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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White crystalline or granular powder Conform Solublity Sli

high purity 118-10-5 Cinchonine

Cas:118-10-5

Min.Order:1 Kilogram

FOB Price: $1.9 / 2.5

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Cinchonine supplier in China

Cas:118-10-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Cinchonine CAS NO.118-10-5

Cas:118-10-5

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Cinchonine Cas 118-10-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White,microcrystalline powder,bitter Storage:Store below +30°C Package:100g,1kg

Factory supply best price Cinchonine Cas 118-10-5 with high quality

Cas:118-10-5

Min.Order:100 Gram

FOB Price: $1.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Cinchonine

Cas:118-10-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Cinchonine

Cas:118-10-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Cinchonine 118-10-5 GMP Manufacturer

Cas:118-10-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Cinchonine

Cas:118-10-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Cinchonine (base and/or unspecified salts)

Cas:118-10-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Hebei Nengqian Chemical Import and Export Co., LTD.. is located in xingtai City, Hebei Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutica

Cinchonine CAS NO.118-10-5

Cas:118-10-5

Min.Order:1 Gram

FOB Price: $12.0 / 15.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM -Cinchonine

Cas:118-10-5

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 118-10-5 with competitive price

Cas:118-10-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:white to light yellow crystal powder Storage:Room temperature Package:25kg/Barrel Application:APIs Transportation:Express/Sea/Air Port:Any port in China

Hot sale Cinchonine;(9S)-Cinchonan-9-ol;D-CINCHONINE;Factory supplier in China

Cas:118-10-5

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Cinchonine 118-10-5

Cas:118-10-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided 4.Suitable package to protect the product the product quality. 5.the lead ti

Cinchonine CAS NO.118-10--5

Cas:118-10-5

Min.Order:1 Gram

FOB Price: $4.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Cinchonine CAS:118-10-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Cinchonine CAS:118-10-5

Cas:118-10-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Wholesale price in bulk supply Cinchonine powder

Cas:118-10-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Cinchonin

Cas:118-10-5

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Cinchonine CAS NO.118-10-5

Cas:118-10-5

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Cinchonine

Cas:118-10-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Cinchonine

Cas:118-10-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Cinchonine

Cas:118-10-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-QUINOLYL(5-VINYL-1-AZABICYCLO[2.2.2]OCT-2-YL)MET

Cas:118-10-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cinchonine

Cas:118-10-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Cinchonine CAS 118-10-5 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Prof

Cinchonine CAS 118-10-5

Cas:118-10-5

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Cinchonine CAS 118-10-5 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality c

Cinchonine CAS 118-10-5

Cas:118-10-5

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Cinchonine

Cas:118-10-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Cinchonine

Cas:118-10-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Cinchonine CAS No.: 118-10-5 Molecule Formula:C19H23N2O Molecule Weight:295.40 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPECIF

Lower Price Cinchonine on stock

Cas:118-10-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

O-tosylcinchonine
189309-24-8

O-tosylcinchonine

A

(Z)-1-(quinolin-4-yl)-3-((3R,4R)-3-vinylpiperidin-4-yl)prop-1-enyl 4-methylbenzene sulfonate
1393446-38-2

(Z)-1-(quinolin-4-yl)-3-((3R,4R)-3-vinylpiperidin-4-yl)prop-1-enyl 4-methylbenzene sulfonate

B

Cinchonin
118-10-5

Cinchonin

Conditions
ConditionsYield
With salicylic acid In ethylene glycol at 95℃; for 0.5h; Microwave irradiation;A 60%
B 15%
C 15%
methanesulfonic acid (quinolin-4-yl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methyl ester
560119-43-9

methanesulfonic acid (quinolin-4-yl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methyl ester

A

Cinchonin
118-10-5

Cinchonin

C

(1S,2R,3S,5S,6R)-2-(quinolin-4-yl)-6-vinyl-1-azabicyclo[3.2.2]nonan-3-ol
560119-45-1

(1S,2R,3S,5S,6R)-2-(quinolin-4-yl)-6-vinyl-1-azabicyclo[3.2.2]nonan-3-ol

D

(E)-cinchene

(E)-cinchene

Conditions
ConditionsYield
With water; tartaric acid at 100℃; Title compound not separated from byproducts;A n/a
B n/a
C 48%
D 1%
acetic acid
64-19-7

acetic acid

iron powder

iron powder

Cinchonin
118-10-5

Cinchonin

ethanol
64-17-5

ethanol

sodium

sodium

Cinchonin
118-10-5

Cinchonin

benzoylcinchonine
14402-57-4

benzoylcinchonine

alcoholic KOH-solution

alcoholic KOH-solution

A

benzoic acid
65-85-0

benzoic acid

B

Cinchonin
118-10-5

Cinchonin

Conditions
ConditionsYield
at 60 - 70℃;
(9S,10Ξ)-10-iodo-10,11-dihydro-cinchonan-9-ol; dihydriodide hydrate

