Appearance:detailed see specifications Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:mainly usded for Pharmaceutical, Petic... Transportation:Common products:Sea/Air/Co
Cas:15761-39-4
Min.Order:100 Metric Ton
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:15761-39-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:15761-39-4
Min.Order:1 Kilogram
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inquiryUnique advantages of BOC-L-Proline Cas 15761-39-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystal or crystalline powder Storage:cool dry place Package:25kg/drum Applic
Cas:15761-39-4
Min.Order:25 Kilogram
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Type:Trading Company
inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable
Cas:15761-39-4
Min.Order:1 Metric Ton
FOB Price: $1.0 / 2.0
Type:Manufacturers
inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008,
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Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:15761-39-4
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:15761-39-4
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:15761-39-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Min.Order:1 Kilogram
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Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:15761-39-4
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inquiryProduct name BOC-L-Proline Alias N-(tert-Butoxycarbonyl)-L-proline; (S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester; N-alpha-tert-BOC-L-proline; Boc-Pro-OH; 1-(tert-butoxycarbonyl)-
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Cas:15761-39-4
Min.Order:100 Gram
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Type:Other
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Cas:15761-39-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
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Cas:15761-39-4
Min.Order:1 Kilogram
FOB Price: $45.0 / 60.0
Type:Trading Company
inquiryBOC-L-Proline CAS:15761-39-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:15761-39-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:15761-39-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:15761-39-4
Min.Order:25 Gram
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Type:Trading Company
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:15761-39-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:15761-39-4
Min.Order:0
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Type:Lab/Research institutions
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Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:15761-39-4
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:15761-39-4
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquirydi-tert-butyl dicarbonate
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 19h; Cooling with ice; | 100% |
With amberlyst-15 In ethanol at 20℃; for 0.0833333h; chemoselective reaction; | 100% |
With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃; for 16h; | 100% |
1-(tert-butyl) 2-(2-oxo-2-phenylethyl) (S)-pyrrolidine-1,2-dicarboxylate
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 2h; Irradiation; | 100% |
With ammonium formate; palladium on activated charcoal In methanol at 20℃; for 0.166667h; Hydrogenolysis; | 95% |
With magnesium; acetic acid In methanol; N,N-dimethyl-formamide at 20℃; for 75h; |
1-tert-butoxycarbonyloxybenzotriazole
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water for 0.166667h; Ambient temperature; | 99% |
tert-butyl pyridin-2-yl carbonate
L-proline
A
2-hydroxypyridin
B
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In water; N,N-dimethyl-formamide for 6h; Ambient temperature; | A n/a B 98% |
(S)-N-(tert-butoxycarbonyl)proline methyl ester
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
Stage #1: (S)-N-(tert-butoxycarbonyl)proline methyl ester With sodium hydroxide In methanol; water for 5h; Reflux; Stage #2: With hydrogenchloride In water pH=3; | 98% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; | 97% |
With lithium hydroxide In tetrahydrofuran; methanol | |
With lithium hydroxide In 1,4-dioxane |
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 1h; Irradiation; | 97% |
tert-butyl pyridin-2-yl carbonate
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In water; N,N-dimethyl-formamide for 6h; Ambient temperature; method for mild t-butoxycarbonylation of amino acids; | 96% |
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In water; N,N-dimethyl-formamide for 6h; Ambient temperature; | 96% |
