DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/881.html Product Name 7-Methoxy-1-naphthylacetonitrile CAS No. 138113-08-3
Cas:138113-08-3
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inquiry7-Methoxy-1-naphthylacetonitrile CAS 138113-08-3 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chem
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inquiryAgomelatine[CAS:138112-76-2] 7-Methoxy-1-Naphthylacetonitrile[CAS:138113-08-3] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of bu
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inquiryhigh quality Appearance:Colorless liquid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryAssay: 99% up; Stable supply with over 50Mt annually; Appearance:Off-white powder Storage:room temprature Package:1kg/bag, 25kg/drum Application:Intermediate of Agmetatin Port:Beijing/Shanghai/Shenzhen/Hangzhou
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryName: 7-Methoxy-1-naphthylacetonitrile CAS NO:138113-08-3 Grade:Lenalidomide intermediate Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Pr
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry7-Methoxy-1-naphthylacetonitrile CAS:138113-08-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality
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inquiryProduct Name: 7-Methoxy-1-naphthylacetonitrile Synonyms: 1-Cyanomethyl-7-methoxynaphthalene;2-(7-Methoxy-1-naphthyl)acetonitrile;7-Methoxy-1-naphthaleneacetinitrile;7-Methoxy-1-naphthylacetonitrile;2-(7-methoxynaphthalen-1-yl)acetonitrile;Agomela
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio
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inquiryWe are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of 7-Methoxy-1-naphthylacetonitrile from Wuhan, Hubei, China. It is mad
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiry(7-methoxy-1-naphthyl)acetonitrile
sodium cyanide
1-bromomethyl-7-methoxynaphthalene
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 140 - 145℃; for 3h; | 99% |
2-(7-methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; under 15.0015 Torr; for 6h; Catalytic behavior; Solvent; Pressure; Green chemistry; | 95% |
With oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; under 15.0015 Torr; for 5h; Solvent; Pressure; Time; | 93% |
With oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; under 15.0015 Torr; for 5h; Pressure; Solvent; | 93% |
7-Methoxy-1-tetralone
cyanoacetic acid
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon In dimethyl sulfoxide at 20℃; for 4.5h; Molecular sieve; | 95% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With acetic acid for 12h; Reflux; | 95% |
1-bromo-7-methoxy-naphthalene
cyanomethyl bromide
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Stage #1: 1-bromo-7-methoxy-naphthalene With iodine; magnesium In tetrahydrofuran at 5 - 38℃; for 2.08333h; Stage #2: cyanomethyl bromide In tetrahydrofuran at 0 - 55℃; for 2h; Temperature; Solvent; Concentration; | 94.6% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With formic acid In toluene for 12h; Reflux; | 94% |
(7-hydroxy-1-naphthyl)acetonitrile
dimethyl sulfate
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 3h; Reflux; | 92.9% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
In toluene for 12h; Reflux; | 92% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With acetic acid In toluene for 12h; Reflux; | 92% |
2-(2-methoxynaphthalen-8-yl)acetamide
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With trichlorophosphate In dichloromethane; N,N-dimethyl-formamide at 85℃; for 2h; | 91% |
With triethylamine; trifluoroacetic anhydride In tetrahydrofuran for 1h; Ambient temperature; | 83% |
With triethylamine; trifluoroacetic anhydride In tetrahydrofuran at 20℃; Cooling with ice; | 80% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With butyric acid In ethyl acetate for 12h; Reflux; | 90% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With acetic acid for 12h; Reflux; | 90% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With acetic acid for 12h; Reflux; | 89% |
1-hydroxy-7-methoxy-3,4-dihydro-1-naphthylacetonitrile
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 1h; Heating; | 88.2% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With acetic acid In toluene for 12h; Reflux; | 88% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen; triethylamine In ethanol at 20℃; under 3000.3 Torr; for 20h; | 67% |
(7-methoxy-1,2-dihydro-1-naphthyl)acetonitrile
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With chloranil In toluene at 80℃; for 2.5h; | 61% |
2-(1-hydroxyl-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetonitrile
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90.7 percent / DDQ / CH2Cl2 / 20 °C 2: 88.2 percent / TsOH*H2O / benzene / 1 h / Heating View Scheme |
