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EAST CHEMSOURCES LIMITED

Properties: White odorless powder or crystalline solid particles, with speical sourness that is as strong as 1.5 times of citric acid. It is soluble in ethanol (5.76g/100g,30℃), slightly soluble in water (0.63g/100ml,25℃) and in ether, and very s

Fumaric Acid

Cas:110-17-8

Min.Order:1 Metric Ton

FOB Price: $1800.0 / 1900.0

Type:Manufacturers

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SJZ THLD IMP & EXP CO LTD

1.Full experience of large numbers containers loading in chinese sea port. 2.Fast shipment by reputed shipping line 3.Packing with pallet as buyer's special request 4.Best service after shipment with email

Fumaric acid

Cas:110-17-8

Min.Order:1000 Kilogram

Negotiable

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Fumaric Acid supplier in China

Cas:110-17-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name Fumaric acid CAS number 110-17-8 Assay ≥99.5% Appearance White crystal or powder Capacity 500mt/year Application Unsaturated polyester resin

Fumaric acid

Cas:110-17-8

Min.Order:100 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Fumaric acid CAS NO.110-17-8

Cas:110-17-8

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Light yellow to white crystalline granular or powder Storage:

Food grade /industrial grade Fumaric acid CAS 110-17-8 with factory price

Cas:110-17-8

Min.Order:500 Kilogram

FOB Price: $2.0 / 5.0

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

Fumaric acid CAS 110-17-8 is white odorless granules or crystalline powder. Slightly soluble in water, ethyl ether, and acetic acid, soluble in ethanol, almost insoluble in chloroform. Fumaric acid is used in food as acidity regulator, in the manuf

Best Quality Fumaric acid TNJ

Cas:110-17-8

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Acidulating Agent Fumaric Acid Powder Xi'an Quanao Biotech Co., Ltd. is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochem

Acidulating Agent Fumaric Acid Trans-Butenedioic Acid Powder

Cas:110-17-8

Min.Order:500 Kilogram

FOB Price: $6.1 / 7.9

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Molecular Formula:C4H4O4 Molecular Weight:116.07 Quality standard:(FCCIV,1996) Structural Formula: Item Standard Assay(dry base C4H4O4)% 99.5-101.0 Melt

Fumaric acid

Cas:110-17-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Fumaric acid

Cas:110-17-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract Fumaric acid HACCP manufacturer

Cas:110-17-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Fumaric Acid

Cas:110-17-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Fumaric acid 110-17-8 /manufacturer/low price/high quality/in stock

Cas:110-17-8

Min.Order:1 Kilogram

FOB Price: $12.0 / 13.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Fumaric Acid

Cas:110-17-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name: Fumaric acid The alias:TRANS-2-BUTEN-1,4-DIOIC ACID;TRANS-2-BUTENEDIOIC ACID; CAS NO:110-17-8 Molecular formula:C4H4O4 Molecular weight: 116.07 Product Quality 12 years of chemical raw materials Mature operation of the industry Syst

Fumaric acid/CAS:110-17-8 /with best price

Cas:110-17-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Fumaric acid Synonyms: Butenedioic acid, (E)-;femanumber:2488;fumaric;Kyselina fumarova;kyselinafumarova;kyselinafumarova(czech);NSC-2752;trans-1,2-ethenedicarboxylicacid CAS: 110-17-8 MF: C4H4O4 MW: 116.07 EINECS: 203-743-0 Pro

110-17-8 Fumaric acid

Cas:110-17-8

Min.Order:1 Kilogram

FOB Price: $300.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Fumaric acid / LIDE PHARMA- Factory supply / Best price

Cas:110-17-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

China Factory Sell Food Grade CAS:110-17-8 Fumaric Acid

Cas:110-17-8

Min.Order:1 Gram

FOB Price: $20.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 110-17-8 with best quality

Cas:110-17-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Fumaric acid CAS No.: 110-17-8 Other Names: Fumaric Acid MF: C4H4O4 Purity: 99.5 Package:25kg/bags Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:Acidity Regulators, Preservatives

