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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Tenofovir Synonyms: (R)-(1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methylphosphonic acid;Tenofovir (PMPA);Tenofovir(Viread);[[(1R)-2(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]ph;Viread;1-(6-AMinopurin-9-yl)propan-2-yloxyMethylphos

Tenofovir 99% Manufactuered in China best quality

Cas:147127-20-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

Product Name Tenofovir Batch No. 14121501 Mfg. date

CAS:147127-20-6 Tenofovir low price

Cas:147127-20-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Tenofovir manufacturer/supplier

Cas:147127-20-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers 3.Safe an

Tenofovir CAS 147127-20-6

Cas:147127-20-6

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

We are very compeitive on TDF .Our mfr is Chinese GMP certified for this item with DMF/CEP document. It has a great function of potassium-sparing diuretics. our advantage of TDF USP/EP/CEP Stable supply. Because the mfr is equipped with GM

factory supply TDF Intermediate PMPA 147127-20-6

Cas:147127-20-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Tenofovir 147127-20-6 ISO Producer

Cas:147127-20-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Tenofovir

Cas:147127-20-6

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Tenofovir

Cas:147127-20-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Tenofovir

Cas:147127-20-6

Min.Order:0

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Tenofovir 147127-20-6 /manufacturer/low price/high quality/in stock

Cas:147127-20-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tenofovir

Cas:147127-20-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

Tenofovir

Cas:147127-20-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Hubei DiBo chemical co., LTD

Name:Tenofovir CAS NO: 147127-20-6 Grade:Medical scientific research and export Molecular formula:C9H14N5O4P Molecular weight:287.21 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data

Tenofovir/cas:147127-20-6/Raw material spot

Cas:147127-20-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Tenofovir

Cas:147127-20-6

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

147127-20-6

Cas:147127-20-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Tenofovir

Cas:147127-20-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 147127-20-6 with fast shipping

Cas:147127-20-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

PMPA/Tenofovir

Cas:147127-20-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Tenofovir Synonyms: 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid CAS:147127-20-6 MF: C9H14N5O4P Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Organic synt

Tenofovir CAS:147127-20-6

Cas:147127-20-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Solid Storage:Store in sealed contai

99% API Tenofovir CAS 147127-20-6 For Anti-HIV Pharma Raw Materials

Cas:147127-20-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed

Supplier Tenofovir 99% low price

Cas:147127-20-6

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Tenofovir Structure: Formula: C9H14N5O4P Molecular Weight : 287.21 Synonyms: D,L-TENOFOVIR;TENOFOVIR;(R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE;1-(6-aminopu

High Quality Factory Supply Tenofovir

Cas:147127-20-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

147127-20-6 cas 100% purity Tenofovir disoprixil fumarato

Cas:147127-20-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Tenofovir/CAS:147127-20-6

Cas:147127-20-6

Min.Order:1 Kilogram

FOB Price: $186.0 / 235.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High-quality Tenofovir CAS 147127-20-6 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and

High-quality Tenofovir CAS 147127-20-6

Cas:147127-20-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Chinese suppliers CAS 147127-20-6 Tenofovir C9H14N5O4P

Cas:147127-20-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tenofovir

Cas:147127-20-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Hot selling high quality Tenofovir 147127-20-6 with reasonable price and fast delivery

Cas:147127-20-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
180587-75-1

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In N,N-dimethyl-formamide at 130℃; under 7500.75 Torr; for 0.0416667h; Solvent; Pressure; Temperature; Inert atmosphere;95%
With trimethylsilyl bromide In acetonitrile at 65℃; for 1h;90%
With sulfuric acid at 90 - 110℃;83.8%
Conditions
ConditionsYield
With sodium hydroxide In water for 5h; Reflux;91.8%
bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine
160616-04-6

bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 130 - 140℃; Microwave irradiation; Sealed tube;91%
With hydrogenchloride In water at 140℃; for 0.5h; Temperature; Time; Reagent/catalyst; Microwave irradiation;90%
With hydrogenchloride In water at 140℃; for 0.5h; Temperature; Reagent/catalyst; Microwave irradiation;90%
Conditions
ConditionsYield
With potassium hydroxide In water for 5h; Reflux;88.7%
tenofovir disoproxil

tenofovir disoproxil

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
In ethyl acetate at 0 - 10℃; for 2h; Cooling with ice;85.4%
(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
180587-75-1

