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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for t

1,3,3-Trimethyl-2-methyleneindoline suppliers in China

Cas:118-12-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 1,3,3-trimethyl-2-methyleneindoline 118-12-7 Producer

Cas:118-12-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Methylene-1,3,3-trimethylindoline

Cas:118-12-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

1,3,3-Trimethyl-2-methyleneindoline 118-12-7

Cas:118-12-7

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

1,3,3-Trimethyl-2-Methyleneindoline 118-12-7

Cas:118-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 118-12-7 with best quality

Cas:118-12-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

SAGECHEM/ 1,3,3-Trimethyl-2-methyleneindoline /Manufacturer in China

Cas:118-12-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:clear red liquid Storage:Store below +30°C. Package:25kg/Barrel Application:Intermediates of Dyes and Pigments Transportation:Express/Sea/Air Port:Any port in China

Factory supply 1,3,3-Trimethyl-2-Methyleneindoline;2-METHYLENE-1,3,3-TRIMETHYLINDOLINE;FISCHER BASE

Cas:118-12-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,3,3-Trimethyl-2-methyleneindoline 118-12-7

Cas:118-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1,3,3-Trimethyl-2-methyleneindoline CAS:118-12-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

1,3,3-Trimethyl-2-methyleneindoline CAS:118-12-7

Cas:118-12-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

1,3,3 TRIMETHYL-2-METHYLENE INDOLINE

Cas:118-12-7

Min.Order:1 Kilogram

FOB Price: $8.0 / 12.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 1,3,3-Trimethyl-2-Methyleneindoline

Cas:118-12-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 1,3,3-Trimethyl-2-Methyleneindoline CAS No.:118-12-7 Molecule Formula:C12H15N Molecule Weight:173.25 Purity: 97.0% Package: 200kg/drum Description:Red liquid Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality 1,3,3-Trimethyl-2-Methyleneindoline on stock

Cas:118-12-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,3-dihydro-1,3,3-trimethyl-2-methylene-1h-indol

Cas:118-12-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name: 1,3,3-Trimethyl-2-methyleneindoline Synonyms: 2,3-Dihydro-1,3,3-trimethyl-2-methyleneindoline;2-methylene-1,3,3-trimethyl-indolin;fischer’smethylenebase;Fischer'S methylene base;Indoline, 1,3,3-trimethy

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

Appearance:powder or granule ( refer to COA) Application:Librium, Valium

Factory Supply 1,3,3-trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:0

Negotiable

Type:Other

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

SAGECHEM/ 1,3,3-Trimethyl-2-methyleneindoline /Manufacturer in China

Cas:118-12-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

SAGECHEM/ 1,3,3-Trimethyl-2-methyleneindoline /Manufacturer in China

Cas:118-12-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

SAGECHEM/ 1,3,3-Trimethyl-2-methyleneindoline /Manufacturer in China

Cas:118-12-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ 1,3,3-Trimethyl-2-methyleneindoline /Manufacturer in China

Cas:118-12-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

1,3,3-Trimethyl-2-methyleneindoline

Cas:118-12-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

SAGECHEM/ 1,3,3-Trimethyl-2-methyleneindoline /Manufacturer in China

Cas:118-12-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

2-(1,3,3-tri-methylindolin-2-ylidene)acetonitrile
5114-82-9

2-(1,3,3-tri-methylindolin-2-ylidene)acetonitrile

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With hydrogenchloride for 6h; Heating;100%
spiro-1,3,3-trimethylindoline<2:3'>-3',4'-dihydroisoxazole
144598-21-0

spiro-1,3,3-trimethylindoline<2:3'>-3',4'-dihydroisoxazole

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With hydrogenchloride for 6h; Heating;100%
1,3,3-trimethyl-2-methyleneacetamidoindoline
301673-89-2

1,3,3-trimethyl-2-methyleneacetamidoindoline

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With hydrogenchloride for 6h; Heating;100%
2,3,3-trimethylindoleniune
1640-39-7

