Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryUnique advantages of N-Benzyloxycarbonyl-L-proline Cas 1148-11-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:10g/
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The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct name N-Carbobenzyloxy-L-proline Alias N-cbz-L-proline crystalline; Z-L-Proline; N-Benzyloxycarbonyl-L-proline; Z-Pro-OH; N-CBZ-L-Proline N-Carbobenzyloxy-L-proline; N-Cbz-L-proline; N-Cbz-L-
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inquiryAppearance:white to light yellow crystal powder Storage:Sealed in dry,Room Temperature Package:25kg/Barrel Application:pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in China
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:1148-11-4
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inquiryProduct name: CBZ-L-Proline CAS No.: 1148-11-4 Molecule Formula:C13H14NO4 Molecule Weight:248.26 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
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inquiryConditions | Yield |
---|---|
With sodium hydroxide In water for 13.5h; Ambient temperature; | 100% |
With sodium carbonate at 0 - 20℃; for 3h; | 100% |
With sodium hydroxide at 0℃; for 0.166667h; | 97% |
N-carbobenzoxy-L-proline phenylmethyl ester
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 50℃; for 5h; Inert atmosphere; | 98% |
With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; palladium on activated charcoal; ethylenediamine In methanol at 20℃; under 760 Torr; for 6h; Hydrogenolysis; | 76% |
With dmap; hydrogen; palladium on activated charcoal; ethylenediamine In methanol at 20℃; for 3h; | 75% |
L-proline methyl ester monohydrochloride
benzyl chloroformate
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With water; sodium hydroxide In toluene at 0 - 5℃; Large scale; | 94% |
With sodium hydroxide In water at 0 - 5℃; Industrial scale; |
Conditions | Yield |
---|---|
With hydrogenchloride In sodium hydroxide; toluene | 98% |
With hydrogenchloride In sodium hydroxide; toluene | 98% |
With hydrogenchloride In sodium hydroxide; toluene | 98% |
With sodium hydroxide In chloroform; water | 96% |
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide; mineral oil at 25℃; for 4h; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide In water; acetone at 20℃; for 24h; | 100% |
With sodium chlorite; Me-AZADO+BF4- In acetonitrile at 25℃; for 1.5h; pH=6.7; aq. phosphate buffer; |
Conditions | Yield |
---|---|
With sodium hydroxide at 0℃; | 95% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; sodium methylate; triethylamine In methanol; water; N,N-dimethyl-formamide | 45.5% |
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate; water In tetrahydrofuran; methanol at 20℃; for 16h; |
diethyl ether
benzyl (1-chloroethyl) carbonate
L-proline
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
In methanol; water; ethyl acetate; Petroleum ether | 88% |
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With sodium hydrogen sulfate; silica gel In dichloromethane at 20℃; for 6h; | 93% |
Conditions | Yield |
---|---|
In chloroform; water; triethylamine for 5h; Ambient temperature; | 95% |
With triethylamine In water; N,N-dimethyl-formamide for 0.3h; Ambient temperature; | 88% |
L-proline
N-Benzyloxycarbonyl-N-trifluoromethylsulfonyl-4-trifluoromethylanilide
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With water; triethylamine In 1,4-dioxane at 20℃; for 3h; Acylation; | 84% |
O-benzyl S-(pyridin-2-yl)carbonothioate
L-proline
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With triethylamine In water; N,N-dimethyl-formamide for 1h; Ambient temperature; | 85% |
Conditions | Yield |
---|---|
With triethylamine In water Ambient temperature; | 86% |
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane for 1h; Ambient temperature; | 83% |
3-benzyloxycarbonyl-2-oxazolone
L-proline
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With triethylamine In water; acetone Ambient temperature; | 93% |
1-benzyloxycarbonyl-1Hbenzo[d][1.2.3]triazole
L-proline
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane for 24h; Ambient temperature; | 84% |
