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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

D(+)-Malic acid Manufacturer/High quality/Best price/In stock

Cas:636-61-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality D(+)-Malic Acid supplier in China

Cas:636-61-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply D(+)-Malic Acid

Cas:636-61-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract D(+)-Malic acid HACCP manufacturer

Cas:636-61-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards. 2. Now we have established long-term stable r

High quality D(+)-Malic acid CAS 636-61-3,Malic acid, D- Malic acid 99%

Cas:636-61-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

D(+)-Malic acid CAS: 636-61-3

Cas:636-61-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

D-(+)-Malic acid

Cas:636-61-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

D(+)-Malic acid

Cas:636-61-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

D(+)-Malic acid-

Cas:636-61-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 636-61-3 with best quality

Cas:636-61-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 636-61-3 ,D-(+)-Malic acid

Cas:636-61-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

D-Malic acid Specifications Product Name: D-Malic acid sort: Pharmaceutical Intermediates CAS No.: 636-61-3 Formula: C4H6O5 Formul

D(+)-Malic acid CAS: 636-61-3

Cas:636-61-3

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

100% Apple Extract Acide Malic Malic Acid Powder Ex-Factory Price

Cas:636-61-3

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

D(+)-Malic acid 636-61-3

Cas:636-61-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

D(+)-Malic acid

Cas:636-61-3

Min.Order:1 Kilogram

FOB Price: $41.0 / 56.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

D(+)-Malic acid CAS:636-61-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

D(+)-Malic acid CAS:636-61-3

Cas:636-61-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

D(+)-Malic acid

Cas:636-61-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:636-61-3

Cas:636-61-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

D-(+)-Malic acid

Cas:636-61-3

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

D (+) -Malic Acid CAS 636-61-3

Cas:636-61-3

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

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Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales D-MALIC ACID CAS 636-61-3 for 500MT/Year

Cas:636-61-3

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

D(+)-Malic acid

Cas:636-61-3

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

D-(+)-Malic acid

Cas:636-61-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

D(+)-Malic acid

Cas:636-61-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

D(+)-Malic acid

Cas:636-61-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality D(+)-Malic Acid

Cas:636-61-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

High Quality D-MALIC ACID/D-APPLE ACID 636-61-3 in stock fast delivery good supplierAppearance:Powder Storage:Dry and ventilated Package:according to customers' requirements Application:APIs Transportation:By air(EMS or EUB or FedEx or TNT ect...) or

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

D(+)-Malic acid CAS: 636-61-3

Cas:636-61-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermed

D(+)-Malic acid

Cas:636-61-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: D-Malic Acid CAS No.: 636-61-3 Molecule Formula:C4H6O5 Molecule Weight:134.09 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price D-Malic Acid on stock

Cas:636-61-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

L-Aspartic acid
56-84-8

L-Aspartic acid

A

D-Malic acid
636-61-3

D-Malic acid

B

(2S)-chlorobutanedioic acid
4198-33-8

(2S)-chlorobutanedioic acid

C

2-butenedioic acid
6915-18-0

2-butenedioic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water at -15 - 0℃; for 8h;A 0.1%
B 86%
C 0.1%
With hydrogenchloride; sodium chloride; sodium nitrite In water at -15 - 0℃; for 7h;A 0.1 - 0.4 %Spectr.
B 80%
C 0.1%
(R)-4,4,4-trichloro-3-hydroxybutanoic acid
80513-23-1

(R)-4,4,4-trichloro-3-hydroxybutanoic acid

A

D-Malic acid
636-61-3

D-Malic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 24h;A 79%
B n/a
maleic acid
110-16-7

maleic acid

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With TETRACYCLINE In water at 37℃; for 18h; Clostridium formicoaceticum, phosphate buffer;75%
biosynthesis by resting cells of Ustilago sphaerogena strain S402;
With 2-(cyclohexylamino)ethanesulfonic acid; potassium chloride; potassium hydroxide pH=9; Kinetics; Reagent/catalyst; Enzymatic reaction;
malic acid-4-methylamide
252330-06-6

malic acid-4-methylamide

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With barium dihydroxide
(R)-Asparagine
2058-58-4

