L-Prolinamide supplier | CasNO.7531-52-4

Name
L-Prolinamide
EINECS 231-397-0
CAS No. 7531-52-4
Article Data43
CAS DataBase
Density 1.106 g/cm³
Solubility Soluble in water and ethanol (50 mg/ml).
Melting Point 97-102 °C
Formula C₅H₁₀N₂O
Boiling Point 303.6 °C at 760 mmHg
Molecular Weight 114.147
Flash Point 137.4 °C
Transport Information
Appearance white crystalline powder
Safety 22-24/25-36/37/39-26
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Prolinamide;(2S)-pyrrolidine-2-carboxamide;H-Pro-NH2;(2S)-2,3,4,5-tetrahydropyrrole-2-carboxamide;(S)-Prolinamide;Pro-NH2;Pro- NH2;L-Prolinmide;
PSA 55.12000
LogP 0.25280

Synthetic route

: 34079-31-7
Z-Pro-NH2

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With 10% palladium on carbon; hydrogen In methanol for 7h;	100%
With hydrogen; palladium on activated charcoal In methanol for 9h; Ambient temperature;	88.4%
With hydrogen; palladium on activated charcoal In methanol under 2068.6 Torr; for 5h;	87%
With hydrogen; palladium In methanol for 3h;

: 16395-58-7
N-acetyl-L-prolinamide

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With hydrogenchloride In water at 103℃; for 2h; Temperature;	95.3%

: 2133-40-6
L-proline methyl ester monohydrochloride

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With ammonia In methanol	91%
With ammonia In methanol at 0 - 20℃; for 15h; Reagent/catalyst; Large scale;	85%
With ammonia In methanol at -25℃; for 96h; Sealed tube;	55%

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With ammonia In methanol at 65℃; for 15h;	90%
With methanol; ammonia
With ammonium hydroxide
With ammonium hydroxide In butan-1-ol at 5 - 30℃;

: 929897-95-0
(2S,1'S)-1-(1'-phenylethyl)pyrrolidine-2-carboxamide

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide In ethanol; ethyl acetate at 20℃; under 760 Torr; for 14h;	77%

: 115134-39-9
(S)-(9H-fluoren-9-yl)methyl 2-carbamoylpyrrolidine-1-carboxylate

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With morpholine In N,N-dimethyl-formamide for 1h;	73%
With alkylamine In N,N-dimethyl-formamide at 20℃; for 1h;

: 147-85-3
L-proline

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Stage #1: L-proline With thionyl chloride In methanol for 2h; Heating; Stage #2: With ammonia In methanol at 20℃; for 96h; Further stages.;	72%
Multi-step reaction with 3 steps 1: sodium hydroxide / H2O / Ambient temperature 2: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 3: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: thionyl chloride / -5 - 70 °C 2: ammonium hydroxide / butan-1-ol / 5 - 30 °C View Scheme

: 6422-36-2
L-prolyl-L-alanine

A: (2R,5S)-2-Methyl-1,3-diazabicyclo<3.3.0>octan-4-on

B: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With ammonium acetate anodic oxidation; Pt electrodes, i = 370 mA*cm-2, current equiv.: 6.2 F/mol;	A 49% B 41%

: 5817-26-5
ethyl (2S)-pyrrolidine-2-carboxylate

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With methanol; ammonia

: 125219-05-8
(S)-2-Carbamoyl-pyrrolidine-1-carboxylic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester

A: 100-06-1
1-(4-methoxyphenyl)ethanone

B: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Irradiation; mild conditions;

: 35150-07-3
(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With trifluoroacetic acid at 0℃; for 1h;
With trifluoroacetic acid acidolysis;
With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;
With trifluoroacetic acid In dichloromethane at 20℃; for 2h;

L-proline benzyl ester: L-proline benzyl ester

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With methanol; ammonia

: 71989-31-6
Fmoc-Pro-OH

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Stage #1: Fmoc-Pro-OH With Rink amide resin; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h; Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.416667h; Stage #3: With trifluoroacetic acid
Multi-step reaction with 2 steps 1: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / 20 °C 2: alkylamine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme

