Agomelatine supplier | CasNO.138112-76-2

Name
Agomelatine
EINECS 629-727-7
CAS No. 138112-76-2
Article Data50
CAS DataBase
Density 1.109 g/cm³
Solubility
Melting Point 107-109 °C
Formula C₁₅H₁₇NO₂
Boiling Point 478.8 °C at 760 mmHg
Molecular Weight 243.305
Flash Point 243.4 °C
Transport Information
Appearance white solid
Safety 61
Risk Codes 50
Molecular Structure
Hazard Symbols N
Synonyms Thymanax;N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;S 20098;Valdoxan;Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-;
PSA 38.33000
LogP 2.91790

Synthetic route

: 139525-77-2
2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With sodium acetate In ethanol for 1h; Reflux;	99.5%
With sodium acetate In Isopropyl acetate	99%
With sodium acetate In ethanol for 1h; Reflux;	95%

: 1331869-01-2
2-(2-methoxynaphthalen-8-yl)acetaldehyde oxime

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With hydrogen; acetic anhydride In tetrahydrofuran at 50℃; under 7500.75 Torr; for 6h; Autoclave; Inert atmosphere;	98%

: N,N-dibenzyl-2-(7-methoxynaphthalen-1-yl)ethanamine

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
Stage #1: N,N-dibenzyl-2-(7-methoxynaphthalen-1-yl)ethanamine With 20% palladium hydroxide-activated charcoal; hydrogen In ethanol; water; ethyl acetate under 3750.38 Torr; for 30h; Autoclave; Stage #2: acetic anhydride With sodium acetate for 4h;	98%

: 138113-09-4
2-(7-methoxynaphth-1-yl)ethylamine

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 6h; Concentration; Temperature;	97.5%
With sodium acetate In ethanol at 65℃; Green chemistry;	92%
With triethylamine In toluene at 20 - 30℃;	90%

: 138113-09-4
2-(7-methoxynaphth-1-yl)ethylamine

: 75-36-5
acetyl chloride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 5℃;	95%
In pyridine	92%
With pyridine for 0.5h; Product distribution / selectivity; Cooling with ice;	92%

: 77-78-1
dimethyl sulfate

: 152302-45-9
N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With potassium carbonate In acetone for 5h; Reflux;	94.5%

: 1424944-40-0
1-(2-nitroethyl)-7-methoxynaphthalene

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen In water; ethyl acetate at 20℃;	92%

: 1384536-35-9
1-[2-(7-methoxynahthalen-1-yl)-ethyl]-2λ5-triaz-1-en-2-yne

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In water; ethyl acetate at 20℃;	92%

: 1352139-51-5
N-[2-(7-methoxy-3,4-dihydro-naphthalen-1-yl)ethyl]acetamide

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃;	91.8%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone for 4h; Product distribution / selectivity; Reflux;	90%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran at 20℃; Product distribution / selectivity;	80%

: 139525-77-2
2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride

: 75-36-5
acetyl chloride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 2h;	91%
Stage #1: 2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride With triethylamine In dichloromethane at 25 - 35℃; for 0.5h; Stage #2: acetyl chloride In dichloromethane at 10 - 20℃; for 1h;	90%
With potassium carbonate In chloroform; water for 0.5h; Ambient temperature;	89%
With potassium carbonate In chloroform; water at 0℃;
Stage #1: 2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride With potassium carbonate In water; ethyl acetate at 20℃; Schotten-Baumann reaction; Stage #2: acetyl chloride In water; ethyl acetate at 0 - 20℃; for 1h; Schotten-Baumann reaction;

: 2-(7-methoxynaphthalen-1-yl)ethanamine carbon dioxide adduct

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With sodium acetate In methanol Reflux;	91%
With sodium acetate In methanol Reflux;	91%
With sodium acetate In methanol Reflux;	91%

