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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

(R)-Methyl 3-amino-4-(2,4,5-trifluoro phenyl) butanoate

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:881995-69-3

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid Methyl Ester

Cas:881995-69-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

(R)-SitagliptinMethyl-EsterImpurity

Cas:881995-69-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

881995-69-3

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Cas:881995-69-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Benzenebutanoic Acid, B-Amino-2,4,5-Trifluoro-, Methyl Ester, (Br)-

Cas:881995-69-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Benzenebutanoic acid, b-amino-2,4,5-trifluoro-, methyl ester, (bR)-

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

(R)-Sitagliptin Methyl-Ester Impurity CAS No.881995-69-3

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(R)-methyl 3-amino-4-(2,4,5-trifluoro phenyl) butanoate

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Other

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

home-produced Application:medicine

Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Shengang Trading Co.,Ltd

we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survi

methyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

Cas:881995-69-3

Min.Order:10 Gram

FOB Price: $1.0

Type:Trading Company

inquiry

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume

ISO 9001 National Research Platform CAS No. 881995-69-3

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

hangzhou verychem science and technology co.ltd

Product name: (R)-methyl 3-amino-4-(2,4,5-trifluoro phenyl) butanoate Cas No: 881995-69-3 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast

(R)-methyl 3-amino-4-(2,4,5-trifluoro phenyl) butanoate

Cas:881995-69-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hanhong Scientific Co.,Ltd.

factory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:c

R-3-Amino-4-(2,4,5-trifluoro-phenyl)butyric acid methyl ester881995-69-3

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chengdu Senior Pharma Technology Co.Ltd

In China, Chengdu Senior Pharma Technology Co., Ltd, known for its R & D capabilities and high-quality products, Senior Pharma has continuously develop new varieties. And also the R&D department can provides customized services ranging fro

Benzenebutanoic acid, β-amino-2,4,5-trifluoro-, methyl ester, (βR)-

Cas:881995-69-3

Min.Order:50 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Forever Synthesis Co.,Ltd.

As a professional chemical R&D and synthesis supplier, Shanghai Forever Synthesis Co.,Ltd. is specialized R&D and synthesizing APIs and Impurities. Besides, we value more special service, that is, to customize chemical synthesis according t

(R)-Sitagliptin Methyl-Ester Impurity

Cas:881995-69-3

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Apeptide Co., Ltd.

Apeptide is a famous-peptide manufacturer in China,We supply high quality peptides(Custom Peptides\Amino acids\API pepitdes and so on )with the best competitive price and short lead time.,Please check our website: www.apeptides.com/en/Appearance:pow

R-3-Amino-4-(2,4,5-trifluoro-phenyl)butyric acid methyl ester

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

Sitagliptin Impurity D

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Cyanochem Co; Ltd.

superior product, rigorous quality test, GMP management and auditable plant, stable supply in industry park, advantage in R&D CMO CROAppearance:white or off-white powder Storage:storage in norm temperature and against damp Package:Aluminum drum or fo

Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(Br)

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

NovaChemistry

High purity Application:Pharmaceutical intermediates, Material synthesis and analyzing the expectant ingredients

(R)-Sitagliptin Methyl-Ester Impurity

Cas:881995-69-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

methanol
67-56-1

methanol

benzyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

benzyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With Ru(OAc)2((R)-dm-Segphos); ammonium acetate; hydrogen; salicylic acid at 40 - 80℃; for 20h; Catalytic behavior; Temperature; Green chemistry;95.2%
(R)-(-)-mandelic acid salt of (R)-methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
1253055-94-5

(R)-(-)-mandelic acid salt of (R)-methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With sodium carbonate In water pH=8 - 9;95%
With sodium carbonate In water pH=8 - 9;90%
methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer In 2,2,2-trifluoroethanol at 50℃; under 5171.62 Torr; for 40h;68%
(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester
881995-70-6