: 929897-92-7
(2S,1'S)-5-hydroxy-2-(1'-phenylethylamino)pentanenitrile

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: NEt3; MsCl; DMAP / CH2Cl2 / 36 h / 0 - 20 °C 1.2: 3380 mg / aq. H2SO4 / CH2Cl2 / 48 h / 20 °C 2.1: 77 percent / H2 / Pd(OH)2/C / ethanol; ethyl acetate / 14 h / 20 °C / 760 Torr View Scheme
Multi-step reaction with 2 steps 1: 78 percent / aq. H2SO4 / CH2Cl2 / 48 h / 20 °C 2: 77 percent / H2 / Pd(OH)2/C / ethanol; ethyl acetate / 14 h / 20 °C / 760 Torr View Scheme

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

Boc-Thr(OBzl)-resin: Boc-Thr(OBzl)-resin

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 99 percent / Boc2O; pyridine; (NH4)2CO3 / dioxane / 18 h / 20 °C 2: TFA / CH2Cl2 / 1 h / 20 °C View Scheme

: 71989-31-6
Fmoc-Pro-OH

Fmoc-Arg(Pbf)-OH: Fmoc-Arg(Pbf)-OH

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 88 percent / NH4HCO3; EEDQ / acetonitrile / 15 h / 20 °C 2: 73 percent / morpholine / dimethylformamide / 1 h View Scheme

: (S)-2-Ethoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid benzyl ester

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3(gas) / CH2Cl2 / 1 h / -20 °C 2: 87 percent / H2 / 5percent Pd/C / methanol / 5 h / 2068.6 Torr View Scheme

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N-methylmorpholine / CH2Cl2 / 2 h / -20 - -15 °C 2: NH3(gas) / CH2Cl2 / 1 h / -20 °C 3: 87 percent / H2 / 5percent Pd/C / methanol / 5 h / 2068.6 Torr View Scheme
Multi-step reaction with 2 steps 1: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 2: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature View Scheme

: 7732-18-5
water

: 17460-56-9
N-[[(Phenylmethoxy)-carbonyl]-D-phenylalanyl]-L-proline

: 543-27-1
isobutyl chloroformate

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With 4-methyl-morpholine In tetrahydrofuran; ethyl acetate	1.5 g (72%)

...Expand

: 175446-63-6
proline acid chloride

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With ammonia In methanol at 20℃; for 72h;

: 97482-27-4
(5S)-2,2-dimethyl-1,3-diazabicyclo<3.3.0>octan-4-one

A: 174089-62-4
(2S)-N-propan-2-ylpyrrolidine-2-carboxamide

B: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol

: (S)-Nα-(benzyloxycarbonyl)proline hydroxamic acid

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol

: C6H11N2OPol

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With trifluoroacetic acid In chloroform-d1 Inert atmosphere; solid phase reaction;

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.58 h / 0 °C 1.2: 4 h / 0 - 20 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme

: 68-95-1
(S)-acetylproline

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 6 h / 3 - 30 °C 2: ammonium hydroxide / dichloromethane / 3 h / 30 °C 3: hydrogenchloride / water / 2 h / 103 °C View Scheme

: 56-86-0
L-glutamic acid

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sulfuric acid / 2 h / 1 - 25 °C 2.1: potassium borohydride / water / 4 h / 3 - 45 °C 3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1.5 h / -10 °C 3.2: 0.5 h / 25 °C View Scheme

: 1119-33-1
(S)-2-Amino-pentanedioic acid 5-ethyl ester

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium borohydride / water / 4 h / 3 - 45 °C 2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1.5 h / -10 °C 2.2: 0.5 h / 25 °C View Scheme

: 76-05-1
trifluoroacetic acid

: 7531-52-4
L-prolinamide

Wang resin-linked N1-tert-butyloxycarbonyl-N2-triflylguanidine: Wang resin-linked N1-tert-butyloxycarbonyl-N2-triflylguanidine

: (S)-1-Carbamimidoyl-pyrrolidine-2-carboxylic acid amide; compound with trifluoro-acetic acid

Conditions

Conditions	Yield
Stage #1: L-prolinamide; Wang resin-linked N1-tert-butyloxycarbonyl-N2-triflylguanidine In dichloromethane at 20℃; Stage #2: trifluoroacetic acid In dichloromethane Further stages.;	100%

