Products

Refine

Country

Business Type

Certificate

Display

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Agomelatine 138112-76-2

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $1550.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Agomelatine CAS NO.138112-76-2

Cas:138112-76-2

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou Hysen Pharma co.,Ltd.

We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&am

Agomelatine factory supply

Cas:138112-76-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

hangzhou verychem science and technology co.ltd

Product name: AGOMELATINE Cas No: 138112-76-2 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years hi

AGOMELATINE

Cas:138112-76-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Agomelatine cas:138112-76-2

Cas:138112-76-2

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Xi'an Yinherb Bio-Tech Co., Ltd.

Xi'an Yinherb Bio-Tech Co., Ltd was founded in 2009, We have more than 10 experienced doctors and scientists and professional managers, specializing in Nootropics, Sarms and Peptides researching and developing, and become the lead

Agomelatine Nootropics powder

Cas:138112-76-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou MyLand Pharm&Nutrition Inc.

Product name Agomelatine Other name N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide; N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide CAS No. 138112-76-2 M

Manufacturer Supplies High Purity Agomelatine 99% Supplement

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 4.0

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Qianyu Unique advantages of high purity CAS138112-76-2 AGOMELATINE Our Advantages A. International Top level Technology Our company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the f

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Agomelatine Manufacturer/High quality/Best price/In stock

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Off-white or white crystalline powder White crystalline powder Mp

High purity Agomelatine CAS:138112-76-2

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Agomelatine supplier in China

Cas:138112-76-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:-20°C Freezer Package:1kg/foil bag; 1kg/

Manfacturer supply Agomelatine CAS 138112-76-2 with best price

Cas:138112-76-2

Min.Order:500 Gram

FOB Price: $5.0

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up by HPLC Agomelatine 138112-76-2

Cas:138112-76-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Agomelatine CAS:138112-76-2 Similar with melatonin , anti-depressants Molecular Formula C15H17NO2 Molecular Weight 243.30 CAS Registry Number 1381

High purity Agomelatine API and intermediate anti-depressants

Cas:138112-76-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Agomelatine

Cas:138112-76-2

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Agomelatine 138112-76-2 ISO Producer

Cas:138112-76-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

We have strong ability to finish your private labels. Most retailers have their own brand, they need customized supplements and packaging services. If you are seeking to a trusted manufacturer, we can promise you that adding your company name, creati

CAS NO.138112-76-2 High Quality Agomelatine

Cas:138112-76-2

Min.Order:1 Gram

FOB Price: $2.0

Type:Trading Company

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

We are manufacturer. Our main products including Tilmicosin Phosphate, Flunixin Meglumine, Imidocarb Dipropionate, Ceftiofur HCl, Ceftiofur Sodium, Probenecid etc. with nice quality and competitive price.

Agomelatine

Cas:138112-76-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Agomelatine

Cas:138112-76-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Agomelatine

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $2600.0 / 3000.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

99% Purity Agomelatine CAS 138112-76-2 with High Quality

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

AGOMELATINE-

Cas:138112-76-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 138112-76-2 with competitive price

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we a

Agomelatine

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $777.0 / 888.0

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

AGOMELATINE 138112-76-2

Cas:138112-76-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Agomelatine

Cas:138112-76-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Agomelatine/ LIDE PHARMA- Factory supply / Best price

Cas:138112-76-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

cas 138112-76-2 99% purity Agomelatine powder Product Name: AGOMELATINE CAS: 138112-76-2 MF: C15H17NO2 MW: 243.3 EINECS: 629-727-7 Appearance:white Storage:room Package:drum Application:Agomelatine, which is developed antidepres

cas 138112-76-2 99% purity Agomelatine powder

Cas:138112-76-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Agomelatine Synonyms: N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide CAS:138112-76-2 MF: C12H18N4O5S Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:APIs Transportation:By sea or

Agomelatine CAS:138112-76-2

Cas:138112-76-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

Nootropics for Major Depressive Disorder Agomelatine CAS:138112-76-2

Cas:138112-76-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Synthetic route

2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride
139525-77-2

2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With sodium acetate In ethanol for 1h; Reflux;99.5%
With sodium acetate In Isopropyl acetate99%
With sodium acetate In ethanol for 1h; Reflux;95%
2-(2-methoxynaphthalen-8-yl)acetaldehyde oxime
1331869-01-2

2-(2-methoxynaphthalen-8-yl)acetaldehyde oxime

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With hydrogen; acetic anhydride In tetrahydrofuran at 50℃; under 7500.75 Torr; for 6h; Autoclave; Inert atmosphere;98%
N,N-dibenzyl-2-(7-methoxynaphthalen-1-yl)ethanamine

