7

3,4-bis(2-methoxyethoxy) benzonitrile

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
2.2: 81 percent / HCl / H2O / 90 - 130 °C
3.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
4.1: 80 percent / dimethylformamide / 1 h / 80 °C
View Scheme
Multi-step reaction with 6 steps
1.1: nitric acid / acetic acid / 4 h / 0 °C
2.1: sodium dithionite / water / 3 h / 50 °C
2.2: 0.5 h / 65 °C
3.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
4.1: acetic acid / toluene / 5 h / 60 °C
5.1: toluene / 5 h / 125 °C
6.1: hydrogenchloride / methanol / 0.05 h / 15 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: nitric acid / acetic acid / 4 h / 0 °C
2.1: sodium dithionite / water / 3 h / 50 °C
2.2: 0.5 h / 65 °C
3.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
4.1: acetic acid / toluene / 125 - 130 °C
5.1: hydrogenchloride / methanol / 0.05 h / 15 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: acetic acid / 20 °C
1.2: 5 - 55 °C
2.1: palladium on activated charcoal; hydrogen / ethanol / 2.5 h / 20 °C / 2585.81 Torr
3.1: 3 h / 20 °C / Reflux
4.1: acetic acid / 2 h / Reflux
5.1: hydrogenchloride / water; methanol / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: nitric acid
2: dihydrogen peroxide
3: palladium on activated charcoal; ammonium formate
4: water / 24 h / 130 °C
5: trichlorophosphate; triethylamine
6: hydrogenchloride / water; N,N-dimethyl-formamide
View Scheme
2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile
236750-65-5

2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
1.2: 81 percent / HCl / H2O / 90 - 130 °C
2.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
3.1: 80 percent / dimethylformamide / 1 h / 80 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium dithionite / water / 3 h / 50 °C
1.2: 0.5 h / 65 °C
2.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
3.1: acetic acid / toluene / 5 h / 60 °C
4.1: toluene / 5 h / 125 °C
5.1: hydrogenchloride / methanol / 0.05 h / 15 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium dithionite / water / 3 h / 50 °C
1.2: 0.5 h / 65 °C
2.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
3.1: acetic acid / toluene / 125 - 130 °C
4.1: hydrogenchloride / methanol / 0.05 h / 15 - 20 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzaldehyde
80407-64-3

3,4-bis(2-methoxyethoxy)benzaldehyde

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating
2.1: acetic anhydride / 110 °C
3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
4.2: 81 percent / HCl / H2O / 90 - 130 °C
5.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
6.1: 80 percent / dimethylformamide / 1 h / 80 °C
View Scheme
Multi-step reaction with 7 steps
1: hydroxylamine hydrochloride; acetic anhydride
2: nitric acid
3: dihydrogen peroxide
4: palladium on activated charcoal; ammonium formate
5: water / 24 h / 130 °C
6: trichlorophosphate; triethylamine
7: hydrogenchloride / water; N,N-dimethyl-formamide
View Scheme
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 98 percent / potassium carbonate / dimethylformamide / 100 °C
2.1: hydroxylamine hydrochloride; pyridine / methanol / Heating
3.1: acetic anhydride / 110 °C
4.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
5.2: 81 percent / HCl / H2O / 90 - 130 °C
6.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
7.1: 80 percent / dimethylformamide / 1 h / 80 °C
View Scheme
Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating
2: acetic acid; nitric acid / 24 h / 20 °C
3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
4: 84 percent / 12 h / 165 - 170 °C
5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
6: pyridine / propan-2-ol
View Scheme
Multi-step reaction with 6 steps
1: potassium carbonate; tetrabutylammonium iodide / acetone
2: acetic acid; nitric acid / 24 h / 20 °C
3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
4: 84 percent / 12 h / 165 - 170 °C
5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
6: pyridine / propan-2-ol
View Scheme
Multi-step reaction with 7 steps
1.1: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C
2.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness
3.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C
3.2: 20 °C
4.1: ammonium formate; triethylamine / 6 h / 160 °C
5.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
6.1: methanol / 3 h / 20 - 30 °C
6.2: 3 h / 50 °C
7.1: hydrogenchloride / water; dichloromethane; methanol / 3 h / 25 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetic acid; nitric acid / 24 h / 20 °C
2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
3: 84 percent / 12 h / 165 - 170 °C
4: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
5: pyridine / propan-2-ol
View Scheme
Multi-step reaction with 6 steps
1.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness
2.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C
2.2: 20 °C
3.1: ammonium formate; triethylamine / 6 h / 160 °C
4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
5.1: methanol / 3 h / 20 - 30 °C
5.2: 3 h / 50 °C
6.1: hydrogenchloride / water; dichloromethane; methanol / 3 h / 25 °C
View Scheme
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
179688-27-8

ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / 12 h / 165 - 170 °C
2: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
3: pyridine / propan-2-ol
View Scheme
2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester
179688-26-7

2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
2: 84 percent / 12 h / 165 - 170 °C
3: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
4: pyridine / propan-2-ol
View Scheme
Multi-step reaction with 4 steps
1.1: tin(II) chloride dihdyrate / methanol / 25 - 35 °C
1.2: 0 - 30 °C
2.1: 25 - 145 °C
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux
4.1: isopropyl alcohol / 4 h / 25 - 45 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C
1.2: 20 °C
2.1: ammonium formate; triethylamine / 6 h / 160 °C
3.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
4.1: methanol / 3 h / 20 - 30 °C
4.2: 3 h / 50 °C
5.1: hydrogenchloride / water; dichloromethane; methanol / 3 h / 25 °C
View Scheme
2-methyl-4-(3-aminophenyl)-3-butyn-2-ol
69088-96-6

2-methyl-4-(3-aminophenyl)-3-butyn-2-ol

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / toluene / 1 h / Heating
2: 98 percent / propan-2-ol / 18 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / toluene / 4 h / 105 - 110 °C / Inert atmosphere
2: toluene; acetonitrile / 25 °C / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: acetonitrile / 5 h / 25 °C / Inert atmosphere; Reflux
2.1: sodium hydroxide / butan-1-ol; water / pH 10 - 12 / Inert atmosphere
2.2: 24 h / 115 - 120 °C
2.3: 20 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: acetonitrile / 5 h / Inert atmosphere; Reflux
2: sodium hydroxide; water / butan-1-ol / pH 10 - 12 / Inert atmosphere
View Scheme
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

A

N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-N-(2-methoxyethyl)quinazolin-4-amine

N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-N-(2-methoxyethyl)quinazolin-4-amine

B

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol for 1.5 - 2h; Product distribution / selectivity; Heating / reflux;
2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile
950596-58-4

2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: 2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile; 3-acetylenephenylamine; orthoformic acid triethyl ester; acetic acid In isopropyl alcohol for 4h; Reflux;
Stage #2: With hydrogenchloride In isopropyl alcohol at 20℃; pH=3.0 - 4.0; Product distribution / selectivity;
erlotinib trifluoroacetate
1246445-24-8

erlotinib trifluoroacetate

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 25 - 30℃; Product distribution / selectivity;
4-(methylthio)-6,7-bis(2-methoxyethoxy)quinazoline
958669-57-3

4-(methylthio)-6,7-bis(2-methoxyethoxy)quinazoline

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

hydrochloric salt of m-aminophenylacetylene

hydrochloric salt of m-aminophenylacetylene

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol for 15h; Reflux;
In isopropyl alcohol for 15h; Reflux;
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine / isopropyl alcohol / 1 h / 80 °C
1.2: 1 h / 20 °C
2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C
2.2: 0.5 h / 0 - 40 °C
3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / 0 °C / Inert atmosphere
3.2: 15 h / 20 °C
3.3: 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine / isopropyl alcohol / 1 h / 80 °C
1.2: 1 h / 20 °C
2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C
2.2: 0.5 h / 0 - 40 °C
3.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 15 h / 20 °C
3.3: 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine / isopropyl alcohol / 1 h / 80 °C
1.2: 20 °C
2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C
2.2: 0 - 40 °C
3.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 0 °C / Inert atmosphere
3.2: 20 °C
3.3: 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine / isopropyl alcohol / 1 h / 80 °C
1.2: 20 °C
2.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C
2.2: 0 - 40 °C
3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0 °C / Inert atmosphere
3.2: 15 h / 20 °C
3.3: 20 °C
View Scheme
With hydrogenchloride In water; N,N-dimethyl-formamide
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