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

A

magnesium para-toluenesulfonate

magnesium para-toluenesulfonate

B

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogen bromide at 100℃; for 15h;A n/a
B 84.6%
Conditions
ConditionsYield
With sodium hydroxide In water for 5h; Reflux;82.5%
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C9H14N5O4P

C9H14N5O4P

B

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 0 - 20℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Molecular sieve;A 12%
B 82%
C12H18N5O5P

C12H18N5O5P

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: C12H18N5O5P With sodium hydroxide In water for 2h; Cooling with ice;
Stage #2: With hydrogenchloride; sodium hydroxide In water at 5℃; for 10h; pH=2.5;
81.3%
C13H20N5O5P

C13H20N5O5P

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;78.1%
1-ethyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

1-ethyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;76.8%
C13H20N5O5P

C13H20N5O5P

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;76.5%
Conditions
ConditionsYield
With sodium hydroxide In water for 5h; Reflux;76.2%
C11H18N5O4P

C11H18N5O4P

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;75.7%
C15H24N5O5P

C15H24N5O5P

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;74%
Stage #1: C15H24N5O5P With lithium hydroxide for 2h; Cooling with ice;
Stage #2: With hydrogenchloride; sodium hydroxide In water at 5℃; for 10h; pH=2.5;
74.5%
(di-tert-butoxyphosphoryl)methyl methanesulfonate

(di-tert-butoxyphosphoryl)methyl methanesulfonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl acetamide at 90℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: (di-tert-butoxyphosphoryl)methyl methanesulfonate In N,N-dimethyl acetamide at 90℃; for 23h; Schlenk technique; Inert atmosphere;
Stage #3: With sulfuric acid at 60℃; Reagent/catalyst; Schlenk technique; Inert atmosphere;
72%
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C10H17N5O7P2

C10H17N5O7P2

B

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With magnesium chloride In 1-methyl-pyrrolidin-2-one at -20 - 20℃; Inert atmosphere;A 6%
B 69%
(di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate

(di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 80℃; Schlenk technique; Inert atmosphere;
Stage #2: (di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate In N,N-dimethyl-formamide at 80℃; for 23h; Schlenk technique; Inert atmosphere;
Stage #3: With sulfuric acid at 60℃; Schlenk technique; Inert atmosphere;
68%
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C10H17N5O7P2

C10H17N5O7P2

B

C9H14N5O4P

C9H14N5O4P

C

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;A 8%
B 11%
C 64%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With bis(isopropoxy) magnesium In N,N-dimethyl-formamide at 45 - 65℃; for 11h; Autoclave; Inert atmosphere; Large scale;59.2%
Stage #1: diethyl (p-toluenesulfonyloxymethane)phosphonate; (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In 1-methyl-pyrrolidin-2-one; toluene at 25 - 75℃; for 6h;
Stage #2: With water; acetic acid In 1-methyl-pyrrolidin-2-one; water; acetic acid; toluene for 1h;
Stage #3: With hydrogen bromide In 1-methyl-pyrrolidin-2-one; water; toluene at 90 - 95℃;
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 20 - 35℃; for 0.5h;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide at 75 - 80℃; for 2h;
Stage #3: With hydrogenchloride In N,N-dimethyl-formamide at 0 - 95℃; for 9h; Temperature; Reagent/catalyst;
82 g
With trimethylsilyl bromide; water; sodium hydroxide In dichloromethane at 0 - 5℃; for 3h; pH=2.5 - 3;
Stage #1: diethyl (p-toluenesulfonyloxymethane)phosphonate; (R)-9-(2-hydroxypropyl)adenine With alumina-supported potassium hydroxide In N,N-dimethyl-formamide at 40 - 130℃; for 18h;
Stage #2: With water at 100 - 105℃; for 18h; Reagent/catalyst; Temperature; Solvent;
(R)-(((1-chloropropan-2-yl)oxy)methyl)phosphonic acid bis(diethylamide)

