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Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryCERTIFICATE OF ANALYSIS Product Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid CAS No. 486460-00-8 Batch No. 2011
Cas:654671-77-9
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryHangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a
Cas:654671-77-9
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryUSDMF EDMF are all available! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the re
Cas:654671-77-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:654671-77-9
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryKONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li
Cas:654671-77-9
Min.Order:0
Negotiable
Type:Trading Company
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquirySpecifications Sitagliptin phosphate 654671-77-9 1.white crystalline powder 2.assay not less than 98.5% 3.Soluble in water Sitagliptin phosphate 654671-77-9 1.white crystalline powder 2.assay not less than 98.5% 3.Soluble in wat
Cas:654671-77-9
Min.Order:1 Kilogram
Negotiable
Type:Other
inquirySleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric
Cas:654671-77-9
Min.Order:10000 Gram
FOB Price: $1300.0
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
CAS RN.: 654671-77-9 Molecular Weight: 523.3241 Molecular Formula: C16H2
Cas:654671-77-9
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:654671-77-9
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $5.0 / 10.0
Type:Manufacturers
inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less
Cas:654671-77-9
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Cas:654671-77-9
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:654671-77-9
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryName:Sitagliptin monohydrate CAS no:654671-77-9 Grade:Scientific research and export Molecular formula:C16H20F6N5O6P Molecular weight:523.3241 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabi
Cas:654671-77-9
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:654671-77-9
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing
Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $15.0 / 50.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:654671-77-9
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:654671-77-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryName: Sitagliptin Phosphate Monohydrate CAS:654671-77-9 MF: C16H20F6N5O6P Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:APIS Transportation:By sea or by air Port:Qingdao Powder
Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
Cas:654671-77-9
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:dry and cool pl
Cas:654671-77-9
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:654671-77-9
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,
Cas:654671-77-9
Min.Order:1 Kilogram
FOB Price: $300.0
Type:Trading Company
inquiryBeluga chemical professional supply High-quality Sitagliptin phosphate monohydrate CAS 654671-77-9 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities
Cas:654671-77-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquirysitagliptin
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
With phosphoric acid In water; isopropyl alcohol at 70 - 80℃; for 2h; Temperature; | 97.7% |
With phosphoric acid; water In isopropyl alcohol at 20 - 75℃; | 95% |
With phosphoric acid; water In isopropyl alcohol at 75℃; |
1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: isopropyl alcohol; acetic acid / 18 h / 50 °C 2: sodium tetrahydroborate; formic acid / tetrahydrofuran / -30 °C 3: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr 4: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C View Scheme | |
Multi-step reaction with 4 steps 1: isopropyl alcohol; acetic acid / 18 h / 50 °C 2: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 3 h / 20 °C 3: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr 4: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux 2.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C 2.2: 13 h / 50 °C / 10343.2 Torr 3.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C View Scheme |
(R,Z)-3-[(1-phenylethyl)amino]-1-{3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5-trifluorophenyl)but-2-en-1-one
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; formic acid / tetrahydrofuran / -30 °C 2: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr 3: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 3 h / 20 °C 2: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr 3: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C View Scheme |
(3R)-3-[[(1R)-1-phenylethyl]amino]-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr 2: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C View Scheme |
3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybutanoic acid