Fumaric acid CAS:110-17-8

Cas:110-17-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White Crystalline Powder Storage:R.T Package:25kg/Barrel Application:It is widely used in the fields of food, coatings, resins and plasticizers. In the food industry, fumaric acid is used as a sour agent. Transportation:Express/Sea/Air Po

99.5%-100.5% Fumaric acid cas:110-17-8 in stock

Cas:110-17-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 1.57

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Supplier Fumaric acid with lower price

Cas:110-17-8

Min.Order:25 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:White crystal powder / Refer to COA Storage:Ref

110-17-8 CAS 99.5% Powder SHIPPING from Factory Fumaric acid

Cas:110-17-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Fumaric acid CAS: 110-17-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Fumaric acid CAS: 110-17-8

Cas:110-17-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Butenedioic acid (2E)-

Cas:110-17-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Fumaric acid CAS NO.110-17-8

Cas:110-17-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in carbomer,carbopol,lead acetate,meglumine diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production ente

Factory Price 99.5% Fumaric Acid CAS 110-17-8

Cas:110-17-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 30.0

Type:Trading Company

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Fumaric acid Synonyms: Butenedioic acid, (E)-;femanumber:2488;fumaric;Kyselina fumarova;kyselinafumarova;kyselinafumarova(czech);NSC-2752;trans-1,2-ethenedicarboxylicacid CAS: 110-17-8 MF: C4H4O4 MW: 116.07 EINECS: 203-743-

factory Fumaric acid with high quality

Cas:110-17-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

maleic acid
110-16-7

maleic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With (E)-4-(2-chlorostyryl)pyridine In methanol at 20℃; for 720h;100%
With maleic anhydride In water at 190℃; for 6h; Reagent/catalyst; Inert atmosphere; Autoclave; Green chemistry;99.5%
With N-Bromosuccinimide; dibenzoyl peroxide; acetic acid for 6h; Heating;90%
C13H10ClN*C4H4O4*0.5C4H4O4

C13H10ClN*C4H4O4*0.5C4H4O4

A

1,3-bis(4-pyridyl)-2,4-bis(2-chlorophenyl)cyclobutane

1,3-bis(4-pyridyl)-2,4-bis(2-chlorophenyl)cyclobutane

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
UV-irradiation;A 100%
B n/a
meso-2,3-dibromosuccinic acid
608-36-6

meso-2,3-dibromosuccinic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With aluminum oxide for 0.0166667h; microwave irradiation;98%
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran at 20℃; for 0.75h;89%
With sodium sulfide oder mit aehnlichen Thiosalzen;
(E)-But-2-enedioic acid bis-(1-phenoxy-ethyl) ester

(E)-But-2-enedioic acid bis-(1-phenoxy-ethyl) ester

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0℃; for 1h;98%
In dichloromethane at 0℃; for 1h; Product distribution; 5percent CF3COOH; other reagent;98%
(+-)-2,3-dibromosuccinic acid
1114-00-7

(+-)-2,3-dibromosuccinic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With aluminum oxide for 0.0166667h; microwave irradiation;98%
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran at 20℃; for 1h;90%
malic acid
617-48-1

malic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
96%
In neat (no solvent) at 200℃; for 4h; Inert atmosphere;96.6%
at 180℃; for 4h; Temperature; Inert atmosphere;88%
C22H18O10

C22H18O10

A

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

B

4,6-dimethoxyanthracene-1,2-dicarboxylic anhydride

4,6-dimethoxyanthracene-1,2-dicarboxylic anhydride

Conditions
ConditionsYield
In diphenylether Heating;A n/a
B 94%
C21H16O9

C21H16O9

A

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

B

4-methoxyanthracene-1,2-dicarboxylic anhydride

4-methoxyanthracene-1,2-dicarboxylic anhydride

Conditions
ConditionsYield
In diphenylether Heating;A n/a
B 90%
trisodium tris(3-sulfophenyl)phosphine
63995-70-0

trisodium tris(3-sulfophenyl)phosphine

Acetylenedicarboxylic acid
142-45-0

Acetylenedicarboxylic acid

A

tris(natrium-m-sulfonatophenyl)phosphanoxid
98511-67-2

tris(natrium-m-sulfonatophenyl)phosphanoxid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
In water for 5h; Ambient temperature;A n/a
B 87%
maleic acid
110-16-7