(S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With sodium chlorite; disodium hydrogenphosphate In various solvent(s) for 1h; | 90.5% |
N-benzyloxycarbonylproline methyl ester
A
methyl (2R)-(benzyloxycarbonyl)pyrrolidine-2-carboxylate
B
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With Candida antarctica lipase In phosphate buffer at 30℃; for 38h; | A 46% B 46% |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / Et3N / acetonitrile / 2 h / 5 °C 2: 86 percent / Et3N / H2O / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 80 percent / (C2H5)3N / CH2Cl2 / 1 h / Ambient temperature 2: 88 percent / (C2H5)3N / dimethylformamide; H2O / 0.3 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 89 percent / quinoline; CH2Cl2 / 12 h / Ambient temperature 2: 95 percent / triethylamine; CHCl3; H2O / 5 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 20 °C 2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 16 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: benzyl alcohol; Fmoc-Pro-Wang resin With tributylphosphine; triethylamine; 1,1'-azodicarbonyl-dipiperidine In 1-methyl-pyrrolidin-2-one at 20℃; for 20h; Solid phase reaction; esterification; Mitsunobu reaction; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 0.5h; Hydrolysis; | 81 % Spectr. |
N-(Benzyloxycarbonyloxy)succinimide
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 81 percent / Et3N / tetrahydrofuran / 17 h / 20 °C 2: 76 percent / H2; 1,4-diazabicyclo[2.2.2]octane / Pd/C-ethylenediamine / methanol / 6 h / 20 °C / 760 Torr View Scheme |
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 81 percent / Et3N / tetrahydrofuran / 17 h / 20 °C 2: 76 percent / H2; 1,4-diazabicyclo[2.2.2]octane / Pd/C-ethylenediamine / methanol / 6 h / 20 °C / 760 Torr View Scheme |
Conditions | Yield |
---|---|
With L-Phenylalanine amide; sodium chloride; calcium chloride In N,N-dimethyl-formamide at 25℃; for 3h; pH=8; aq. buffer; | A n/a B 5% |
N-(benzyloxycarbonyl)succinimide
L-proline
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With sodium hydrogencarbonate | 82% |
methyl 4-bromo-5,6-O-isopropylidene-2,3,4-trideoxy-D-threo-hexonate
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 65 percent / LiN3 / dimethylformamide / 168 h / Ambient temperature 2: 77 percent / DIBAL / light petroleum; toluene; hexane / 1 h / -78 °C 3: 62.5 percent / H2 / 10percent Pd/C / methanol / 6 h / 760 Torr 4: 65 percent / NaHCO3 / aq. ethanol 5: 90 percent / 80percent aq. AcOH / 120 h / Ambient temperature 6: 80 percent / aq. NaIO4 / methanol / 2 h 7: 90.5 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h View Scheme |
(S)-4-Azido-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 62.5 percent / H2 / 10percent Pd/C / methanol / 6 h / 760 Torr 2: 65 percent / NaHCO3 / aq. ethanol 3: 90 percent / 80percent aq. AcOH / 120 h / Ambient temperature 4: 80 percent / aq. NaIO4 / methanol / 2 h 5: 90.5 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h View Scheme |
(S)-4-Azido-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyric acid methyl ester
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 77 percent / DIBAL / light petroleum; toluene; hexane / 1 h / -78 °C 2: 62.5 percent / H2 / 10percent Pd/C / methanol / 6 h / 760 Torr 3: 65 percent / NaHCO3 / aq. ethanol 4: 90 percent / 80percent aq. AcOH / 120 h / Ambient temperature 5: 80 percent / aq. NaIO4 / methanol / 2 h 6: 90.5 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h View Scheme |
benzyl chloroformate
rac-Pro-OH
A
Z-D-proline
B
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; sodium carbonate In water; acetonitrile at 50℃; for 1h; pH=9.5; Substitution; |
N-Benzyloxycarbonyl-L-proline
(S)-benzyloxycarbonyl-proline acid chloride
Conditions | Yield |
---|---|
With oxalyl dichloride; N,N-dimethyl-formamide | 100% |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 0.5h; | 100% |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 0.5h; | 100% |
diazomethane
N-Benzyloxycarbonyl-L-proline
N-carbobenzyloxy-L-proline methyl ester
Conditions | Yield |
---|---|
In diethyl ether | 100% |
In diethyl ether for 3h; Ambient temperature; |
methanol
