Vildagliptin 274901-16-5

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0 Metric Ton	Negotiable

0 Metric Ton

Negotiable

Min.Order :0 Metric Ton
Purity: 99.85%
Payment Terms : L/C

Keywords

pyrrolidine-2-carbonitrile Hydroxytricyclo 274901-16-5

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Application:drug intermidiate
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Name: Vildagliptin
CAS No.: 274901-16-5
MF: C17H25N3O2
Use: Anti-diabetic agent
Appearance: White powder

General introduction: Vildagliptin (previously identified as LAF237, trade name ZOMELIS) is an oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIPby DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas.
Vildagliptin has been shown to reduce hyperglycemia in type 2 diabetes mellitus.
The Food and Drug Administration had demanded additional clinical data before it could approve vildagliptin including extra evidence that skin lesions and kidney impairment seen during an early study on animals have not occurred in human trials.
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Appearance	White crystalline powder	Conforms
Identification	IR/HPLC	Conforms
Melting point	148.0-150.0°C	148.5-149.2°C
Loss on drying	≤ 1.0%	0.18%
Residue on ignition	≤ 0.1%	0.05%
Heavy metals	≤20ppm	Conforms
Sulphate	≤ 0.02%	Conforms
Chloride	≤ 0.05%	Conforms
Ethyl acetate	≤ 0.5%	0.11%
Related impurity	Single impurity≤ 0.5% Total impurities≤ 1.0%	0.15% Conforms
Purity	≥99.0%	99.85%

Details:

Appearance	White crystalline powder	Conforms
Identification	IR/HPLC	Conforms
Melting point	148.0-150.0°C	148.5-149.2°C
Loss on drying	≤ 1.0%	0.18%
Residue on ignition	≤ 0.1%	0.05%
Heavy metals	≤20ppm	Conforms
Sulphate	≤ 0.02%	Conforms
Chloride	≤ 0.05%	Conforms
Ethyl acetate	≤ 0.5%	0.11%
Related impurity	Single impurity≤ 0.5% Total impurities≤ 1.0%	0.15% Conforms
Purity	≥99.0%	99.85%