maleic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

Butane-1,4-diol
110-63-4

Butane-1,4-diol

D

4-hydroxybutanoic acid
591-81-1

4-hydroxybutanoic acid

E

malic acid
617-48-1

malic acid

F

succinic acid
110-15-6

succinic acid

G

terephthalic acid
100-21-0

terephthalic acid

H

acetic acid
64-19-7

acetic acid

I

propionic acid
802294-64-0

propionic acid

J

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With hydrogen; 0.5percent Pd/0.2percent Re on Rutile TiO2 at 110℃; for 170 - 1009h; Product distribution / selectivity;A 0.86%
B 4.34%
C 0.28%
D 1.24%
E 0%
F 85.51%
G 0%
H 0.04%
I 0%
J 0%
C19H14O6

C19H14O6

A

2-anthroic acid
613-08-1

2-anthroic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
In diphenylether Heating;A 84%
B n/a
maleic anhydride
108-31-6

maleic anhydride

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With thiourea In water at 25 - 30℃;83.6%
With hydrogenchloride
With water; thiourea
Stage #1: maleic anhydride With water at 45 - 50℃; for 2.25h;
Stage #2: With thiourea at 45 - 50℃; for 1h;
290 g
carbon monoxide
201230-82-2

carbon monoxide

acetylene
74-86-2

acetylene

A

succinic acid
110-15-6

succinic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With 8-nitroquinoline; water; hydrogen bromide; lithium bromide; palladium(II) bromide In acetonitrile at 30℃; for 4.26667h; Reagent/catalyst; Temperature; Overall yield = 2.56 g;A 80.27%
B 17.12%
(R)-4,4,4-trichloro-3-hydroxybutanoic acid
80513-23-1

(R)-4,4,4-trichloro-3-hydroxybutanoic acid

A

D-Malic acid
636-61-3

D-Malic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 24h;A 79%
B n/a
(+/-)-9,10-ethanoanthracene-2,3,trans-11,12-tetracarboxylic acid

(+/-)-9,10-ethanoanthracene-2,3,trans-11,12-tetracarboxylic acid

A

2,3-anthracenedicarboxylic acid anhydride
6812-14-2

2,3-anthracenedicarboxylic acid anhydride

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
In diphenylether Heating;A 79%
B n/a
maleic anhydride
108-31-6

maleic anhydride

2-allyloxy-2-phenylethan-1-ol
75455-48-0

2-allyloxy-2-phenylethan-1-ol

A

mono(2-allyloxy-2-phenylethyl) fumarate

mono(2-allyloxy-2-phenylethyl) fumarate

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
Stage #1: maleic anhydride; 2-allyloxy-2-phenylethan-1-ol With 4-methoxy-phenol In toluene at 130℃; for 5h;
Stage #2: With hydrogenchloride In water; toluene at 130℃; for 10h;
A 75.1%
B n/a
(E)-but-2-enoic acid
107-93-7

(E)-but-2-enoic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With sodium hypochlorite; nickel dichloride In dichloromethane; water at 0 - 20℃; for 4h;75%
tartaric acid
87-69-4

tartaric acid

A

glycolic Acid
79-14-1

glycolic Acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With oxygen In water at 160℃; under 13680.9 Torr; for 10h; Reagent/catalyst;A 27%
B 73%
maleic anhydride
108-31-6

maleic anhydride

A

malic acid
617-48-1

malic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With water at 190℃; for 1h; Temperature; Concentration; Time; Sealed tube; Green chemistry;A n/a
B 72%
(S)-Malic acid
97-67-6

(S)-Malic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 120℃;71%
With propan-1-ol Bei der Einw. von Bact. coli unter anaeroben Bedingungen;
bei der Einw. von Muskelextrakt oder Muskelbrei;
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With copper; copper(II) perchlorate In methanol for 2h; Ambient temperature;71%
With sodium sulfide oder mit aehnlichen Thiosalzen;
With sodium thioethylate oder mit aehnlichen Thiosalzen;
d,l-dibromo succinic acid
526-78-3, 608-35-5, 608-36-6, 1114-00-7

d,l-dibromo succinic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With copper; copper(II) perchlorate In methanol for 3.5h; Ambient temperature;70%
(S)-3,4-Epoxybutyric Acid
33278-09-0

