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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pro

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Cas:769195-26-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Methyl 3-oxo-4-(2,4,5-trifluorophenyl)-butanoate

Cas:769195-26-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate CAS:769195-26-8

Cas:769195-26-8

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 769195-26-8

Cas:769195-26-8

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 769195-26-8 with competitive price

Cas:769195-26-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER CAS769195-26-8

Cas:769195-26-8

Min.Order:1 Kilogram

FOB Price: $289.0 / 494.0

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off white solid Storage:ln stock Package:25kg/Barrel Application:Sitagliptin intermediate Transportation:Express/Sea/Air Port:Any port in china

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Cas:769195-26-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8

Cas:769195-26-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate CAS:769195-26-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate CAS:769195-26-8

Cas:769195-26-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

Cas:769195-26-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

Cas:769195-26-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

stock,low price,high quality,high purity,good sevice Appearance:769195-26-8 Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,50g,100g,1kg...more Application:R&D Transportation:by land,by

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

METHYL 3-OXO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOATE

Cas:769195-26-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

Cas:769195-26-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER/High quality/Best price

Cas:769195-26-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3-Oxo-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid Methyl Ester

Cas:769195-26-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Methyl 3-oxo-4-(2,4,5-Trifluorophenyl)butanoate CAS No.: 769195-26-8 Molecule Formula:C11H9F3O3 Molecule Weight:246.18 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Lower Price Methyl 3-oxo-4-(2,4,5-Trifluorophenyl)butanoate on stock

Cas:769195-26-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Methyl3-oxo-4-(2,4,5-trifluorophenyl)butanoate

Cas:769195-26-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate

Cas:769195-26-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Cas:769195-26-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER

Cas:769195-26-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

2-(2,4,5-trifluorophenyl)acetyl chloride
1176895-65-0

2-(2,4,5-trifluorophenyl)acetyl chloride

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
Stage #1: bromoacetic acid methyl ester With iodine; magnesium In tetrahydrofuran at 45 - 50℃; Inert atmosphere;
Stage #2: 2-(2,4,5-trifluorophenyl)acetyl chloride With copper(l) iodide In tetrahydrofuran at -20 - 5℃; Grignard Reaction; Inert atmosphere;
91%
methanol
67-56-1

methanol

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
In toluene for 3h; Heating;88.7%
at 60 - 63℃;
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
With methanol at 60 - 63℃;85%
In methanol Reflux;
monomethyl monopotassium malonate
38330-80-2

monomethyl monopotassium malonate

(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
Stage #1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h;
Stage #2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h;
Stage #3: In acetonitrile at 30℃; for 26h;
84%
Stage #1: monomethyl monopotassium malonate With triethylamine In acetonitrile at 30 - 50℃; for 8.3h;
Stage #2: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile at 30℃; for 3.5h;
83%
Stage #1: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 30 - 50℃; Inert atmosphere;
Stage #2: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile at 30℃; for 5.5h; Inert atmosphere;
83%
magnesium monomethyl malonate

magnesium monomethyl malonate

(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
Stage #1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃;
Stage #2: magnesium monomethyl malonate In tetrahydrofuran at 20℃; for 24h;
77.3%
monomethyl monopotassium malonate
38330-80-2

monomethyl monopotassium malonate

(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

A

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

B

1,3-bis-(2,4,5-trifluoro-phenyl)-propan-2-one

1,3-bis-(2,4,5-trifluoro-phenyl)-propan-2-one

Conditions
ConditionsYield
Stage #1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h;
Stage #2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h;
Stage #3: In acetonitrile at 30℃; for 26h;
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / N,N-dimethylaminopyridine; N,N-diisopropylethylamine; trimethylacetylchloride / acetonitrile / 3 h / 45 °C
2: 88.7 percent / toluene / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: oxalic acid / dichloromethane; N,N-dimethyl-formamide / 25 - 30 °C
1.2: -5 °C
2.1: methanol / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 25 - 30 °C
1.2: 6 h / 50 - 55 °C
2.1: 60 - 63 °C
View Scheme
Multi-step reaction with 2 steps
1.1: thionyl chloride / chloroform / 2 h / 0 - 30 °C
2.1: magnesium; iodine / tetrahydrofuran / 45 - 50 °C / Inert atmosphere
2.2: -20 - 5 °C / Inert atmosphere
View Scheme
methanol
67-56-1

methanol

sodium 1-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-(2,4,5-trifluorophenyl)ethanolate
1253055-91-2

sodium 1-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-(2,4,5-trifluorophenyl)ethanolate