(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester

A

methyl (3S)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

methyl (3S)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

B

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; chiral ferrocenyl ligand; hydrogen In 2,2,2-trifluoroethanol at 40℃; under 10343 Torr; for 24h;
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
View Scheme
Multi-step reaction with 2 steps
1: 91 percent / ammonium acetate / methanol / 2 h / Heating
2: [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / 2,2,2-trifluoro-ethanol / 24 h / 40 °C / 10343 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: ammonium acetate / methanol / 60 - 63 °C
2.1: sulfuric acid / methanol / -10 - 0 °C
2.2: 2 h / -10 - 0 °C
2.3: pH 8 - 9
3.1: isopropyl alcohol / 3 h / 25 - 30 °C
4.1: sodium carbonate / water / pH 8 - 9
View Scheme
With transaminase; pyridoxal 5'-phosphate; isopropylamine In water; dimethyl sulfoxide at 45℃; for 8h; Enzymatic reaction;
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / N,N-dimethylaminopyridine; N,N-diisopropylethylamine; trimethylacetylchloride / acetonitrile / 3 h / 45 °C
2: 88.7 percent / toluene / 3 h / Heating
3: 95 percent / ammonium acetate / methanol / 7 h / Heating
4: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: 1,1'-carbonyldiimidazole / acetonitrile / 3.5 h
1.2: Et3N; MgCl2 / acetonitrile / 8 h / 50 °C
1.3: 84 percent / acetonitrile / 26 h / 30 °C
2.1: 91 percent / ammonium acetate / methanol / 2 h / Heating
3.1: [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / 2,2,2-trifluoro-ethanol / 24 h / 40 °C / 10343 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: 1,1'-carbonyldiimidazole / acetonitrile / 3.5 h
1.2: Et3N; MgCl2 / acetonitrile / 8 h / 50 °C
1.3: acetonitrile / 26 h / 30 °C
2.1: 91 percent / ammonium acetate / methanol / 2 h / Heating
3.1: [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / 2,2,2-trifluoro-ethanol / 24 h / 40 °C / 10343 Torr
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: 60 - 63 °C
2.1: ammonium acetate / methanol / 60 - 63 °C
3.1: sulfuric acid / methanol / -10 - 0 °C
3.2: 2 h / -10 - 0 °C
3.3: pH 8 - 9
4.1: isopropyl alcohol / 3 h / 25 - 30 °C
5.1: sodium carbonate / water / pH 8 - 9
View Scheme
Multi-step reaction with 2 steps
1: acetonitrile / 24 h / 80 - 84 °C / Inert atmosphere
2: salicylic acid; ammonium acetate; Ru(OAc)2((R)-dm-Segphos); hydrogen / 20 h / 40 - 80 °C / Green chemistry
View Scheme
3-(R)-[(R)-(α-methylbenzyl)benzylamino]-4-(2,4,5-trifluoro-phenyl)butyric acid methyl ester
1260029-46-6

3-(R)-[(R)-(α-methylbenzyl)benzylamino]-4-(2,4,5-trifluoro-phenyl)butyric acid methyl ester

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With 20 % Pd(OH)2/C; hydrogen In methanol at 20℃; under 3800.26 Torr;
(R)-methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
1138326-05-2

(R)-methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With sodium azide; triphenylphosphine In tetrachloromethane; N,N-dimethyl-formamide at 90℃; for 8h;
(R)-methyl 3-(1,3-dioxoisoindolin-2-yl)-4-(2,4,5-trifluorophenyl)butanoate
1253056-07-3

(R)-methyl 3-(1,3-dioxoisoindolin-2-yl)-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With methylamine In water; toluene at 25 - 40℃;
(R)-methyl 3-(p-toluenesulfonyloxy)-4-(2,4,5-trifluorophenyl)butanoate
1253056-08-4

(R)-methyl 3-(p-toluenesulfonyloxy)-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With ammonia In methanol for 3h; Reflux;
(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester
881995-70-6

(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid / methanol / -10 - 0 °C
1.2: 2 h / -10 - 0 °C
1.3: pH 8 - 9
2.1: isopropyl alcohol / 3 h / 25 - 30 °C
3.1: sodium carbonate / water / pH 8 - 9
View Scheme
methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
1253055-92-3

methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: isopropyl alcohol / 3 h / 25 - 30 °C
2: sodium carbonate / water / pH 8 - 9
View Scheme
Multi-step reaction with 2 steps
1: ethyl acetate / 1 h / 65 - 70 °C
2: sodium hydrogencarbonate / water
View Scheme
C11H12F3NO2*C14H19NO3
1449289-64-8

C11H12F3NO2*C14H19NO3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In water3 g
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

A

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

B

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With pyridoxal 5'-phosphate; recombinant aminotransferase from Arthobacter sp.; water; isopropylamine In dimethyl sulfoxide at 45℃; for 8h; pH=8.5; Catalytic behavior; Concentration; Time; Enzymatic reaction; enantioselective reaction;
C17H22F3NO5S

C17H22F3NO5S

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
With hydrogenchloride In water at 50 - 115℃;3.1 g
C16H25NOS