(R)-Asparagine

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With cis-nitrous acid
L-asparagine
70-47-3

L-asparagine

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With nitrogen oxides; acetic acid at 95℃;
malic acid
617-48-1

malic acid

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
bei der enzymatischen Spaltung unter dem Einfluss von Hunde- oder Kaninchenmuskelbrei bleibt optisch unreine d(+)-Aepfelsaeure zurueck;
With Cinchonin
With rac-methylbenzylamine
chlorosuccinic acid
16045-92-4

chlorosuccinic acid

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With silver nitrate
With silver(l) oxide
With water; potassium carbonate; silver nitrate
With alkali
chlorosuccinic acid
16045-92-4

chlorosuccinic acid

A

D-Malic acid
636-61-3

D-Malic acid

B

(S)-Malic acid
97-67-6

(S)-Malic acid

Conditions
ConditionsYield
With alkali Hydrolysis.bei der Hydrolyse der Dinatriumsalze;
With water Hydrolysis.bei der Hydrolyse der Dinatriumsalze;
bromosuccinic acid
923-06-8, 584-98-5

bromosuccinic acid

A

D-Malic acid
636-61-3

D-Malic acid

B

(S)-Malic acid
97-67-6

(S)-Malic acid

Conditions
ConditionsYield
With alkali Hydrolysis.bei der Hydrolyse der Kupfer(II)-salze;
With water Hydrolysis.bei der Hydrolyse der Kupfer(II)-salze;
Hydrolysis.in saurer oder anfangs neutraler Loesung;
iodo-succinic acid
20629-30-5

iodo-succinic acid

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With ammonia
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With cis-nitrous acid
(R)-(+)-2-acetoxysuccinic anhydride
14189-99-2, 24766-96-9, 59025-03-5, 79814-40-7

(R)-(+)-2-acetoxysuccinic anhydride

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With sodium hydroxide Ambient temperature;
deacetylboronolide

deacetylboronolide

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With potassium hydroxide; sodium periodate; ozone 1.) H2O, 16 h, room temperature, 2.) HOAc-HCOOH (9:1) 10 deg C, 110 deg C, 12 h, 3.) H2O, 30 min; Multistep reaction;
(R)-4,4,4-Trichloro-3-(1-ethoxy-ethoxy)-butyric acid methyl ester

(R)-4,4,4-Trichloro-3-(1-ethoxy-ethoxy)-butyric acid methyl ester

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
With sodium hydroxide for 48h; Heating;
(+/-)-propylammonium hydrogen malate

(+/-)-propylammonium hydrogen malate

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
In methanol at 10℃; Yield given;
(+/-)-1,1,3,3-tetramethylbutylammonium hydrogen malate

(+/-)-1,1,3,3-tetramethylbutylammonium hydrogen malate

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
In water at 10℃; Yield given;
nitric acid
7697-37-2

nitric acid

3-hydroxyoxolan-2-one
19444-84-9

3-hydroxyoxolan-2-one

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
at 45 - 50℃; lactone of/the/ dextrorotatory α.γ-dioxy-butyric acid;
hydrogenchloride
7647-01-0

hydrogenchloride

methanol
67-56-1

methanol

(2S,3S)-2-Acetoxy-3-chlor-bernsteinsaeuredimethylester
72229-28-8

(2S,3S)-2-Acetoxy-3-chlor-bernsteinsaeuredimethylester

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
nachfolgenden Reduktion mit einem mit Platindraht umwickelten Zinkstab in Wasser.Hydrolysis;
L-Tartaric acid
87-69-4