(S)-3,4-Epoxybutyric Acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With sodium hypochlorite; nickel dichloride In dichloromethane; water at 0 - 20℃; for 4h;69%
tartaric acid
87-69-4

tartaric acid

A

glycolic Acid
79-14-1

glycolic Acid

B

LACTIC ACID
849585-22-4

LACTIC ACID

C

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With oxygen In water at 160℃; under 13680.9 Torr; for 10h;A 69%
B 7%
C 24%
furfural
98-01-1

furfural

A

2-furanoic acid
88-14-2

2-furanoic acid

B

succinic acid
110-15-6

succinic acid

C

maleic acid
110-16-7

maleic acid

D

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With dihydrogen peroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate; methyltrioxorhenium(VII) In water at 20℃;A 7%
B 12%
C 66%
D 13%
furfural
98-01-1

furfural

A

maleic acid
110-16-7

maleic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With dihydrogen peroxide; acidine In water at 100℃; for 0.5h; Temperature;A 61%
B 31%
With dihydrogen peroxide; acidine In water at 100℃; for 2h; Time;A 10%
B 48%
With sodium chlorate; vanadium pentoxide In water at 85 - 95℃; for 19h;A n/a
B 47%
With sodium chlorate; vanadia In water at 80 - 90℃; for 13h; Overall yield = 58 %; Overall yield = 42.3 g;A n/a
B n/a
With choline chloride; dihydrogen peroxide; oxalic acid In water at 50℃; for 24h; Reagent/catalyst; Green chemistry; Overall yield = 95.7 %Chromat.;
malic acid
617-48-1

malic acid

A

maleic acid
110-16-7

maleic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

C

acrylic acid
79-10-7

acrylic acid

Conditions
ConditionsYield
sodium hydroxide In water at 340℃; under 129290 Torr; pH=3.17; Product distribution / selectivity;A 10.52%
B 6.88%
C 59.23%
toluene-4-sulfonamide
70-55-3

toluene-4-sulfonamide

diethyl Fumarate
623-91-6

diethyl Fumarate

A

p-toluenesulfonamidosuccinic acid ethyl ester
104830-35-5

p-toluenesulfonamidosuccinic acid ethyl ester

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With potassium hydroxide In neat (no solvent) at 53℃; for 1h; Michael Addition; Sonication;A 50%
B n/a
malic acid
617-48-1

malic acid

A

succinic acid
110-15-6

succinic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With hydrogen iodide; propionic acid at 160℃; under 25858.1 Torr; for 2h; Kinetics; Inert atmosphere;A 46%
B 10%
cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

norbornene-5,6-dicarboxylic acid
1200-88-0

norbornene-5,6-dicarboxylic acid

Conditions
ConditionsYield
In water; acetone at 50℃; for 24h; Diels-Alder Cycloaddition;100%
In 1,4-dioxane at 60℃; for 1h;94%
With N,N-dimethyl-formamide andere polare Loesungsmittel;
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

2-(3-phthalimidopropyl)-8H-indeno[1,2-d]thiazole
172259-74-4

2-(3-phthalimidopropyl)-8H-indeno[1,2-d]thiazole

2-(3-aminopropyl)-8H-indeno[1,2-d]thiazole fumarate

2-(3-aminopropyl)-8H-indeno[1,2-d]thiazole fumarate

Conditions
ConditionsYield
Stage #1: 2-(3-phthalimidopropyl)-8H-indeno[1,2-d]thiazole With methylamine In methanol at 20℃; for 16h;
Stage #2: (2E)-but-2-enedioic acid In methanol
100%
(+)-N-(3-amino-propyl)-N-[(R)-1-(6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidin-5-yl)-2-methyl-propyl]-4-methyl-benzamide hydrochloride

(+)-N-(3-amino-propyl)-N-[(R)-1-(6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidin-5-yl)-2-methyl-propyl]-4-methyl-benzamide hydrochloride

