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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc

High Quality Sitagliptin phosphate monohydrate 654671-77-9 Manufacturer

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

CERTIFICATE OF ANALYSIS Product Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid CAS No. 486460-00-8 Batch No. 2011

Good supply Sitagliptin Phosphate Monohydrate Manufacture

Cas:654671-77-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Hysen Pharma co.,Ltd.

Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a

Sitagliptin phosphate monohydrate factory supplier in China

Cas:654671-77-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

USDMF EDMF are all available! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the re

Sitagliptin phosphate monohydrate USDMF EDMF

Cas:654671-77-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Sitagliptin phosphate monohydrate 654671-77-9

Cas:654671-77-9

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

Sitagliptin Phosphate Monohydrate

Cas:654671-77-9

Min.Order:0

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Sitagliptin phosphate monohydrate Manufacturer/High quality/Best price/In stock

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

Specifications Sitagliptin phosphate 654671-77-9 1.white crystalline powder 2.assay not less than 98.5% 3.Soluble in water Sitagliptin phosphate 654671-77-9 1.white crystalline powder 2.assay not less than 98.5% 3.Soluble in wat

CAS:654671-77-9 Sitagliptin phosphate monohydrate

Cas:654671-77-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

Sitagliptin phosphate monohydrate

Cas:654671-77-9

Min.Order:10000 Gram

FOB Price: $1300.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Sitagliptin Phosphate

Cas:654671-77-9

Min.Order:1

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

CAS RN.: 654671-77-9 Molecular Weight: 523.3241 Molecular Formula: C16H2

Sitagliptin phosphate monohydrate 654671-77-9

Cas:654671-77-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 654671-77-9 sitagliptin phosphate Manufacturer

Cas:654671-77-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Sitagliptin phosphate monohydrate

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less

ASitagliptin phosphate monohydrate

Cas:654671-77-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Sitagliptin Phosphate Monohydrate

Cas:654671-77-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Sitagliptin phosphate monohydrate

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Sitagliptin phosphate

Cas:654671-77-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Sitagliptin monohydrate CAS no:654671-77-9 Grade:Scientific research and export Molecular formula:C16H20F6N5O6P Molecular weight:523.3241 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabi

Sitagliptin monohydrate/cas:654671-77-9/high quality/Sitagliptin monohydrate material

Cas:654671-77-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

discount Sitagliptin phosphate monohydrate

Cas:654671-77-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing

Sitagliptin phosphate monohydrate CAS:654671-77-9

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 654671-77-9 with best quality

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Sitagliptin phosphate monohydrate

Cas:654671-77-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Sitagliptin phosphate monohydrate/ LIDE PHARMA- Factory supply / Best price

Cas:654671-77-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: Sitagliptin Phosphate Monohydrate CAS:654671-77-9 MF: C16H20F6N5O6P Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:APIS Transportation:By sea or by air Port:Qingdao Powder

Sitagliptin Phosphate Monohydrate

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Sitagliptin Phosphate Monohydrate Manufacturer New Hypoglycemic Agents

Cas:654671-77-9

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Factory Price Sitagliptin Phosphate Monohydrate CAS 654671-77-9 Sitagliptin Phosphate Hydrate

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:dry and cool pl

Sitagliptin phosphate monohydrate

Cas:654671-77-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Factory Supply Best Price Sitagliptin phosphate monohydrate powder

Cas:654671-77-9

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

Sitagliptin phosphate monohydrate WITH BEST PRICE

Cas:654671-77-9

Min.Order:1 Kilogram

FOB Price: $300.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High-quality Sitagliptin phosphate monohydrate CAS 654671-77-9 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities

High-quality Sitagliptin phosphate monohydrate CAS 654671-77-9

Cas:654671-77-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

sitagliptin
486460-32-6

sitagliptin

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
With phosphoric acid In water; isopropyl alcohol at 70 - 80℃; for 2h; Temperature;97.7%
With phosphoric acid; water In isopropyl alcohol at 20 - 75℃;95%
With phosphoric acid; water In isopropyl alcohol at 75℃;
1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione
764667-65-4

1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: isopropyl alcohol; acetic acid / 18 h / 50 °C
2: sodium tetrahydroborate; formic acid / tetrahydrofuran / -30 °C
3: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr
4: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C
View Scheme
Multi-step reaction with 4 steps
1: isopropyl alcohol; acetic acid / 18 h / 50 °C
2: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 3 h / 20 °C
3: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr
4: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux
2.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C
2.2: 13 h / 50 °C / 10343.2 Torr
3.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C
View Scheme
(R,Z)-3-[(1-phenylethyl)amino]-1-{3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5-trifluorophenyl)but-2-en-1-one
1169707-29-2

(R,Z)-3-[(1-phenylethyl)amino]-1-{3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5-trifluorophenyl)but-2-en-1-one

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; formic acid / tetrahydrofuran / -30 °C
2: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr
3: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 3 h / 20 °C
2: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr
3: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C
View Scheme
(3R)-3-[[(1R)-1-phenylethyl]amino]-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
1169707-30-5