7-Methoxy-1-tetralone
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 2: 90.7 percent / DDQ / CH2Cl2 / 20 °C 3: 88.2 percent / TsOH*H2O / benzene / 1 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1.1: zinc / iodine / toluene / Reflux 1.2: Reflux 1.3: 3 h / Reflux 2.1: sulfur / ethyl acetate / 10 h / 215 °C 3.1: sodium hydroxide; water / ethanol / 3 h / 20 °C 4.1: thionyl chloride / dichloromethane / 2 h / Reflux 5.1: ammonia / ethyl acetate; water / Cooling with ice 6.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: ammonium acetate / toluene / Azeotropic reflux 2: sulfur / 0.17 h / 175 °C View Scheme |
2-(7-methoxynaphthalen-1-yl)acetic acid
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: SOCl2 / CHCl3 / 2 h / Heating 2: conc. aq. NH3 / diethyl ether / 0.5 h 3: 83 percent / Et3N, (CF3CO)2O / tetrahydrofuran / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / CHCl3 2: aq. NH4OH / diethyl ether / 0 °C 3: (CF3CO)2O / tetrahydrofuran / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 2 h / Reflux 2: ammonia / ethyl acetate; water / Cooling with ice 3: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 2: ammonia / toluene / 0 - 5 °C / pH 10 - 11 3: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C View Scheme |
(7-methoxy-1-naphthyl)acetic acid chloride
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: conc. aq. NH3 / diethyl ether / 0.5 h 2: 83 percent / Et3N, (CF3CO)2O / tetrahydrofuran / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: aq. NH4OH / diethyl ether / 0 °C 2: (CF3CO)2O / tetrahydrofuran / 0 °C View Scheme |
ethyl 2-(7-methoxynaphthalen-1-yl)acetate
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide; water / ethanol / 3 h / 20 °C 2: thionyl chloride / dichloromethane / 2 h / Reflux 3: ammonia / ethyl acetate; water / Cooling with ice 4: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice View Scheme |
ethyl (1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)acetate
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sulfur / ethyl acetate / 10 h / 215 °C 2: sodium hydroxide; water / ethanol / 3 h / 20 °C 3: thionyl chloride / dichloromethane / 2 h / Reflux 4: ammonia / ethyl acetate; water / Cooling with ice 5: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice View Scheme |
1-methyl-7-methoxynaphthalene
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1.5 h / Reflux; Microwave irradiation 2: dimethyl sulfoxide / 3 h / 140 - 145 °C View Scheme |
(7-methoxy-4-oxo-1,2,3,4-tetrahydro-1-naphthyl)acetonitrile
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aluminum isopropoxide / isopropyl alcohol / 20 °C / Reflux 1.2: 1 h / Dean-Stark; Reflux 2.1: chloranil / toluene / 2.5 h / 80 °C View Scheme |
O-ethyl S-2-(4-methoxyphenyl)-2-oxoethyl carbonodithioate
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: ethyl acetate / 0.25 h / Reflux; Inert atmosphere 1.2: Reflux 2.1: chlorobenzene / 0.25 h / Reflux; Inert atmosphere 2.2: Reflux 3.1: aluminum isopropoxide / isopropyl alcohol / 20 °C / Reflux 3.2: 1 h / Dean-Stark; Reflux 4.1: chloranil / toluene / 2.5 h / 80 °C View Scheme |
S-[1-(cyanomethyl)-4-(4-methoxyphenyl)-4-oxobutyl]-O-ethyl dithiocarbonate
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: chlorobenzene / 0.25 h / Reflux; Inert atmosphere 1.2: Reflux 2.1: aluminum isopropoxide / isopropyl alcohol / 20 °C / Reflux 2.2: 1 h / Dean-Stark; Reflux 3.1: chloranil / toluene / 2.5 h / 80 °C View Scheme |
[7-Methoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-acetic acid
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium on activated charcoal; sodium carbonate; acrylic acid / water / 100 - 105 °C 2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 3: ammonia / toluene / 0 - 5 °C / pH 10 - 11 4: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C View Scheme |
ethyl (7-methoxy-1,2,3,4-tetrahydro-1-naphthalenylidene)acetate
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium hydroxide / tert-butyl alcohol / 2 h / 85 - 90 °C 2: palladium on activated charcoal; sodium carbonate; acrylic acid / water / 100 - 105 °C 3: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 4: ammonia / toluene / 0 - 5 °C / pH 10 - 11 5: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C View Scheme |
(7-methoxy-1-naphthyl)acetonitrile
2-(7-methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile
Conditions | Yield |
---|---|
With allyl methacrylate; 5% active carbon-supported ruthenium In toluene at 80℃; for 4h; Catalytic behavior; Temperature; Solvent; | 96.2% |
(7-methoxy-1-naphthyl)acetonitrile
2-(7-methoxynaphth-1-yl)ethylamine
Conditions | Yield |
---|---|
With ammonia; hydrogen In ethanol; water at 60℃; under 228015 Torr; for 12h; Autoclave; | 95% |
