As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryUnique advantages of BOC-L-Prolinol Cas 69610-40-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:25kg/drum Application:phar
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inquiryhe company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryDensity: 1.0948 (rough estimate) Melting point: 62-64 ° C (lit.) Boiling point: 150 ° C/4mmHg Specific rotation: -52 º (c=1, CHCl3) Flash point: 128.9 ° C Water solubility: insoluble Steam pressure: 0.000241mmHg at 25 ° C Solubil
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name: N-Boc-L-prolinol CAS No.: 69610-40-8 Molecular formula: C10H19NO3 Molecular weight: 201 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package:
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
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inquiryBOC-L-Prolinol CAS:69610-40-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquirymoderate price & quick delivery Appearance:White powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Used as Pharmaceutical Intermediates
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:69610-40-8
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inquiryHigh quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle
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inquiry1-(tert-butoxycarbonyl)-L-proline
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With borane-THF In tetrahydrofuran at 0 - 20℃; | 100% |
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 5h; | 100% |
With borane-THF at 0℃; for 1h; | 99% |
di-tert-butyl dicarbonate
(S)-1-Pyrrolidin-2-yl-methanol
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate at 0 - 20℃; for 11.5h; | 100% |
With triethylamine In ethyl acetate at 0 - 20℃; for 11.5h; | 100% |
With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃; Inert atmosphere; | 100% |
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With tert.-butylnitrite; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In chlorobenzene at 100℃; under 760.051 Torr; for 2h; | 95% |
With tert.-butylnitrite; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In monoethylene glycol diethyl ether at 120℃; under 1500.15 Torr; for 2h; | 93% |
With 4,4'-bipyridine; (phthalocyaninato)iron(II); oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 80℃; under 3000.3 Torr; for 18h; Pressure; Autoclave; | 91% |
(S)-N-(tert-butoxycarbonyl)proline methyl ester
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With lithium borohydride In tetrahydrofuran at 20℃; | 97% |
With lithium aluminium tetrahydride In diethyl ether | 95% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1h; | 95% |
Boc-L-Pro-H
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.333333h; | 93% |
With sodium tetrahydroborate In ethanol for 0.75h; | 86% |
With sodium tetrahydroborate In methanol at 20℃; for 1.5h; | 80% |
(S)-1-Pyrrolidin-2-yl-methanol
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With triethylamine In water; ethyl acetate | 80.8% |
[tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate]
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Stage #1: With sodium borohydride; lithium chloride In tetrahydrofuran; ethanol at 0℃; for 0.416667h; Stage #2: [tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate] at 0 - 20℃; for 18h; Stage #3: With acetic acid In water |
L-proline
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium hydride / tetrahydrofuran / 0 - 25 °C 2: 39.1 g / tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 75 percent / LiAlH4 / tetrahydrofuran 2: NaOH View Scheme | |
Multi-step reaction with 2 steps 1: LiAlH4 / tetrahydrofuran 2: NaCl, NaHCO3 / CHCl3; H2O / Heating View Scheme |
1-(tert-butoxycarbonyl)-L-proline
chloroformic acid ethyl ester
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With sodium borohydrid; sodium hydrogencarbonate; triethylamine; silica gel In tetrahydrofuran |