...Expand

: 598-21-0
2-Bromoacetyl bromide

: 7531-52-4
L-prolinamide

: 253309-37-4
(S)-1-(2-bromoacetyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane for 2h; cooling;	100%
Stage #1: 2-Bromoacetyl bromide; L-prolinamide In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With potassium carbonate In tetrahydrofuran at 0 - 20℃; for 4h;	85.8%

: 24424-99-5
di-tert-butyl dicarbonate

: 7531-52-4
L-prolinamide

: 35150-07-3
(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

Conditions

Conditions	Yield
In 1,4-dioxane; water at 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 6h;
With potassium carbonate In dichloromethane at 10 - 15℃; Inert atmosphere;
With triethylamine In dichloromethane at -15℃; for 12h; Concentration;
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In dichloromethane at 10 - 15℃; for 2h;

: 10193-84-7
2,4-di-tertbutyl-6-chloromethylphenol

: 7531-52-4
L-prolinamide

: (2S)-1-(3,5-di-tert-butyl-2-hydroxybenzyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In acetonitrile for 24h; Inert atmosphere; Schlenk technique; Reflux;	100%

: 4313-73-9
N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-L-leucine

: 7531-52-4
L-prolinamide

: Z-Phe-Leu-Pro-NH2

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	100%

: 2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid

: 7531-52-4
L-prolinamide

: (S)-1-(2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carbonyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
Stage #1: 2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere; Stage #2: L-prolinamide In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere;	99.7%
Stage #1: 2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere; Stage #2: L-prolinamide In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere;	79%

: 627-63-4
fumaryl dichloride

: 7531-52-4
L-prolinamide

: 913978-88-8
C14H16N4O2

Conditions

Conditions	Yield
Stage #1: fumaryl dichloride; L-prolinamide With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h; Stage #2: With trifluoroacetic anhydride In dichloromethane at 0 - 20℃; for 24 - 48h;	98%

: 5435-64-3
3,5,5-trimethyl hexanal

: 7531-52-4
L-prolinamide

: 1378479-21-0
(7aS)-3-(2,4,4-trimethylpentyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one

Conditions

Conditions	Yield
With triethylamine In methanol for 18h; Inert atmosphere; Reflux;	98%

: 16251-77-7
3-Phenylbutyraldehyde

: 7531-52-4
L-prolinamide

: 1084907-50-5
(7aS)-3-(2-phenylpropyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 60℃; for 24h;	97%
With potassium carbonate In ethanol at 60℃; for 24h; Inert atmosphere;	97%

: 1170-76-9
Z-Gly-(L)-Phe

: 7531-52-4
L-prolinamide

: Z-Gly-L-Phe-L-Pro-NH2

Conditions

Conditions	Yield
With O-(3,4-dihydro-4-oxo-azabenzo-1,2,3-triazinyl)C(NMe2)2*PF6; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	96.5%
With 2,4,6-trimethyl-pyridine; [(Me2N)(1H-1,2,3-triazolo[4,5-b]pyridinyl-1)CH=]Me2N*PF6 3-O In N,N-dimethyl-formamide	96.5%
With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide In dichloromethane Condensation;	94.8%

: 79-04-9
chloroacetyl chloride

: 7531-52-4
L-prolinamide

: 214398-99-9
(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 5℃; for 2h; Reagent/catalyst; Inert atmosphere;	96%
With triethylamine In dichloromethane at -5 - 0℃; for 0.5h; Inert atmosphere;	96.3%
In tetrahydrofuran at 0℃; Reflux; Large scale;	92%

: 7051-34-5
cyclopropylcarbinyl bromide

: 7531-52-4
L-prolinamide

: 114812-44-1
(-)-(S)-1-cyclopropylmethyl-2-pyrrolidinecarboxamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 24h;	96%

: 4530-20-5
BOC-glycine

: 7531-52-4
L-prolinamide

: 52293-28-4
(S)-tert-butyl 2-(2-carbamoylpyrrolidine-1-yl)-2-oxoethylcarbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 20℃;	95.8%
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 20℃;	95.8%
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 20℃;	95.8%
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 20℃;	95.8%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h;	71%

: 5491-18-9, 17609-52-8, 53990-33-3, 60584-76-1
(S)-N-(benzyloxycarbonyl)phenylglycine

