Product Name: Tenofovir Synonyms: (R)-(1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methylphosphonic acid;Tenofovir (PMPA);Tenofovir(Viread);[[(1R)-2(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]ph;Viread;1-(6-AMinopurin-9-yl)propan-2-yloxyMethylphos
Cas:147127-20-6
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name Tenofovir Batch No. 14121501 Mfg. date
Cas:147127-20-6
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:147127-20-6
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiry1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers 3.Safe an
Cas:147127-20-6
Min.Order:10 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiryWe are very compeitive on TDF .Our mfr is Chinese GMP certified for this item with DMF/CEP document. It has a great function of potassium-sparing diuretics. our advantage of TDF USP/EP/CEP Stable supply. Because the mfr is equipped with GM
Cas:147127-20-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:147127-20-6
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:147127-20-6
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:147127-20-6
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c
Cas:147127-20-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
Name:Tenofovir CAS NO: 147127-20-6 Grade:Medical scientific research and export Molecular formula:C9H14N5O4P Molecular weight:287.21 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data
Cas:147127-20-6
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.
Cas:147127-20-6
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
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WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:147127-20-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Name: Tenofovir Synonyms: 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid CAS:147127-20-6 MF: C9H14N5O4P Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Organic synt
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Solid Storage:Store in sealed contai
Cas:147127-20-6
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed
Cas:147127-20-6
Min.Order:10 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Tenofovir Structure: Formula: C9H14N5O4P Molecular Weight : 287.21 Synonyms: D,L-TENOFOVIR;TENOFOVIR;(R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE;1-(6-aminopu
Cas:147127-20-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:147127-20-6
Min.Order:1 Kilogram
FOB Price: $155.0
Type:Trading Company
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
Cas:147127-20-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:147127-20-6
Min.Order:1 Kilogram
FOB Price: $186.0 / 235.0
Type:Trading Company
inquiryBeluga chemical professional supply High-quality Tenofovir CAS 147127-20-6 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and
Cas:147127-20-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful
Cas:147127-20-6
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:147127-20-6
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
tenofovir
Conditions | Yield |
---|---|
With hydrogenchloride In N,N-dimethyl-formamide at 130℃; under 7500.75 Torr; for 0.0416667h; Solvent; Pressure; Temperature; Inert atmosphere; | 95% |
With trimethylsilyl bromide In acetonitrile at 65℃; for 1h; | 90% |
With sulfuric acid at 90 - 110℃; | 83.8% |
tenofovir
Conditions | Yield |
---|---|
With sodium hydroxide In water for 5h; Reflux; | 91.8% |
bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine
tenofovir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 130 - 140℃; Microwave irradiation; Sealed tube; | 91% |
With hydrogenchloride In water at 140℃; for 0.5h; Temperature; Time; Reagent/catalyst; Microwave irradiation; | 90% |
With hydrogenchloride In water at 140℃; for 0.5h; Temperature; Reagent/catalyst; Microwave irradiation; | 90% |
tenofovir
Conditions | Yield |
---|---|
With potassium hydroxide In water for 5h; Reflux; | 88.7% |
tenofovir
Conditions | Yield |
---|---|
In ethyl acetate at 0 - 10℃; for 2h; Cooling with ice; | 85.4% |
(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
B
tenofovir
Conditions | Yield |
---|---|
With hydrogen bromide at 100℃; for 15h; | A n/a B 84.6% |
tenofovir
Conditions | Yield |
---|---|
