As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryOur own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin
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inquiryFactory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquirybulk?production Application:Pharmaceutical intermediates
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inquiryhome-produced Application:medicine
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquirywe have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survi
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inquiry1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume
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inquiryProduct name: (R)-methyl 3-amino-4-(2,4,5-trifluoro phenyl) butanoate Cas No: 881995-69-3 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast
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inquiryfactory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:c
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inquiryIn China, Chengdu Senior Pharma Technology Co., Ltd, known for its R & D capabilities and high-quality products, Senior Pharma has continuously develop new varieties. And also the R&D department can provides customized services ranging fro
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inquiryAs a professional chemical R&D and synthesis supplier, Shanghai Forever Synthesis Co.,Ltd. is specialized R&D and synthesizing APIs and Impurities. Besides, we value more special service, that is, to customize chemical synthesis according t
Cas:881995-69-3
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inquiryApeptide is a famous-peptide manufacturer in China,We supply high quality peptides(Custom Peptides\Amino acids\API pepitdes and so on )with the best competitive price and short lead time.,Please check our website: www.apeptides.com/en/Appearance:pow
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inquiryThe system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin
superior product, rigorous quality test, GMP management and auditable plant, stable supply in industry park, advantage in R&D CMO CROAppearance:white or off-white powder Storage:storage in norm temperature and against damp Package:Aluminum drum or fo
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inquiryHigh purity Application:Pharmaceutical intermediates, Material synthesis and analyzing the expectant ingredients
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inquirymethanol
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With Ru(OAc)2((R)-dm-Segphos); ammonium acetate; hydrogen; salicylic acid at 40 - 80℃; for 20h; Catalytic behavior; Temperature; Green chemistry; | 95.2% |
(R)-(-)-mandelic acid salt of (R)-methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With sodium carbonate In water pH=8 - 9; | 95% |
With sodium carbonate In water pH=8 - 9; | 90% |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer In 2,2,2-trifluoroethanol at 50℃; under 5171.62 Torr; for 40h; | 68% |
(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester
B
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; chiral ferrocenyl ligand; hydrogen In 2,2,2-trifluoroethanol at 40℃; under 10343 Torr; for 24h; |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / ammonium acetate / methanol / 7 h / Heating 2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / ammonium acetate / methanol / 2 h / Heating 2: [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / 2,2,2-trifluoro-ethanol / 24 h / 40 °C / 10343 Torr View Scheme | |
Multi-step reaction with 4 steps 1.1: ammonium acetate / methanol / 60 - 63 °C 2.1: sulfuric acid / methanol / -10 - 0 °C 2.2: 2 h / -10 - 0 °C 2.3: pH 8 - 9 3.1: isopropyl alcohol / 3 h / 25 - 30 °C 4.1: sodium carbonate / water / pH 8 - 9 View Scheme | |
With transaminase; pyridoxal 5'-phosphate; isopropylamine In water; dimethyl sulfoxide at 45℃; for 8h; Enzymatic reaction; |
(2,4,5-trifluorophenyl)acetic acid
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 95 percent / N,N-dimethylaminopyridine; N,N-diisopropylethylamine; trimethylacetylchloride / acetonitrile / 3 h / 45 °C 2: 88.7 percent / toluene / 3 h / Heating 3: 95 percent / ammonium acetate / methanol / 7 h / Heating 4: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / acetonitrile / 3.5 h 1.2: Et3N; MgCl2 / acetonitrile / 8 h / 50 °C 1.3: 84 percent / acetonitrile / 26 h / 30 °C 2.1: 91 percent / ammonium acetate / methanol / 2 h / Heating 3.1: [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / 2,2,2-trifluoro-ethanol / 24 h / 40 °C / 10343 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / acetonitrile / 3.5 h 1.2: Et3N; MgCl2 / acetonitrile / 8 h / 50 °C 1.3: acetonitrile / 26 h / 30 °C 2.1: 91 percent / ammonium acetate / methanol / 2 h / Heating 3.1: [Rh(COD)Cl]2; chiral ferrocenyl ligand; H2 / 2,2,2-trifluoro-ethanol / 24 h / 40 °C / 10343 Torr View Scheme |
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88.7 percent / toluene / 3 h / Heating 2: 95 percent / ammonium acetate / methanol / 7 h / Heating 3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr View Scheme | |
Multi-step reaction with 5 steps 1.1: 60 - 63 °C 2.1: ammonium acetate / methanol / 60 - 63 °C 3.1: sulfuric acid / methanol / -10 - 0 °C 3.2: 2 h / -10 - 0 °C 3.3: pH 8 - 9 4.1: isopropyl alcohol / 3 h / 25 - 30 °C 5.1: sodium carbonate / water / pH 8 - 9 View Scheme | |
Multi-step reaction with 2 steps 1: acetonitrile / 24 h / 80 - 84 °C / Inert atmosphere 2: salicylic acid; ammonium acetate; Ru(OAc)2((R)-dm-Segphos); hydrogen / 20 h / 40 - 80 °C / Green chemistry View Scheme |
3-(R)-[(R)-(α-methylbenzyl)benzylamino]-4-(2,4,5-trifluoro-phenyl)butyric acid methyl ester
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With 20 % Pd(OH)2/C; hydrogen In methanol at 20℃; under 3800.26 Torr; |