L-Tartaric acid

hydrogen iodide
10034-85-2

hydrogen iodide

D-Malic acid
636-61-3

D-Malic acid

(R)-2,4-dihydroxy-butyric acid
157543-57-2

(R)-2,4-dihydroxy-butyric acid

nitric acid
7697-37-2

nitric acid

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
at 45 - 50℃;
bromosuccinic acid
923-06-8, 584-98-5

bromosuccinic acid

hydrazine
302-01-2

hydrazine

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
beim Verseifen des Reaktionsprodukts; levorotatory bromo-succinic acid;
chlorosuccinic acid
16045-92-4

chlorosuccinic acid

alkali

alkali

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
Dinatriumsalz reagiert; l(-)-chlorosuccinic acid;
D-malic acid-4-propylamide

D-malic acid-4-propylamide

aqueous alkaline solution

aqueous alkaline solution

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
Hydrolysis;
D-β-malamic acid
82310-91-6

D-β-malamic acid

-base

-base

D-Malic acid
636-61-3

D-Malic acid

d-β-malamidoic acid

d-β-malamidoic acid

D-Malic acid
636-61-3

D-Malic acid

Conditions
ConditionsYield
Verseifung;
methanol
67-56-1

methanol

D-Malic acid
636-61-3

D-Malic acid

(R)-dimethyl malate
70681-41-3

(R)-dimethyl malate

Conditions
ConditionsYield
With thionyl chloride100%
Stage #1: methanol With acetyl chloride at 0℃; for 1h;
Stage #2: D-Malic acid at 20℃; for 16h;
100%
With thionyl chloride at 0 - 20℃; Inert atmosphere;99%
D-Malic acid
636-61-3

D-Malic acid

(R)-1,2,4-butanetriol
70005-88-8

(R)-1,2,4-butanetriol

Conditions
ConditionsYield
With Trimethyl borate; dimethylsulfide borane complex In tetrahydrofuran Inert atmosphere;100%
With Trimethyl borate; dimethylsulfide borane complex In tetrahydrofuran for 20h; Ambient temperature;98%
With Trimethyl borate; dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃;97%
D-Malic acid
636-61-3

D-Malic acid

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

(R)-2,5-dioxotetrahydrofuran-3-yl 2,2,2-trifluoroacetate
83541-02-0

(R)-2,5-dioxotetrahydrofuran-3-yl 2,2,2-trifluoroacetate

Conditions
ConditionsYield
at 20℃; for 4h; Cooling with ice; Inert atmosphere;100%
at 0℃; for 2h;
for 2h; Ambient temperature;
at 0 - 20℃; for 3h;
for 2h;
D-Malic acid
636-61-3

D-Malic acid

β-naphthol
135-19-3

β-naphthol

(R)-(+)-malic acid di(2-naphthyl)ester

(R)-(+)-malic acid di(2-naphthyl)ester

Conditions
ConditionsYield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine100%
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine In acetonitrile Esterification;
D-Malic acid
636-61-3

D-Malic acid

acetyl chloride
75-36-5

acetyl chloride

(R)-(+)-2-acetoxysuccinic anhydride
14189-99-2, 24766-96-9, 59025-03-5, 79814-40-7

(R)-(+)-2-acetoxysuccinic anhydride

Conditions
ConditionsYield
at 45℃; for 6h;100%
at 45℃; for 6h;90%
at 45℃; for 6h;90%
bortezomib
390800-88-1

bortezomib

D-Malic acid
636-61-3

D-Malic acid

2-((R)-2-((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)-5-oxo-1,3,2-dioxaborolan-4-yl)acetic acid
1201902-99-9

2-((R)-2-((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)-5-oxo-1,3,2-dioxaborolan-4-yl)acetic acid

Conditions
ConditionsYield
In acetone at 25℃; Heating;100%
D-Malic acid
636-61-3

D-Malic acid

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

(S)-methane-sulphonyloxysuccinic Acid
107314-06-7

(S)-methane-sulphonyloxysuccinic Acid

Conditions
ConditionsYield
In tetrahydrofuran for 10h; Heating / reflux;99%
D-Malic acid
636-61-3