: 7531-52-4
L-prolinamide

: Cbz-Phg-Pro-NH2

Conditions

Conditions	Yield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazine In chloroform; 2,2,2-trifluoroethanol at 20℃;	95.4%
Stage #1: (S)-N-(benzyloxycarbonyl)phenylglycine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: L-prolinamide In N,N-dimethyl-formamide at 20℃; Further stages.;	93%
With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-diethoxyphosphinyloxy-7-azabenzotriazole	92.8%

: Z-Hle-OPfp

: 7531-52-4
L-prolinamide

: Z-Hle-Pro-NH2

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Ambient temperature;	95%

: (Sa)-3,3'-diformyl-2,2'-dihydroxy-1,1'-binaphthalene

: 7531-52-4
L-prolinamide

: C32H30N4O4

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	95%

: 2-chloro-6-(piperidin-1-ylmethyl)-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)thieno[2,3-d]pyrimidin-4-amine

: 7531-52-4
L-prolinamide

: (S)-1-(6-(piperidin-1-ylmethyl)-4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)thieno[2,3-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 150℃; for 5h; Microwave irradiation;	95%

: 88-16-4
1-chloro-2-(trifluoromethyl)benzene

: 7531-52-4
L-prolinamide

: 403478-68-2
(S)-N'-((2-trifluoromethyl)phenyl)prolinylamide

Conditions

Conditions	Yield
With 4-diphenylphosphino-13-dicyclohexylphosphino-[2.2]paracyclophane; water; palladium diacetate; caesium carbonate In 1,4-dioxane at 125℃; for 24h; Buchwald-Hartwig coupling;	94%

: 13123-00-7
(2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanoyl)amino]-3-methylbutanoic acid

: 7531-52-4
L-prolinamide

: 164861-48-7
Z-L-Phe-L-Val-L-Pro-NH2

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; [Me2N(1H-1,2,3-triazolo[4,5-b]pyridinyl)CH=]Me2N 3-oxide*PF6; 4-(N,N-dimethylamino)-2,6-di-tert-butylpyridine In N,N-dimethyl-formamide at 20℃;	93.5%
With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; 1-diethoxyphosphinyloxy-7-azabenzotriazole In N,N-dimethyl-formamide	93.4%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Product distribution; Further Variations:; Reagents;	87.4%

: 1416564-42-5
4-oxo-1-pentyl-7-(phenylthio)-1,4-dihydroquinoline-3-carboxylic acid

: 7531-52-4
L-prolinamide

: 1416564-35-6
C26H29N3O3S

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18.5h; Inert atmosphere;	93%

: 4-(5-((1-(2-ethyl-2-fluorobutyl)piperidin-4-yl)methyloxy)pyrimidin-2-yl)benzoic acid

: 7531-52-4
L-prolinamide

: (S)-1-(4-(5-((1-(2-ethyl-2-fluorobutyl)piperidin-4-yl)methoxy)pyrimidin-2-yl)benzoyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	93%

: N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)benzyl)-N-phenylethenesulfonamide

: 7531-52-4
L-prolinamide

: (S)-1-(2-(N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)benzyl)-N-phenylsulfamoyl)ethyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	92.9%

: 7531-52-4
L-prolinamide

: 147-85-3
L-proline

Conditions

Conditions	Yield
Stage #1: L-prolinamide With hydrogenchloride for 10h; Heating; Stage #2: With methyloxirane In ethanol at 20℃; for 5h;	92%

: 79-04-9
chloroacetyl chloride

: 7531-52-4
L-prolinamide

: 207557-35-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

Conditions

Conditions	Yield
Stage #1: chloroacetyl chloride; L-prolinamide With potassium carbonate In acetonitrile at 0 - 15℃; Stage #2: With trifluoroacetic anhydride at 0 - 15℃;	92%
Stage #1: chloroacetyl chloride; L-prolinamide With potassium carbonate In acetonitrile at 0 - 20℃; Stage #2: With trifluoroacetic anhydride at 0 - 25℃;	92%
Stage #1: chloroacetyl chloride; L-prolinamide With trifluoroacetyl chloride In N,N-dimethyl-formamide at 50℃; for 1.5h; Stage #2: With trifluoroacetyl chloride In N,N-dimethyl-formamide at 60℃; for 1.5h; Reagent/catalyst; Temperature;	83.4%