A

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

B

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline With pyridine In isopropyl alcohol at 80℃; for 1h;
Stage #2: With hydrogenchloride In 1,4-dioxane; diethyl ether; chloroform at 20℃; for 1h; Product distribution / selectivity;
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline With pyridine In isopropyl alcohol at 80℃; for 1h;
Stage #2: With hydrogenchloride In 1,4-dioxane; diethyl ether; chloroform at 20℃;
methanesulfonic acid
75-75-2

methanesulfonic acid

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, methanesulfonic acid salt

N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, methanesulfonic acid salt

Conditions
ConditionsYield
Stage #1: erlotinib hydrochloride With sodium hydroxide In water; ethyl acetate at 60 - 70℃; pH=10 - 11;
Stage #2: methanesulfonic acid In ethyl acetate Heating / reflux;
100%
Stage #1: erlotinib hydrochloride With sodium hydroxide In water; ethyl acetate pH=8 - 9;
Stage #2: In isopropyl alcohol
Stage #3: methanesulfonic acid at 62 - 70℃; for 34h;
93%
Stage #1: erlotinib hydrochloride With sodium hydrogencarbonate In dichloromethane; water
Stage #2: In isopropyl alcohol
Stage #3: methanesulfonic acid
69%
Stage #1: erlotinib hydrochloride With 50percent NaOH In water; ethyl acetate at 50℃; for 0.25h;
Stage #2: methanesulfonic acid at 50℃; for 4h; Further stages.;
111.76 g
sodium docusate
577-11-7

sodium docusate

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

erlotinib 1,4-bis(2-ethylhexoxy)-1 ,4-dioxobutane-2-sulfonate

erlotinib 1,4-bis(2-ethylhexoxy)-1 ,4-dioxobutane-2-sulfonate

Conditions
ConditionsYield
In dichloromethane; water at 20℃;98%
erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
With sodium hydroxide In water pH=5 - 12; Product distribution / selectivity;96.3%
With ammonia In water for 2h; pH=9.4; Product distribution / selectivity;94.3%
With sodium hydroxide In water; ethyl acetate at 20℃; Product distribution / selectivity;
water
7732-18-5

water

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

erlotinib hydrochloride monohydrate

erlotinib hydrochloride monohydrate

Conditions
ConditionsYield
In dimethyl sulfoxide at 45℃; Temperature;92.5%
maleic acid
110-16-7

maleic acid

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

[6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine maleate

[6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine maleate

Conditions
ConditionsYield
Stage #1: erlotinib hydrochloride With ammonium hydroxide In water; ethyl acetate at 50℃; for 0.5h;
Stage #2: maleic acid In ethanol; ethyl acetate at 20℃; for 24h;
89%
erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

C22H25N3O5

C22H25N3O5

Conditions
ConditionsYield
With sulfuric acid at 50℃; Reagent/catalyst; Temperature; Cooling with ice;84%
Adipic acid
124-04-9

Adipic acid

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

[6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate
1429636-54-3

[6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate

Conditions
ConditionsYield
Stage #1: erlotinib hydrochloride With ammonium hydroxide In water; ethyl acetate at 50℃; for 0.5h;
Stage #2: Adipic acid In ethanol; ethyl acetate for 24h; Cooling with ice;
72%
ethylenediamine platinum(II) nitrate
50475-22-4

ethylenediamine platinum(II) nitrate

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

C24H31ClN5O4Pt

C24H31ClN5O4Pt

Conditions
ConditionsYield
Stage #1: erlotinib hydrochloride With triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: ethylenediamine platinum(II) nitrate In N,N-dimethyl-formamide at 65℃; for 17h;
29%
cis-Pt(ethylenediamine)nitrate-chloride
468724-95-0

cis-Pt(ethylenediamine)nitrate-chloride

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

C24H31ClN5O4Pt

C24H31ClN5O4Pt

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 65℃; for 17h;22%

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