N,N-dibenzyl-2-(7-methoxynaphthalen-1-yl)ethanamine

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
Stage #1: N,N-dibenzyl-2-(7-methoxynaphthalen-1-yl)ethanamine With 20% palladium hydroxide-activated charcoal; hydrogen In ethanol; water; ethyl acetate under 3750.38 Torr; for 30h; Autoclave;
Stage #2: acetic anhydride With sodium acetate for 4h;
98%
2-(7-methoxynaphth-1-yl)ethylamine
138113-09-4

2-(7-methoxynaphth-1-yl)ethylamine

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 6h; Concentration; Temperature;97.5%
With sodium acetate In ethanol at 65℃; Green chemistry;92%
With triethylamine In toluene at 20 - 30℃;90%
2-(7-methoxynaphth-1-yl)ethylamine
138113-09-4

2-(7-methoxynaphth-1-yl)ethylamine

acetyl chloride
75-36-5

acetyl chloride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 5℃;95%
In pyridine92%
With pyridine for 0.5h; Product distribution / selectivity; Cooling with ice;92%
dimethyl sulfate
77-78-1

dimethyl sulfate

N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide
152302-45-9

N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With potassium carbonate In acetone for 5h; Reflux;94.5%
1-(2-nitroethyl)-7-methoxynaphthalene
1424944-40-0

1-(2-nitroethyl)-7-methoxynaphthalene

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In water; ethyl acetate at 20℃;92%
1-[2-(7-methoxynahthalen-1-yl)-ethyl]-2λ5-triaz-1-en-2-yne
1384536-35-9

1-[2-(7-methoxynahthalen-1-yl)-ethyl]-2λ5-triaz-1-en-2-yne

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In water; ethyl acetate at 20℃;92%
N-[2-(7-methoxy-3,4-dihydro-naphthalen-1-yl)ethyl]acetamide
1352139-51-5

N-[2-(7-methoxy-3,4-dihydro-naphthalen-1-yl)ethyl]acetamide

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃;91.8%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone for 4h; Product distribution / selectivity; Reflux;90%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran at 20℃; Product distribution / selectivity;80%
2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride
139525-77-2

2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride

acetyl chloride
75-36-5

acetyl chloride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 2h;91%
Stage #1: 2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride With triethylamine In dichloromethane at 25 - 35℃; for 0.5h;
Stage #2: acetyl chloride In dichloromethane at 10 - 20℃; for 1h;
90%
With potassium carbonate In chloroform; water for 0.5h; Ambient temperature;89%
With potassium carbonate In chloroform; water at 0℃;
Stage #1: 2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride With potassium carbonate In water; ethyl acetate at 20℃; Schotten-Baumann reaction;
Stage #2: acetyl chloride In water; ethyl acetate at 0 - 20℃; for 1h; Schotten-Baumann reaction;
2-(7-methoxynaphthalen-1-yl)ethanamine carbon dioxide adduct

2-(7-methoxynaphthalen-1-yl)ethanamine carbon dioxide adduct

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With sodium acetate In methanol Reflux;91%
With sodium acetate In methanol Reflux;91%
With sodium acetate In methanol Reflux;91%
acetic anhydride
108-24-7

acetic anhydride

(7-methoxy-1-naphthyl)acetonitrile
138113-08-3

(7-methoxy-1-naphthyl)acetonitrile

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With hydrogen; Raney nickel In ethanol; water at 70℃; under 22502.3 Torr;89%
With hydrogen In ethanol; water at 70℃; under 22502.3 Torr;89%
With hydrogen In ethanol; water at 70℃; under 22502.3 Torr; for 1h;89%
With hydrogen In ethanol at 60℃; under 37503.8 Torr; for 4h;
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With hydrogen; sodium hydroxide In methanol; water at 30℃; under 3000.3 Torr;
Stage #2: acetic anhydride In methanol at 15 - 25℃;
2-(7-methoxynaphthalen-1-yl)ethen-1-amine

2-(7-methoxynaphthalen-1-yl)ethen-1-amine

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With sodium acetate In ethanol; acetic anhydride at 25℃; for 1h; Temperature;88.1%
1-[2-(acetylamino)ethyl]-7-methoxynaphthalen-2-yl propane-1-sulphonate

1-[2-(acetylamino)ethyl]-7-methoxynaphthalen-2-yl propane-1-sulphonate

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With palladium 10% on activated carbon; ammonium acetate; magnesium In ethanol for 16h;87%
N-[2-(1-hydroxyl-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)ethyl]-acetamide
1352139-49-1

