Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008,
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:7531-52-4
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryItems Standard Result Appearance White to off-white solid Conforms Specific rotation[a]20/D (C=2,E
Cas:7531-52-4
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:7531-52-4
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryL-Prolinamide CAS:7531-52-4 /Nutrition supplements Product Detail Product name L-Prolinamide Color White form crystals
Cas:7531-52-4
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1048.html Product Name L-Prolinamide CAS No. 7531-52-4
Cas:7531-52-4
Min.Order:1 Gram
FOB Price: $63.0
Type:Lab/Research institutions
inquiryAppearance White to off-white crystalline powder Inner controlling standard of enterprise White crystalline pwd Solubility
Cas:7531-52-4
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:7531-52-4
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:7531-52-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:7531-52-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:7531-52-4
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me
Cas:7531-52-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:7531-52-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:7531-52-4
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:7531-52-4
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryProduct name L-Prolinamide Alias H-Pro-NH2; (S)-pyrrolidine-2-carboxamide; (2S)-2-carbamoylpyrrolidinium; (2R)-2-carbamoylpyrrolidinium; 2-Pyrrolidinecarboxamide, (2S)- CAS NO
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:7531-52-4
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:7531-52-4
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:7531-52-4
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White crystalline powder Storage: Ke
Cas:7531-52-4
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:7531-52-4
Min.Order:1 Kilogram
FOB Price: $130.0 / 136.0
Type:Trading Company
inquiryL-Prolinamide CAS: 7531-52-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:7531-52-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:7531-52-4
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryZ-Pro-NH2
L-prolinamide
Conditions | Yield |
---|---|
With 10% palladium on carbon; hydrogen In methanol for 7h; | 100% |
With hydrogen; palladium on activated charcoal In methanol for 9h; Ambient temperature; | 88.4% |
With hydrogen; palladium on activated charcoal In methanol under 2068.6 Torr; for 5h; | 87% |
With hydrogen; palladium In methanol for 3h; |
N-acetyl-L-prolinamide
L-prolinamide
Conditions | Yield |
---|---|
With hydrogenchloride In water at 103℃; for 2h; Temperature; | 95.3% |
Conditions | Yield |
---|---|
With ammonia In methanol | 91% |
With ammonia In methanol at 0 - 20℃; for 15h; Reagent/catalyst; Large scale; | 85% |
With ammonia In methanol at -25℃; for 96h; Sealed tube; | 55% |
Conditions | Yield |
---|---|
With ammonia In methanol at 65℃; for 15h; | 90% |
With methanol; ammonia | |
With ammonium hydroxide | |
With ammonium hydroxide In butan-1-ol at 5 - 30℃; |
(2S,1'S)-1-(1'-phenylethyl)pyrrolidine-2-carboxamide
L-prolinamide
Conditions | Yield |
---|---|
With hydrogen; palladium dihydroxide In ethanol; ethyl acetate at 20℃; under 760 Torr; for 14h; | 77% |
(S)-(9H-fluoren-9-yl)methyl 2-carbamoylpyrrolidine-1-carboxylate
L-prolinamide
Conditions | Yield |
---|---|
With morpholine In N,N-dimethyl-formamide for 1h; | 73% |
With alkylamine In N,N-dimethyl-formamide at 20℃; for 1h; |
Conditions | Yield |
---|---|
Stage #1: L-proline With thionyl chloride In methanol for 2h; Heating; Stage #2: With ammonia In methanol at 20℃; for 96h; Further stages.; | 72% |
