Products

Refine

Country

Business Type

Certificate

Display

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Vildagliptin

Cas:274901-16-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

We are the manufacturer of this product in China. Our price is the lowest in China. CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and techni

Vildagliptin high purity, lowest price in China

Cas:274901-16-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Hysen Pharma co.,Ltd.

We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&am

Vildagliptin factory

Cas:274901-16-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Vildagliptin Manufacturer/High quality/Best price/In stock

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) W

99% up Vildagliptin 274901-16-5

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $825.0 / 1100.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 274901-16-5 Vildagliptin

Cas:274901-16-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Vildagliptin

Cas:274901-16-5

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Powder Storage:-20°C Freezer Package:1kg/foil bag; 1kg/tin ;

High purity Vildagliptin CAS 274901-16-5 supplied by Chinese manufacturer

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Name Vildagliptin Synonyms (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile Molecular Structure

High purity Vildagliptin API and intermediates factory with competitive price

Cas:274901-16-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dry, m

Vildagliptin

Cas:274901-16-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Vildagliptin

Cas:274901-16-5

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Vildagliptin 274901-16-5 GMP Manufacturer

Cas:274901-16-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Vildagliptin

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

SICHUAN TONGSHENG AMINOACID CO.LTD

Name: Vildagliptin CAS No.: 274901-16-5 MF: C17H25N3O2 Use: Anti-diabetic agent Appearance: White powder General introduction: Vildagliptin (previously identified as LAF237, trade name ZOMELIS) is an oral anti-hyperglycemic agent (anti-diabetic

Vildagliptin 274901-16-5

Cas:274901-16-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

1. We are committed to protect the integrity of our products and services. 2. Our Research and Development professional team is consisted of PhDs and Masters in biochemistry and pharmacy. 3. Our Production facility is operated by the seasoned s

Vildagliptin CAS No:274901-16-5

Cas:274901-16-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Vidagliptin

Cas:274901-16-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Vildagliptin

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Vildagliptin

Cas:274901-16-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Vildagliptin CAS 274901-16-5 In stock

Cas:274901-16-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Vildagliptin CAS NO: 274901-16-5 Grade:Medical scientific research and export Molecular formula: C18H20F6N3O5P Molecular weight:503.3326802 Product Quality 12 years of chemical raw materials Mature operation of the industry System sta

Vildagliptin/ CAS:274901-16-5/Vildagliptin raw material/ high-quality

Cas:274901-16-5

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

discount Vildagliptin

Cas:274901-16-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Density: 1.27 Melting point: 153-155 C Boiling point: 531.3 ± 50.0 ° C (Predicted) Specific rotation: -78.3 ° (c=9.73 in methanol) Flash point: 275.1 ℃ Solubility: Double in DMSO (up to 45 mg/ml), in DMF (up to 20 mg/ml), or in Ethano

Vildagliptin 274901-16-5

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 274901-16-5 with competitive price

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Vildagliptin CAS No.:274901-16-5 MF: C17H25N3O2 Purity: 99% Appearance:White powder Vildagliptin,Vildagliptin powder Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:

Vildagliptin

Cas:274901-16-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Applications Lithium hydride is used as condensation agent, reducing agent, alkylation reagent and desiccant in organic synthesis, and is also a good hydrogen storage material Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned

Hot Sell 99% High Putiry Vildagliptin Lowest price Vildagliptin CAS 274901-16-5

Cas:274901-16-5

Min.Order:10 Metric Ton

FOB Price: $1500.0 / 2000.0

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Good Quality Vildagliptin CAS 274901-16-5 Glyptins for Antidiabetic

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Pyrrolidinecarbonitrile,1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S)- 274901-16-5

Cas:274901-16-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Top Quality 99.0% purity Vildagliptin/ Galvus / Laf 237 / Vildagliptin (NVP-LAF 237)

Cas:274901-16-5

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Vildagliptin Chemical Properties Melting point 153-155 C alpha -78.3° (c = 9.73 in methanol) Boiling point 531.3±50.0 °C(Predicted) density 1.27 Fp 275.1℃ storage temp. Keep in dark place,Inert atmosphere,Store