With sodium hydroxide In water for 5h; Reflux; | 82.5% |
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
(R)-9-(2-hydroxypropyl)adenine
B
tenofovir
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 0 - 20℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Molecular sieve; | A 12% B 82% |
tenofovir
Conditions | Yield |
---|---|
Stage #1: C12H18N5O5P With sodium hydroxide In water for 2h; Cooling with ice; Stage #2: With hydrogenchloride; sodium hydroxide In water at 5℃; for 10h; pH=2.5; | 81.3% |
tenofovir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 90 - 110℃; | 78.1% |
tenofovir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 90 - 110℃; | 76.8% |
tenofovir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 90 - 110℃; | 76.5% |
tenofovir
Conditions | Yield |
---|---|
With sodium hydroxide In water for 5h; Reflux; | 76.2% |
tenofovir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 90 - 110℃; | 75.7% |
tenofovir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 90 - 110℃; | 74% |
Stage #1: C15H24N5O5P With lithium hydroxide for 2h; Cooling with ice; Stage #2: With hydrogenchloride; sodium hydroxide In water at 5℃; for 10h; pH=2.5; | 74.5% |
(R)-9-(2-hydroxypropyl)adenine
tenofovir
Conditions | Yield |
---|---|
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl acetamide at 90℃; for 0.5h; Schlenk technique; Inert atmosphere; Stage #2: (di-tert-butoxyphosphoryl)methyl methanesulfonate In N,N-dimethyl acetamide at 90℃; for 23h; Schlenk technique; Inert atmosphere; Stage #3: With sulfuric acid at 60℃; Reagent/catalyst; Schlenk technique; Inert atmosphere; | 72% |
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
(R)-9-(2-hydroxypropyl)adenine
B
tenofovir
Conditions | Yield |
---|---|
With magnesium chloride In 1-methyl-pyrrolidin-2-one at -20 - 20℃; Inert atmosphere; | A 6% B 69% |
(R)-9-(2-hydroxypropyl)adenine
tenofovir
Conditions | Yield |
---|---|
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 80℃; Schlenk technique; Inert atmosphere; Stage #2: (di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate In N,N-dimethyl-formamide at 80℃; for 23h; Schlenk technique; Inert atmosphere; Stage #3: With sulfuric acid at 60℃; Schlenk technique; Inert atmosphere; | 68% |
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
(R)-9-(2-hydroxypropyl)adenine
C
tenofovir
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | A 8% B 11% C 64% |
diethyl (p-toluenesulfonyloxymethane)phosphonate
(R)-9-(2-hydroxypropyl)adenine
tenofovir
Conditions | Yield |
---|---|
With bis(isopropoxy) magnesium In N,N-dimethyl-formamide at 45 - 65℃; for 11h; Autoclave; Inert atmosphere; Large scale; | 59.2% |
Stage #1: diethyl (p-toluenesulfonyloxymethane)phosphonate; (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In 1-methyl-pyrrolidin-2-one; toluene at 25 - 75℃; for 6h; Stage #2: With water; acetic acid In 1-methyl-pyrrolidin-2-one; water; acetic acid; toluene for 1h; Stage #3: With hydrogen bromide In 1-methyl-pyrrolidin-2-one; water; toluene at 90 - 95℃; | |
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 20 - 35℃; for 0.5h; Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide at 75 - 80℃; for 2h; Stage #3: With hydrogenchloride In N,N-dimethyl-formamide at 0 - 95℃; for 9h; Temperature; Reagent/catalyst; | 82 g |
With trimethylsilyl bromide; water; sodium hydroxide In dichloromethane at 0 - 5℃; for 3h; pH=2.5 - 3; | |
Stage #1: diethyl (p-toluenesulfonyloxymethane)phosphonate; (R)-9-(2-hydroxypropyl)adenine With alumina-supported potassium hydroxide In N,N-dimethyl-formamide at 40 - 130℃; for 18h; Stage #2: With water at 100 - 105℃; for 18h; Reagent/catalyst; Temperature; Solvent; |
7H-purin-6-ylamine
tenofovir
Conditions | Yield |
---|---|
Stage #1: (R)-(((1-chloropropan-2-yl)oxy)methyl)phosphonic acid bis(diethylamide); 7H-purin-6-ylamine With potassium phosphate In N,N-dimethyl acetamide at 120℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 80℃; for 0.75h; Inert atmosphere; | 41% |
(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
A
tenofovir
Conditions | Yield |
---|---|
With hydrogenchloride |
tenofovir
Conditions | Yield |
---|---|
With water | 30.3 g |
With water In acetonitrile |
tenofovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaOH / dimethylformamide / 20 h / 140 °C 2: LiOt-Bu / dimethylformamide; tetrahydrofuran / 1 h / 30 - 35 °C 3: 1.) bromotrimethylsilane, 2.) NaOH / 1.) acetonitrile, reflux, 2.) H2O, pH 3 View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / N,N-dimethyl-formamide / 120 °C 2: magnesium 2-methylpropan-2-olate / 1-methyl-pyrrolidin-2-one / 70 - 74 °C 3: chloro-trimethyl-silane; sodium bromide / 1-methyl-pyrrolidin-2-one / 0 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 25 - 30 °C 1.2: 25 - 120 °C 1.3: 0.17 h / 55 - 70 °C 2.1: magnesium 2-methylpropan-2-olate / dimethyl sulfoxide / 70 °C 3.1: sodium bromide; chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one / 16 h / 0 - 75 °C View Scheme |
(R)-9-(2-hydroxypropyl)adenine
tenofovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LiOt-Bu / dimethylformamide; tetrahydrofuran / 1 h / 30 - 35 °C 2: 1.) bromotrimethylsilane, 2.) NaOH / 1.) acetonitrile, reflux, 2.) H2O, pH 3 View Scheme | |
Multi-step reaction with 2 steps 1: 44 percent / NaH / dimethylformamide / 0 - 20 °C 2: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C View Scheme | |
Multi-step reaction with 4 steps 1: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h 2: sodium hydride / dimethylformamide / 48 h / Ambient temperature 3: sodium methoxide / dimethylformamide / Ambient temperature 4: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature View Scheme |
(R)-1-(5-Amino-6-chloro-pyrimidin-4-ylamino)-propan-2-ol
tenofovir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 86 percent / conc. HCl / Ambient temperature 2: 91 percent / NH3 / 65 °C 3: 44 percent / NaH / dimethylformamide / 0 - 20 °C 4: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C View Scheme |
(R)-1-(6-chloro-9H-purin-9-yl) propan-2-ol
tenofovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 91 percent / NH3 / 65 °C 2: 44 percent / NaH / dimethylformamide / 0 - 20 °C 3: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C View Scheme | |
Multi-step reaction with 2 steps 1: ammonium hydroxide / 1,4-dioxane / 100 - 110 °C / Sealed tube; Large scale 2: bis(isopropoxy) magnesium / N,N-dimethyl-formamide / 11 h / 45 - 65 °C / Autoclave; Inert atmosphere; Large scale View Scheme |
(R)-9-<2-(2-tetrahydropyranyloxy)propyl>adenine
tenofovir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 85 percent / sulfuric acid / Ambient temperature 2: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h 3: sodium hydride / dimethylformamide / 48 h / Ambient temperature 4: sodium methoxide / dimethylformamide / Ambient temperature 5: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature View Scheme |
(R)-9-(2-hydroxypropyl)-N6-benzoyladenine
tenofovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / dimethylformamide / 48 h / Ambient temperature 2: sodium methoxide / dimethylformamide / Ambient temperature 3: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature View Scheme |
[(R)-2-(6-Benzoylamino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropyl ester
tenofovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium methoxide / dimethylformamide / Ambient temperature 2: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
With oxalyl dichloride In dichloromethane at 20℃; for 3h; Inert atmosphere; | 100% |
With oxalyl dichloride In dichloromethane at 20℃; for 3h; Inert atmosphere; | 100% |
tenofovir
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In water at 40℃; | 99.5% |
triphenyl phosphite
tenofovir
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With pyridine at 50 - 115℃; for 6h; | 98% |
With dmap; triethylamine at 100 - 110℃; Reagent/catalyst; Temperature; | 91% |
With dmap; triethylamine In N,N-dimethyl acetamide at 105 - 110℃; for 20h; Reagent/catalyst; Temperature; | 89.03% |
tenofovir
Conditions | Yield |
---|---|
With caesium carbonate In water; acetone at 30℃; | 97.6% |
tenofovir
Conditions | Yield |
---|---|
With lithium hydroxide In acetone at 30℃; | 96.5% |
diphenyl hydrogen phosphite
tenofovir
phenol
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With pyridine at 100 - 110℃; for 2h; | 95% |
tenofovir
phenol
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With pyridine; dicyclohexyl-carbodiimide at 70℃; for 4h; | 93.63% |