(R)-(((1-chloropropan-2-yl)oxy)methyl)phosphonic acid bis(diethylamide)

7H-purin-6-ylamine
73-24-5

7H-purin-6-ylamine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: (R)-(((1-chloropropan-2-yl)oxy)methyl)phosphonic acid bis(diethylamide); 7H-purin-6-ylamine With potassium phosphate In N,N-dimethyl acetamide at 120℃; for 24h; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 80℃; for 0.75h; Inert atmosphere;
41%
(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
180587-75-1

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

A

tenofovir
147127-20-6

tenofovir

B

(R)-9-(2-phosphonomethoxypropyl)hypoxanthine

(R)-9-(2-phosphonomethoxypropyl)hypoxanthine

Conditions
ConditionsYield
With hydrogenchloride
C15H30N5O4PSi2

C15H30N5O4PSi2

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With water30.3 g
With water In acetonitrile
Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaOH / dimethylformamide / 20 h / 140 °C
2: LiOt-Bu / dimethylformamide; tetrahydrofuran / 1 h / 30 - 35 °C
3: 1.) bromotrimethylsilane, 2.) NaOH / 1.) acetonitrile, reflux, 2.) H2O, pH 3
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / N,N-dimethyl-formamide / 120 °C
2: magnesium 2-methylpropan-2-olate / 1-methyl-pyrrolidin-2-one / 70 - 74 °C
3: chloro-trimethyl-silane; sodium bromide / 1-methyl-pyrrolidin-2-one / 0 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 25 - 30 °C
1.2: 25 - 120 °C
1.3: 0.17 h / 55 - 70 °C
2.1: magnesium 2-methylpropan-2-olate / dimethyl sulfoxide / 70 °C
3.1: sodium bromide; chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one / 16 h / 0 - 75 °C
View Scheme
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiOt-Bu / dimethylformamide; tetrahydrofuran / 1 h / 30 - 35 °C
2: 1.) bromotrimethylsilane, 2.) NaOH / 1.) acetonitrile, reflux, 2.) H2O, pH 3
View Scheme
Multi-step reaction with 2 steps
1: 44 percent / NaH / dimethylformamide / 0 - 20 °C
2: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C
View Scheme
Multi-step reaction with 4 steps
1: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h
2: sodium hydride / dimethylformamide / 48 h / Ambient temperature
3: sodium methoxide / dimethylformamide / Ambient temperature
4: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
(R)-1-(5-Amino-6-chloro-pyrimidin-4-ylamino)-propan-2-ol
17435-30-2

(R)-1-(5-Amino-6-chloro-pyrimidin-4-ylamino)-propan-2-ol

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 86 percent / conc. HCl / Ambient temperature
2: 91 percent / NH3 / 65 °C
3: 44 percent / NaH / dimethylformamide / 0 - 20 °C
4: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C
View Scheme
(R)-1-(6-chloro-9H-purin-9-yl) propan-2-ol
180587-74-0

(R)-1-(6-chloro-9H-purin-9-yl) propan-2-ol

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / NH3 / 65 °C
2: 44 percent / NaH / dimethylformamide / 0 - 20 °C
3: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C
View Scheme
Multi-step reaction with 2 steps
1: ammonium hydroxide / 1,4-dioxane / 100 - 110 °C / Sealed tube; Large scale
2: bis(isopropoxy) magnesium / N,N-dimethyl-formamide / 11 h / 45 - 65 °C / Autoclave; Inert atmosphere; Large scale
View Scheme
(R)-9-<2-(2-tetrahydropyranyloxy)propyl>adenine
160616-02-4

(R)-9-<2-(2-tetrahydropyranyloxy)propyl>adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 85 percent / sulfuric acid / Ambient temperature
2: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h
3: sodium hydride / dimethylformamide / 48 h / Ambient temperature
4: sodium methoxide / dimethylformamide / Ambient temperature
5: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
(R)-9-(2-hydroxypropyl)-N6-benzoyladenine
160616-03-5

(R)-9-(2-hydroxypropyl)-N6-benzoyladenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / dimethylformamide / 48 h / Ambient temperature
2: sodium methoxide / dimethylformamide / Ambient temperature
3: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
[(R)-2-(6-Benzoylamino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropyl ester
627510-49-0