2,3,3-trimethylindoleniune

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
at 180 - 220℃; under 22502.3 - 37503.8 Torr; Inert atmosphere; Sealed tube; Autoclave;97.8%
1,2,3,3-tetramethyl-3H-indolium iodide
5418-63-3

1,2,3,3-tetramethyl-3H-indolium iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With sodium hydroxide In diethyl ether; water for 0.5h;71%
With potassium hydroxide at 20℃; for 1h;55%
With potassium hydroxide Ambient temperature;
(S)-1-phenyl-1-propanol
613-87-6

(S)-1-phenyl-1-propanol

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
10%
indole
120-72-9

indole

methyl iodide
74-88-4

methyl iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With methanol; sodium carbonate at 130℃;
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

methanol
67-56-1

methanol

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With hydrogenchloride at 160℃;
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

methyl iodide
74-88-4

methyl iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

1-methylindole
603-76-9

1-methylindole

methyl iodide
74-88-4

methyl iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With potassium hydroxide at 40℃;
With methanol at 100℃;
3-Methylindole
83-34-1

3-Methylindole

methyl iodide
74-88-4

methyl iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With methanol at 130℃;
2,3-dimethylindole
91-55-4

2,3-dimethylindole

methyl iodide
74-88-4

methyl iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
at 100℃;
With methanol at 100℃;
2,3,3-trimethylindoleniune
1640-39-7

2,3,3-trimethylindoleniune

methyl iodide
74-88-4

methyl iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

1,2,3-trimethylindole
1971-46-6

1,2,3-trimethylindole

methyl iodide
74-88-4

methyl iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
at 100℃;
2-tert-butylindole
1805-65-8

2-tert-butylindole

methyl iodide
74-88-4

methyl iodide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
at 110℃;
3-methyl-butan-2-one-(methyl-phenyl-hydrazone)
15754-36-6

3-methyl-butan-2-one-(methyl-phenyl-hydrazone)

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With ethanol; zinc(II) chloride Zersetzen der erhaltenen Zinkverbindung mit Kalilauge;
2,3,3-trimethylindoleniune
1640-39-7

2,3,3-trimethylindoleniune

Trimethylsilylmethyl trifluoromethanesulfonate
64035-64-9

Trimethylsilylmethyl trifluoromethanesulfonate

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
Yield given. Multistep reaction;
2,3,3-trimethylindoleniune
1640-39-7

2,3,3-trimethylindoleniune

Trimethylsilylmethyl trifluoromethanesulfonate
64035-64-9

Trimethylsilylmethyl trifluoromethanesulfonate

dimethyl cis-but-2-ene-1,4-dioate
624-48-6

dimethyl cis-but-2-ene-1,4-dioate

A

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

(1S,2R,9aS)-9,9,9a-Trimethyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-1,2-dicarboxylic acid dimethyl ester

(1S,2R,9aS)-9,9,9a-Trimethyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-1,2-dicarboxylic acid dimethyl ester

(1R,2S,9aS)-9,9,9a-Trimethyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-1,2-dicarboxylic acid dimethyl ester

(1R,2S,9aS)-9,9,9a-Trimethyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-1,2-dicarboxylic acid dimethyl ester

Conditions
ConditionsYield
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
2,3,3-trimethylindoleniune
1640-39-7

2,3,3-trimethylindoleniune

Trimethylsilylmethyl trifluoromethanesulfonate
64035-64-9

Trimethylsilylmethyl trifluoromethanesulfonate

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

A

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

B

dimethyl 9,9a-dihydro-9,9,9a-trimethyl-3H-pyrrolo<1,2a>indole-1,2-dicarboxylate
114676-05-0

dimethyl 9,9a-dihydro-9,9,9a-trimethyl-3H-pyrrolo<1,2a>indole-1,2-dicarboxylate

Conditions
ConditionsYield
Yield given. Multistep reaction;
1,3-Bis(1,3,3-trimethyl-2-indolinyl)-2-phospha-trimethinium-tetrafluoroborat