: 108-24-7
acetic anhydride

: 138113-08-3
(7-methoxy-1-naphthyl)acetonitrile

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With hydrogen; Raney nickel In ethanol; water at 70℃; under 22502.3 Torr;	89%
With hydrogen In ethanol; water at 70℃; under 22502.3 Torr;	89%
With hydrogen In ethanol; water at 70℃; under 22502.3 Torr; for 1h;	89%
With hydrogen In ethanol at 60℃; under 37503.8 Torr; for 4h;
Stage #1: (7-methoxy-1-naphthyl)acetonitrile With hydrogen; sodium hydroxide In methanol; water at 30℃; under 3000.3 Torr; Stage #2: acetic anhydride In methanol at 15 - 25℃;

: 2-(7-methoxynaphthalen-1-yl)ethen-1-amine

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With sodium acetate In ethanol; acetic anhydride at 25℃; for 1h; Temperature;	88.1%

: 1-[2-(acetylamino)ethyl]-7-methoxynaphthalen-2-yl propane-1-sulphonate

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; ammonium acetate; magnesium In ethanol for 16h;	87%

: 1352139-49-1
N-[2-(1-hydroxyl-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)ethyl]-acetamide

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 40℃; for 5h;	85%
With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 40℃; for 5h;
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C 2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C View Scheme

: 1206788-15-9
2-(2-(7-methoxynaphthalen-1-yl)ethyl) isoindoline-1,3-dione

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
Stage #1: 2-(2-(7-methoxynaphthalen-1-yl)ethyl) isoindoline-1,3-dione With hydrazine hydrate In methanol; dichloromethane at 30℃; for 14h; Stage #2: acetic anhydride With triethylamine In methanol; dichloromethane; toluene at 25℃; for 0.333333h;	85%

: 1-[2-(acetylamino)ethyl]-7-methoxynaphthalen-2-yl-4-methylbenzenesulphonate

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate; nickel dichloride at 20℃; for 0.5h; Sealed tube; Inert atmosphere;	80%

: 138113-07-2
2-(2-methoxynaphthalen-8-yl)acetamide

: 64-19-7
acetic acid

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With sodium tetrahydroborate In 1,4-dioxane at 95 - 98℃; for 22h;	76.3%

: 108-24-7
acetic anhydride

: 185336-04-3
2-(7-methoxynaphthalen-1-yl)ethyl methanesulphonate

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
Stage #1: 2-(7-methoxynaphthalen-1-yl)ethyl methanesulphonate With ammonia In water; acetonitrile at 110℃; for 3h; Stage #2: acetic anhydride With sodium acetate for 1h;	74%

: 1384261-25-9
N-[2-(4-chloro-7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With potassium tert-butylate In tert-butyl alcohol for 3h; Reflux;	68%

: 1384261-27-1
N-[2-(4-bromo-7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With potassium tert-butylate In tert-butyl alcohol for 3h; Reflux;	68%

: 1415243-95-6
(E)-7-methoxy-1-(2-nitrovinyl)naphthalene

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; acetic acid	65%

: 138113-09-4
2-(7-methoxynaphth-1-yl)ethylamine

: 127-09-3
sodium acetate

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With acetic anhydride In ethanol at 20℃; for 1h;	61%

: 1384261-23-7
N-[2-(7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane for 48h;	48%

: 1-[2-(2,5-dioxopyrrolidin-1-yl)ethyl]-7-methoxynaphthalen-2-yl propane-1-sulphonate

: 108-24-7
acetic anhydride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
Stage #1: 1-[2-(2,5-dioxopyrrolidin-1-yl)ethyl]-7-methoxynaphthalen-2-yl propane-1-sulphonate With palladium 10% on activated carbon; ammonium acetate; magnesium In methanol at 30℃; for 12h; Stage #2: acetic anhydride With sodium acetate; sodium hydroxide In ethanol; water for 1h; Sealed tube;	37%