(2S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 16h; | 96% |
Nα,N,N-tris(tert-butoxycarbonyl)-(S)-prolinamide
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In ethanol at 20℃; | 84% |
tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate
(S)-1-Pyrrolidin-2-yl-methanol
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; |
(S)-(1-(4-methoxybenzyl)pyrrolidin-2-yl)methanol
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2, HCl / 10percent Pd/C / methanol / 760 Torr 2: diethyl ether View Scheme |
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With sodium tetrahydroborate; water; sodium hydroxide at -10 - 20℃; |
di-tert-butyl dicarbonate
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 94 percent / triethylamine / CH2Cl2 / 2.5 h / 0 °C 2: 82 percent / borane-tetrahydrofuran complex / tetrahydrofuran / 3 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 95 percent / Et3N / CH2Cl2 / 2.5 h / 0 °C 2: 76 percent / B2H6*THF / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) r.t., 1 h View Scheme | |
Multi-step reaction with 2 steps 1: 96 percent / triethylamine / CH2Cl2 / 0 - 20 °C 2: 92.4 percent / lithium chloride, sodium borohydride / ethanol; tetrahydrofuran / 4 h / Ambient temperature View Scheme |
(S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With sodium tetrahydroborate; iodine In tetrahydrofuran at 0 - 20℃; for 5.5h; | |
With sodium tetrahydroborate; sodium hydroxide In tetrahydrofuran; water at 20℃; Inert atmosphere; | 4.3 g |
di-tert-butyl dicarbonate
sodium hydrogencarbonate
(S)-1-Pyrrolidin-2-yl-methanol
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane |
1-(tert-butoxycarbonyl)-L-proline
benzyl bromide
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With sodium hydride In tetrahydrofuran at 20℃; for 1h; Stage #2: benzyl bromide In tetrahydrofuran at 20℃; for 20h; | 80.4% |
chlorobromomethane
(R)-tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine-1-carboxylate
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Stage #1: chlorobromomethane; (R)-tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine-1-carboxylate With n-butyllithium In diethyl ether; hexane at -78 - 20℃; Stage #2: In chloroform at 70℃; for 20h; Stage #3: With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran; water at 0℃; for 2h; | 79% |
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With sodium tetrahydroborate; iodine In tetrahydrofuran at 20℃; Reduction; | 64% |
(S)-1-tert-butoxycarbonyl-2-(3,3,3-trifluoroprop-1-enyl)pyrrolidine
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Stage #1: (S)-1-tert-butoxycarbonyl-2-(3,3,3-trifluoroprop-1-enyl)pyrrolidine With ozone In methanol; dichloromethane at -78℃; for 0.833333h; Stage #2: With sodium tetrahydroborate In methanol; dichloromethane at 0℃; for 3.5h; | 40% |
methyl (2S)-pyrrolidine carboxylate
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N 2: 86 percent / LiAlH4 / diethyl ether / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / dimethylformamide / 4 h 2: 36 percent / di-isobutylaluminium hydride / toluene; hexane / -78 deg C, 30 min, -> RT, 3 h View Scheme | |
Multi-step reaction with 2 steps 1: 94 percent / Et3N, 4-dimethylaminopyridine / CH2Cl2 / 18 h / Ambient temperature 2: 90 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C View Scheme |
O-(tert-butyl) S-(pyridin-2-yl)carbonothioate
(S)-1-Pyrrolidin-2-yl-methanol
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
In dichloromethane at 20℃; chemoselective reaction; | 88% |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diethyl ether; methanol 2: 84 percent / LiBH4 / tetrahydrofuran / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: NaBH4; LiCl View Scheme | |
Multi-step reaction with 2 steps 1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -5 °C 2: I2; NaBH4 / tetrahydrofuran / 5.5 h / 0 - 20 °C View Scheme |
L-proline
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LiAlH4 View Scheme | |