1,3-Bis(1,3,3-trimethyl-2-indolinyl)-2-phospha-trimethinium-tetrafluoroborat

A

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

B

1,2,3,3-tetramethylindoline
13034-76-9

1,2,3,3-tetramethylindoline

C

1,2,3,3-tetramethyl-3H-indolium tetrafluoroborate
21654-46-6

1,2,3,3-tetramethyl-3H-indolium tetrafluoroborate

Conditions
ConditionsYield
With water Product distribution; hydrolysis/protonation, also in chloroform (some weeks);
2-acetylmethylene-1,3,3-trimethylindoline
74145-97-4

2-acetylmethylene-1,3,3-trimethylindoline

concentrated acids

concentrated acids

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

methyl iodide
74-88-4

methyl iodide

N-methyl-indole

N-methyl-indole

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With methanol at 130℃;
methylene chloride
74-87-3

methylene chloride

lithium 2,3,3-trimethylindolenide
115590-27-7

lithium 2,3,3-trimethylindolenide

A

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

B

C-methylated product

C-methylated product

Conditions
ConditionsYield
In tetrahydrofuran at 19℃; for 1h; Product distribution; further solvent;
1,2,3,3-tetramethyl-3H-indolium iodide
5418-63-3

1,2,3,3-tetramethyl-3H-indolium iodide

A

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

B

1,3,3-trimethyl-2-dideuteriomethyleneindoline

1,3,3-trimethyl-2-dideuteriomethyleneindoline

C

C12H14(2)HN

C12H14(2)HN

Conditions
ConditionsYield
With potassium deuteroxide; water-d2 at 20℃; Title compound not separated from byproducts.;A 32 % Spectr.
B 50 % Spectr.
C 18 % Spectr.
(2E)-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)acetaldehyde
84-83-3, 85654-15-5

(2E)-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)acetaldehyde

A

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

B

zinc dust

zinc dust

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / hydroxylamine hydrochloride, pyridine / ethanol / 3 h / Heating
2: 100 percent / HCl / 6 h / Heating
View Scheme
1,3,3-trimethyl-2-methyleneiminohydroxindoline
144598-22-1

1,3,3-trimethyl-2-methyleneiminohydroxindoline

A

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

B

zinc dust

zinc dust

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / 70 °C
2: 100 percent / HCl / 6 h / Heating
View Scheme
3,3-dimethyl-butan-2-one-phenylhydrazone
39263-43-9

3,3-dimethyl-butan-2-one-phenylhydrazone

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: zinc chloride / 190 °C
2: 110 °C
View Scheme
2,3,3-trimethylindoleniune
1640-39-7

2,3,3-trimethylindoleniune

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,2-dichloro-ethane / 5 h / 20 °C / Reflux
2: sodium hydroxide / water; acetone
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 4 h / Reflux
2: sodium hydroxide / water
View Scheme
Multi-step reaction with 2 steps
1: diethyl ether; hexane
2: sodium hydroxide / diethyl ether
View Scheme
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

1,2,3,3-tetramethylindoline
13034-76-9

1,2,3,3-tetramethylindoline

Conditions
ConditionsYield
With [P(H)t-Bu2][B(C6F5)4]; 1,3-diisopropylimidazol-2-ylidene-9-borabicyclo[3.3.1]nonane; hydrogen In chlorobenzene at 100℃; under 77525.2 Torr; for 4h; Time; Temperature; Reagent/catalyst; Glovebox;100%
With 2C2H3O2(1-)*Pd(2+)*3Na(1+)*C18H12O9PS3(3-); hydrogen; glycerol at 100℃; under 2250.23 Torr; for 2h; Schlenk technique;96%
With [1,3-diisopropylimidazol-2-ylidene-9-borabicyclo[3.3.1]nonane][tetrakis (pentafluorophenyl)borate]; hydrogen In chlorobenzene at 20℃; under 77525.2 Torr; for 4h; Solvent; Inert atmosphere;94%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