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
With methanesulfonic acid Reflux;
methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
1253056-13-1

methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Conditions
ConditionsYield
With potassium dichromate; sulfuric acid; acetic acid at 25 - 30℃; for 24h;
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

(Z)-3-(((R)-1-phenylethyl)amino)-4-(2,3,5-trifluorophenyl)-2-butenoic acid methyl ester

(Z)-3-(((R)-1-phenylethyl)amino)-4-(2,3,5-trifluorophenyl)-2-butenoic acid methyl ester

Conditions
ConditionsYield
With acetic acid In methanol Reflux; Large scale;98.5%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
1138326-05-2

(R)-methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
With [Ir(H)2((R)-N-((1,3-dithian-2-yl)methyl)-7'-(bis(3,5-di-tert-butylphenyl)phosphanyl)-1,1'-spirobiindanyl-7-amine)Cl]; hydrogen; sodium hydroxide In methanol at 25 - 30℃; under 7600.51 Torr; for 2h; Reagent/catalyst; Autoclave; enantioselective reaction;98%
Stage #1: 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In toluene at 0 - 5℃; Inert atmosphere;
Stage #2: With methanol In toluene
With hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) In methanol; acetic acid at 70℃; under 3620.13 Torr; for 6h; Inert atmosphere;
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

Conditions
ConditionsYield
With ammonium acetate In methanol for 7h; Heating;95%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

benzamide
55-21-0

benzamide

methyl 3-benzoylamino-4-(2,4,5-trifluorophenyl)-2-butenoate

methyl 3-benzoylamino-4-(2,4,5-trifluorophenyl)-2-butenoate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 110℃;95%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
1253056-13-1

methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0℃;92%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester
868071-16-3

3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester

Conditions
ConditionsYield
With formic acid In methanol at 65℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;91.1%
With hydrogen; (S)-BINAP RuCl2-triethylamine In methanol at 80 - 85℃; under 4413.43 - 4781.22 Torr;
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester
881995-70-6

(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester

Conditions
ConditionsYield
With ammonium acetate In methanol for 2h; Heating;91%
With ammonium acetate In methanol for 4h; Reflux;89.6%
With ammonium acetate In methanol at 60 - 63℃;85%
With ammonium acetate In methanol at 60 - 63℃;
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

methyl 4-(2,4,5-trifluorophenyl)-3-[(R)-1-phenylethylamino]-2-butenoate

methyl 4-(2,4,5-trifluorophenyl)-3-[(R)-1-phenylethylamino]-2-butenoate

Conditions
ConditionsYield
With acetic acid In toluene for 3h; Reflux;87%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybutanoic acid
868071-17-4

3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybutanoic acid

Conditions
ConditionsYield
With dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); hydrogen In methanol; acetic acid at 70℃; under 3620.13 Torr; Inert atmosphere; Autoclave;86%
Multi-step reaction with 2 steps
1.1: hydrogen / dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) / acetic acid; methanol / 6 h / 70 °C / 3620.13 Torr / Inert atmosphere
2.1: sodium hydroxide; methanol / water / 1.5 h / 20 - 25 °C
2.2: 2 h / 10 - 15 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / (S)-BINAP RuCl2-triethylamine / methanol / 80 - 85 °C / 4413.43 - 4781.22 Torr
2: sodium hydroxide; water / 65 - 70 °C / Reflux
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

benzamide
55-21-0

benzamide

(Z)-methyl 3-benzamido-4-(2,4,5-trifluorophenyl) but-2-enoate

(Z)-methyl 3-benzamido-4-(2,4,5-trifluorophenyl) but-2-enoate

Conditions
ConditionsYield
With diphenylammonium trifluoromethanesulfonate In toluene for 8h; Reflux; Green chemistry; stereoselective reaction;83%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

L-phenylglycine amide
6485-52-5

L-phenylglycine amide

(S,Z)-methyl 3-(2-amino-2-oxo-1-phenylethylamino)-4-(2,4,5-trifluorophenyl)but-2-enoate

(S,Z)-methyl 3-(2-amino-2-oxo-1-phenylethylamino)-4-(2,4,5-trifluorophenyl)but-2-enoate

Conditions
ConditionsYield
With acetic acid In ethanol at 40℃; for 16h; Solvent; Schiff Reaction; Inert atmosphere;80%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