D-Malic acid

boric acid
11113-50-1

boric acid

sodium hydroxide
1310-73-2

sodium hydroxide

sodium (S,S,S)-dimalatoborate

sodium (S,S,S)-dimalatoborate

Conditions
ConditionsYield
In water malic acid dissolved in H2O, treated with boric acid, aq. NaOH added, stirred in open flask at 100 °C for ca. 4 h; mixt. evapd.; detd. by NMR, XRD;99%
D-Malic acid
636-61-3

D-Malic acid

(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one
1130137-76-6

(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one (R)-malate

(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one (R)-malate

Conditions
ConditionsYield
In methanol; water at 20 - 50℃; Darkness;99%
methanol
67-56-1

methanol

D-Malic acid
636-61-3

D-Malic acid

(3R)-3-hydroxy-4-methoxy-4-oxobutanoic acid
83540-94-7

(3R)-3-hydroxy-4-methoxy-4-oxobutanoic acid

Conditions
ConditionsYield
Stage #1: D-Malic acid With trifluoroacetic acid at 20℃; for 0.666667h; Inert atmosphere;
Stage #2: methanol at 20℃; for 1.5h; Inert atmosphere;
99%
Stage #1: D-Malic acid With trifluoroacetic anhydride for 0.666667h;
Stage #2: methanol at 20℃; for 1.5h;
84%
Stage #1: D-Malic acid With trifluoroacetic anhydride at 20℃; for 3h;
Stage #2: methanol at 20℃;
D-Malic acid
636-61-3

D-Malic acid

boric acid
11113-50-1

boric acid

potassium hydroxide

potassium hydroxide

C8H8BO10(1-)*K(1+)

C8H8BO10(1-)*K(1+)

Conditions
ConditionsYield
In water at 95℃;99%
D-Malic acid
636-61-3

D-Malic acid

pivalaldehyde
630-19-3

pivalaldehyde

2-((2R, 4R)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl) acetic acid
186906-71-8

2-((2R, 4R)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl) acetic acid

Conditions
ConditionsYield
With sulfuric acid; toluene-4-sulfonic acid In pentane for 36h; Heating;98%
With sulfuric acid; toluene-4-sulfonic acid In pentane for 6h; Heating;92%
Stage #1: D-Malic acid With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 23℃; Inert atmosphere;
Stage #2: pivalaldehyde With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -25℃; Inert atmosphere;
82%
D-Malic acid
636-61-3

D-Malic acid

cyclohexanone
108-94-1

cyclohexanone

2-[(4R)-2-cyclohexylidene-5-oxo-1,3-dioxolan-4-yl]acetic acid
632357-87-0

2-[(4R)-2-cyclohexylidene-5-oxo-1,3-dioxolan-4-yl]acetic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In diethyl ether at 0 - 20℃; for 19h;98%
With boron trifluoride diethyl etherate In diethyl ether at 0 - 20℃; for 25h;93%
With boron trifluoride diethyl etherate In diethyl ether at 0 - 20℃; for 25h;
With boron trifluoride diethyl etherate In diethyl ether at 0 - 20℃; for 20h;
Stage #1: D-Malic acid; cyclohexanone With boron trifluoride diethyl etherate In diethyl ether at 0 - 20℃; for 97h;
Stage #2: With water; sodium acetate In diethyl ether for 2h;
ethanol
64-17-5

ethanol

D-Malic acid
636-61-3

D-Malic acid

diethyl (R)-malate
7554-28-1

diethyl (R)-malate

Conditions
ConditionsYield
With thionyl chloride Esterification;97%
With thionyl chloride for 7h; Reflux;95%
With sulfuric acid at 90℃; for 12h; Inert atmosphere;95%
D-Malic acid
636-61-3

D-Malic acid

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid
73991-95-4, 114458-03-6, 119618-59-6, 113278-68-5