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium hydroxide; dicyclohexyl-carbodiimide / tetrahydrofuran; water; cis-1,2-Dichloroethylene / 3 h / 20 - 22 °C 1.2: 18.5 h / 10 - 20 °C 2.1: lithium hydroxide / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3 2.2: 3 h / 0 - 5 °C 3.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C 4.1: sodium hydroxide / water / 1 h / 0 - 5 °C 5.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h View Scheme |
N-(benzyloxy)-4(R)-[1-methyl-(2,4,5-trifluorophenyl)]-2-oxoazetidine
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium hydroxide / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3 1.2: 3 h / 0 - 5 °C 2.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C 3.1: sodium hydroxide / water / 1 h / 0 - 5 °C 4.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h View Scheme |
3(R)-3-[(benzyloxy)amino]-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C 2: sodium hydroxide / water / 1 h / 0 - 5 °C 3: phosphoric acid; water / water; isopropyl alcohol / 0.25 h View Scheme |
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 1 h / 0 - 5 °C 2: phosphoric acid; water / water; isopropyl alcohol / 0.25 h View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) / methanol; acetic acid / 70 °C / 3620.13 Torr / Inert atmosphere; Autoclave 2.1: lithium hydroxide; dicyclohexyl-carbodiimide / tetrahydrofuran; water; cis-1,2-Dichloroethylene / 3 h / 20 - 22 °C 2.2: 18.5 h / 10 - 20 °C 3.1: lithium hydroxide / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3 3.2: 3 h / 0 - 5 °C 4.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C 5.1: sodium hydroxide / water / 1 h / 0 - 5 °C 6.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h View Scheme |
(2,4,5-trifluorophenyl)acetic acid
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: triethylamine; magnesium chloride / acetonitrile / 30 - 50 °C / Inert atmosphere 1.2: 5.5 h / 30 °C / Inert atmosphere 2.1: hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) / methanol; acetic acid / 70 °C / 3620.13 Torr / Inert atmosphere; Autoclave 3.1: lithium hydroxide; dicyclohexyl-carbodiimide / tetrahydrofuran; water; cis-1,2-Dichloroethylene / 3 h / 20 - 22 °C 3.2: 18.5 h / 10 - 20 °C 4.1: lithium hydroxide / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3 4.2: 3 h / 0 - 5 °C 5.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C 6.1: sodium hydroxide / water / 1 h / 0 - 5 °C 7.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h View Scheme | |
Multi-step reaction with 5 steps 1.1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 20 - 40 °C 1.2: 2 - 3 h / 0 - 5 °C 2.1: N,N-dimethyl acetamide / 1 h / 40 - 70 °C 2.2: 3 - 5 h / 20 - 45 °C 3.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux 4.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C 4.2: 13 h / 50 °C / 10343.2 Torr 5.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C View Scheme |
2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogenchloride / methanol; water / 0.75 h / 55 °C 2.1: N,N-dimethyl acetamide / 1 h / 40 - 70 °C 2.2: 3 - 5 h / 20 - 45 °C 3.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux 4.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C 4.2: 13 h / 50 °C / 10343.2 Torr 5.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C View Scheme |
(Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C 1.2: 13 h / 50 °C / 10343.2 Torr 2.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C View Scheme |
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N,N-dimethyl acetamide / 1 h / 40 - 70 °C 1.2: 3 - 5 h / 20 - 45 °C 2.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux 3.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C 3.2: 13 h / 50 °C / 10343.2 Torr 4.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C View Scheme |
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N,N-dimethyl acetamide / 1 h / 40 - 70 °C 1.2: 3 - 5 h / 20 - 45 °C 2.1: ammonium acetate; ammonia / methanol; water / 2 h / 30 °C / Heating / reflux 3.1: (R, S) t-butyl Josiphos / chloro(1,5-cyclooctadiene)rhodium(I) dimer / methanol / 1 h / 20 °C 3.2: 13 h / 50 °C / 10343.2 Torr 4.1: phosphoric acid; water / isopropyl alcohol / 2 h / 68 - 75 °C View Scheme |
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 0 °C 2: hydrogenchloride / methanol / 3 h / 20 °C 3: phosphoric acid / isopropyl alcohol; water / Reflux View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 10 h / 20 °C 2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 0 °C 3: hydrogenchloride / methanol / 3 h / 20 °C 4: phosphoric acid / isopropyl alcohol; water / Reflux View Scheme |
sitagliptin phosphate monohydrate
Conditions | Yield |
---|---|
In water Purification / work up; | |
at 58 - 140℃; for 1 - 8h; |
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