Vildagliptin,

Cas:274901-16-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Vildagliptin

Cas:274901-16-5

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1400.0

Type:Trading Company

inquiry

Synthetic route

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile calcium(II)-chloride

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile calcium(II)-chloride

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
With sodium carbonate; sodium chloride In dichloromethane at 20 - 40℃; Product distribution / selectivity;95%
With sodium carbonate In water at 40℃; for 0.0333333h; Product distribution / selectivity;75%
(2S)‐1‐[[(3-hydroxytricyclo[3.3.1.1[3,7]]decane-1-yl)imino]acetyl]pyrrolidine-2-carbonitrile

(2S)‐1‐[[(3-hydroxytricyclo[3.3.1.1[3,7]]decane-1-yl)imino]acetyl]pyrrolidine-2-carbonitrile

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
With palladium on activated charcoal; ammonium formate In tetrahydrofuran at 20℃; for 8h; Reagent/catalyst; Solvent; Temperature;91.9%
With palladium on activated charcoal; ammonium formate In tetrahydrofuran at 20℃; for 10h; Solvent; Reagent/catalyst; Temperature;91.9%
(3-hydroxyadamantan-1-ylamino)acetic acid
1032564-18-3

(3-hydroxyadamantan-1-ylamino)acetic acid

(S)-pyrrolidine-2-carbonitrile p-toluenesulfonate

(S)-pyrrolidine-2-carbonitrile p-toluenesulfonate

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Stage #1: C12H14N2O3S With sodium hydroxide In dichloromethane at 0℃; for 1.5h;
Stage #2: (3-hydroxyadamantan-1-ylamino)acetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; Concentration;
90.8%
C16H33NOSi2

C16H33NOSi2

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
207557-35-5

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Stage #1: C16H33NOSi2; (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile With N-ethyl-N,N-diisopropylamine; potassium iodide In acetonitrile at 75 - 80℃; for 3h;
Stage #2: With ethanol In acetonitrile for 2h; Reagent/catalyst;
88.3%
3-aminoadamantan-1-ol
702-82-9

3-aminoadamantan-1-ol

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
207557-35-5

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In tetrahydrofuran; butanone at 40℃; for 3h;82%
With potassium carbonate; potassium iodide In tetrahydrofuran; butanone at 40℃; for 3h; Reflux;82%
With potassium carbonate; potassium iodide In acetone at 50 - 55℃; for 3h; Solvent;82.2%
3-aminoadamantan-1-ol
702-82-9

3-aminoadamantan-1-ol

(S)-pyrrolidine-2-carbonitrile p-toluenesulfonate

(S)-pyrrolidine-2-carbonitrile p-toluenesulfonate

chloroacetyl chloride
79-04-9

chloroacetyl chloride

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Stage #1: (S)-pyrrolidine-2-carbonitrile p-toluenesulfonate; chloroacetyl chloride With triethylamine In dichloromethane at 0 - 5℃; for 2h;
Stage #2: 3-aminoadamantan-1-ol In water for 4h; Temperature; Reflux;
76.9%
(S)-1-[2-(3-hydroxyadamantan-1-ylamino)acetyl]pyrrolidine-2-carboxylic acid amide

(S)-1-[2-(3-hydroxyadamantan-1-ylamino)acetyl]pyrrolidine-2-carboxylic acid amide

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Stage #1: (S)-1-[2-(3-hydroxyadamantan-1-ylamino)acetyl]pyrrolidine-2-carboxylic acid amide With trifluoroacetic acid; trifluoroacetic anhydride In 2-methyltetrahydrofuran Reflux;
Stage #2: With potassium carbonate In 2-methyltetrahydrofuran; water at 5 - 10℃; Reagent/catalyst;
75%
With trichlorophosphate In dichloromethane at 10℃; for 4h; Reagent/catalyst; Solvent; Temperature; Time; Reflux;4.53 g
3-aminoadamantan-1-ol
702-82-9

3-aminoadamantan-1-ol

(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide
214398-99-9

(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Stage #1: (S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide With trifluoroacetic anhydride In tetrahydrofuran at 20℃; for 2h; Cooling with ice;
Stage #2: 3-aminoadamantan-1-ol With potassium carbonate; potassium iodide In tetrahydrofuran at 40℃; for 8.5h; Time; Reflux;
71%
(S)-1-{2-[benzyl(3-hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile

(S)-1-{2-[benzyl(3-hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃;61.5%
With palladium 10% on activated carbon; hydrogen In methanol for 22h;
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide
214398-99-9

(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 7.82 g / trifluoroacetic anhydride / tetrahydrofuran / 1 h / 20 °C
2: K2CO3 / tetrahydrofuran / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
2: potassium carbonate; potassium iodide / tetrahydrofuran / 5 h / 60 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 35 - 48 °C
2.1: potassium carbonate; potassium iodide / butanone / 40 °C
2.2: 3 h / 38 - 75 °C
View Scheme
Multi-step reaction with 2 steps
1.1: trichlorophosphate / -5 - 20 °C
2.1: potassium carbonate; potassium iodide / acetone / 0.25 h / 20 °C
2.2: 40 - 65 °C
View Scheme
L-prolinamide
7531-52-4

L-prolinamide

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 89 percent / K2CO3 / tetrahydrofuran
2: 7.82 g / trifluoroacetic anhydride / tetrahydrofuran / 1 h / 20 °C
3: K2CO3 / tetrahydrofuran / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 0 - 30 °C
1.2: 1 h / 0 - 5 °C
2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / tetrahydrofuran / 0.17 h / 0 °C
1.2: 5 h / 0 - 20 °C
2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
3.1: potassium carbonate; potassium iodide / tetrahydrofuran / 5 h / 60 - 65 °C
View Scheme
3-aminoadamantan-1-ol
702-82-9

3-aminoadamantan-1-ol

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
207557-35-5

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

A

(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile
1036959-23-5

(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile

B

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In tetrahydrofuran at 66℃; for 2 - 14h; Product distribution / selectivity; Heating / reflux;
With potassium carbonate In Isopropyl acetate at 45℃; for 14h; Product distribution / selectivity;
With potassium carbonate In tetrahydrofuran for 14h; Product distribution / selectivity; Heating / reflux;
(3-hydroxyadamantan-1-ylamino)acetic acid
1032564-18-3

(3-hydroxyadamantan-1-ylamino)acetic acid

(2S)-pyrrolidine-2-carbonitrile
204387-53-1

(2S)-pyrrolidine-2-carbonitrile

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 6h;
L-proline
147-85-3

L-proline

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 2.5 h / 65 - 70 °C
2.1: dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 - 30 °C
2.2: 3 h / 25 - 30 °C
3.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
4.1: potassium carbonate; potassium iodide / tetrahydrofuran / 5 h / 60 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 3 h / Reflux
2.1: dicyclohexyl-carbodiimide / dichloromethane / 5 h / 20 °C / Cooling with ice
2.2: 6 h / 20 °C
3.1: trifluoroacetic anhydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice
3.2: 8.5 h / 40 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 2.75 h / 90 °C / Cooling with ice
2.1: 1,3,5-trichloro-2,4,6-triazine / dichloromethane / 3 h / 0 °C / Reflux
2.2: 2 h
3.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 35 - 48 °C
4.1: potassium carbonate; potassium iodide / butanone / 40 °C
4.2: 3 h / 38 - 75 °C
View Scheme
3-aminoadamantan-1-ol
702-82-9

3-aminoadamantan-1-ol

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / tetrahydrofuran / 5 h / Reflux
2: potassium hydroxide; water / 12 h / 20 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran / 3 h / Reflux
2: sodium tetrahydroborate; methanol / 0.5 h
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: water / 48 h / 20 - 30 °C
2: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 3 h / 20 - 30 °C / Inert atmosphere
3: triethylamine / dichloromethane / 5 h / 0 - 10 °C / Inert atmosphere
4: potassium carbonate; methanol / 4 h / 40 °C
5: hydrogenchloride / water / 7 h / 70 °C
View Scheme
1-Adamantanamine
768-94-5