Stage #1: tenofovir; phenol In acetic acid butyl ester at 20℃; for 1h; Stage #2: With dmap; triethylamine; dicyclohexyl-carbodiimide In acetic acid butyl ester at 90℃; for 24h; | 85% |
With triphenyl phosphite; dmap; triethylamine In toluene; acetonitrile at 100℃; for 28h; Solvent; Temperature; | 83% |
tenofovir
Conditions | Yield |
---|---|
With pyridine; dmap; phosphoric acid triphenyl ester In toluene; acetonitrile for 24h; Solvent; Temperature; Reagent/catalyst; Reflux; | 92.9% |
With pyridine; triethylamine; dicyclohexyl-carbodiimide at 70℃; for 3h; Temperature; Reagent/catalyst; | 88.7% |
With triethylamine; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 90 - 100℃; for 22h; Solvent; Reagent/catalyst; Temperature; | 45.5% |
phosphoric acid triphenyl ester
tenofovir
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With dmap; triethylamine In 5,5-dimethyl-1,3-cyclohexadiene at 100 - 110℃; for 12h; Temperature; Solvent; | 91.97% |
diphenyl hydrogen phosphite
tenofovir
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With pyridine at 110 - 120℃; for 4h; | 91.7% |
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 50℃; Temperature; | 91.5% |
With triethylamine; N-butylpyridinium tetrafluoroborate at 40℃; for 1.5h; Reagent/catalyst; Temperature; | 90.6% |
Stage #1: tenofovir With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 50℃; for 0.5h; Stage #2: chloromethyl isopropyl carbonate In 1-methyl-pyrrolidin-2-one at 60℃; for 4h; Reagent/catalyst; Solvent; | 87.6% |
tenofovir
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetone at 30℃; Reagent/catalyst; Solvent; Temperature; | 90.6% |
chloromethyl isopropyl carbonate
(2E)-but-2-enedioic acid
tenofovir
tenofovir disoproxyl fumarate
Conditions | Yield |
---|---|
Stage #1: tenofovir With triethylamine In 1-methyl-pyrrolidin-2-one at 63℃; for 0.5h; Stage #2: chloromethyl isopropyl carbonate In 1-methyl-pyrrolidin-2-one at 63℃; for 4h; Stage #3: (2E)-but-2-enedioic acid In isopropyl alcohol at 50℃; for 0.5h; Concentration; | 90% |
Stage #1: chloromethyl isopropyl carbonate; tenofovir With tetrabutylammomium bromide; triethylamine at 50℃; for 3h; Inert atmosphere; Stage #2: (2E)-but-2-enedioic acid In isopropyl alcohol Reagent/catalyst; Temperature; Reflux; | 78.8% |
Stage #1: chloromethyl isopropyl carbonate; tenofovir With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one; toluene at 45 - 55℃; for 5h; Stage #2: (2E)-but-2-enedioic acid In isopropyl alcohol at 50 - 55℃; for 2h; | 63.6% |
Conditions | Yield |
---|---|
Stage #1: formaldehyd With hydrogenchloride In N,N-dimethyl-formamide at 35 - 40℃; for 1h; Stage #2: tenofovir at 10 - 15℃; for 48h; | 89.5% |
Diphenyliodonium triflate
tenofovir
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With triethylamine In toluene Inert atmosphere; Heating; | 88.3% |
tenofovir
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With dmap In acetic acid butyl ester Inert atmosphere; Heating; | 87% |
diphenyliodonium bromide
tenofovir
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With toluene In acetic acid butyl ester at 80℃; Inert atmosphere; | 86.3% |
tenofovir
phenol
Conditions | Yield |
---|---|
Stage #1: tenofovir With thionyl chloride In acetonitrile at 70℃; for 2h; Inert atmosphere; Large scale; Stage #2: phenol In acetonitrile at 80℃; for 13h; Large scale; | 85% |
diphenyliodonium hexafluorophosphate
tenofovir
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile Inert atmosphere; Heating; | 84.2% |
tenofovir
((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
Conditions | Yield |
---|---|
With potassium tert-butylate In dichloromethane Inert atmosphere; Heating; | 80.1% |
alanine isopropyl ester hydrochloride
tenofovir
Conditions | Yield |
---|---|
Stage #1: tenofovir With thionyl chloride In toluene at 80 - 90℃; for 20h; Stage #2: alanine isopropyl ester hydrochloride With sodium sulfate In dichloromethane; toluene at -15℃; for 4h; Inert atmosphere; | 80% |
With 1,2-dichloro-ethane; triethylamine In water at 20 - 40℃; for 16h; pH=7.2 - 7.6; | |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In water at 80 - 90℃; for 48h; |
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