: 138113-09-4
2-(7-methoxynaphth-1-yl)ethylamine

[14C]acetyl-CoA: [14C]acetyl-CoA

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
With sheep pineal supernatant (serotonin-N-acetyl transferase); Pargyline In phosphate buffer at 37℃; for 0.166667h; pH=6.8; Enzyme kinetics;

: 6836-22-2
2-(7-methoxynaphthalen-1-yl)acetic acid

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: thionyl chloride / CHCl3 2: aq. NH4OH / diethyl ether / 0 °C 3: AlH4 / diethyl ether 4: K2CO3 / H2O; CHCl3 / 0 °C View Scheme
Multi-step reaction with 5 steps 1: thionyl chloride / CHCl3 2: aq. NH4OH / diethyl ether / 0 °C 3: (CF3CO)2O / tetrahydrofuran / 0 °C 4: H2, HCl / Ni Raney / diethyl ether 5: K2CO3 / H2O; CHCl3 / 0 °C View Scheme
Multi-step reaction with 5 steps 1.1: thionyl chloride / dichloromethane / 2 h / Reflux 2.1: ammonia / ethyl acetate; water / Cooling with ice 3.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice 4.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave 5.1: pyridine / 40 °C 5.2: 20 °C / Cooling with ice View Scheme

: 138113-07-2
2-(2-methoxynaphthalen-8-yl)acetamide

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlH4 / diethyl ether 2: K2CO3 / H2O; CHCl3 / 0 °C View Scheme
Multi-step reaction with 3 steps 1: (CF3CO)2O / tetrahydrofuran / 0 °C 2: H2, HCl / Ni Raney / diethyl ether 3: K2CO3 / H2O; CHCl3 / 0 °C View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice 2.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave 3.1: pyridine / 40 °C 3.2: 20 °C / Cooling with ice View Scheme
Multi-step reaction with 3 steps 1.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C 2.1: sodium hydroxide; hydrogen / water; methanol; isopropyl alcohol / 25 - 30 °C / 7500.75 Torr 2.2: 1 h / 50 - 55 °C 3.1: sodium hydroxide / water; toluene / 0.25 h / 20 - 25 °C 3.2: 35 - 40 °C View Scheme

: 138113-08-3
(7-methoxy-1-naphthyl)acetonitrile

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2, HCl / Ni Raney / diethyl ether 2: K2CO3 / H2O; CHCl3 / 0 °C View Scheme
Multi-step reaction with 2 steps 1.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave 2.1: pyridine / 40 °C 2.2: 20 °C / Cooling with ice View Scheme
Multi-step reaction with 2 steps 1.1: sodium hydroxide; hydrogen / water; methanol; isopropyl alcohol / 25 - 30 °C / 7500.75 Torr 1.2: 1 h / 50 - 55 °C 2.1: sodium hydroxide / water; toluene / 0.25 h / 20 - 25 °C 2.2: 35 - 40 °C View Scheme
Multi-step reaction with 2 steps 1.1: ammonia; hydrogen / methanol / 15 - 55 °C / 3750.38 Torr / Autoclave 1.2: 1 h / 0 - 5 °C 2.1: triethylamine / dichloromethane / 0.5 h / 25 - 35 °C 2.2: 1 h / 10 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: ammonia; hydrogen / ethanol / 24 h / 30 - 40 °C / 2250.23 - 3000.3 Torr / Autoclave 2: triethylamine / toluene / 0.5 h / 0 - 30 °C View Scheme