1-Adamantanamine

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate; potassium iodide / tetrahydrofuran / 5 h / Reflux
2: potassium hydroxide; potassium permanganate / water / 1.5 h / 60 - 90 °C
3: potassium hydroxide; water / 12 h / 20 °C
4: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sulfuric acid; nitric acid / water / 5 - 25 °C
1.2: 1 h / 0 - 40 °C
2.1: potassium carbonate; potassium iodide / dichloromethane / 0.5 h / Reflux; Inert atmosphere
2.2: 6 h / Reflux
3.1: ammonia / methanol / 10 - 75 °C
4.1: trifluoroacetic anhydride; trifluoroacetic acid / 2-methyltetrahydrofuran / Reflux
4.2: 5 - 10 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sulfuric acid; nitric acid / water / 5 - 25 °C
1.2: 1 h / 0 - 40 °C
2.1: potassium carbonate; potassium iodide / ethyl acetate / 75 °C
3.1: sodium hydroxide; water / 65 - 70 °C
4.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetone
5.1: trifluoroacetic anhydride; trifluoroacetic acid / 2-methyltetrahydrofuran / Reflux
5.2: 5 - 10 °C
View Scheme
amantadine hydrochloride
665-66-7

amantadine hydrochloride

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: nitric acid; sulfuric acid / 2 h / 0 - 12 °C
1.2: Cooling with ice
2.1: potassium carbonate; potassium iodide / tetrahydrofuran / 5 h / Reflux
3.1: potassium hydroxide; water / 12 h / 20 °C
4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: nitric acid; sulfuric acid / 2 h / 0 - 12 °C
1.2: Cooling with ice
2.1: potassium carbonate; potassium iodide / tetrahydrofuran / 5 h / 60 - 65 °C
View Scheme
Multi-step reaction with 4 steps
1.1: nitric acid; sulfuric acid / 2 h / 0 - 12 °C
1.2: Cooling with ice
2.1: tetrahydrofuran / 3 h / Reflux
3.1: sodium tetrahydroborate; methanol / 0.5 h
4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: water; sulfuric acid; nitric acid / 14 h / 0 - 20 °C
2: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 60 °C
View Scheme
(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid
23500-10-9

(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 - 30 °C
1.2: 3 h / 25 - 30 °C
2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
3.1: potassium carbonate; potassium iodide / tetrahydrofuran / 5 h / 60 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1.1: dicyclohexyl-carbodiimide / dichloromethane / 5 h / 20 °C / Cooling with ice
1.2: 6 h / 20 °C
2.1: trifluoroacetic anhydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice
2.2: 8.5 h / 40 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: 1,3,5-trichloro-2,4,6-triazine / dichloromethane / 3 h / 0 °C / Reflux
1.2: 2 h
2.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 35 - 48 °C
3.1: potassium carbonate; potassium iodide / butanone / 40 °C
3.2: 3 h / 38 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: ammonium bicarbonate; pyridine; di-tert-butyl dicarbonate / acetonitrile / 1.5 h / 25 °C
2: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 40 °C
3: potassium carbonate; potassium iodide / tetrahydrofuran; butanone / 3 h / 40 °C
View Scheme
[(3-hydroxyadamantan-1-yl)imino]acetic acid
1334337-69-7

[(3-hydroxyadamantan-1-yl)imino]acetic acid

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; methanol / 0.5 h
2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
t-butyl 2-(adamantan-1-ylamino)acetate
924281-70-9

t-butyl 2-(adamantan-1-ylamino)acetate

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydroxide; potassium permanganate / water / 1.5 h / 60 - 90 °C
2: potassium hydroxide; water / 12 h / 20 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
t-butyl 2-(3-hydroxyadamantan-1-ylamino)acetate
1334337-68-6

t-butyl 2-(3-hydroxyadamantan-1-ylamino)acetate

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide; water / 12 h / 20 °C
2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 20 °C
View Scheme
1-[N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetyl]pyrrolidine-2-nitrile
1354835-83-8

1-[N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetyl]pyrrolidine-2-nitrile

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Stage #1: 1-[N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetyl]pyrrolidine-2-nitrile With hydrogenchloride In water at 70℃; for 7h;
Stage #2: With sodium carbonate In water Product distribution / selectivity;
N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetic acid
1354835-81-6