N-[2-(1-hydroxyl-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)ethyl]-acetamide

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 40℃; for 5h;85%
With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 40℃; for 5h;
Multi-step reaction with 2 steps
1: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C
2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C
View Scheme
2-(2-(7-methoxynaphthalen-1-yl)ethyl) isoindoline-1,3-dione
1206788-15-9

2-(2-(7-methoxynaphthalen-1-yl)ethyl) isoindoline-1,3-dione

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
Stage #1: 2-(2-(7-methoxynaphthalen-1-yl)ethyl) isoindoline-1,3-dione With hydrazine hydrate In methanol; dichloromethane at 30℃; for 14h;
Stage #2: acetic anhydride With triethylamine In methanol; dichloromethane; toluene at 25℃; for 0.333333h;
85%
1-[2-(acetylamino)ethyl]-7-methoxynaphthalen-2-yl-4-methylbenzenesulphonate

1-[2-(acetylamino)ethyl]-7-methoxynaphthalen-2-yl-4-methylbenzenesulphonate

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate; nickel dichloride at 20℃; for 0.5h; Sealed tube; Inert atmosphere;80%
2-(2-methoxynaphthalen-8-yl)acetamide
138113-07-2

2-(2-methoxynaphthalen-8-yl)acetamide

acetic acid
64-19-7

acetic acid

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With sodium tetrahydroborate In 1,4-dioxane at 95 - 98℃; for 22h;76.3%
acetic anhydride
108-24-7

acetic anhydride

2-(7-methoxynaphthalen-1-yl)ethyl methanesulphonate
185336-04-3

2-(7-methoxynaphthalen-1-yl)ethyl methanesulphonate

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
Stage #1: 2-(7-methoxynaphthalen-1-yl)ethyl methanesulphonate With ammonia In water; acetonitrile at 110℃; for 3h;
Stage #2: acetic anhydride With sodium acetate for 1h;
74%
N-[2-(4-chloro-7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide
1384261-25-9

N-[2-(4-chloro-7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol for 3h; Reflux;68%
N-[2-(4-bromo-7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide
1384261-27-1

N-[2-(4-bromo-7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol for 3h; Reflux;68%
(E)-7-methoxy-1-(2-nitrovinyl)naphthalene
1415243-95-6

(E)-7-methoxy-1-(2-nitrovinyl)naphthalene

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With palladium 10% on activated carbon; acetic acid65%
2-(7-methoxynaphth-1-yl)ethylamine
138113-09-4

2-(7-methoxynaphth-1-yl)ethylamine

sodium acetate
127-09-3

sodium acetate

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With acetic anhydride In ethanol at 20℃; for 1h;61%
N-[2-(7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide
1384261-23-7

N-[2-(7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane for 48h;48%
1-[2-(2,5-dioxopyrrolidin-1-yl)ethyl]-7-methoxynaphthalen-2-yl propane-1-sulphonate

1-[2-(2,5-dioxopyrrolidin-1-yl)ethyl]-7-methoxynaphthalen-2-yl propane-1-sulphonate

acetic anhydride
108-24-7

acetic anhydride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
Stage #1: 1-[2-(2,5-dioxopyrrolidin-1-yl)ethyl]-7-methoxynaphthalen-2-yl propane-1-sulphonate With palladium 10% on activated carbon; ammonium acetate; magnesium In methanol at 30℃; for 12h;
Stage #2: acetic anhydride With sodium acetate; sodium hydroxide In ethanol; water for 1h; Sealed tube;
37%
2-(7-methoxynaphth-1-yl)ethylamine
138113-09-4

2-(7-methoxynaphth-1-yl)ethylamine

[14C]acetyl-CoA

[14C]acetyl-CoA

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
With sheep pineal supernatant (serotonin-N-acetyl transferase); Pargyline In phosphate buffer at 37℃; for 0.166667h; pH=6.8; Enzyme kinetics;
2-(7-methoxynaphthalen-1-yl)acetic acid
6836-22-2