With hydrogen; ammonium hydroxide; nickel In methanol at 20℃; under 3102.97 Torr; for 20h; | 92% |
With ammonia; hydrogen In ethanol at 45℃; under 15001.5 Torr; Temperature; Pressure; Green chemistry; | 71.2% |
(7-methoxy-1-naphthyl)acetonitrile
d2-(7-methoxy-naphthalen-1-yl)acetonitrile
Conditions | Yield |
---|---|
With d(4)-methanol; water-d2; potassium carbonate In tetrahydrofuran at 20℃; for 5h; | 95% |
(7-methoxy-1-naphthyl)acetonitrile
2-(7-methoxynaphthalen-1-yl)acetic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide at 120℃; for 0.666667h; Microwave irradiation; | 93% |
(7-methoxy-1-naphthyl)acetonitrile
2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride
Conditions | Yield |
---|---|
With hydrogen; sodium hydroxide In methanol; water at 30℃; under 3000.3 Torr; | 92% |
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With hydrogen; sodium hydroxide In methanol; water; isopropyl alcohol at 25 - 30℃; under 7500.75 Torr; Stage #2: With hydrogenchloride In methanol; water; isopropyl alcohol at 50 - 55℃; for 1h; | 90% |
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With ammonia; hydrogen In methanol at 15 - 55℃; under 3750.38 Torr; Autoclave; Stage #2: With hydrogenchloride In methanol; water; ethyl acetate at 0 - 5℃; for 1h; | 83% |
Conditions | Yield |
---|---|
With hydrogen; Raney nickel In ethanol; water at 70℃; under 22502.3 Torr; | 89% |
With hydrogen In ethanol; water at 70℃; under 22502.3 Torr; | 89% |
With hydrogen In ethanol; water at 70℃; under 22502.3 Torr; for 1h; | 89% |
With hydrogen In ethanol at 60℃; under 37503.8 Torr; for 4h; | |
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With hydrogen; sodium hydroxide In methanol; water at 30℃; under 3000.3 Torr; Stage #2: acetic anhydride In methanol at 15 - 25℃; |
(7-methoxy-1-naphthyl)acetonitrile
carbonic acid dimethyl ester
methyl 2-cyano-2-(7-methoxynaphthalen-1-yl)acetate
Conditions | Yield |
---|---|
With sodium at 110℃; for 1h; | 88% |
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Reflux; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran; mineral oil for 0.5h; Reflux; | 80% |
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Heating / reflux; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran for 0.5h; Heating / reflux; | |
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Heating / reflux; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran for 0.5h; Heating / reflux; Stage #3: With hydrogenchloride In water |
(7-methoxy-1-naphthyl)acetonitrile
methyl iodide
2-(7-methoxynaphthalen-1-yl)propionitrile
Conditions | Yield |
---|---|
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Metallation; Stage #2: methyl iodide In N,N-dimethyl-formamide for 1h; Methylation; | 84% |
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 21℃; for 12h; | 83% |
carbon dioxide
(7-methoxy-1-naphthyl)acetonitrile
Conditions | Yield |
---|---|
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With ammonium hydroxide; hydrogen In methanol; water at 40℃; Stage #2: carbon dioxide In toluene at 10 - 15℃; | 81% |
(7-methoxy-1-naphthyl)acetonitrile
methyl iodide
2-(7-methoxynaphthalen-1-yl)-2-methylpropanenitrile
Conditions | Yield |
---|---|
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at -30℃; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at -30 - 65℃; | 80.3% |
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With potassium carbonate In acetone for 0.5h; Reflux; Stage #2: methyl iodide In acetone for 2h; Reflux; | 75% |
di-tert-butyl dicarbonate
(7-methoxy-1-naphthyl)acetonitrile
Tert-butyl (2-(7-methoxynaphthalen-1-yl)ethyl)carbamate
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride In methanol at 20℃; for 12h; Inert atmosphere; | 80% |
bromoacetic acid methyl ester
(7-methoxy-1-naphthyl)acetonitrile
methyl 3-cyano-3-(7-methoxynaphthalen-1-yl)propanoate
Conditions | Yield |
---|---|
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With tetrabutylammomium bromide; potassium carbonate In acetone for 0.5h; Reflux; Stage #2: bromoacetic acid methyl ester In acetone for 24h; Reflux; | 75% |
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With sodium hydride In tetrahydrofuran at 50℃; for 1h; Metallation; Stage #2: bromoacetic acid methyl ester In tetrahydrofuran for 1h; Alkylation; Heating; | 67% |
(7-methoxy-1-naphthyl)acetonitrile
α-bromoacetophenone
Conditions | Yield |
---|---|
Stage #1: (7-methoxy-1-naphthyl)acetonitrile; α-bromoacetophenone With chloro-trimethyl-silane; zinc In tetrahydrofuran for 6h; Blaise Reaction; Reflux; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 100℃; for 0.5h; pH=2; Blaise Reaction; Inert atmosphere; | 75% |
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