2-[(E)-2-(4-Dimethylamino-phenyl)-vinyl]-1,3,3-trimethyl-3H-indolium; dihydrogen phosphate

2-[(E)-2-(4-Dimethylamino-phenyl)-vinyl]-1,3,3-trimethyl-3H-indolium; dihydrogen phosphate

Conditions
ConditionsYield
With phosphoric acid In water; isopropyl alcohol for 6h; Heating;100%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

2-hydroxy-5-t-butylisophthalaldehyde
84501-28-0

2-hydroxy-5-t-butylisophthalaldehyde

6-(tert-butyl)-1′,3′,3′-trimethylspiro[chromene-2,2′-indoline]-8-carbaldehyde
1370284-34-6

6-(tert-butyl)-1′,3′,3′-trimethylspiro[chromene-2,2′-indoline]-8-carbaldehyde

Conditions
ConditionsYield
In ethanol Reflux;99%
In ethanol at 85℃; for 12h;80%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

2,3-dihydroxybenzaldehyde
24677-78-9

2,3-dihydroxybenzaldehyde

spiro[2H-1-benzopyran-2,2’-(8-hydroxy-1’,3’,3’-trimethylindoline)]
23022-12-0

spiro[2H-1-benzopyran-2,2’-(8-hydroxy-1’,3’,3’-trimethylindoline)]

Conditions
ConditionsYield
In neat (no solvent) for 0.166667h; Microwave irradiation; Green chemistry;99%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

C4H7F3N(1+)*BF4(1-)

C4H7F3N(1+)*BF4(1-)

1,1-difluoro-3-(1,3,3-trimethylindolin-2-ylidene)propan-2-one

1,1-difluoro-3-(1,3,3-trimethylindolin-2-ylidene)propan-2-one

Conditions
ConditionsYield
In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;99%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
15568-86-2

5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

2,2-Dimethyl-5-{2-[1,3,3-trimethyl-1,3-dihydro-indol-(2E)-ylidene]-ethylidene}-[1,3]dioxane-4,6-dione

2,2-Dimethyl-5-{2-[1,3,3-trimethyl-1,3-dihydro-indol-(2E)-ylidene]-ethylidene}-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In toluene 1.) 60 deg C, 20 min, 2.) r.t., 2 h;98%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

4-methoxy-aniline
104-94-9

4-methoxy-aniline

2,3-Dihydro-1,3,3-trimethylindol-2-ylidenmethanaza(4'-methoxybenzol)
40842-68-0

2,3-Dihydro-1,3,3-trimethylindol-2-ylidenmethanaza(4'-methoxybenzol)

Conditions
ConditionsYield
With carbon dioxide; sodium nitrite In water at 35 - 40℃; under 37503 Torr; for 3h;98%
N-(2-iodo-phenyl)-4-methyl-N-(3-phenyl-propynoyl)-benzenesulfonamide
845958-95-4

N-(2-iodo-phenyl)-4-methyl-N-(3-phenyl-propynoyl)-benzenesulfonamide

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

phenylacetylene
536-74-3

phenylacetylene

(E)-3-((2Z,4Z)-1,3-diphenyl-4-(1,3,3-trimethylindolin-2-ylidene)but-2-en-1-ylidene)-1-tosylindolin-2-one

(E)-3-((2Z,4Z)-1,3-diphenyl-4-(1,3,3-trimethylindolin-2-ylidene)but-2-en-1-ylidene)-1-tosylindolin-2-one