(9S,10Ξ)-10-iodo-10,11-dihydro-cinchonan-9-ol; dihydriodide hydrate

water

water

A

Cinchonin
118-10-5

Cinchonin

B

9,10-Epoxy-10,11-dihydro-cinchonan
7299-23-2

9,10-Epoxy-10,11-dihydro-cinchonan

C

apocinchonine

apocinchonine

Conditions
ConditionsYield
at 150 - 160℃; im Rohr; isomer(ic) I;
Cinchonin
118-10-5

Cinchonin

Tert-butyl isocyanate
1609-86-5

Tert-butyl isocyanate

(9S)-9-deoxy-cinchonin-9-yl tert-butylcarbamate

(9S)-9-deoxy-cinchonin-9-yl tert-butylcarbamate

Conditions
ConditionsYield
With dibutyltin(II) dilaurate In toluene at 110℃; for 48h;99%
methyllithium
917-54-4

methyllithium

Cinchonin
118-10-5

Cinchonin

2'-methylcinchonine

2'-methylcinchonine

Conditions
ConditionsYield
In tetrahydrofuran at -10 - 50℃; for 6h; Inert atmosphere; Schlenk technique;99%
In tetrahydrofuran at -78.16℃; for 12h; Inert atmosphere;
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

Cinchonin
118-10-5

Cinchonin

(2R,5R,1'S)-1-(9-anthracenyl)methyl-5-ethylene-2-[1-hydroxy-1-(quinol-4-yl)]methyl-1-azoniabicyclo[2.2.2]octane chloride

(2R,5R,1'S)-1-(9-anthracenyl)methyl-5-ethylene-2-[1-hydroxy-1-(quinol-4-yl)]methyl-1-azoniabicyclo[2.2.2]octane chloride

Conditions
ConditionsYield
In toluene at 110℃; for 2h;98%
In toluene Reflux;94%
In toluene for 24h; Heating;80%
(1E,4E)-1,5-bis(4-(bromomethyl)phenyl)penta-1,4-dien-3-one

(1E,4E)-1,5-bis(4-(bromomethyl)phenyl)penta-1,4-dien-3-one

Cinchonin
118-10-5

Cinchonin

C57H60N4O3(2+)*2Br(1-)

C57H60N4O3(2+)*2Br(1-)

Conditions
ConditionsYield
In tetrahydrofuran; N,N-dimethyl-formamide Reflux;98%
5,5'-bis(bromomethyl)-2,2'-bipyridine
92642-09-6

5,5'-bis(bromomethyl)-2,2'-bipyridine

Cinchonin
118-10-5

Cinchonin

C50H54N6O2(2+)*2Br(1-)

C50H54N6O2(2+)*2Br(1-)

Conditions
ConditionsYield
In tetrahydrofuran Reflux;96%
benzyl chloride
100-44-7

benzyl chloride

Cinchonin
118-10-5

Cinchonin

(9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride
69221-14-3

(9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride

Conditions
ConditionsYield
In ethanol; chloroform; N,N-dimethyl-formamide at 100℃; for 10h;95%
With ethanol
In N,N-dimethyl-formamide at 80℃; for 3h; N-quaternization;
(1E)-1,2-bis[3-(bromomethyl)phenyl]diazene
60682-97-5, 66888-72-0, 29477-66-5

(1E)-1,2-bis[3-(bromomethyl)phenyl]diazene

Cinchonin
118-10-5

Cinchonin

C54H58N4O2(2+)*2Br(1-)

C54H58N4O2(2+)*2Br(1-)

Conditions
ConditionsYield
In tetrahydrofuran; acetonitrile Reflux;95%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Cinchonin
118-10-5

Cinchonin

O-tosylcinchonine
189309-24-8

O-tosylcinchonine

Conditions
ConditionsYield
Stage #1: Cinchonin With sodium hydride In tetrahydrofuran at 70℃; for 2h; deprotonation;
Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran at 60 - 70℃; for 10h; Tosylation;
94%
With tributyl-amine; potassium hydroxide In dichloromethane; water at 20℃; for 24h;90%
With pyridine
Cinchonin
118-10-5

Cinchonin

dihydrocinchonine
485-65-4

dihydrocinchonine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 10h;92%
With sulfuric acid; palladium Hydrogenation;
With palladium; acetic acid Hydrogenation;
Cinchonin
118-10-5