: 6836-23-3
(7-methoxy-1-naphthyl)acetic acid chloride

: 138112-76-2
agomelatine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. NH4OH / diethyl ether / 0 °C 2: AlH4 / diethyl ether 3: K2CO3 / H2O; CHCl3 / 0 °C View Scheme
Multi-step reaction with 4 steps 1: aq. NH4OH / diethyl ether / 0 °C 2: (CF3CO)2O / tetrahydrofuran / 0 °C 3: H2, HCl / Ni Raney / diethyl ether 4: K2CO3 / H2O; CHCl3 / 0 °C View Scheme
Multi-step reaction with 4 steps 1.1: ammonia / ethyl acetate; water / Cooling with ice 2.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice 3.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave 4.1: pyridine / 40 °C 4.2: 20 °C / Cooling with ice View Scheme
Multi-step reaction with 4 steps 1.1: ammonia / toluene / 0 - 5 °C / pH 10 - 11 2.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C 3.1: sodium hydroxide; hydrogen / water; methanol; isopropyl alcohol / 25 - 30 °C / 7500.75 Torr 3.2: 1 h / 50 - 55 °C 4.1: sodium hydroxide / water; toluene / 0.25 h / 20 - 25 °C 4.2: 35 - 40 °C View Scheme

: 138112-76-2
agomelatine

: 110-16-7
maleic acid

: 1403960-82-6
agomelatine maleic acid

Conditions

Conditions	Yield
In ethanol for 0.75h;	100%
In methanol; ethyl acetate at 20℃; for 168h; Product distribution / selectivity;
for 1h;

: 138112-76-2
agomelatine

: 77-92-9
citric acid

: 1403960-81-5
agomelatine citric acid

Conditions

Conditions	Yield
In acetone at 20℃;	100%
In methanol; ethyl acetate at 2 - 5℃; Product distribution / selectivity; Reflux;
In methanol at 20℃; for 20h; Product distribution / selectivity;

: 490-79-9
2,5-dihydroxybenzoic acid.

: 138112-76-2
agomelatine

: 1419379-42-2
agomelatine gentisic acid

Conditions

Conditions	Yield
In toluene for 0.75h;	100%

: 107-21-1
ethylene glycol

: 138112-76-2
agomelatine

: 1259393-47-9
C2H6O2*C15H17NO2

Conditions

Conditions	Yield
at 110 - 130℃; for 5h;	98%

: 1453-82-3
isonicotinamide

: 138112-76-2
agomelatine

: 1366181-84-1
agomelatine isonicotinamide adduct

Conditions

Conditions	Yield
at 135℃; Neat (no solvent);	98%

: 99-76-3
methyl 4-hydroxylbenzoate

: 138112-76-2
agomelatine

: 1366181-85-2
agomelatine methyl 4-hydroxybenzoate adduct

Conditions

Conditions	Yield
at 110℃; Neat (no solvent);	98%

: 138112-76-2
agomelatine

: N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide hydrogen sulfate

Conditions

Conditions	Yield
With sulfuric acid In acetone at 10 - 20℃; Solvent; Temperature;	96.9%
With sulfuric acid In acetone at 10 - 20℃; Solvent; Temperature;	13.6 g
With sulfuric acid In ethyl acetate at 20℃;

: 64-19-7
acetic acid

: 138112-76-2
agomelatine

: 1259393-46-8
agomelatine 1:1 cocrystal with acetic acid

Conditions

Conditions	Yield
In diethyl ether for 48h;	96%
at 20 - 45℃; for 480h; Sealed tube;

: 138112-76-2
agomelatine

: 57-13-6
urea

: 1366181-82-9
agomelatine urea adduct

Conditions

Conditions	Yield
at 120℃; for 0.333333h; Neat (no solvent);	96%
In ethanol at 20℃; for 2h; Time;	70%
In isopropyl alcohol at 20℃; for 20h;	41%

: 138112-76-2
agomelatine

: 98-11-3
benzenesulfonic acid

: 1402317-73-0
N-[2-(7-methoxyl-1-naphthyl)ethyl]acetamide benzenesulfonic acid

Conditions

Conditions	Yield
In acetone at 25℃; Solvent; Temperature;	95.8%
In methanol; ethyl acetate at 2 - 20℃; Product distribution / selectivity;
In dichloromethane at 10 - 20℃; Solvent; Temperature;	15.6 g
In methanol; ethyl acetate Heating;