Conditions
ConditionsYield
Stage #1: N-(2-iodo-phenyl)-4-methyl-N-(3-phenyl-propynoyl)-benzenesulfonamide; phenylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;
Stage #2: 1,3,3-Trimethyl-2-methyleneindoline With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethanol at 80℃; for 48h; Inert atmosphere; Sealed tube; diastereoselective reaction;
98%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

o-carboxybenzaldehyde
119-67-5

o-carboxybenzaldehyde

3-[(1,3,3-trimethylindolin-2-ylidene)methyl]isobenzofuran-1(3H)-one
84548-42-5

3-[(1,3,3-trimethylindolin-2-ylidene)methyl]isobenzofuran-1(3H)-one

Conditions
ConditionsYield
for 0.0833333h; Microwave irradiation; Green chemistry;98%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

salicylaldehyde
90-02-8

salicylaldehyde

1',3',3'-trimethylspiro(2H-1-benzopyran-2,2'-indoline)
1485-92-3

1',3',3'-trimethylspiro(2H-1-benzopyran-2,2'-indoline)

Conditions
ConditionsYield
In ethanol for 5h; Reflux;97%
In neat (no solvent) for 0.166667h; Microwave irradiation; Green chemistry;93%
In isopropyl alcohol Inert atmosphere; Reflux;90%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Methanesulfonyl azide
624-90-8, 1516-70-7

Methanesulfonyl azide

2,3-Dihydro-1,3,3-trimethyl-2-<(methylsulfonyl)imino>-1H-indol
143268-71-7

2,3-Dihydro-1,3,3-trimethyl-2-<(methylsulfonyl)imino>-1H-indol

Conditions
ConditionsYield
In toluene 1) 0 to 5 deg C, 1 h, 2) 20 deg C, 1 h;97%
In (2)H8-toluene at 0℃;
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

1,3-Bis(trifluoromethylsulfonyl)-5-nitro-2,4,6-trichlorobenzene
111222-84-5

1,3-Bis(trifluoromethylsulfonyl)-5-nitro-2,4,6-trichlorobenzene

1,3,3-Trimethyl-2-<2',6'-bis(trifluoromethylsulfonyl)-3',5'-dichloro-4'-nitrophenylmethylene>-2H-indole
115848-44-7

1,3,3-Trimethyl-2-<2',6'-bis(trifluoromethylsulfonyl)-3',5'-dichloro-4'-nitrophenylmethylene>-2H-indole

Conditions
ConditionsYield
With triethylamine In acetonitrile; benzene at 20℃; for 15h;97%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

sodium 1,3,3-trimethyl-2-methyleneindoline-5-sulfonate
128814-41-5

sodium 1,3,3-trimethyl-2-methyleneindoline-5-sulfonate

Conditions
ConditionsYield
With sulfuric acid; sulfur trioxide; sodium carbonate97%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

5-formyl-2-hydroxybenzaldehyde
3328-70-9

5-formyl-2-hydroxybenzaldehyde

6-formyl-1',3',3'-trimethylspiro<2H-1-benzopyran-2,2'-<1H>-indole>
20200-69-5

6-formyl-1',3',3'-trimethylspiro<2H-1-benzopyran-2,2'-<1H>-indole>

Conditions
ConditionsYield
In ethanol Addition; Heating;97%
In ethanol for 14.5h;80%
In ethanol Heating;75%
In ethanol for 5h; Heating;
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

2,5-Dihydroxybenzaldehyde
1194-98-5

2,5-Dihydroxybenzaldehyde

6-hydroxy spiropyran
23001-29-8

6-hydroxy spiropyran

Conditions
ConditionsYield
In neat (no solvent) for 0.166667h; Microwave irradiation; Green chemistry;97%
In ethanol Addition; Heating;90%
In ethanol for 2h; Inert atmosphere; Reflux;84.8%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

5-sulfonic acid 1,3,3-trimethyl-2-methyleneindoline

5-sulfonic acid 1,3,3-trimethyl-2-methyleneindoline

Conditions
ConditionsYield
With sulfuric acid at 0 - 5℃; for 5h;97%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Hexafluoroacetone
684-16-2

Hexafluoroacetone

1,3,3-trimethyl-2-<2-hydroxy-2-(trifluoromethyl)-3,3,3-trifluoropropylidene>indoline
127870-87-5, 127870-89-7