(3R)-3-[[(1R)-1-phenylethyl]amino]-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr
2: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C
View Scheme
3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybutanoic acid
868071-17-4

3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybutanoic acid

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium hydroxide; dicyclohexyl-carbodiimide / tetrahydrofuran; water; cis-1,2-Dichloroethylene / 3 h / 20 - 22 °C
1.2: 18.5 h / 10 - 20 °C
2.1: lithium hydroxide / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3
2.2: 3 h / 0 - 5 °C
3.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C
4.1: sodium hydroxide / water / 1 h / 0 - 5 °C
5.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h
View Scheme
N-(benzyloxy)-4(R)-[1-methyl-(2,4,5-trifluorophenyl)]-2-oxoazetidine
767352-30-7

N-(benzyloxy)-4(R)-[1-methyl-(2,4,5-trifluorophenyl)]-2-oxoazetidine

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium hydroxide / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3
1.2: 3 h / 0 - 5 °C
2.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C
3.1: sodium hydroxide / water / 1 h / 0 - 5 °C
4.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h
View Scheme
3(R)-3-[(benzyloxy)amino]-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
1361389-75-4

3(R)-3-[(benzyloxy)amino]-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C
2: sodium hydroxide / water / 1 h / 0 - 5 °C
3: phosphoric acid; water / water; isopropyl alcohol / 0.25 h
View Scheme
sitagliptin phosphate

sitagliptin phosphate

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 1 h / 0 - 5 °C
2: phosphoric acid; water / water; isopropyl alcohol / 0.25 h
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) / methanol; acetic acid / 70 °C / 3620.13 Torr / Inert atmosphere; Autoclave
2.1: lithium hydroxide; dicyclohexyl-carbodiimide / tetrahydrofuran; water; cis-1,2-Dichloroethylene / 3 h / 20 - 22 °C
2.2: 18.5 h / 10 - 20 °C
3.1: lithium hydroxide / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3
3.2: 3 h / 0 - 5 °C
4.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C
5.1: sodium hydroxide / water / 1 h / 0 - 5 °C
6.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h
View Scheme
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: triethylamine; magnesium chloride / acetonitrile / 30 - 50 °C / Inert atmosphere
1.2: 5.5 h / 30 °C / Inert atmosphere
2.1: hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) / methanol; acetic acid / 70 °C / 3620.13 Torr / Inert atmosphere; Autoclave
3.1: lithium hydroxide; dicyclohexyl-carbodiimide / tetrahydrofuran; water; cis-1,2-Dichloroethylene / 3 h / 20 - 22 °C
3.2: 18.5 h / 10 - 20 °C
4.1: lithium hydroxide / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3
4.2: 3 h / 0 - 5 °C
5.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C
6.1: sodium hydroxide / water / 1 h / 0 - 5 °C
7.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h
View Scheme
Multi-step reaction with 5 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 20 - 40 °C
1.2: 2 - 3 h / 0 - 5 °C
2.1: N,N-dimethyl acetamide / 1 h / 40 - 70 °C
2.2: 3 - 5 h / 20 - 45 °C
3.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux
4.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C
4.2: 13 h / 50 °C / 10343.2 Torr
5.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C
View Scheme
2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide
763105-70-0

2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / methanol; water / 0.75 h / 55 °C
2.1: N,N-dimethyl acetamide / 1 h / 40 - 70 °C
2.2: 3 - 5 h / 20 - 45 °C
3.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux
4.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C
4.2: 13 h / 50 °C / 10343.2 Torr
5.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C
View Scheme
(Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one
767340-03-4

(Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C
1.2: 13 h / 50 °C / 10343.2 Torr
2.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C
View Scheme
C15H13F3O4

C15H13F3O4

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N,N-dimethyl acetamide / 1 h / 40 - 70 °C
1.2: 3 - 5 h / 20 - 45 °C
2.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux
3.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C
3.2: 13 h / 50 °C / 10343.2 Torr
4.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C
View Scheme
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
762240-92-6

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N,N-dimethyl acetamide / 1 h / 40 - 70 °C
1.2: 3 - 5 h / 20 - 45 °C
2.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux
3.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C
3.2: 13 h / 50 °C / 10343.2 Torr
4.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C
View Scheme
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 0 °C
2: hydrogenchloride / methanol / 3 h / 20 °C
3: phosphoric acid / isopropyl alcohol; water / Reflux
View Scheme
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 10 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 0 °C
3: hydrogenchloride / methanol / 3 h / 20 °C
4: phosphoric acid / isopropyl alcohol; water / Reflux
View Scheme
sitagliptin phosphate monohydrate
654671-77-9

sitagliptin phosphate monohydrate

sitagliptin phosphate

sitagliptin phosphate

Conditions
ConditionsYield
In water Purification / work up;
at 58 - 140℃; for 1 - 8h;
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