N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetic acid

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 3 h / 20 - 30 °C / Inert atmosphere
2: triethylamine / dichloromethane / 5 h / 0 - 10 °C / Inert atmosphere
3: potassium carbonate; methanol / 4 h / 40 °C
4: hydrogenchloride / water / 7 h / 70 °C
View Scheme
1-[N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetyl]pyrrolidine-2-amide
1354835-82-7

1-[N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetyl]pyrrolidine-2-amide

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 5 h / 0 - 10 °C / Inert atmosphere
2: potassium carbonate; methanol / 4 h / 40 °C
3: hydrogenchloride / water / 7 h / 70 °C
View Scheme
t-butyl 2-(3-hydroxyadamantan-1-ylamino)acetate
1334337-68-6

t-butyl 2-(3-hydroxyadamantan-1-ylamino)acetate

(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate
35150-07-3

(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Stage #1: (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate With trifluoroacetic anhydride
Stage #2: t-butyl 2-(3-hydroxyadamantan-1-ylamino)acetate
methyl (2S)-pyrrolidine carboxylate
2577-48-2

methyl (2S)-pyrrolidine carboxylate

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ammonium hydroxide
2.1: tetrahydrofuran
3.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 35 - 48 °C
4.1: potassium carbonate; potassium iodide / butanone / 40 °C
4.2: 3 h / 38 - 75 °C
View Scheme
(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate
35150-07-3

(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 - 40 °C / Inert atmosphere
2: methanesulfonic acid / 40 - 45 °C
3: triethylamine / 20 - 30 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 10 h / 40 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: trifluoroacetic anhydride; triethylamine / dichloromethane / 3 h / -15 °C
2.1: acetonitrile / 10 h / 10 °C
3.1: sodium hydroxide / dichloromethane / 1.5 h / 0 °C
3.2: 0 °C
View Scheme
tert-butyl (2S)-2-cyanopyrrolidine-1-carboxylate
228244-04-0

tert-butyl (2S)-2-cyanopyrrolidine-1-carboxylate

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanesulfonic acid / 40 - 45 °C
2: triethylamine / 20 - 30 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 10 h / 40 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: acetonitrile / 10 h / 10 °C
2.1: sodium hydroxide / dichloromethane / 1.5 h / 0 °C
2.2: 0 °C
View Scheme
Multi-step reaction with 3 steps
1: methanesulfonic acid / dichloromethane / 2 h / Reflux
2: triethylamine / dichloromethane / 2 h / Reflux
3: potassium carbonate / dichloromethane / 5 h / Reflux
View Scheme
3-aminoadamantan-1-ol
702-82-9

3-aminoadamantan-1-ol

(2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

(2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Stage #1: 3-aminoadamantan-1-ol With potassium carbonate; potassium iodide In acetone at 20℃; for 0.25h;
Stage #2: (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile In acetone at 40 - 65℃; Solvent; Temperature;
[benzyl(3-hydroxyadamantan-1-yl)amino]acetic acid ethyl ester

[benzyl(3-hydroxyadamantan-1-yl)amino]acetic acid ethyl ester

vildagliptin
274901-16-5

vildagliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide; water / methanol / 2 h / 65 °C
2: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide; ethyl acetate / 2 h / 25 °C / Inert atmosphere
3: trifluoroacetic anhydride / 2-methyltetrahydrofuran / Inert atmosphere
4: palladium 10% on activated carbon; hydrogen / methanol / 22 h
View Scheme
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

vildagliptin
274901-16-5

vildagliptin

vildagliptin hydrogen fumarate
924667-20-9

vildagliptin hydrogen fumarate

Conditions
ConditionsYield
In ethanol at 3 - 50℃; for 5h;97.1%
copper dichloride

copper dichloride

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile copper(II)-chloride

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile copper(II)-chloride

Conditions
ConditionsYield
In ethanol at 20 - 50℃;97%
In ethanol at 20℃; for 2h;97%
calcium(II) chloride dihydrate

calcium(II) chloride dihydrate

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile calcium(II)-chloride

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile calcium(II)-chloride

Conditions
ConditionsYield
In ethanol; water; isopropyl alcohol at 35 - 40℃; Product distribution / selectivity;97%
vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile calcium(II)-chloride