N-Benzyloxycarbonyl-L-proline
N-carbobenzyloxy-L-proline methyl ester
Conditions | Yield |
---|---|
With thionyl chloride rt., 1 h, then reflux, 2 h; | 100% |
With thionyl chloride In dichloromethane 1.) -10 deg C, 2 h, 2.) RT, overnight; | 99% |
With thionyl chloride Inert atmosphere; | 96% |
di-tert-butyl dicarbonate
N-Benzyloxycarbonyl-L-proline
(S)-2-tert-butyl-1-benzylpyrrolidine-1,2-dicarboxylate
Conditions | Yield |
---|---|
With dmap In tert-butyl alcohol for 0.916667h; Ambient temperature; | 100% |
With dmap In neat (no solvent) for 1h; Milling; | 67% |
With pyridine; dmap; 1-amino-3-(dimethylamino)propane 1.) t-BuOH, EtOAc, 15 to 20 deg C, 16-20 h, 2.) t-BuOH, EtOAc, 15 min; Yield given. Multistep reaction; | |
With polyethylene-g-polyacrylic acid immobilized dimethylaminopyridine In toluene at 20℃; for 76h; Flow reactor; |
(S)-1-phenyl-ethylamine
N-Benzyloxycarbonyl-L-proline
(2S)-2-((1S)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid benzyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; chloroformic acid ethyl ester In ethyl acetate at 0 - 20℃; for 15h; Inert atmosphere; Schlenk technique; | 100% |
With nickel ferrite nanoparticle In neat (no solvent) for 0.166667h; Irradiation; Sealed tube; | 58% |
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide Ambient temperature; | |
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; |
L-Phenylalaninol
N-Benzyloxycarbonyl-L-proline
benzyl 2-[(1-benzyl-2-hydroxyethyl)carbamoyl]pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 25℃; for 2.5h; | 100% |
Stage #1: N-Benzyloxycarbonyl-L-proline With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran; N,N-dimethyl-formamide at -9 - -5℃; for 0.1h; Stage #2: L-Phenylalaninol In tetrahydrofuran; N,N-dimethyl-formamide at -5 - 20℃; for 20h; Solvent; Temperature; Reagent/catalyst; | 95% |
With 4-methyl-morpholine; chloroformic acid ethyl ester In ethyl acetate at -15 - 20℃; for 15h; Inert atmosphere; Schlenk technique; | 75% |
Stage #1: N-Benzyloxycarbonyl-L-proline With TEA; chloroformic acid ethyl ester In tetrahydrofuran at 0℃; for 0.5h; Stage #2: L-Phenylalaninol In tetrahydrofuran for 20h; |
glycinamide hydrochloride
N-Benzyloxycarbonyl-L-proline
Nα-benzyloxycarbonyl-L-prolyl-glycinamide
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 100% |
Stage #1: N-Benzyloxycarbonyl-L-proline With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; Stage #2: glycinamide hydrochloride With triethylamine In tetrahydrofuran at 20℃; Further stages.; | 53% |
With 4-methyl-morpholine; isobutyl chloroformate 1) DMF, -15 deg C, 15 min, 2) -10 deg C, 14h; Yield given. Multistep reaction; |
glycine ethyl ester hydrochloride
N-Benzyloxycarbonyl-L-proline
ethyl (N-benzoxycarbonyl-L-prolyl)glycinate
Conditions | Yield |
---|---|
Stage #1: N-Benzyloxycarbonyl-L-proline With 1,1'-carbonyldioxydi[2(1H)-pyridone] In dichloromethane at 20℃; Stage #2: glycine ethyl ester hydrochloride With triethylamine In dichloromethane at -18℃; | 100% |
Stage #1: N-Benzyloxycarbonyl-L-proline With iodine; N-ethyl-N,N-diisopropylamine; phosphorous acid trimethyl ester In ethyl acetate for 0.166667h; Cooling with ice; Inert atmosphere; Stage #2: glycine ethyl ester hydrochloride In ethyl acetate at 20℃; for 6h; Inert atmosphere; Cooling with ice; | 87% |
With 2,6-dimethylpyridine; 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate In tetrahydrofuran; water at 20 - 25℃; Solvent; | 85% |
With N,N'-dicyclopentylcarbodiimide; triethylamine In dichloromethane for 24h; | 62% |
With Lawessons reagent; triethylamine 1.) CH2Cl2, 20 min, room temperature 2.) 0 deg C for 1 h, room temperature for 15 h.; Yield given. Multistep reaction; |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-Benzyloxycarbonyl-L-proline
N-carbobenzoxy-L-prolyl-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
With N-Ethylmaleimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 25℃; for 18h; pH 7.0-7.5; | 100% |
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 19h; | 92% |
With triethylamine; 2-Pyridon-1-yl diphenyl phosphate In N,N-dimethyl-formamide for 3h; Ambient temperature; | 85% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane for 4h; | 100% |