Cinchonin

methyl iodide
74-88-4

methyl iodide

(1S,4S,5R)-2-((S)-methoxy(quinolin-4-yl)methyl)-5-vinylquinuclidine

(1S,4S,5R)-2-((S)-methoxy(quinolin-4-yl)methyl)-5-vinylquinuclidine

Conditions
ConditionsYield
Stage #1: Cinchonin With potassium hydride In N,N-dimethyl-formamide; mineral oil; pentane at 0 - 50℃; for 3h; Inert atmosphere;
Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil; pentane at 0 - 20℃; Inert atmosphere;
91%
Stage #1: Cinchonin With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃;
Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 20℃;
60%
Stage #1: Cinchonin With potassium hydride In tetrahydrofuran; mineral oil at 0 - 50℃; for 3h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; Inert atmosphere;
59%
p-(chloromethyl)benzoyl chloride
876-08-4

p-(chloromethyl)benzoyl chloride

Cinchonin
118-10-5

Cinchonin

C27H27ClN2O2

C27H27ClN2O2

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; under 760.051 Torr; for 16h;90%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Cinchonin
118-10-5

Cinchonin

methanesulfonic acid (quinolin-4-yl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methyl ester
560119-43-9

methanesulfonic acid (quinolin-4-yl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methyl ester

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;88%
4-chlorobenzyl bromide
622-95-7

4-chlorobenzyl bromide

Cinchonin
118-10-5

Cinchonin

N-(4-chlorobenzyl)cinchoninium bromide

N-(4-chlorobenzyl)cinchoninium bromide

Conditions
ConditionsYield
In tetrahydrofuran for 5.5h; Reflux;87.8%
In tetrahydrofuran for 84h; Heating;52%
benzyl chloride
100-44-7

benzyl chloride

Cinchonin
118-10-5

Cinchonin

O-benzylcinchonine
1261665-86-4

O-benzylcinchonine

Conditions
ConditionsYield
Stage #1: Cinchonin With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;
Stage #2: benzyl chloride In N,N-dimethyl-formamide; mineral oil
87%
Stage #1: Cinchonin With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;
Stage #2: benzyl chloride In N,N-dimethyl-formamide; mineral oil
86%
allyl bromide
106-95-6

allyl bromide

Cinchonin
118-10-5

Cinchonin

O-allylcinchonine
852951-76-9

O-allylcinchonine

Conditions
ConditionsYield
Stage #1: Cinchonin With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;
Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil
87%
Stage #1: Cinchonin With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;
Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil
87%
Stage #1: Cinchonin With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;
Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃;
87%
With sodium hydride In N,N-dimethyl-formamide at 30℃; for 2h;87%
benzyl bromide
100-39-0

benzyl bromide

Cinchonin
118-10-5

Cinchonin

(1S,2R,4S,5R)-1-benzyl-2-((S)-(1-benzylquinolin-1-ium-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium bromide

(1S,2R,4S,5R)-1-benzyl-2-((S)-(1-benzylquinolin-1-ium-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium bromide

Conditions
ConditionsYield
In N,N-dimethyl-formamide; isopropyl alcohol at 70℃; for 12h; Inert atmosphere;87%
4,6-dichloro-2,5-diphenylpyrimidine
29133-99-1

4,6-dichloro-2,5-diphenylpyrimidine

Cinchonin
118-10-5

Cinchonin

C35H31ClN4O

C35H31ClN4O

Conditions
ConditionsYield
With potassium hydroxide In toluene for 1h; Inert atmosphere; Reflux;87%
benzyl bromide
100-39-0

benzyl bromide

Cinchonin
118-10-5

Cinchonin

(+)-N-benzylcinchonineammonium bromide
85653-34-5

(+)-N-benzylcinchonineammonium bromide

Conditions
ConditionsYield
In tetrahydrofuran for 4.5h; Reflux;86.9%
In tetrahydrofuran for 16h; Reflux;82%
In acetonitrile at 20℃; for 24h; Inert atmosphere;
C27H31Br

C27H31Br

Cinchonin
118-10-5

Cinchonin

C46H53N2O(1+)*Br(1-)

C46H53N2O(1+)*Br(1-)

Conditions
ConditionsYield
In tetrahydrofuran for 16h; Reflux;86%
3,5-bis(trifluoromethyl)benzyl bromide
32247-96-4