1,3,3-trimethyl-2-<2-hydroxy-2-(trifluoromethyl)-3,3,3-trifluoropropylidene>indoline

Conditions
ConditionsYield
In hexane at 0℃; Product distribution; other perfluorinated carbonyl compounds;96%
In hexane at 0℃;96%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

4,4'-dihydroxybenzophenone-3-carboxaldehyde
219560-21-1

4,4'-dihydroxybenzophenone-3-carboxaldehyde

C26H23NO3

C26H23NO3

Conditions
ConditionsYield
In methanol at 50℃;96%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

bis<(1,3,3-trimethyl-2-indolinylidene)methyl>phosphinous chloride
76372-77-5

bis<(1,3,3-trimethyl-2-indolinylidene)methyl>phosphinous chloride

Conditions
ConditionsYield
With triethylamine; phosphorus trichloride In chloroform; benzene for 6h; Heating;94.7%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

2-diethoxyphosphonyl-1,2,3,3-tetramethylindoline
109350-75-6

2-diethoxyphosphonyl-1,2,3,3-tetramethylindoline

Conditions
ConditionsYield
for 48h; Ambient temperature;94%
5,5'-thiobis(3-nitrosalicylaldehyde)
381732-60-1

5,5'-thiobis(3-nitrosalicylaldehyde)

1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

C38H34N4O6S

C38H34N4O6S

Conditions
ConditionsYield
94%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

5-mesyl-2-phenyl-4-tosyloxazole

5-mesyl-2-phenyl-4-tosyloxazole

4-[(4-methylphenyl)sulfonyl]-5-[(1,3,3-trimethylindolin-2-ylidene)methyl]-2-phenyl-1,3-oxazole

4-[(4-methylphenyl)sulfonyl]-5-[(1,3,3-trimethylindolin-2-ylidene)methyl]-2-phenyl-1,3-oxazole

Conditions
ConditionsYield
In ethanol for 5h; Reflux;94%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

1,2,3,3-tetramethyl-3H-indolium tetrafluoroborate
21654-46-6

1,2,3,3-tetramethyl-3H-indolium tetrafluoroborate

Conditions
ConditionsYield
With tetrafluoroboric acid In ethanol 1) 10 min, 20 deg C, 2) 15 min, ice-cooled;93%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

C7H10N2O4
219774-63-7

C7H10N2O4

2,2',3,3'-tetrahydro-1,3,3,5'-tetramethyl-4'-methoxycarbonyl-1'-(methoxycarbonylamino)spiro[1H-indole-2,2'-pyrrole]

2,2',3,3'-tetrahydro-1,3,3,5'-tetramethyl-4'-methoxycarbonyl-1'-(methoxycarbonylamino)spiro[1H-indole-2,2'-pyrrole]

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 2h;93%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

3,3'-[naphthalene-1,5-diylidi(E)diazene-2,1-diyl]bis(4,4'-diethylamino-6-hydroxy benzaldehyde)
1449790-53-7

3,3'-[naphthalene-1,5-diylidi(E)diazene-2,1-diyl]bis(4,4'-diethylamino-6-hydroxy benzaldehyde)

3,3'-[naphthalene-1,5-diylidi(E)diazene-2,1-diyl]bis(4,4'-diethylamino-6-hydroxy benzaldehyde)
1449790-58-2

3,3'-[naphthalene-1,5-diylidi(E)diazene-2,1-diyl]bis(4,4'-diethylamino-6-hydroxy benzaldehyde)

Conditions
ConditionsYield
In chloroform for 2h; Reflux;93%
1,3,3-Trimethyl-2-methyleneindoline
118-12-7

1,3,3-Trimethyl-2-methyleneindoline

Dimethyl phosphite
868-85-9

Dimethyl phosphite

2-dimethoxyphosphonyl-1,2,3,3-tetramethylindoline

2-dimethoxyphosphonyl-1,2,3,3-tetramethylindoline

Conditions
ConditionsYield
Ambient temperature;92%

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