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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiryAppearance:White to off white solid Storage:ln stock Package:25kg/Barrel Application:Sitagliptin intermediate Transportation:Express/Sea/Air Port:Any port in china
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inquiryMethyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate CAS:769195-26-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquirystock,low price,high quality,high purity,good sevice Appearance:769195-26-8 Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,50g,100g,1kg...more Application:R&D Transportation:by land,by
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inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
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inquiryProduct name: Methyl 3-oxo-4-(2,4,5-Trifluorophenyl)butanoate CAS No.: 769195-26-8 Molecule Formula:C11H9F3O3 Molecule Weight:246.18 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard
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Min.Order:1 Kilogram
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inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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Min.Order:1 Kilogram
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inquiry2-(2,4,5-trifluorophenyl)acetyl chloride
bromoacetic acid methyl ester
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
Stage #1: bromoacetic acid methyl ester With iodine; magnesium In tetrahydrofuran at 45 - 50℃; Inert atmosphere; Stage #2: 2-(2,4,5-trifluorophenyl)acetyl chloride With copper(l) iodide In tetrahydrofuran at -20 - 5℃; Grignard Reaction; Inert atmosphere; | 91% |
methanol
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
In toluene for 3h; Heating; | 88.7% |
at 60 - 63℃; |
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
With methanol at 60 - 63℃; | 85% |
In methanol Reflux; |
monomethyl monopotassium malonate
(2,4,5-trifluorophenyl)acetic acid
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
Stage #1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h; Stage #2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h; Stage #3: In acetonitrile at 30℃; for 26h; | 84% |
Stage #1: monomethyl monopotassium malonate With triethylamine In acetonitrile at 30 - 50℃; for 8.3h; Stage #2: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile at 30℃; for 3.5h; | 83% |
Stage #1: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 30 - 50℃; Inert atmosphere; Stage #2: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile at 30℃; for 5.5h; Inert atmosphere; | 83% |
(2,4,5-trifluorophenyl)acetic acid
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
Stage #1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; Stage #2: magnesium monomethyl malonate In tetrahydrofuran at 20℃; for 24h; | 77.3% |
monomethyl monopotassium malonate
(2,4,5-trifluorophenyl)acetic acid
A
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
Stage #1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h; Stage #2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h; Stage #3: In acetonitrile at 30℃; for 26h; |
(2,4,5-trifluorophenyl)acetic acid
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / N,N-dimethylaminopyridine; N,N-diisopropylethylamine; trimethylacetylchloride / acetonitrile / 3 h / 45 °C 2: 88.7 percent / toluene / 3 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: oxalic acid / dichloromethane; N,N-dimethyl-formamide / 25 - 30 °C 1.2: -5 °C 2.1: methanol / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 25 - 30 °C 1.2: 6 h / 50 - 55 °C 2.1: 60 - 63 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: thionyl chloride / chloroform / 2 h / 0 - 30 °C 2.1: magnesium; iodine / tetrahydrofuran / 45 - 50 °C / Inert atmosphere 2.2: -20 - 5 °C / Inert atmosphere View Scheme |
methanol
sodium 1-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-(2,4,5-trifluorophenyl)ethanolate
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
With methanesulfonic acid Reflux; |
methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
With potassium dichromate; sulfuric acid; acetic acid at 25 - 30℃; for 24h; |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-1-phenyl-ethyl-amine
Conditions | Yield |
---|---|
With acetic acid In methanol Reflux; Large scale; | 98.5% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
Conditions | Yield |
---|---|
With [Ir(H)2((R)-N-((1,3-dithian-2-yl)methyl)-7'-(bis(3,5-di-tert-butylphenyl)phosphanyl)-1,1'-spirobiindanyl-7-amine)Cl]; hydrogen; sodium hydroxide In methanol at 25 - 30℃; under 7600.51 Torr; for 2h; Reagent/catalyst; Autoclave; enantioselective reaction; | 98% |
Stage #1: 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In toluene at 0 - 5℃; Inert atmosphere; Stage #2: With methanol In toluene | |
With hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) In methanol; acetic acid at 70℃; under 3620.13 Torr; for 6h; Inert atmosphere; |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
With ammonium acetate In methanol for 7h; Heating; | 95% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
benzamide
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene at 110℃; | 95% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 0℃; | 92% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester
Conditions | Yield |
---|---|
With formic acid In methanol at 65℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere; | 91.1% |
With hydrogen; (S)-BINAP RuCl2-triethylamine In methanol at 80 - 85℃; under 4413.43 - 4781.22 Torr; |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester
Conditions | Yield |
---|---|