Multi-step reaction with 3 steps 1: thionyl chloride / 4 h / 0 - 20 °C 2: triethylamine / tetrahydrofuran / 5 h / 0 - 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C View Scheme |
L-proline
N-tert-Butoxycarbonyl-N-trifluoromethylsulfonyl-4-trifluoromethylanilide
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With water; triethylamine In 1,4-dioxane at 20℃; for 24h; Acylation; | 96% |
O-(tert-butyl) S-(pyridin-2-yl)carbonothioate
L-proline
A
2-Mercaptopyridine
B
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In water; N,N-dimethyl-formamide for 4h; Ambient temperature; | A n/a B 95% |
Conditions | Yield |
---|---|
In water | 94% |
With sodium hydroxide In tetrahydrofuran | 85% |
tert-butyl 2-oxo-1,3-oxazole-3(2H)-carboxylate
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water for 15h; Ambient temperature; | 92% |
N-BOC-proline tert-butyl ester
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With water; iodine In acetonitrile for 5h; Heating; | 92% |
1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water at 20℃; for 6h; | 91% |
With triethylamine In 1,4-dioxane; water at 20℃; for 5h; | 91% |
1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate
L-proline
A
1-(tert-butoxycarbonyl)-L-proline
B
chloral
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water at 20℃; for 5h; Product distribution; var. amines, other 1-chloroalkyl carbonate, other basic reagent and time; | A 91% B n/a |
1-(t-butoxycarbonyl)-1,2,4-triazolo<4,3-a>pyridinium-3-olate
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With sodium hydroxide In acetone for 2h; Ambient temperature; | 88% |
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With sodium iodide; zirconium(IV) chloride In acetonitrile for 2h; Heating; | 88% |
di-tert-butyl dicarbonate
(S)-N-benzyl-O-benzylpyrrolidine-2-carboxylate
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With PMHS; palladium dihydroxide In ethanol at 20℃; for 5h; | 86% |
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In water; acetone at 25℃; for 12h; | 86% |
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With polymethylhydrosiloxane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; | 85% |
(S)-1-tert-butyl 2-((R)-1-phenylprop-2-yn-1-yl)-pyrrolidine-1,2-dicarboxylate
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With copper(l) chloride In methanol at 40℃; Inert atmosphere; optical yield given as %ee; | 82% |
(S)-1-tert-butyl 2-((R)-1-(2-methoxyphenyl)prop-2-yn-1-yl)pyrrolidine-1,2-dicarboxylate
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With copper(l) chloride In methanol at 40℃; Inert atmosphere; optical yield given as %ee; | 81% |
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With trimethyltin(IV) hydroxide In 1,2-dichloro-ethane for 9h; Heating; | 80% |
N-(tert-butyloxycarbonyl) azide
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 72h; Product distribution / selectivity; | 80% |
2-t-butoxycarbonyloxy-3,6-diisopropylpyrazine
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With triethylamine In water; acetonitrile for 24h; Ambient temperature; | 79% |
t-butylpentachlorophenyl carbonate
2-pyridone lithium salt
N,N-dimethyl-formamide
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
In sodium hydroxide; chloroform; water | 79% |
Conditions | Yield |
---|---|
With triethylamine In water Ambient temperature; | 75% |
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With magnesium bromide In dichloromethane for 2.5h; Ambient temperature; addition at -20 deg C, 0.5 h; | 70% |
t-butyl S-3,6-diisopropylpyrazin-2-ylthiolcarbonate
L-proline
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With dmap; triethylamine In water; acetonitrile for 24h; Ambient temperature; | 61% |
1-(tert-butoxycarbonyl)-L-proline
L-alanine methyl ester hydrochloride
(S) tert-butyl 2-(((S)-1-methoxy-1-oxopropan-2-yl)carbamoyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine In dichloromethane | 100% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 25h; Inert atmosphere; | 84% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline; L-alanine methyl ester hydrochloride With dmap; triethylamine In tetrahydrofuran for 0.5h; Inert atmosphere; Stage #2: With 3,5,5-trichloro-5H-dibenzo[b,d]silole In tetrahydrofuran at 20 - 60℃; Inert atmosphere; | 65% |
1-(tert-butoxycarbonyl)-L-proline
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride
N-(tert-butyloxycarbonyl)-prolyl-proline benzyl ester