2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate at 25℃;97%
With pyridinium p-toluenesulfonate for 48h; Ambient temperature;96%
With toluene-4-sulfonic acid In dichloromethane for 4h; Ambient temperature;90%
D-Malic acid
636-61-3

D-Malic acid

(S)-(+)-tylophorine
482-20-2

(S)-(+)-tylophorine

C24H27NO4*C4H6O5

C24H27NO4*C4H6O5

Conditions
ConditionsYield
In methanol; dichloromethane at 20℃; for 8h;97%
D-Malic acid
636-61-3

D-Malic acid

benzyl alcohol
100-51-6

benzyl alcohol

(R)-dibenzyl 2-hydroxysuccinate
99266-22-5

(R)-dibenzyl 2-hydroxysuccinate

Conditions
ConditionsYield
With 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt95%
With toluene-4-sulfonic acid In toluene Heating;95%
chloral hydrate
302-17-0

chloral hydrate

D-Malic acid
636-61-3

D-Malic acid

(2RS,5R)-5-carboxymethyl-2-trichloromethyl-4-oxo-1,3-dioxolane

(2RS,5R)-5-carboxymethyl-2-trichloromethyl-4-oxo-1,3-dioxolane

Conditions
ConditionsYield
With sulfuric acid at 20℃; for 3h;95%
D-Malic acid
636-61-3

D-Malic acid

acetyl chloride
75-36-5

acetyl chloride

diethyl (R)-malate
7554-28-1

diethyl (R)-malate

Conditions
ConditionsYield
In ethanol at 20℃; for 69h;95%
D-Malic acid
636-61-3

D-Malic acid

Besifovir
441785-25-7

Besifovir

C4H6O5*2C10H14N5O4P

C4H6O5*2C10H14N5O4P

Conditions
ConditionsYield
In methanol at 15 - 45℃;93.51%
D-Malic acid
636-61-3

D-Malic acid

5-bromo-3-(N,N-dimethylaminomethyl)-N-methylindole
252639-05-7

5-bromo-3-(N,N-dimethylaminomethyl)-N-methylindole

1-methyl-5-bromogramine D-malate

1-methyl-5-bromogramine D-malate

Conditions
ConditionsYield
In methanol for 2h; Reflux;93%
D-Malic acid
636-61-3

D-Malic acid

benzyl alcohol
100-51-6

benzyl alcohol

2-R-hydroxysuccinic acid 1-benzylester
83477-74-1

2-R-hydroxysuccinic acid 1-benzylester

Conditions
ConditionsYield
With trifluoroacetic anhydride Inert atmosphere;92%
Stage #1: D-Malic acid With trifluoroacetic anhydride at 0℃;
Stage #2: benzyl alcohol at 20℃; Further stages.;
86%
Stage #1: D-Malic acid With trifluoroacetic anhydride at 0℃; for 2.5h;
Stage #2: benzyl alcohol at 20℃; for 2h;
Stage #1: D-Malic acid With trifluoroacetic anhydride at 20℃; for 4h; Cooling;
Stage #2: benzyl alcohol
28 g
tetraethylammonium hydroxide

tetraethylammonium hydroxide

tricarbonyl(cycloheptatriene)molybdenum(0)
12125-77-8

tricarbonyl(cycloheptatriene)molybdenum(0)

D-Malic acid
636-61-3

D-Malic acid

[Et4N]2[(D-mallic acid(-2H))Mo(CO)3]

[Et4N]2[(D-mallic acid(-2H))Mo(CO)3]

Conditions
ConditionsYield
In methanol (N2); Schlenk technique; soln. of Et4OH in MeOH was added dropwise with stirring to soln. of acid in MeOH at room temp.; solvent was removed (vac.); dissolved in MeOH; obtained soln. was added to soln. of Mo complex in MeOH; mixt. was stirred overnight; solvent removed (vac.); extd. (MeCN/MeOH); layered with ether; elem. anal.;90%
D-Malic acid
636-61-3