[(R)-2-(6-Benzoylamino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropyl ester

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium methoxide / dimethylformamide / Ambient temperature
2: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

tenofovir
147127-20-6

tenofovir

C12H17Cl2N6O2P

C12H17Cl2N6O2P

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane at 20℃; for 3h; Inert atmosphere;100%
With oxalyl dichloride In dichloromethane at 20℃; for 3h; Inert atmosphere;100%
tenofovir
147127-20-6

tenofovir

C9H13N5O4P(1-)*K(1+)

C9H13N5O4P(1-)*K(1+)

Conditions
ConditionsYield
With potassium hydrogencarbonate In water at 40℃;99.5%
triphenyl phosphite
101-02-0

triphenyl phosphite

tenofovir
147127-20-6

tenofovir

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With pyridine at 50 - 115℃; for 6h;98%
With dmap; triethylamine at 100 - 110℃; Reagent/catalyst; Temperature;91%
With dmap; triethylamine In N,N-dimethyl acetamide at 105 - 110℃; for 20h; Reagent/catalyst; Temperature;89.03%
tenofovir
147127-20-6

tenofovir

C9H13N5O4P(1-)*Cs(1+)

C9H13N5O4P(1-)*Cs(1+)

Conditions
ConditionsYield
With caesium carbonate In water; acetone at 30℃;97.6%
tenofovir
147127-20-6

tenofovir

C9H13N5O4P(1-)*Li(1+)

C9H13N5O4P(1-)*Li(1+)

Conditions
ConditionsYield
With lithium hydroxide In acetone at 30℃;96.5%
diphenyl hydrogen phosphite
4712-55-4

diphenyl hydrogen phosphite

tenofovir
147127-20-6

tenofovir

phenol
108-95-2

phenol

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With pyridine at 100 - 110℃; for 2h;95%
tenofovir
147127-20-6

tenofovir

phenol
108-95-2

phenol

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With pyridine; dicyclohexyl-carbodiimide at 70℃; for 4h;93.63%
Stage #1: tenofovir; phenol In acetic acid butyl ester at 20℃; for 1h;
Stage #2: With dmap; triethylamine; dicyclohexyl-carbodiimide In acetic acid butyl ester at 90℃; for 24h;
85%
With triphenyl phosphite; dmap; triethylamine In toluene; acetonitrile at 100℃; for 28h; Solvent; Temperature;83%
tenofovir
147127-20-6

tenofovir

C18H26N10O7P2

C18H26N10O7P2

Conditions
ConditionsYield
With pyridine; dmap; phosphoric acid triphenyl ester In toluene; acetonitrile for 24h; Solvent; Temperature; Reagent/catalyst; Reflux;92.9%
With pyridine; triethylamine; dicyclohexyl-carbodiimide at 70℃; for 3h; Temperature; Reagent/catalyst;88.7%
With triethylamine; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 90 - 100℃; for 22h; Solvent; Reagent/catalyst; Temperature;45.5%
phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

tenofovir
147127-20-6

tenofovir

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With dmap; triethylamine In 5,5-dimethyl-1,3-cyclohexadiene at 100 - 110℃; for 12h; Temperature; Solvent;91.97%
diphenyl hydrogen phosphite
4712-55-4

diphenyl hydrogen phosphite

tenofovir
147127-20-6

tenofovir

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With pyridine at 110 - 120℃; for 4h;91.7%
chloromethyl isopropyl carbonate
35180-01-9

chloromethyl isopropyl carbonate

tenofovir
147127-20-6

tenofovir

tenofovir disoproxil

tenofovir disoproxil

Conditions
ConditionsYield
With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 50℃; Temperature;91.5%
With triethylamine; N-butylpyridinium tetrafluoroborate at 40℃; for 1.5h; Reagent/catalyst; Temperature;90.6%
Stage #1: tenofovir With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 50℃; for 0.5h;
Stage #2: chloromethyl isopropyl carbonate In 1-methyl-pyrrolidin-2-one at 60℃; for 4h; Reagent/catalyst; Solvent;
87.6%
tenofovir
147127-20-6

tenofovir

C9H13N5O4P(1-)*Na(1+)