Multi-step reaction with 3 steps 1: sodium hydroxide / H2O / Ambient temperature 2: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 3: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / -5 - 70 °C 2: ammonium hydroxide / butan-1-ol / 5 - 30 °C View Scheme |
Conditions | Yield |
---|---|
With ammonium acetate anodic oxidation; Pt electrodes, i = 370 mA*cm-2, current equiv.: 6.2 F/mol; | A 49% B 41% |
Conditions | Yield |
---|---|
With methanol; ammonia |
(S)-2-Carbamoyl-pyrrolidine-1-carboxylic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester
A
1-(4-methoxyphenyl)ethanone
B
L-prolinamide
Conditions | Yield |
---|---|
Irradiation; mild conditions; |
(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate
L-prolinamide
Conditions | Yield |
---|---|
With trifluoroacetic acid at 0℃; for 1h; | |
With trifluoroacetic acid acidolysis; | |
With trifluoroacetic acid In dichloromethane at 20℃; for 1h; | |
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere; | |
With trifluoroacetic acid In dichloromethane at 20℃; for 2h; |
L-prolinamide
Conditions | Yield |
---|---|
With methanol; ammonia |
Fmoc-Pro-OH
L-prolinamide
Conditions | Yield |
---|---|
Stage #1: Fmoc-Pro-OH With Rink amide resin; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h; Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.416667h; Stage #3: With trifluoroacetic acid | |
Multi-step reaction with 2 steps 1: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / 20 °C 2: alkylamine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme |
(2S,1'S)-5-hydroxy-2-(1'-phenylethylamino)pentanenitrile
L-prolinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NEt3; MsCl; DMAP / CH2Cl2 / 36 h / 0 - 20 °C 1.2: 3380 mg / aq. H2SO4 / CH2Cl2 / 48 h / 20 °C 2.1: 77 percent / H2 / Pd(OH)2/C / ethanol; ethyl acetate / 14 h / 20 °C / 760 Torr View Scheme | |
Multi-step reaction with 2 steps 1: 78 percent / aq. H2SO4 / CH2Cl2 / 48 h / 20 °C 2: 77 percent / H2 / Pd(OH)2/C / ethanol; ethyl acetate / 14 h / 20 °C / 760 Torr View Scheme |
1-(tert-butoxycarbonyl)-L-proline
L-prolinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 99 percent / Boc2O; pyridine; (NH4)2CO3 / dioxane / 18 h / 20 °C 2: TFA / CH2Cl2 / 1 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 88 percent / NH4HCO3; EEDQ / acetonitrile / 15 h / 20 °C 2: 73 percent / morpholine / dimethylformamide / 1 h View Scheme |
L-prolinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NH3(gas) / CH2Cl2 / 1 h / -20 °C 2: 87 percent / H2 / 5percent Pd/C / methanol / 5 h / 2068.6 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-methylmorpholine / CH2Cl2 / 2 h / -20 - -15 °C 2: NH3(gas) / CH2Cl2 / 1 h / -20 °C 3: 87 percent / H2 / 5percent Pd/C / methanol / 5 h / 2068.6 Torr View Scheme | |
Multi-step reaction with 2 steps 1: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 2: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature View Scheme |
water
N-[[(Phenylmethoxy)-carbonyl]-D-phenylalanyl]-L-proline
isobutyl chloroformate
L-prolinamide
Conditions | Yield |
---|---|
With 4-methyl-morpholine In tetrahydrofuran; ethyl acetate | 1.5 g (72%) |
proline acid chloride
L-prolinamide
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; for 72h; |
(5S)-2,2-dimethyl-1,3-diazabicyclo<3.3.0>octan-4-one
A
(2S)-N-propan-2-ylpyrrolidine-2-carboxamide
B
L-prolinamide
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol |
L-prolinamide
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol |
L-prolinamide
Conditions | Yield |
---|---|
With trifluoroacetic acid In chloroform-d1 Inert atmosphere; solid phase reaction; |
1-(tert-butoxycarbonyl)-L-proline