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile calcium(II)-chloride

Conditions
ConditionsYield
With calcium(II) chloride dihydrate In ethanol; water at 35 - 40℃; for 1.5h; Product distribution / selectivity;97%
vildagliptin
274901-16-5

vildagliptin

Vildagliptin hydrochloride
924914-75-0

Vildagliptin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol at 30 - 70℃; for 0.0833333h;93.8%
zinc diacetate
557-34-6

zinc diacetate

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-acetate

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-acetate

Conditions
ConditionsYield
In ethanol at 20 - 50℃;92%
zinc(II) acetate dihydrate
5970-45-6

zinc(II) acetate dihydrate

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-acetate

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-acetate

Conditions
ConditionsYield
In ethanol at 20℃; for 2h;92%
zinc(II) chloride
7646-85-7

zinc(II) chloride

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-chloride

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-chloride

Conditions
ConditionsYield
In ethanol at 20 - 50℃;90%
zinc(II) chloride
7646-85-7

zinc(II) chloride

vildagliptin
274901-16-5

vildagliptin

vildagliptin zinc(II) chloride complex

vildagliptin zinc(II) chloride complex

Conditions
ConditionsYield
In ethanol at 20℃; for 2h;90%
vildagliptin
274901-16-5

vildagliptin

N-(3-hydroxyadamantan-1-yl)-1-imino-hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one

N-(3-hydroxyadamantan-1-yl)-1-imino-hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one

Conditions
ConditionsYield
With potassium hydroxide In water; N,N-dimethyl-formamide at 70℃; for 5h; Solvent; Reagent/catalyst; Temperature;90%
With triethylamine In ethyl acetate at 90℃; for 168h; Temperature; Reagent/catalyst; Solvent;21%
In 5,5-dimethyl-1,3-cyclohexadiene at 135 - 140℃; Concentration; Temperature; Solvent;10%
malonic acid
141-82-2

malonic acid

vildagliptin
274901-16-5

vildagliptin

vildagliptin hydrogen malonate
924667-41-4

vildagliptin hydrogen malonate

Conditions
ConditionsYield
In ethanol at 3 - 45℃; for 5h;88%
(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
207557-35-5

(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

vildagliptin
274901-16-5

vildagliptin

(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile
1036959-23-5

(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In tetrahydrofuran at 20℃; for 24h; Time; Reflux;87%
zinc dibromide

zinc dibromide

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-bromide

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-bromide

Conditions
ConditionsYield
In ethanol at 20 - 50℃;85%
In ethanol at 20℃; for 2h;85%
zinc(II) chloride
7646-85-7

zinc(II) chloride

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-chloride

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile zinc(II)-chloride

Conditions
ConditionsYield
In ethanol at 20 - 50℃;82%
In ethanol at 20℃; for 2h;82%
vildagliptin
274901-16-5

vildagliptin

vildagliptin hydrogen sulfate form II
924667-83-4

vildagliptin hydrogen sulfate form II

Conditions
ConditionsYield
With sulfuric acid In butan-1-ol at 0 - 60℃; for 22.08h;81.3%
With sulfuric acid In methanol at 20 - 40℃;
magnesium(II) chloride hexahydrate

magnesium(II) chloride hexahydrate

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile magnesium(II)-chloride

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile magnesium(II)-chloride

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 50℃;78%
vildagliptin
274901-16-5

vildagliptin

vildagliptin magnesium(II) chloride complex

vildagliptin magnesium(II) chloride complex

Conditions
ConditionsYield
With magnesium(II) chloride hexahydrate In isopropyl alcohol at 20℃; for 2h;78%
strontium nitrate

strontium nitrate

vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile stroncium(II)-nitrate

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile stroncium(II)-nitrate

Conditions
ConditionsYield
In ethanol at 20 - 50℃;77%
vildagliptin
274901-16-5

vildagliptin

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile stroncium(II)-nitrate

1-[2-(3-hydroxyadamant-1-yl-amino)acetyl]pyrrolidin-(2S)-carbonitrile stroncium(II)-nitrate

Conditions
ConditionsYield
With strontium nitrate In ethanol at 20℃; for 2h;77%
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View