Multi-step reaction with 2 steps 1: 94 percent / triethylamine / CH2Cl2 / 2.5 h / 0 °C 2: 82 percent / borane-tetrahydrofuran complex / tetrahydrofuran / 3 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 94 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 2: 84 percent / Et3N / CH2Cl2 / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 95 percent / SOCl2 2: 85 percent / Et3N / CH2Cl2 3: 85 percent / NaBH4; LiCl; EtOH / tetrahydrofuran View Scheme |
C23H29NO3
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With tert.-butylnitrite; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In chlorobenzene at 100℃; under 760.051 Torr; for 7h; |
2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile
(S)-1-Pyrrolidin-2-yl-methanol
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
In hydrous dioxane |
N-(tert-butoxycarbonyl)-D-proline
N-(tert-butoxycarbonyl)-L-prolinol
tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In water at 0℃; | 0.313 g |
N-(tert-butoxycarbonyl)-2,3-dihydropyrrole
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen, Rh(acac)(CO)2, (R)-2-(diphenylphosphino)-1,1'-binaphthalen-2'-yl (S)-1,1'-binaphthalene-2,2'-diyl phosphite / benzene / 72 h / 60 °C / 76000 Torr / other reagent: (R)-2-(diphenylphosphino)-1,1'-binaphthalen-2'-yl (S)-3,3'-dimethyl-1,1'-binaphthalene-2,2'-diyl phosphite 2: borane-THF / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) room temperature, overnight View Scheme |
N-(tert-butoxycarbonyl)-L-prolinol
Boc-L-Pro-H
Conditions | Yield |
---|---|
With oxalyl dichloride; dimethyl sulfoxide In triethylamine | 100% |
With pyridine-SO3 complex; triethylamine In dimethyl sulfoxide Oxidation; | 100% |
With Dess-Martin periodane; tert-butyl alcohol In dichloromethane Ambient temperature; | 99% |
N-(tert-butoxycarbonyl)-L-prolinol
methanesulfonyl chloride
tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 3h; | 100% |
With triethylamine In dichloromethane at 0℃; Mesylation; | 100% |
With triethylamine In dichloromethane for 2h; | 100% |
N-(tert-butoxycarbonyl)-L-prolinol
p-toluenesulfonyl chloride
(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; | 100% |
With pyridine In dichloromethane at 0 - 20℃; | 100% |
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere; | 100% |
4-[(4-fluorobenzyl)oxy]-1-[4-(methanesulfonyloxymethyl)phenyl]pyridin-2(1H)-one
N-(tert-butoxycarbonyl)-L-prolinol
tert-butyl (2S)-2-[({4-[4-[(4-fluorobenzyl)oxy]-2-oxopyridin-1(2H)-yl]benzyl}oxy)methyl]pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h; | 100% |
N-hydroxyphthalimide
N-(tert-butoxycarbonyl)-L-prolinol
tert-butyl (2S)-2-[[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]methyl]-pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -10 - 20℃; | 100% |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -10 - 20℃; for 16h; | 98% |
Stage #1: N-(tert-butoxycarbonyl)-L-prolinol With 5,10,15,20-tetraphenyl-21H,23H-porphine; diethylazodicarboxylate In tetrahydrofuran at -10℃; for 0.833333h; Stage #2: N-hydroxyphthalimide In tetrahydrofuran at 20℃; for 16h; | 98% |
phthalimide
N-(tert-butoxycarbonyl)-L-prolinol
tert-butyl (S)-2-((1,3-dioxoisoindolin-2-yl)methyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In toluene at 20 - 60℃; for 5.5h; | 100% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; Mitsunobu reaction; | 88% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere; | 62.14% |
N-(tert-butoxycarbonyl)-L-prolinol
4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine
(S)-tert-butyl 2-((4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h; | 100% |
With N-ethyl-N,N-diisopropylamine; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h; | 100% |
With N-ethyl-N,N-diisopropylamine; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h; | 100% |
With N-ethyl-N,N-diisopropylamine; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h; | 100% |
N-(tert-butoxycarbonyl)-L-prolinol
4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h; Mitsunobu Displacement; | 100% |