2-(7-methoxynaphthalen-1-yl)acetic acid

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / CHCl3
2: aq. NH4OH / diethyl ether / 0 °C
3: AlH4 / diethyl ether
4: K2CO3 / H2O; CHCl3 / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: thionyl chloride / CHCl3
2: aq. NH4OH / diethyl ether / 0 °C
3: (CF3CO)2O / tetrahydrofuran / 0 °C
4: H2, HCl / Ni Raney / diethyl ether
5: K2CO3 / H2O; CHCl3 / 0 °C
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride / dichloromethane / 2 h / Reflux
2.1: ammonia / ethyl acetate; water / Cooling with ice
3.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice
4.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave
5.1: pyridine / 40 °C
5.2: 20 °C / Cooling with ice
View Scheme
2-(2-methoxynaphthalen-8-yl)acetamide
138113-07-2

2-(2-methoxynaphthalen-8-yl)acetamide

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AlH4 / diethyl ether
2: K2CO3 / H2O; CHCl3 / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: (CF3CO)2O / tetrahydrofuran / 0 °C
2: H2, HCl / Ni Raney / diethyl ether
3: K2CO3 / H2O; CHCl3 / 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice
2.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave
3.1: pyridine / 40 °C
3.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C
2.1: sodium hydroxide; hydrogen / water; methanol; isopropyl alcohol / 25 - 30 °C / 7500.75 Torr
2.2: 1 h / 50 - 55 °C
3.1: sodium hydroxide / water; toluene / 0.25 h / 20 - 25 °C
3.2: 35 - 40 °C
View Scheme
(7-methoxy-1-naphthyl)acetonitrile
138113-08-3

(7-methoxy-1-naphthyl)acetonitrile

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2, HCl / Ni Raney / diethyl ether
2: K2CO3 / H2O; CHCl3 / 0 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave
2.1: pyridine / 40 °C
2.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; hydrogen / water; methanol; isopropyl alcohol / 25 - 30 °C / 7500.75 Torr
1.2: 1 h / 50 - 55 °C
2.1: sodium hydroxide / water; toluene / 0.25 h / 20 - 25 °C
2.2: 35 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1.1: ammonia; hydrogen / methanol / 15 - 55 °C / 3750.38 Torr / Autoclave
1.2: 1 h / 0 - 5 °C
2.1: triethylamine / dichloromethane / 0.5 h / 25 - 35 °C
2.2: 1 h / 10 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: ammonia; hydrogen / ethanol / 24 h / 30 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave
2: triethylamine / toluene / 0.5 h / 0 - 30 °C
View Scheme
(7-methoxy-1-naphthyl)acetic acid chloride
6836-23-3

(7-methoxy-1-naphthyl)acetic acid chloride

agomelatine
138112-76-2

agomelatine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. NH4OH / diethyl ether / 0 °C
2: AlH4 / diethyl ether
3: K2CO3 / H2O; CHCl3 / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: aq. NH4OH / diethyl ether / 0 °C
2: (CF3CO)2O / tetrahydrofuran / 0 °C
3: H2, HCl / Ni Raney / diethyl ether
4: K2CO3 / H2O; CHCl3 / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ammonia / ethyl acetate; water / Cooling with ice
2.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice
3.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave
4.1: pyridine / 40 °C
4.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1.1: ammonia / toluene / 0 - 5 °C / pH 10 - 11
2.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C
3.1: sodium hydroxide; hydrogen / water; methanol; isopropyl alcohol / 25 - 30 °C / 7500.75 Torr
3.2: 1 h / 50 - 55 °C
4.1: sodium hydroxide / water; toluene / 0.25 h / 20 - 25 °C
4.2: 35 - 40 °C
View Scheme
agomelatine
138112-76-2

agomelatine

maleic acid
110-16-7

maleic acid

agomelatine maleic acid
1403960-82-6

agomelatine maleic acid

Conditions
ConditionsYield
In ethanol for 0.75h;100%
In methanol; ethyl acetate at 20℃; for 168h; Product distribution / selectivity;
for 1h;
agomelatine
138112-76-2

agomelatine

citric acid
77-92-9

citric acid

agomelatine citric acid
1403960-81-5

agomelatine citric acid

Conditions
ConditionsYield
In acetone at 20℃;100%
In methanol; ethyl acetate at 2 - 5℃; Product distribution / selectivity; Reflux;
In methanol at 20℃; for 20h; Product distribution / selectivity;
2,5-dihydroxybenzoic acid.
490-79-9

2,5-dihydroxybenzoic acid.