C9H13N5O4P(1-)*Na(1+)

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 30℃; Reagent/catalyst; Solvent; Temperature;90.6%
chloromethyl isopropyl carbonate
35180-01-9

chloromethyl isopropyl carbonate

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

tenofovir
147127-20-6

tenofovir

tenofovir disoproxyl fumarate
202138-50-9

tenofovir disoproxyl fumarate

Conditions
ConditionsYield
Stage #1: tenofovir With triethylamine In 1-methyl-pyrrolidin-2-one at 63℃; for 0.5h;
Stage #2: chloromethyl isopropyl carbonate In 1-methyl-pyrrolidin-2-one at 63℃; for 4h;
Stage #3: (2E)-but-2-enedioic acid In isopropyl alcohol at 50℃; for 0.5h; Concentration;
90%
Stage #1: chloromethyl isopropyl carbonate; tenofovir With tetrabutylammomium bromide; triethylamine at 50℃; for 3h; Inert atmosphere;
Stage #2: (2E)-but-2-enedioic acid In isopropyl alcohol Reagent/catalyst; Temperature; Reflux;
78.8%
Stage #1: chloromethyl isopropyl carbonate; tenofovir With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one; toluene at 45 - 55℃; for 5h;
Stage #2: (2E)-but-2-enedioic acid In isopropyl alcohol at 50 - 55℃; for 2h;
63.6%
formaldehyd
50-00-0

formaldehyd

tenofovir
147127-20-6

tenofovir

C19H28N10O8P2

C19H28N10O8P2

Conditions
ConditionsYield
Stage #1: formaldehyd With hydrogenchloride In N,N-dimethyl-formamide at 35 - 40℃; for 1h;
Stage #2: tenofovir at 10 - 15℃; for 48h;
89.5%
Diphenyliodonium triflate
66003-76-7

Diphenyliodonium triflate

tenofovir
147127-20-6

tenofovir

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With triethylamine In toluene Inert atmosphere; Heating;88.3%
diphenyliodonium tetrafluoroborate

diphenyliodonium tetrafluoroborate

tenofovir
147127-20-6

tenofovir

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With dmap In acetic acid butyl ester Inert atmosphere; Heating;87%
diphenyliodonium bromide
1483-73-4

diphenyliodonium bromide

tenofovir
147127-20-6

tenofovir

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With toluene In acetic acid butyl ester at 80℃; Inert atmosphere;86.3%
tenofovir
147127-20-6

tenofovir

phenol
108-95-2

phenol

9-[(R)-2-[[(S)-[bis(phenoxy)phosphinyl]]methoxy]propyl]adenine

9-[(R)-2-[[(S)-[bis(phenoxy)phosphinyl]]methoxy]propyl]adenine

Conditions
ConditionsYield
Stage #1: tenofovir With thionyl chloride In acetonitrile at 70℃; for 2h; Inert atmosphere; Large scale;
Stage #2: phenol In acetonitrile at 80℃; for 13h; Large scale;
85%
diphenyliodonium hexafluorophosphate
58109-40-3

diphenyliodonium hexafluorophosphate

tenofovir
147127-20-6

tenofovir

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile Inert atmosphere; Heating;84.2%
diphenyliodonium nitrate

diphenyliodonium nitrate

tenofovir
147127-20-6

tenofovir

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester
379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With potassium tert-butylate In dichloromethane Inert atmosphere; Heating;80.1%
alanine isopropyl ester hydrochloride
39613-92-8, 62062-56-0, 62062-65-1

alanine isopropyl ester hydrochloride

tenofovir
147127-20-6

tenofovir

P-{[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}-N-[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]phosphonamidic acid

P-{[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}-N-[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]phosphonamidic acid

Conditions
ConditionsYield
Stage #1: tenofovir With thionyl chloride In toluene at 80 - 90℃; for 20h;
Stage #2: alanine isopropyl ester hydrochloride With sodium sulfate In dichloromethane; toluene at -15℃; for 4h; Inert atmosphere;
80%
With 1,2-dichloro-ethane; triethylamine In water at 20 - 40℃; for 16h; pH=7.2 - 7.6;
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In water at 80 - 90℃; for 48h;

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