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In acetonitrile at 0℃; for 3h; | 100% |
With 2-fluoro-1-ethylpyridinium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Acylation; coupling; | 94% |
With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - 20℃; Acylation; | 90.2% |
1-(tert-butoxycarbonyl)-L-proline
L-phenylalanine benzyl ester hydrochloride
(S)-tert-butyl 2-((S)-1-(benzyloxy)-1-oxo-3-phenylpropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 1,2-dichloro-ethane at 20℃; for 2h; | 100% |
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide 1.) chloroform; Multistep reaction; |
1-(tert-butoxycarbonyl)-L-proline
phenacyl 4-(hydroxymethyl)benzoate
phenacyl 4-<<<(tert-butoxycarbonyl)-L-prolyl>oxy>methyl>benzoate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane 1) 0 deg C, 2 h, 2) r.t., 18 h; | 100% |
1-(tert-butoxycarbonyl)-L-proline
ethyl iodide
(2S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 16h; Ambient temperature; | 100% |
With 18-crown-6 ether; potassium carbonate In tetrahydrofuran for 21h; Inert atmosphere; Reflux; |
1-(tert-butoxycarbonyl)-L-proline
para-bromophenacyl bromide
(S)-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromophenyl)-2-oxoethyl]ester 1-tert-butyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; | 100% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; | 95% |
With triethylamine In acetonitrile at 20℃; | 91% |
1-(tert-butoxycarbonyl)-L-proline
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With borane-THF In tetrahydrofuran at 0 - 20℃; | 100% |
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 5h; | 100% |
With borane-THF at 0℃; for 1h; | 99% |
1-(tert-butoxycarbonyl)-L-proline
(S)-proline-N-carboxyanhydride
Conditions | Yield |
---|---|
With phosphorus trichloride In dichloromethane at 0℃; for 3h; | 100% |
With phosphorus trichloride In dichloromethane at 0℃; for 2h; | 96% |
With bis(trichloromethyl) carbonate; triethylamine In tetrahydrofuran at 20℃; for 6.5h; Inert atmosphere; | 50% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With bis(trichloromethyl) carbonate In tetrahydrofuran for 0.166667h; Inert atmosphere; Stage #2: With triethylamine In tetrahydrofuran at 0 - 20℃; for 6.5h; Inert atmosphere; | 30% |
1-(tert-butoxycarbonyl)-L-proline
Boc-Pro-D-Val-Leu-OPac
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 3h; Ambient temperature; | 100% |
1-(tert-butoxycarbonyl)-L-proline
(S)-2-({(R)-[((S)-Benzyloxycarbonyl-cyclopropyl-methyl)-carbamoyl]-cyclopentyl-methyl}-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; | 100% |
1-(tert-butoxycarbonyl)-L-proline
L-proline
Conditions | Yield |
---|---|
With water at 170℃; for 0.05h; Microwave irradiation; | 100% |
With tin(IV) chloride In ethyl acetate for 0.583333h; Ambient temperature; | 98% |
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid; | 96% |
1-(tert-butoxycarbonyl)-L-proline
benzyl alcohol
Boc-L-proline benzyl ester
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 22h; | 100% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h; | 99% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With trichloroisocyanuric acid; triphenylphosphine In dichloromethane at 0℃; for 0.75h; Stage #2: benzyl alcohol With triethylamine In dichloromethane at 20℃; for 1h; | 96% |
1-(tert-butoxycarbonyl)-L-proline
glycine benzyl ester p-toluenesulfonic acid salt
N-tert-butyloxycarbonyl-(2S)-prolyl-glycine benzyl ester
Conditions | Yield |
---|---|
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane | 100% |
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 48h; | 83% |
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide | 79% |
1-(tert-butoxycarbonyl)-L-proline
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride
Conditions | Yield |
---|---|
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation; | 100% |
1-(tert-butoxycarbonyl)-L-proline
isopropylamine
tert-butyl (2S)-2-(isopropylcarbamoyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide | 100% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h; Stage #2: isopropylamine In tetrahydrofuran at 20℃; for 16h; | 80% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.5h; Stage #2: isopropylamine In dichloromethane | 55% |
With 1,1'-carbonyldiimidazole In ethyl acetate Goldberg Reaction; Inert atmosphere; | |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 140 mg |
1-(tert-butoxycarbonyl)-L-proline
aniline