L-prolinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.58 h / 0 °C 1.2: 4 h / 0 - 20 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 6 h / 3 - 30 °C 2: ammonium hydroxide / dichloromethane / 3 h / 30 °C 3: hydrogenchloride / water / 2 h / 103 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid / 2 h / 1 - 25 °C 2.1: potassium borohydride / water / 4 h / 3 - 45 °C 3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1.5 h / -10 °C 3.2: 0.5 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium borohydride / water / 4 h / 3 - 45 °C 2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1.5 h / -10 °C 2.2: 0.5 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: L-prolinamide; Wang resin-linked N1-tert-butyloxycarbonyl-N2-triflylguanidine In dichloromethane at 20℃; Stage #2: trifluoroacetic acid In dichloromethane Further stages.; | 100% |
2-Bromoacetyl bromide
L-prolinamide
(S)-1-(2-bromoacetyl)pyrrolidine-2-carboxamide
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 2h; cooling; | 100% |
Stage #1: 2-Bromoacetyl bromide; L-prolinamide In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With potassium carbonate In tetrahydrofuran at 0 - 20℃; for 4h; | 85.8% |
di-tert-butyl dicarbonate
L-prolinamide
(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
In 1,4-dioxane; water at 20℃; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 6h; | |
With potassium carbonate In dichloromethane at 10 - 15℃; Inert atmosphere; | |
With triethylamine In dichloromethane at -15℃; for 12h; Concentration; | |
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In dichloromethane at 10 - 15℃; for 2h; |
2,4-di-tertbutyl-6-chloromethylphenol
L-prolinamide
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In acetonitrile for 24h; Inert atmosphere; Schlenk technique; Reflux; | 100% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 100% |
L-prolinamide
Conditions | Yield |
---|---|
Stage #1: 2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere; Stage #2: L-prolinamide In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere; | 99.7% |
Stage #1: 2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere; Stage #2: L-prolinamide In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere; | 79% |
Conditions | Yield |
---|---|
Stage #1: fumaryl dichloride; L-prolinamide With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h; Stage #2: With trifluoroacetic anhydride In dichloromethane at 0 - 20℃; for 24 - 48h; | 98% |
3,5,5-trimethyl hexanal
L-prolinamide
(7aS)-3-(2,4,4-trimethylpentyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
Conditions | Yield |
---|---|
With triethylamine In methanol for 18h; Inert atmosphere; Reflux; | 98% |
3-Phenylbutyraldehyde
L-prolinamide
(7aS)-3-(2-phenylpropyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
Conditions | Yield |
---|---|
With potassium carbonate In ethanol at 60℃; for 24h; | 97% |
With potassium carbonate In ethanol at 60℃; for 24h; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
With O-(3,4-dihydro-4-oxo-azabenzo-1,2,3-triazinyl)C(NMe2)2*PF6; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; | 96.5% |
With 2,4,6-trimethyl-pyridine; [(Me2N)(1H-1,2,3-triazolo[4,5-b]pyridinyl-1)CH=]Me2N*PF6 3-O In N,N-dimethyl-formamide | 96.5% |
With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide In dichloromethane Condensation; | 94.8% |
chloroacetyl chloride
L-prolinamide
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 5℃; for 2h; Reagent/catalyst; Inert atmosphere; | 96% |
With triethylamine In dichloromethane at -5 - 0℃; for 0.5h; Inert atmosphere; | 96.3% |
In tetrahydrofuran at 0℃; Reflux; Large scale; | 92% |
cyclopropylcarbinyl bromide
L-prolinamide
(-)-(S)-1-cyclopropylmethyl-2-pyrrolidinecarboxamide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran for 24h; | 96% |
BOC-glycine
L-prolinamide
(S)-tert-butyl 2-(2-carbamoylpyrrolidine-1-yl)-2-oxoethylcarbamate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; | 95.8% |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; | 95.8% |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; | 95.8% |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; | 95.8% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h; | 71% |