: 1011521-39-3
(2S)-2-[(t-butoxycarbonyl)amino]-3-{4-[(5-nitropyridin-2-yl)oxy]phenyl}propanoic acid

: 7531-52-4
L-prolinamide

: (2S)-1-{(2S)-2-[(t-butoxycarbonyl)amino]-3-[4-(5-nitro pyridin-2-yloxy)phenyl]propanoyl}pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
Stage #1: (2S)-2-[(t-butoxycarbonyl)amino]-3-{4-[(5-nitropyridin-2-yl)oxy]phenyl}propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: L-prolinamide In N,N-dimethyl-formamide at 20℃; for 15h;	92%

: 1215841-60-3
9-bromo-10-(bromomethyl)-2,3,6-trimethoxyphenanthrene

: 7531-52-4
L-prolinamide

: 1309782-29-3
(2S)-1-[(10-bromo-3,6,7-trimethoxy-9-phenanthryl)methyl]pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 8h; Reflux;	92%

: 1215841-59-0
9-bromo-10-(bromomethyl)-2,3,6,7-tetramethoxyphenanthrene

: 7531-52-4
L-prolinamide

: 1309782-28-2
(S)-1-[(9-bromo-2,3,6,7-tetramethoxyphenanthren-10-yl)methyl]pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 8h; Reflux;	92%
With potassium carbonate In N,N-dimethyl-formamide for 8h; Reflux;	92%

: 2’-cyano-3-fluoro-4’-((1-(2-fluoro-2-methylpropyl)piperidin-4-yl)methoxy)biphenyl-4-carboxylic acid

: 7531-52-4
L-prolinamide

: (S)-1-(2'-cyano-3-fluoro-4’-((1-(2-fluoro-2-methylpropyl)piperidin-4-yl)methoxy)biphenylcarbonyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	92%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	92%

L-Prolinamide Chemical Properties

IUPAC Name of L-Prolinamide (CAS NO.7531-52-4): pyrrolidine-2-carboxamide
Molecular Formula: C₅H₁₀N₂O
Molecular Weight: 114.15 g/mol
Following is the molecular structure of L-Prolinamide (CAS NO.7531-52-4):

BRN: 80807
EINECS: 231-397-0
Density: 1.106 g/cm³
Flash Point: 137.4 °C
Index of Refraction: 1.491
Melting Point: 95-97 °C(lit.)
Surface Tension: 41.4 dyne/cm
Solubility in water: Very soluble
Enthalpy of Vaporization: 54.39 kJ/mol
Boiling Point: 303.6 °C at 760 mmHg
Vapour Pressure: 0.000923 mmHg at 25 °C
Appearance: white to off-white microcrystalline powder
Product Categories: Aminoacids Derivatives;APIs;Amino Acids;Proline [Pro, P];Amino Acids and Derivatives;Amides (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Amino Acid Derivatives;Peptide Synthesis;Proline

L-Prolinamide Toxicity Data With Reference

L-Prolinamide (CAS NO.7531-52-4) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.

L-Prolinamide Safety Profile

Safty informations about L-Prolinamide (7531-52-4):
Hazard Codes: Harmful Xn ( Harmful)
Risk Statements: 22-36/37/38
R22:Harmful if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25
S22:Do not breathe dust
S24/25:Avoid contact with skin and eyes
WGK Germany: 3

L-Prolinamide Specification

L-Prolinamide , its cas register number is 7531-52-4. It also can be called Proline-nh2 ; Prolinamide ; (s)-Pyrrolidine-2-carboxylic acid amide ; (s)-Prolinamide ; H-Pro-nh2 ; L-Proline amide ; L-(-)-Prolinamide;l-prolinamide .
L-Prolinamide (CAS NO.7531-52-4) is stable under normal temperatures and pressures. L-Prolinamide (CAS NO.7531-52-4) should avoid the condition like incompatible materials. It is incompatible with other materials strong oxidizing agents. Its hazardous decomposition products are nitrogen oxides, carbon monoxide, carbon dioxide. Its hazardous polymerization has not been reported.

Product Name

L-Prolinamide

Synthetic route

L-Prolinamide Chemical Properties

L-Prolinamide Toxicity Data With Reference

L-Prolinamide Safety Profile

L-Prolinamide Specification

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