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-(3-amino-propyl)-N-[(R)-1-(6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidin-5-yl)-2-methyl-propyl]-4-methyl-benzamide fumarate

N-(3-amino-propyl)-N-[(R)-1-(6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidin-5-yl)-2-methyl-propyl]-4-methyl-benzamide fumarate

Conditions
ConditionsYield
In ethanol for 0.116667h; Heating / reflux;100%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

dihydro-2(3H)furanone-[3,4,5,5-D4]

dihydro-2(3H)furanone-[3,4,5,5-D4]

Conditions
ConditionsYield
With deuterium; Ru4H4(CO)8(PBu3)4 In tetrahydrofuran at 180℃; for 48h;100%
(1R,5S)-3-methyl-6-(6-phenyl-pyridazin-3-yl)-3,6-diaza-bicyclo[3.2.0]heptane

(1R,5S)-3-methyl-6-(6-phenyl-pyridazin-3-yl)-3,6-diaza-bicyclo[3.2.0]heptane

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(1R,5S)-3-methyl-6-(6-phenyl-pyridazin-3-yl)-3,6-diaza-bicyclo[3.2.0]heptane fumarate

(1R,5S)-3-methyl-6-(6-phenyl-pyridazin-3-yl)-3,6-diaza-bicyclo[3.2.0]heptane fumarate

Conditions
ConditionsYield
In methanol; ethyl acetate at 20℃; for 18h;100%
(1RS,3aRS)-1-[1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one

(1RS,3aRS)-1-[1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

C4H4O4*C25H29N3O

C4H4O4*C25H29N3O

Conditions
ConditionsYield
In ethanol100%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol
207679-81-0

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

(R)-5-hydroxymethyl tolterodine fumarate salt
380636-50-0

(R)-5-hydroxymethyl tolterodine fumarate salt

Conditions
ConditionsYield
In acetone at 20℃; for 0.5h;100%
In acetone at 25 - 30℃; for 1h;2.4 g
3-[6-(1H-indol-3-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane
855738-90-8

3-[6-(1H-indol-3-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

3-[6-(1H-indol-3-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane hemifumarate

3-[6-(1H-indol-3-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane hemifumarate

Conditions
ConditionsYield
In methanol; ethyl acetate at 20℃;100%
N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-sulphonamide
766558-09-2

N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-sulphonamide

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-sulphonamide difumarate

N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-sulphonamide difumarate

Conditions
ConditionsYield
In methanol for 0.5h;100%
2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide
863613-79-0

2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(Trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide fumarate

2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(Trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide fumarate

Conditions
ConditionsYield
In ethanol100%
4,4'-bipyridine
553-26-4

4,4'-bipyridine

zinc diacetate
557-34-6

zinc diacetate

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

[Zn2(fumarate)2(4,4'-bipyridyl)]n

[Zn2(fumarate)2(4,4'-bipyridyl)]n

Conditions
ConditionsYield
100%
1-[1-(toluene-4-sulfonyl)-1H-indol-5-yl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
1198187-79-9

1-[1-(toluene-4-sulfonyl)-1H-indol-5-yl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-(1H-indol-5-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine fumarate
1198187-81-3

1-(1H-indol-5-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine fumarate

Conditions
ConditionsYield
Stage #1: 1-[1-(toluene-4-sulfonyl)-1H-indol-5-yl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine With sodium ethanolate In ethanol for 2h; Reflux;
Stage #2: (2E)-but-2-enedioic acid In ethanol
100%
(2S,5R)-3-bromo-5-pyrrolidin-2-yl-4,5-dihydroisoxazole
1262011-69-7

(2S,5R)-3-bromo-5-pyrrolidin-2-yl-4,5-dihydroisoxazole

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(2S,5R)-3-bromo-5-pyrrolidin-2-yl-4,5-dihydroisoxazole fumarate
1262011-74-4

(2S,5R)-3-bromo-5-pyrrolidin-2-yl-4,5-dihydroisoxazole fumarate

Conditions
ConditionsYield
In methanol at 20℃; for 16h;100%
Bisegliptin

Bisegliptin

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(2S,4S)-1-[2-[(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile fumarate
1218908-87-2