: 104-15-4
toluene-4-sulfonic acid

: 138112-76-2
agomelatine

: agomelatine p-toluenesulfonic acid monohydrate

Conditions

Conditions	Yield
In tetrahydrofuran; hexane for 0.5h; Solvent; Temperature; Reflux;	95.8%

: 138112-76-2
agomelatine

: 152302-45-9
N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at -10 - 20℃; for 2h;	93.3%
Stage #1: agomelatine With boron tribromide In dichloromethane at 0℃; for 2h; Stage #2: With water In dichloromethane at 0℃;	80%
With hydrogenchloride In water at 80℃;	74.8%

: 79-14-1
glycolic Acid

: 138112-76-2
agomelatine

: 1366181-83-0
agomelatine glycolic acid adduct

Conditions

Conditions	Yield
In acetonitrile for 2h; Reflux;	93%
for 0.25h;

: 138112-76-2
agomelatine

: 1176316-99-6
N [2-(7-methoxynaphthalen-1-yl)ethyl]acetamide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water; ethyl acetate at 10℃; Product distribution / selectivity;	88.7%
With hydrogenchloride In water; ethyl acetate at 10℃; for 1h;	88.7%
With hydrogenchloride In water; ethyl acetate at 10℃; for 1h;	88.7%

: 104-15-4
toluene-4-sulfonic acid

: 138112-76-2
agomelatine

: agomelatine p-toluenesulfonic acid

Conditions

Conditions	Yield
In acetone at 0 - 10℃;	88.2%
In acetone at 0 - 10℃;	1.5 g

: 138112-76-2
agomelatine

: 1176317-02-4
N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide hydrobromide

Conditions

Conditions	Yield
With hydrogen bromide In water; ethyl acetate at 20℃; for 1h; Product distribution / selectivity;	85.3%
With hydrogen bromide In water; ethyl acetate at 20℃; for 1h; Temperature;	85.3%
With hydrogen bromide In water; ethyl acetate for 1h;	85.3%

Agomelatine Specification

1. Introduction of Agomelatine
Agomelatine is one kind of off-white or white crystalline powder or white solid. The IUPAC Name of this chemical is N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide. This chemical belongs to Aromatics Compounds;Aromatics;Neurochemicals;APIS. It should be store at -20°C Freezer. Agomelatine Solubility: Soluble in Chloroform and Methanol. DMSO ≥49mg/mL Water <1mg/mL Ethanol ≥49mg/mL.

Its Classification Code is Central Nervous System Agents; Central Nervous System; Depressants; Drug / Therapeutic Agent; Hypnotics and sedatives.

2. Properties of Agomelatine
Physical properties about Agomelatine are:
(1)Melting Point: 107-109°C; (2)Boiling point: 478.8 °C at 760 mmHg; (3)Flash Point: 243.4 °C ; (4)Density: 1.109 g/cm3; (5)Surface Tension: 41.5 dyne/cm ; (6)Enthalpy of Vaporization: 74.3 kJ/mol ; (7)Vapour Pressure: 2.49E-09 mmHg at 25°C; (8)XLogP3-AA: 2.7; (9)H-Bond Donor: 1; (10)H-Bond Acceptor: 2.

3. Structure Descriptors of Agomelatine
(1)Canonical SMILES: CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC;
(2)InChI: InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17) ;
(3)InChIKey: YJYPHIXNFHFHND-UHFFFAOYSA-N.

4. Toxicity of Agomelatine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	> 1gm/kg (1000mg/kg)		United States Patent Document. Vol. #5318994,

5. Uses of Agomelatine
As a Pharmaceutical Intermediates, Agomelatine is used in the treatment of major depressive disorder, emotional disorder. Agomelatine is used in the treatment of major depressive disorder, emotional disorder. The drug substance for Nervous system. Antidepressant, anxiolytic, adjusting the rhythm of sleep and regulating biological clock. Agomelatine is a melatoninergic agonist and selective antagonist of 5-ht2c receptors. Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant.

Product Name

Agomelatine

Synthetic route

Agomelatine Specification

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