agomelatine
138112-76-2

agomelatine

agomelatine gentisic acid
1419379-42-2

agomelatine gentisic acid

Conditions
ConditionsYield
In toluene for 0.75h;100%
ethylene glycol
107-21-1

ethylene glycol

agomelatine
138112-76-2

agomelatine

C2H6O2*C15H17NO2
1259393-47-9

C2H6O2*C15H17NO2

Conditions
ConditionsYield
at 110 - 130℃; for 5h;98%
isonicotinamide
1453-82-3

isonicotinamide

agomelatine
138112-76-2

agomelatine

agomelatine isonicotinamide adduct
1366181-84-1

agomelatine isonicotinamide adduct

Conditions
ConditionsYield
at 135℃; Neat (no solvent);98%
methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

agomelatine
138112-76-2

agomelatine

agomelatine methyl 4-hydroxybenzoate adduct
1366181-85-2

agomelatine methyl 4-hydroxybenzoate adduct

Conditions
ConditionsYield
at 110℃; Neat (no solvent);98%
agomelatine
138112-76-2

agomelatine

N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide hydrogen sulfate

N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide hydrogen sulfate

Conditions
ConditionsYield
With sulfuric acid In acetone at 10 - 20℃; Solvent; Temperature;96.9%
With sulfuric acid In acetone at 10 - 20℃; Solvent; Temperature;13.6 g
With sulfuric acid In ethyl acetate at 20℃;
acetic acid
64-19-7

acetic acid

agomelatine
138112-76-2

agomelatine

agomelatine 1:1 cocrystal with acetic acid
1259393-46-8

agomelatine 1:1 cocrystal with acetic acid

Conditions
ConditionsYield
In diethyl ether for 48h;96%
at 20 - 45℃; for 480h; Sealed tube;
agomelatine
138112-76-2

agomelatine

urea
57-13-6

urea

agomelatine urea adduct
1366181-82-9

agomelatine urea adduct

Conditions
ConditionsYield
at 120℃; for 0.333333h; Neat (no solvent);96%
In ethanol at 20℃; for 2h; Time;70%
In isopropyl alcohol at 20℃; for 20h;41%
agomelatine
138112-76-2

agomelatine

benzenesulfonic acid
98-11-3

benzenesulfonic acid

N-[2-(7-methoxyl-1-naphthyl)ethyl]acetamide benzenesulfonic acid
1402317-73-0

N-[2-(7-methoxyl-1-naphthyl)ethyl]acetamide benzenesulfonic acid

Conditions
ConditionsYield
In acetone at 25℃; Solvent; Temperature;95.8%
In methanol; ethyl acetate at 2 - 20℃; Product distribution / selectivity;
In dichloromethane at 10 - 20℃; Solvent; Temperature;15.6 g
In methanol; ethyl acetate Heating;
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

agomelatine
138112-76-2

agomelatine

agomelatine p-toluenesulfonic acid monohydrate

agomelatine p-toluenesulfonic acid monohydrate

Conditions
ConditionsYield
In tetrahydrofuran; hexane for 0.5h; Solvent; Temperature; Reflux;95.8%
agomelatine
138112-76-2

agomelatine

N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide
152302-45-9

N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide

Conditions
ConditionsYield
With boron tribromide In dichloromethane at -10 - 20℃; for 2h;93.3%
Stage #1: agomelatine With boron tribromide In dichloromethane at 0℃; for 2h;
Stage #2: With water In dichloromethane at 0℃;
80%
With hydrogenchloride In water at 80℃;74.8%
glycolic Acid
79-14-1

glycolic Acid

agomelatine
138112-76-2

agomelatine

agomelatine glycolic acid adduct
1366181-83-0

agomelatine glycolic acid adduct

Conditions
ConditionsYield
In acetonitrile for 2h; Reflux;93%
for 0.25h;
agomelatine
138112-76-2

agomelatine

N [2-(7-methoxynaphthalen-1-yl)ethyl]acetamide hydrochloride
1176316-99-6

N [2-(7-methoxynaphthalen-1-yl)ethyl]acetamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate at 10℃; Product distribution / selectivity;88.7%
With hydrogenchloride In water; ethyl acetate at 10℃; for 1h;88.7%
With hydrogenchloride In water; ethyl acetate at 10℃; for 1h;88.7%
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

agomelatine
138112-76-2

agomelatine

agomelatine p-toluenesulfonic acid

agomelatine p-toluenesulfonic acid

Conditions
ConditionsYield
In acetone at 0 - 10℃;88.2%
In acetone at 0 - 10℃;1.5 g
agomelatine
138112-76-2

agomelatine

N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide hydrobromide
1176317-02-4

N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water; ethyl acetate at 20℃; for 1h; Product distribution / selectivity;85.3%
With hydrogen bromide In water; ethyl acetate at 20℃; for 1h; Temperature;85.3%
With hydrogen bromide In water; ethyl acetate for 1h;85.3%
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View