(S)-N-(benzyloxycarbonyl)phenylglycine
L-prolinamide
Conditions | Yield |
---|---|
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazine In chloroform; 2,2,2-trifluoroethanol at 20℃; | 95.4% |
Stage #1: (S)-N-(benzyloxycarbonyl)phenylglycine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: L-prolinamide In N,N-dimethyl-formamide at 20℃; Further stages.; | 93% |
With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-diethoxyphosphinyloxy-7-azabenzotriazole | 92.8% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide Ambient temperature; | 95% |
Conditions | Yield |
---|---|
In ethanol for 3h; Reflux; | 95% |
L-prolinamide
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 150℃; for 5h; Microwave irradiation; | 95% |
1-chloro-2-(trifluoromethyl)benzene
L-prolinamide
(S)-N'-((2-trifluoromethyl)phenyl)prolinylamide
Conditions | Yield |
---|---|
With 4-diphenylphosphino-13-dicyclohexylphosphino-[2.2]paracyclophane; water; palladium diacetate; caesium carbonate In 1,4-dioxane at 125℃; for 24h; Buchwald-Hartwig coupling; | 94% |
(2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanoyl)amino]-3-methylbutanoic acid
L-prolinamide
Z-L-Phe-L-Val-L-Pro-NH2
Conditions | Yield |
---|---|
With 1-hydroxy-7-aza-benzotriazole; [Me2N(1H-1,2,3-triazolo[4,5-b]pyridinyl)CH=]Me2N 3-oxide*PF6; 4-(N,N-dimethylamino)-2,6-di-tert-butylpyridine In N,N-dimethyl-formamide at 20℃; | 93.5% |
With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; 1-diethoxyphosphinyloxy-7-azabenzotriazole In N,N-dimethyl-formamide | 93.4% |
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Product distribution; Further Variations:; Reagents; | 87.4% |
4-oxo-1-pentyl-7-(phenylthio)-1,4-dihydroquinoline-3-carboxylic acid
L-prolinamide
C26H29N3O3S
Conditions | Yield |
---|---|
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18.5h; Inert atmosphere; | 93% |
L-prolinamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 93% |
L-prolinamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 92.9% |
Conditions | Yield |
---|---|
Stage #1: L-prolinamide With hydrogenchloride for 10h; Heating; Stage #2: With methyloxirane In ethanol at 20℃; for 5h; | 92% |
chloroacetyl chloride
L-prolinamide
(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: chloroacetyl chloride; L-prolinamide With potassium carbonate In acetonitrile at 0 - 15℃; Stage #2: With trifluoroacetic anhydride at 0 - 15℃; | 92% |
Stage #1: chloroacetyl chloride; L-prolinamide With potassium carbonate In acetonitrile at 0 - 20℃; Stage #2: With trifluoroacetic anhydride at 0 - 25℃; | 92% |
Stage #1: chloroacetyl chloride; L-prolinamide With trifluoroacetyl chloride In N,N-dimethyl-formamide at 50℃; for 1.5h; Stage #2: With trifluoroacetyl chloride In N,N-dimethyl-formamide at 60℃; for 1.5h; Reagent/catalyst; Temperature; | 83.4% |
(2S)-2-[(t-butoxycarbonyl)amino]-3-{4-[(5-nitropyridin-2-yl)oxy]phenyl}propanoic acid
L-prolinamide
Conditions | Yield |
---|---|
Stage #1: (2S)-2-[(t-butoxycarbonyl)amino]-3-{4-[(5-nitropyridin-2-yl)oxy]phenyl}propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: L-prolinamide In N,N-dimethyl-formamide at 20℃; for 15h; | 92% |
9-bromo-10-(bromomethyl)-2,3,6-trimethoxyphenanthrene
L-prolinamide
(2S)-1-[(10-bromo-3,6,7-trimethoxy-9-phenanthryl)methyl]pyrrolidine-2-carboxamide
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 8h; Reflux; | 92% |
9-bromo-10-(bromomethyl)-2,3,6,7-tetramethoxyphenanthrene
L-prolinamide
(S)-1-[(9-bromo-2,3,6,7-tetramethoxyphenanthren-10-yl)methyl]pyrrolidine-2-carboxamide
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 8h; Reflux; | 92% |
With potassium carbonate In N,N-dimethyl-formamide for 8h; Reflux; | 92% |
L-prolinamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 92% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 92% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View