N-(tert-butoxycarbonyl)-L-prolinol
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; dichloromethane at 0 - 15℃; for 0.5h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3h; Inert atmosphere; | 100% |
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h; Cooling with ice; | 100% |
N-(tert-butoxycarbonyl)-L-prolinol
acrylonitrile
(S)-2-(2-cyanoethoxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In water; toluene at 20℃; for 20h; Michael addition; | 99% |
N-(tert-butoxycarbonyl)-L-prolinol
Boc-L-Pro-H
Conditions | Yield |
---|---|
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane | 99% |
N-(tert-butoxycarbonyl)-L-prolinol
tert-butyldimethylsilyl chloride
(2S)-1-(tert-Butoxycarbonyl)-2-<(tert-butyldimethylsilyl)oxymethyl>pyrrolidine
Conditions | Yield |
---|---|
With dmap; TEA In N,N-dimethyl-formamide for 3h; Ambient temperature; | 98% |
With 1H-imidazole In N,N-dimethyl-formamide for 16h; Ambient temperature; | 83% |
Conditions | Yield |
---|---|
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In chloroform at 20℃; for 15h; Inert atmosphere; | 98% |
N-(tert-butoxycarbonyl)-L-prolinol
2-Bromoacetyl bromide
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 24h; | 97.1% |
methyl 4-hydroxy-3-chlorobenzoate
N-(tert-butoxycarbonyl)-L-prolinol
methyl 4-[1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]-3-chlorobenzoate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 6.5h; Mitsunobu reaction; Heating; | 97% |
N-(tert-butoxycarbonyl)-L-prolinol
5-bromo-6-chloropyridin-3-ol
5-bromo-6-chloro-3-(1-tert-butyloxycarbonyl-2-(S)-pyrrolidinylmethoxy)pyridine
Conditions | Yield |
---|---|
Stage #1: With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0℃; for 0.5h; Stage #2: N-(tert-butoxycarbonyl)-L-prolinol; 5-bromo-6-chloropyridin-3-ol In tetrahydrofuran at 20℃; | 97% |
N-(tert-butoxycarbonyl)-L-prolinol
acetic anhydride
tert-butyl (S)-2-(acetoxymethyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane at 0 - 20℃; for 1h; | 97% |
With pyridine; dmap In ethyl acetate at 20℃; for 1h; | |
With dmap; triethylamine In dichloromethane |
N-(tert-butoxycarbonyl)-L-prolinol
methanesulfonyl chloride
2S-N-tert-Butyloxycarbonyl-2-methylsulphonylmethylpyrrolidine
Conditions | Yield |
---|---|
In dichloromethane | 97% |
With triethylamine In dichloromethane at 20℃; for 4h; |
N-(tert-butoxycarbonyl)-L-prolinol
methanesulfonyl chloride
tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
In dichloromethane | 97% |
With triethylamine In dichloromethane at 20℃; for 4h; |
N-(tert-butoxycarbonyl)-L-prolinol
bis(((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)methyl) phosphonate
Conditions | Yield |
---|---|
Stage #1: N-(tert-butoxycarbonyl)-L-prolinol With triethylamine; phosphorus trichloride In dichloromethane at 0℃; for 3h; Inert atmosphere; Reflux; Stage #2: With water In dichloromethane at 20℃; for 1h; | 96% |
N-(tert-butoxycarbonyl)-L-prolinol
benzoyl chloride
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; for 6h; | 96% |
With dmap In dichloromethane at 20℃; Inert atmosphere; | 82% |
N-(tert-butoxycarbonyl)-L-prolinol
2-fluoro-3-hydroxypyridine
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 16h; Mitsunobu Displacement; Inert atmosphere; | 95.4% |
N-(tert-butoxycarbonyl)-L-prolinol
(S)-2-iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With 1H-imidazole; diphenylphosphinopolystyrene; iodine In dichloromethane for 1h; Heating; | 95% |
With 1H-imidazole; iodine; triphenylphosphine In diethyl ether at 20℃; for 12h; | 89% |
With 1H-imidazole; iodine; triphenylphosphine In diethyl ether; dichloromethane at 20℃; for 16h; | 83% |
N-(tert-butoxycarbonyl)-L-prolinol
p-toluenesulfonyl chloride
(S)-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-pyrrolidinecarboxylic acid,1,1-dimethylethyl ester
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; for 15h; Inert atmosphere; | 95% |
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