(R)-methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With sodium azide; triphenylphosphine In tetrachloromethane; N,N-dimethyl-formamide at 90℃; for 8h; |
(R)-methyl 3-(1,3-dioxoisoindolin-2-yl)-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With methylamine In water; toluene at 25 - 40℃; |
(R)-methyl 3-(p-toluenesulfonyloxy)-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With ammonia In methanol for 3h; Reflux; |
(2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid / methanol / -10 - 0 °C 1.2: 2 h / -10 - 0 °C 1.3: pH 8 - 9 2.1: isopropyl alcohol / 3 h / 25 - 30 °C 3.1: sodium carbonate / water / pH 8 - 9 View Scheme |
methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: isopropyl alcohol / 3 h / 25 - 30 °C 2: sodium carbonate / water / pH 8 - 9 View Scheme | |
Multi-step reaction with 2 steps 1: ethyl acetate / 1 h / 65 - 70 °C 2: sodium hydrogencarbonate / water View Scheme |
C11H12F3NO2*C14H19NO3
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water | 3 g |
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
A
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
B
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With pyridoxal 5'-phosphate; recombinant aminotransferase from Arthobacter sp.; water; isopropylamine In dimethyl sulfoxide at 45℃; for 8h; pH=8.5; Catalytic behavior; Concentration; Time; Enzymatic reaction; enantioselective reaction; |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In water at 50 - 115℃; | 3.1 g |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / 120 h / -30 - 20 °C 2: hydrogenchloride / water / 50 - 115 °C View Scheme |
2-(2,4,5-trifluorophenyl)ethanol
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; magnesium sulfate / dichloromethane / 24 h / -20 - 20 °C 2: sodium hydrogencarbonate / 120 h / -30 - 20 °C 3: hydrogenchloride / water / 50 - 115 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
di-tert-butyl dicarbonate
3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 3h; | 93% |
Stage #1: (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester With sodium hydroxide In tetrahydrofuran; water at 0℃; for 1h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water-d2 at 20℃; | 91.3% |
With triethylamine In dichloromethane at 20℃; for 8h; optical yield given as %ee; | 54.6 g |
With lithium hydroxide In tetrahydrofuran; water at 0 - 5℃; for 1.5h; |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
di-tert-butyl dicarbonate
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Stage #1: (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester; di-tert-butyl dicarbonate With triethylamine In ethyl acetate at 20 - 30℃; for 7h; Stage #2: With water; sodium hydroxide In ethanol at 20 - 30℃; for 2h; | 85.5% |
Stage #1: (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester With water; lithium hydroxide In tetrahydrofuran at 0 - 30℃; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 25 - 30℃; for 6h; Stage #3: With sodium hydrogen sulfate In water pH=2; | 80% |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
(R)-[3-oxo-3-pyrazolidin-1-yl-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
(R)-[3-oxo-3-(tetrahydropyridazin-1-yl)-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 4: 99 percent / HCl / ethyl acetate; dioxane / 16 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
(R)-[3-(2-benzoylcarbamoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 4: 85 percent / CH2Cl2 / 2 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
(R)-[3-oxo-3-(2-(toluene-4-sulfonyl)pyrazolidin-1-yl)-1-(2,4,5-trifluorbenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 4: 76 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
(R)-[3-(2-benzoylpyrazolidin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 4: 86 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
(R)-[3-(2-benzoyltetrahydropyridazin-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C 4: 99 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C 4: 84 percent / Et3N / CH2Cl2 / 3 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 4: 85 percent / CH2Cl2 / 2 h / 20 °C 5: 38 percent / HCl / ethyl acetate; dioxane / 12 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 4: 76 percent / Et3N / CH2Cl2 / 2 h / 20 °C 5: 51 percent / HCl / ethyl acetate; dioxane / 12 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 47 percent / EDCI; triethylamine / CH2Cl2 / 1 h / 20 °C 4: 86 percent / Et3N / CH2Cl2 / 2 h / 20 °C 5: 38 percent / HCl / ethyl acetate; dioxane / 12 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 66 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C 4: 99 percent / Et3N / CH2Cl2 / 2 h / 20 °C 5: 92 percent / HCl / ethyl acetate; dioxane / 12 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C 3: 90 percent / EDCI; triethylamine / CH2Cl2 / 12 h / 20 °C 4: 84 percent / Et3N / CH2Cl2 / 3 h / 20 °C 5: 75 percent / HCl / ethyl acetate; dioxane / 16 h / 20 °C View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / CH2Cl2 / 3 h / 20 °C 2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: water; lithium hydroxide / tetrahydrofuran / 0 - 30 °C 2.1: water; tetrahydrofuran / 6 h / 25 - 30 °C 2.2: pH 2 View Scheme |
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
sitagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: water; lithium hydroxide / tetrahydrofuran / 0 - 30 °C 2.1: water; tetrahydrofuran / 6 h / 25 - 30 °C 2.2: pH 2 3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 13 h / 0 - 30 °C 4.1: hydrogenchloride / methanol / 12 h / 25 - 45 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 0 °C 1.2: 20 °C 2.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1,2-dichloro-ethane / N,N-dimethyl-formamide / -15 - 20 °C 3.1: hydrogenchloride / water; methanol / 20 °C View Scheme |
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