C16H25NOS

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / 120 h / -30 - 20 °C
2: hydrogenchloride / water / 50 - 115 °C
View Scheme
2-(2,4,5-trifluorophenyl)ethanol
883267-70-7

2-(2,4,5-trifluorophenyl)ethanol

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; magnesium sulfate / dichloromethane / 24 h / -20 - 20 °C
2: sodium hydrogencarbonate / 120 h / -30 - 20 °C
3: hydrogenchloride / water / 50 - 115 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-73-9

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃; for 3h;93%
Stage #1: (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester With sodium hydroxide In tetrahydrofuran; water at 0℃; for 1h;
Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water-d2 at 20℃;
91.3%
With triethylamine In dichloromethane at 20℃; for 8h; optical yield given as %ee;54.6 g
With lithium hydroxide In tetrahydrofuran; water at 0 - 5℃; for 1.5h;
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester; di-tert-butyl dicarbonate With triethylamine In ethyl acetate at 20 - 30℃; for 7h;
Stage #2: With water; sodium hydroxide In ethanol at 20 - 30℃; for 2h;
85.5%
Stage #1: (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester With water; lithium hydroxide In tetrahydrofuran at 0 - 30℃;
Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 25 - 30℃; for 6h;
Stage #3: With sodium hydrogen sulfate In water pH=2;
80%
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(R)-[3-oxo-3-pyrazolidin-1-yl-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-16-6

(R)-[3-oxo-3-pyrazolidin-1-yl-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-17-7

(R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-18-8

(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

C13H16F3N3O*HCl

C13H16F3N3O*HCl

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
4: 99 percent / HCl / ethyl acetate; dioxane / 16 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(R)-[3-(2-benzoylcarbamoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-27-9

(R)-[3-(2-benzoylcarbamoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
4: 85 percent / CH2Cl2 / 2 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(R)-[3-oxo-3-(2-(toluene-4-sulfonyl)pyrazolidin-1-yl)-1-(2,4,5-trifluorbenzyl)propyl]carbamic acid tert-butyl ester
939964-28-0

(R)-[3-oxo-3-(2-(toluene-4-sulfonyl)pyrazolidin-1-yl)-1-(2,4,5-trifluorbenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
4: 76 percent / Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(R)-[3-(2-benzoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-29-1

(R)-[3-(2-benzoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
4: 86 percent / Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(R)-[3-(2-benzoyltetrahydropyridazin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-30-4

(R)-[3-(2-benzoyltetrahydropyridazin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
4: 99 percent / Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
939964-31-5

tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
4: 84 percent / Et3N / CH2Cl2 / 3 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

C20H21F3N4O2*HCl

C20H21F3N4O2*HCl

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
4: 85 percent / CH2Cl2 / 2 h / 20 °C
5: 38 percent / HCl / ethyl acetate; dioxane / 12 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

C20H22F3N3O3S*HCl

C20H22F3N3O3S*HCl

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
4: 76 percent / Et3N / CH2Cl2 / 2 h / 20 °C
5: 51 percent / HCl / ethyl acetate; dioxane / 12 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

C20H20F3N3O2*HCl

C20H20F3N3O2*HCl

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C
4: 86 percent / Et3N / CH2Cl2 / 2 h / 20 °C
5: 38 percent / HCl / ethyl acetate; dioxane / 12 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

KR 64300

KR 64300

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
4: 99 percent / Et3N / CH2Cl2 / 2 h / 20 °C
5: 92 percent / HCl / ethyl acetate; dioxane / 12 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

KR 64301

KR 64301

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
3: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C
4: 84 percent / Et3N / CH2Cl2 / 3 h / 20 °C
5: 75 percent / HCl / ethyl acetate; dioxane / 16 h / 20 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: water; lithium hydroxide / tetrahydrofuran / 0 - 30 °C
2.1: water; tetrahydrofuran / 6 h / 25 - 30 °C
2.2: pH 2
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

sitagliptin
486460-32-6

sitagliptin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water; lithium hydroxide / tetrahydrofuran / 0 - 30 °C
2.1: water; tetrahydrofuran / 6 h / 25 - 30 °C
2.2: pH 2
3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 13 h / 0 - 30 °C
4.1: hydrogenchloride / methanol / 12 h / 25 - 45 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 0 °C
1.2: 20 °C
2.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1,2-dichloro-ethane / N,N-dimethyl-formamide / -15 - 20 °C
3.1: hydrogenchloride / water; methanol / 20 °C
View Scheme

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