3,5-bis(trifluoromethyl)benzyl bromide

Cinchonin
118-10-5

Cinchonin

N1-3,5-bis(trifluoromethyl)benzylcinchonium bromide

N1-3,5-bis(trifluoromethyl)benzylcinchonium bromide

Conditions
ConditionsYield
In tetrahydrofuran for 12h; Heating;85%
In tetrahydrofuran for 24h; Reflux;79%
In toluene at 80℃; Inert atmosphere;72%
succinic acid anhydride
108-30-5

succinic acid anhydride

Cinchonin
118-10-5

Cinchonin

C23H26N2O4

C23H26N2O4

Conditions
ConditionsYield
With dmap In dichloromethane at 50℃;84%
2-bromomethylnaphthyl bromide
939-26-4

2-bromomethylnaphthyl bromide

Cinchonin
118-10-5

Cinchonin

N-(2-napthylmethyl)cinchoninium bromide
207561-98-6

N-(2-napthylmethyl)cinchoninium bromide

Conditions
ConditionsYield
In tetrahydrofuran for 16h; Reflux;83%
2-Iodobenzyl bromide
40400-13-3

2-Iodobenzyl bromide

Cinchonin
118-10-5

Cinchonin

N-2-iodobenzylcinchoninium bromide
1410875-87-4

N-2-iodobenzylcinchoninium bromide

Conditions
ConditionsYield
In tetrahydrofuran for 12h; Reflux; Inert atmosphere;82%
1-bromomethyl-2-chlorobenzene
611-17-6

1-bromomethyl-2-chlorobenzene

Cinchonin
118-10-5

Cinchonin

N-(2-chlorobenzyl)cinchoninium bromide
1261665-70-6

N-(2-chlorobenzyl)cinchoninium bromide

Conditions
ConditionsYield
In tetrahydrofuran for 6h; Reflux;81.2%
Cinchonin
118-10-5

Cinchonin

(8R,9R)-9-amino(9-deoxy)epicinchonin

(8R,9R)-9-amino(9-deoxy)epicinchonin

Conditions
ConditionsYield
Stage #1: Cinchonin With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere;
Stage #2: With diphenylphosphoranyl azide In tetrahydrofuran at 0 - 50℃; Inert atmosphere;
Stage #3: With hydrogenchloride In dichloromethane; water
81%
Stage #1: Cinchonin With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 0.0833333h; Inert atmosphere;
Stage #2: With ammonia In tetrahydrofuran; chloroform at 0 - 60℃;
78%
Multi-step reaction with 2 steps
1.1: diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 50 °C
2.1: triphenylphosphine / 15 h / 50 °C
2.2: 24 h / 20 °C
View Scheme
9,1-bis(chloromethyl)anthracene
10387-13-0

9,1-bis(chloromethyl)anthracene

Cinchonin
118-10-5

Cinchonin

C54H56N4O2(2+)*2Cl(1-)

C54H56N4O2(2+)*2Cl(1-)

Conditions
ConditionsYield
In ethanol; chloroform; N,N-dimethyl-formamide at 100℃;80%
9-bromoethylanthracene
2417-77-8

9-bromoethylanthracene

Cinchonin
118-10-5

Cinchonin

N-(anthracen-9-ylmethyl)cinchoninium bromide
365567-24-4

N-(anthracen-9-ylmethyl)cinchoninium bromide

Conditions
ConditionsYield
In tetrahydrofuran for 4.5h; Reflux;79.6%
In tetrahydrofuran for 8h; Inert atmosphere; Reflux;71%
In tetrahydrofuran for 16h; Reflux;52%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Cinchonin
118-10-5

Cinchonin

N-(4-methoxybenzyl)cinchoninium bromide
207561-99-7

N-(4-methoxybenzyl)cinchoninium bromide

Conditions
ConditionsYield
In tetrahydrofuran for 3.5h; Reflux;78.6%
1-bromomethyl-4-bromobenzene
589-15-1

1-bromomethyl-4-bromobenzene

Cinchonin
118-10-5

Cinchonin

N-(p-bromobenzyl)-cinchoninium bromide

N-(p-bromobenzyl)-cinchoninium bromide

Conditions
ConditionsYield
In chloroform 1.) reflux, 40 min, 2.) room temperature, 19 h;77%
In tetrahydrofuran for 5.5h; Reflux;66.3%
In tetrahydrofuran for 44h; Heating;41%
3-phenylprop-2-en-1-yl bromide
4392-24-9

3-phenylprop-2-en-1-yl bromide

Cinchonin
118-10-5

Cinchonin

N-cinnamyl-cinchoninium bromide

N-cinnamyl-cinchoninium bromide

Conditions
ConditionsYield
In chloroform 1.) reflux, 2.) room temperature;77%

Raw Materials

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