isopropylamine
N-Benzyloxycarbonyl-L-proline
(S)-N-isopropyl-(Nα-benzyloxycarbonyl)prolinamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0 - 25℃; for 2.5h; | 100% |
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide | 85% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane for 4h; | 100% |
N-Benzyloxycarbonyl-L-proline
Z-Pro-NH2
Conditions | Yield |
---|---|
With ammonium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 24h; | 100% |
With ammonium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 20℃; | 100% |
Stage #1: N-Benzyloxycarbonyl-L-proline With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at 0℃; for 0.25h; Stage #2: With ammonia In tetrahydrofuran; water at 0 - 20℃; for 15h; | 100% |
ethanol
N-Benzyloxycarbonyl-L-proline
1,2-pyrrolidinedicarboxylic acid 2-ethyl 1-(phenylmethyl) ester
Conditions | Yield |
---|---|
With (+)-10-camphorsulfonic acid for 20h; Heating; | 100% |
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline for 5h; Heating; | 88% |
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate at 80℃; for 0.0833333h; Microwave irradiation; | 100% |
With hydrogen; hydroxyapatite-bound Pd In methanol at 40℃; for 1h; | 99% |
With hydrogen; palladium on activated charcoal In ethyl acetate at 80℃; under 2585.81 Torr; for 0.0833333h; microwave irradiation; | 99% |
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With 1,3-dimethyl-chloroimidazolinium chloride; triethylamine In dichloromethane at 20℃; for 3h; | 100% |
tert-butyl 1,4-diazepine-1-carboxylate
N-Benzyloxycarbonyl-L-proline
4-(1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane | 100% |
methyl 3-aminopropanoate hydrochloride
N-Benzyloxycarbonyl-L-proline
N-benzyloxycarbonyl-L-prolyl-β-alanine methyl ester
Conditions | Yield |
---|---|
Stage #1: N-Benzyloxycarbonyl-L-proline With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -25℃; for 0.166667h; Stage #2: methyl 3-aminopropanoate hydrochloride With 4-methyl-morpholine In tetrahydrofuran at -25℃; for 2h; | 100% |
Conditions | Yield |
---|---|
With 4-methyl-morpholine; ammonium hydroxide In tetrahydrofuran | 100% |
(3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one
N-Benzyloxycarbonyl-L-proline
N-[(phenylmethoxy)carbonyl]-L-proline-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 0 - 25℃; for 72h; Inert atmosphere; | 100% |
Stage #1: N-Benzyloxycarbonyl-L-proline With dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.25h; Stage #2: (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one With dmap In N,N-dimethyl-formamide at 20℃; | 96% |
Conditions | Yield |
---|---|
With 4-methyl-morpholine; chloroformic acid ethyl ester In ethyl acetate at 0 - 20℃; for 15h; Inert atmosphere; Schlenk technique; | 100% |
With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran |
(S)-(3-bromo-4,5-dihydroisoxazol-5-yl)methanamine
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.5h; | 100% |
3,5-dimethyl-1H-pyrazole
N-Benzyloxycarbonyl-L-proline
(S)-2-(3,5-Dimethyl-pyrazole-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane 1.) 0 deg C, 30 min, 2.) room temperature, overnight; | 99.5% |
4-nitro-aniline
N-Benzyloxycarbonyl-L-proline
benzyl (2S)-2-[(4-nitrophenyl)carbamoyl]pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 80℃; Inert atmosphere; | 99% |
With pyridine; phosphorus trichloride 1.) -10 deg C, 15 min, 2.) a) 60 deg C, 3 h, b) RT, overnight; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With dimethylsulfide borane complex | 99% |
With borane-dimethyl sulfide complex In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 99% |
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 25h; Inert atmosphere; | 99% |
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate
N-Benzyloxycarbonyl-L-proline
Conditions | Yield |
---|---|
99% |
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In dichloromethane at 20℃; for 24h; | 99% |
1-indoline
N-Benzyloxycarbonyl-L-proline
benzyl (S)-(-)-2-(1-indolinylcarbonyl)-1-pyrrolidinecarboxylate
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane at -5 - 25℃; Inert atmosphere; | 99% |
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