(2S,4S)-1-[2-[(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile fumarate

Conditions
ConditionsYield
In acetone at 45℃; for 0.5h; Product distribution / selectivity;100%
N-(3,4-Dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide
1212022-70-2

N-(3,4-Dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-(3,4-dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide fumarate

N-(3,4-dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide fumarate

Conditions
ConditionsYield
In methanol; dichloromethane100%
meloxicam
71125-38-7

meloxicam

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

C4H4O4*2C14H13N3O4S2

C4H4O4*2C14H13N3O4S2

Conditions
ConditionsYield
In tetrahydrofuran for 0.5h;100%
(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester
1236549-06-6

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxypropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-(2-propan-2-yl)nonanamide hemifumarate
173334-58-2

(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxypropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-(2-propan-2-yl)nonanamide hemifumarate

Conditions
ConditionsYield
Stage #1: (1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester With palladium 10% on activated carbon; hydrogen In isopropyl alcohol at 20℃; under 760.051 Torr;
Stage #2: (2E)-but-2-enedioic acid In ethanol
100%
Stage #1: (1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester With palladium 10% on activated carbon In isopropyl alcohol at 20℃; under 760.051 Torr;
Stage #2: (2E)-but-2-enedioic acid In ethanol
85%
C7H13N3O2S
1579943-67-1

C7H13N3O2S

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

2-(4-methoxy-1,2,5-thiadiazol-3-yloxy)-N,N-dimethylethanamine fumarate
1580000-49-2

2-(4-methoxy-1,2,5-thiadiazol-3-yloxy)-N,N-dimethylethanamine fumarate

Conditions
ConditionsYield
In ethanol Inert atmosphere;100%
(R)-6-methylamino-2-methylheptene
1620401-56-0

(R)-6-methylamino-2-methylheptene

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(R)-isometheptene fumarate

(R)-isometheptene fumarate

Conditions
ConditionsYield
In ethanol at -20℃; Solvent; Temperature;100%
dispirocyclopropyldehydrocostus lactone
1403389-47-8

dispirocyclopropyldehydrocostus lactone

N,N-dimethylammonium chloride
506-59-2

N,N-dimethylammonium chloride

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

dispirocyclopropyldehydrocostus lactone

dispirocyclopropyldehydrocostus lactone

Conditions
ConditionsYield
Stage #1: dispirocyclopropyldehydrocostus lactone; N,N-dimethylammonium chloride With potassium carbonate In dichloromethane for 4h; Reflux;
Stage #2: (2E)-but-2-enedioic acid In methanol for 0.5h;
100%
1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(methoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(methoxymethyl)phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(methoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(methoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(ethoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(ethoxymethyl)phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(ethoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(ethoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-[5-(ethoxymethyl)-2-(2-hydroxy-3-(isopropylamino)propoxy)-phenyl]ethanone

1-[5-(ethoxymethyl)-2-(2-hydroxy-3-(isopropylamino)propoxy)-phenyl]ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-[5-(ethoxymethyl)-2-(2-hydroxy-3-(isopropylamino)propoxy)-phenyl]ethanone, fumarate salt

1-[5-(ethoxymethyl)-2-(2-hydroxy-3-(isopropylamino)propoxy)-phenyl]ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(propoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(propoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(propoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(propoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[2-hydroxy-3-(isopropylamino)propoxy]-5-(propoxymethyl)phenyl}ethanone

1-{2-[2-hydroxy-3-(isopropylamino)propoxy]-5-(propoxymethyl)phenyl}ethanone

1-{2-[2-hydroxy-3-(isopropylamino)propoxy]-5-(propoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[2-hydroxy-3-(isopropylamino)propoxy]-5-(propoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(isopropoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(isopropoxymethyl)phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(isopropoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(isopropoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-{5-(butoxymethyl)-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethanone

1-{5-(butoxymethyl)-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{5-(butoxymethyl)-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethanone, fumarate salt

1-{5-(butoxymethyl)-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(pentyloxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(pentyloxymethyl)phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(pentyloxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(pentyloxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
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