N-benzyloxyamine
622-33-3

N-benzyloxyamine

methyl (R)-3-(benzyloxyamino)-4-(2,4,5-trifluorophenyl)butanoate
868125-58-0

methyl (R)-3-(benzyloxyamino)-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Stage #1: 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester; N-benzyloxyamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: With (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; [(p-cymene)RuCl2]2 In tetrahydrofuran for 0.5h; Inert atmosphere;
Stage #3: With sodium cyanoborohydride; zinc(II) chloride In tetrahydrofuran for 0.333333h; Inert atmosphere;
74%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

Benzeneacetamide
103-81-1

Benzeneacetamide

(Z)-methyl-3-(2-phenylacetamido)-4-(2,4,5-trifluorophenyl) but-2-enoate

(Z)-methyl-3-(2-phenylacetamido)-4-(2,4,5-trifluorophenyl) but-2-enoate

Conditions
ConditionsYield
With diphenylammonium trifluoromethanesulfonate In toluene for 8h; Reflux; Green chemistry; stereoselective reaction;73%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

acetamide
60-35-5

acetamide

(Z)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl) but-2-enoate
1234321-81-3

(Z)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl) but-2-enoate

Conditions
ConditionsYield
With diphenylammonium trifluoromethanesulfonate In toluene for 8h; Reflux; Green chemistry; stereoselective reaction;61%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

tert-butyl carbamate
4248-19-5

tert-butyl carbamate

3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester
1151240-93-5

3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 25℃; Molecular sieve;54.1%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
1253055-92-3

methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
With ammonium acetate; sodium cyanoborohydride In methanol at 20℃;52%
Multi-step reaction with 2 steps
1.1: ammonium acetate / methanol / 60 - 63 °C
2.1: sulfuric acid / methanol / -10 - 0 °C
2.2: 2 h / -10 - 0 °C
2.3: pH 8 - 9
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
View Scheme
Multi-step reaction with 2 steps
1: 91 percent / ammonium acetate / methanol / 2 h / Heating
2: [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / 2,2,2-trifluoro-ethanol / 24 h / 40 °C / 10343 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: ammonium acetate / methanol / 60 - 63 °C
2.1: sulfuric acid / methanol / -10 - 0 °C
2.2: 2 h / -10 - 0 °C
2.3: pH 8 - 9
3.1: isopropyl alcohol / 3 h / 25 - 30 °C
4.1: sodium carbonate / water / pH 8 - 9
View Scheme
With transaminase; pyridoxal 5'-phosphate; isopropylamine In water; dimethyl sulfoxide at 45℃; for 8h; Enzymatic reaction;
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-73-9

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
3: 93 percent / CH2Cl2 / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 91 percent / ammonium acetate / methanol / 2 h / Heating
2: 75 percent / [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / methanol / 24 h / 30 °C / 4654.33 Torr
View Scheme
Multi-step reaction with 3 steps
1: acetic acid / methanol / Reflux; Large scale
2: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 1.5 h / -78 - 0 °C / Large scale
3: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 25 °C
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-[3-oxo-3-pyrazolidin-1-yl-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-16-6

(R)-[3-oxo-3-pyrazolidin-1-yl-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
3: 93 percent / CH2Cl2 / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
5: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-17-7

(R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
3: 93 percent / CH2Cl2 / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
5: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-18-8

(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
3: 93 percent / CH2Cl2 / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
5: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

C13H16F3N3O*HCl

C13H16F3N3O*HCl

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
3: 93 percent / CH2Cl2 / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
5: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
6: 99 percent / HCl / ethyl acetate; dioxane / 16 h / 20 °C
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-[3-(2-benzoylcarbamoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-27-9

(R)-[3-(2-benzoylcarbamoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
3: 93 percent / CH2Cl2 / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
5: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
6: 85 percent / CH2Cl2 / 2 h / 20 °C
View Scheme
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-[3-oxo-3-(2-(toluene-4-sulfonyl)pyrazolidin-1-yl)-1-(2,4,5-trifluorbenzyl)propyl]carbamic acid tert-butyl ester
939964-28-0

(R)-[3-oxo-3-(2-(toluene-4-sulfonyl)pyrazolidin-1-yl)-1-(2,4,5-trifluorbenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
3: 93 percent / CH2Cl2 / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
5: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
6: 76 percent / Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
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