With ammonium acetate In methanol for 2h; Heating; | 91% |
With ammonium acetate In methanol for 4h; Reflux; | 89.6% |
With ammonium acetate In methanol at 60 - 63℃; | 85% |
With ammonium acetate In methanol at 60 - 63℃; |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-1-phenyl-ethyl-amine
Conditions | Yield |
---|---|
With acetic acid In toluene for 3h; Reflux; | 87% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybutanoic acid
Conditions | Yield |
---|---|
With dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); hydrogen In methanol; acetic acid at 70℃; under 3620.13 Torr; Inert atmosphere; Autoclave; | 86% |
Multi-step reaction with 2 steps 1.1: hydrogen / dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) / acetic acid; methanol / 6 h / 70 °C / 3620.13 Torr / Inert atmosphere 2.1: sodium hydroxide; methanol / water / 1.5 h / 20 - 25 °C 2.2: 2 h / 10 - 15 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / (S)-BINAP RuCl2-triethylamine / methanol / 80 - 85 °C / 4413.43 - 4781.22 Torr 2: sodium hydroxide; water / 65 - 70 °C / Reflux View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
benzamide
Conditions | Yield |
---|---|
With diphenylammonium trifluoromethanesulfonate In toluene for 8h; Reflux; Green chemistry; stereoselective reaction; | 83% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
L-phenylglycine amide
Conditions | Yield |
---|---|
With acetic acid In ethanol at 40℃; for 16h; Solvent; Schiff Reaction; Inert atmosphere; | 80% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
N-benzyloxyamine
methyl (R)-3-(benzyloxyamino)-4-(2,4,5-trifluorophenyl)butanoate
Conditions | Yield |
---|---|
Stage #1: 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester; N-benzyloxyamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Stage #2: With (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; [(p-cymene)RuCl2]2 In tetrahydrofuran for 0.5h; Inert atmosphere; Stage #3: With sodium cyanoborohydride; zinc(II) chloride In tetrahydrofuran for 0.333333h; Inert atmosphere; | 74% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Benzeneacetamide
Conditions | Yield |
---|---|
With diphenylammonium trifluoromethanesulfonate In toluene for 8h; Reflux; Green chemistry; stereoselective reaction; | 73% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
acetamide
(Z)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl) but-2-enoate
Conditions | Yield |
---|---|
With diphenylammonium trifluoromethanesulfonate In toluene for 8h; Reflux; Green chemistry; stereoselective reaction; | 61% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
tert-butyl carbamate
3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane at 25℃; Molecular sieve; | 54.1% |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
Conditions | Yield |
---|---|
With ammonium acetate; sodium cyanoborohydride In methanol at 20℃; | 52% |
Multi-step reaction with 2 steps 1.1: ammonium acetate / methanol / 60 - 63 °C 2.1: sulfuric acid / methanol / -10 - 0 °C 2.2: 2 h / -10 - 0 °C 2.3: pH 8 - 9 View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / ammonium acetate / methanol / 2 h / Heating 2: [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / 2,2,2-trifluoro-ethanol / 24 h / 40 °C / 10343 Torr View Scheme | |
Multi-step reaction with 4 steps 1.1: ammonium acetate / methanol / 60 - 63 °C 2.1: sulfuric acid / methanol / -10 - 0 °C 2.2: 2 h / -10 - 0 °C 2.3: pH 8 - 9 3.1: isopropyl alcohol / 3 h / 25 - 30 °C 4.1: sodium carbonate / water / pH 8 - 9 View Scheme | |
With transaminase; pyridoxal 5'-phosphate; isopropylamine In water; dimethyl sulfoxide at 45℃; for 8h; Enzymatic reaction; |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr 3: 93 percent / CH2Cl2 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / ammonium acetate / methanol / 2 h / Heating 2: 75 percent / [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / methanol / 24 h / 30 °C / 4654.33 Torr View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid / methanol / Reflux; Large scale 2: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 1.5 h / -78 - 0 °C / Large scale 3: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 25 °C View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-[3-oxo-3-pyrazolidin-1-yl-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr 3: 93 percent / CH2Cl2 / 3 h / 20 °C 4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 5: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr 3: 93 percent / CH2Cl2 / 3 h / 20 °C 4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 5: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr 3: 93 percent / CH2Cl2 / 3 h / 20 °C 4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 5: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr 3: 93 percent / CH2Cl2 / 3 h / 20 °C 4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 5: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 6: 99 percent / HCl / ethyl acetate; dioxane / 16 h / 20 °C View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-[3-(2-benzoylcarbamoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr 3: 93 percent / CH2Cl2 / 3 h / 20 °C 4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 5: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 6: 85 percent / CH2Cl2 / 2 h / 20 °C View Scheme |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-[3-oxo-3-(2-(toluene-4-sulfonyl)pyrazolidin-1-yl)-1-(2,4,5-trifluorbenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr 3: 93 percent / CH2Cl2 / 3 h / 20 °C 4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 5: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 6: 76 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme |
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