D-Malic acid

4-methoxy-benzylamine
2393-23-9

4-methoxy-benzylamine

(R)-3-hydroxy-1-(4-methoxybenzyl)pyrrolidine-2,5-dione
1312764-95-6

(R)-3-hydroxy-1-(4-methoxybenzyl)pyrrolidine-2,5-dione

Conditions
ConditionsYield
In 5,5-dimethyl-1,3-cyclohexadiene for 8h; Reflux; optical yield given as %ee;90%
In m-xylene Reflux;78%
D-Malic acid
636-61-3

D-Malic acid

(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine
1218935-59-1

(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine

(R)-2-(2,5-difluorophenyl)-pyrrolidine (R)-2-hydroxy-succinate

(R)-2-(2,5-difluorophenyl)-pyrrolidine (R)-2-hydroxy-succinate

Conditions
ConditionsYield
With triethylamine In ethanol at 20 - 65℃; Inert atmosphere;90%
D-Malic acid
636-61-3

D-Malic acid

eszopiclone
138729-47-2

eszopiclone

(S)-(+)-6-(5-chloro-2-pyridinyl)-7-(4-methylpiperazin-1-yl-carbonyloxy)-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-one D-(+)-malate
863393-46-8

(S)-(+)-6-(5-chloro-2-pyridinyl)-7-(4-methylpiperazin-1-yl-carbonyloxy)-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-one D-(+)-malate

Conditions
ConditionsYield
In ethyl acetate for 18h;89%
ethanol
64-17-5

ethanol

D-Malic acid
636-61-3

D-Malic acid

(R)-2-Hydroxy-succinic acid 1-ethyl ester
83540-96-9

(R)-2-Hydroxy-succinic acid 1-ethyl ester

Conditions
ConditionsYield
With salicylaldehyde at 80℃; for 14h; Inert atmosphere; chemoselective reaction;89%
D-Malic acid
636-61-3

D-Malic acid

zopiclon
43200-80-2

zopiclon

(S)-(+)-6-(5-chloro-2-pyridinyl)-7-(4-methylpiperazin-1-yl-carbonyloxy)-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-one D-(+)-malate
863393-46-8

(S)-(+)-6-(5-chloro-2-pyridinyl)-7-(4-methylpiperazin-1-yl-carbonyloxy)-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-one D-(+)-malate

Conditions
ConditionsYield
In methanol; acetone at 10 - 48℃; for 4h;88%
In methanol; acetone at 55 - 56℃; for 0.5h; Product distribution / selectivity;41%
malic acid
617-48-1

malic acid

D-Malic acid
636-61-3

D-Malic acid

(R)-4-methyloxetan-2-one
32082-74-9

(R)-4-methyloxetan-2-one

Conditions
ConditionsYield
With hydrogenchloride; sodium borohydrid; lithium chloride In tetrahydrofuran; methanol88%
D-Malic acid
636-61-3

D-Malic acid

4-methoxy-benzylamine
2393-23-9

4-methoxy-benzylamine

acetyl chloride
75-36-5

acetyl chloride

(R)-1-(4-methoxybenzyl)-2,5-dioxopyrrolidin-3-yl acetate

(R)-1-(4-methoxybenzyl)-2,5-dioxopyrrolidin-3-yl acetate

Conditions
ConditionsYield
Stage #1: D-Malic acid; acetyl chloride for 20h; Reflux;
Stage #2: 4-methoxy-benzylamine In tetrahydrofuran at 0 - 25℃; for 18h;
87%
Stage #1: D-Malic acid; acetyl chloride Reflux;
Stage #2: 4-methoxy-benzylamine With acetyl chloride In dichloromethane Reflux;
Stage #3: With acetyl chloride In dichloromethane Reflux;
Stage #1: D-Malic acid; acetyl chloride for 16h; Reflux;
Stage #2: 4-methoxy-benzylamine In tetrahydrofuran at 20℃; for 18h;
Stage #3: acetyl chloride for 18h; Reflux;
660 mg
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