tert-butyl (S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; | 100% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With triethylamine; isobutyl chloroformate In dichloromethane at 0℃; for 0.333333h; Stage #2: aniline In dichloromethane at 0 - 23℃; | 98% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; | 92% |
1-(tert-butoxycarbonyl)-L-proline
Tosyl isocyanate
(S)-tert-butyl 2-(tosylcarbamoyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
100% |
1-(tert-butoxycarbonyl)-L-proline
4,4'-bis(bromoacetyl)biphenyl
1,2-pyrrolidinedicarboxylic acid, 2,2’-[[1,1’-biphenyl]-4,4’-diylbis(2-oxo-2,1-ethanediyl)] bis[1-(1,1-dimethylethyl)] ester, (2S)-
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20 - 30℃; for 3h; Large scale; | 100% |
With triethylamine In acetonitrile at 20℃; for 3h; | 98% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20 - 25℃; for 3h; |
1-(tert-butoxycarbonyl)-L-proline
phenylhydrazine
(S)-tert-butyl 2-(2-phenylhydrazinecarbonyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 3h; Inert atmosphere; | 100% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine |
1-(tert-butoxycarbonyl)-L-proline
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; 4-pyrrolidin-1-ylpyridine In dichloromethane at 20℃; for 20h; | 100% |
1-(tert-butoxycarbonyl)-L-proline
methyl aminolevulinate
N-(N-tert-butoxycarbonyl-L-prolyl)-5-aminolaevulinic acid methyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; | 100% |
1-(tert-butoxycarbonyl)-L-proline
2-butyl-3-(4-aminophenyl)-4H-pyrido[1,2-a]pyrimidin-4-one
(S)-tert-butyl 2-{[4-(2-butyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)phenyl]carbamoyl}-pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0℃; for 0.5h; Stage #2: 2-butyl-3-(4-aminophenyl)-4H-pyrido[1,2-a]pyrimidin-4-one With diisopropylamine In dichloromethane for 16h; | 100% |
1-(tert-butoxycarbonyl)-L-proline
Propargylamine
(S)-tert-butyl 2-(prop-2-ynylcarbamoyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane for 2h; Inert atmosphere; Reflux; | 100% |
With triethylamine; HATU In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 99% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 93% |
1-(tert-butoxycarbonyl)-L-proline
1-amino-4-methoxy-9H-xanthen-9-one
C24H26N2O6
Conditions | Yield |
---|---|
With triethylamine; isobutyl chloroformate In tetrahydrofuran at 0℃; | 100% |
1-(tert-butoxycarbonyl)-L-proline
(2-aminophenyl)(phenyl)methanone
(S)-tert-butyl 2-{[(2-benzoylphenyl)amino]carbonyl}pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine; isobutyl chloroformate In tetrahydrofuran at 0℃; | 100% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With triethylamine; isobutyl chloroformate In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Stage #2: (2-aminophenyl)(phenyl)methanone In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 100% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20 - 55℃; for 12h; Reagent/catalyst; | 97% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With 1-methyl-1H-imidazole; methanesulfonyl chloride In dichloromethane at 25℃; for 0.166667h; Stage #2: (2-aminophenyl)(phenyl)methanone In dichloromethane at 50℃; for 36h; | 91% |
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -5 - 25℃; Large scale; Stage #2: (2-aminophenyl)(phenyl)methanone In tetrahydrofuran at 20 - 25℃; Large scale; | 75% |
1-(tert-butoxycarbonyl)-L-proline
3-(4-methoxyphenyl)propane-1-thiol
3-(p-methoxyhenyl)-1-mercaptyl N-(tert-butyloxycarbonyl)pyrrolidine-2-carboxylate
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane | 100% |
1-(tert-butoxycarbonyl)-L-proline
t-Boc-L-valine
N-(tert-butyloxycarbonyl)-L-isoleucine
N-tert-butoxycarbonyl-L-leucine
N-tert-butoxycarbonyl-L-phenylalanine
Boc-L-homophenylalanine
H-Hphe-Leu-Ile-Ile-Leu-Val-Pro-Pro-Phe-OH
Conditions | Yield |
---|---|
Stage #1: Boc-L-homophenylalanine solid phase reaction; Stage #2: With trifluoroacetic acid In dichloromethane solid phase reaction; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-leucine; N-tert-butoxycarbonyl-L-phenylalanine Further stages; | 100% |
1-(tert-butoxycarbonyl)-L-proline
t-Boc-L-valine
N-(tert-butyloxycarbonyl)-L-isoleucine
N-tert-butoxycarbonyl-L-leucine
N-tert-butoxycarbonyl-L-phenylalanine
Boc-L-homophenylalanine
H-Ile-Ile-Leu-Val-Pro-Pro-Hphe-Hphe-Leu-OH
Conditions | Yield |
---|---|
Stage #1: N-tert-butoxycarbonyl-L-leucine solid phase reaction; Stage #2: With trifluoroacetic acid In dichloromethane solid phase reaction; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-phenylalanine; Boc-L-homophenylalanine Further stages; | 100% |
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