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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Henan Tianfu Chemical Co., Ltd.

CAS No.936630-57-8 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher S

CAS No.936630-57-8 (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 936630-57-8 with best quality

Cas:936630-57-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid CAS936630-57-8

Cas:936630-57-8

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product Name (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid CAS No. 936630-57-8 Appearance

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:1 Gram

FOB Price: $6.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Benzenebutanoic acid, b-amino-2,4,5-trifluoro-, (bR)-/ LIDE PHARMA- Factory supply / Best price

Cas:936630-57-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

organic intermediates, (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid CAS:936630-57-8

Cas:936630-57-8

Min.Order:1 Kilogram

FOB Price: $38.0 / 42.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid CAS:936630-57-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializin

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid CAS:936630-57-8

Cas:936630-57-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid cas:936630-57-8

Cas:936630-57-8

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenebutanoic acid, b-amino-2,4,5-trifluoro-, (bR)-

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTYRIC ACID

Cas:936630-57-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzenebutanoic acid, b-amino-2,4,5-trifluoro-, (bR)-

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

we are reliable supplier for APIs and intermediates for international markets. We supply good quality with competitive price. We pursue long term business relations and win-win. Package:25kg/drum Application:Sitagliptin Phosphate in

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric?acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

highest purity most favorable priceAppearance:solid or liquid Storage:room temperature under 25℃ Package:drum or bag Application:for pharmaceutical Transportation:by sea and air

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Other

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butyric Acid

Cas:936630-57-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid 25g

Cas:936630-57-8

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

tert-butyl (R)-1-(Methoxycarbonyl)-3-(2,4,5-trifluorophenyl)propan-2-ylcarbaMate

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

Benzenebutanoic acid, b-amino-2,4,5-trifluoro-, (bR)-

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid CAS No.936630-57-8

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acidAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Other

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

Cas:936630-57-8

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C35H27Cl3F3N3NiO3

C35H27Cl3F3N3NiO3

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

(R)-N-(2-benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methyl]-2-pyrrolidinecarboxamide
1644308-43-9

(R)-N-(2-benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methyl]-2-pyrrolidinecarboxamide

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 50℃;A 85%
B 96%
(R)-3-benzoylamino-4-(2,4,5-trifluorophenyl)butanoic acid methyl ester
1402570-02-8

(R)-3-benzoylamino-4-(2,4,5-trifluorophenyl)butanoic acid methyl ester

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With hydrogenchloride In water Reflux;95%
(S)-methyl 3-(dibenzylamino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoate
1334630-72-6

(S)-methyl 3-(dibenzylamino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: (S)-methyl 3-(dibenzylamino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoate With palladium 10% on activated carbon; hydrogen In ethanol at 25℃; for 5h;
Stage #2: With hydrogenchloride; water pH=5 - 6;
93.2%
(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester
1151240-91-3

(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 27℃; for 6h; Reflux;92%
With lithium hydroxide pH=> 10;
(R)-3-((benzyloxy)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
767352-29-4

(R)-3-((benzyloxy)amino)-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 2068.65 Torr; for 12h;91%
C18H22F3NO5S

C18H22F3NO5S

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃; pH=1;91%
methyl (R)-3-(benzyloxyamino)-4-(2,4,5-trifluorophenyl)butanoate
868125-58-0

methyl (R)-3-(benzyloxyamino)-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: methyl N-benzyloxy-4-(2,4,5-trifluorophenyl)-3(R)-aminobutanoate With palladium on activated charcoal In chloroform for 6h; Autoclave;
Stage #2: With hydrogenchloride In water for 6h; pH=4; Reflux;
77%
ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
1151240-92-4

ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

(S)-ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
1151240-90-2

(S)-ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
With Burkholderia cepacia lipase; water In di-isopropyl ether at 45℃; for 120h; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;A 43%
B n/a
methyl (3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate (1S)-(+)-10-camphorsulfonic acid

methyl (3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate (1S)-(+)-10-camphorsulfonic acid

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; water for 24h;
(S)-1-(2,4,5-trifluorophenyl)pent-4-en-2-amine
1253056-05-1

(S)-1-(2,4,5-trifluorophenyl)pent-4-en-2-amine

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With sodium periodate; rhodium(III) chloride hydrate In acetonitrile at 12 - 20℃; for 2h;
(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate
1246961-45-4

(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 6h;
(2,4,5-trifluorophenyl)-magnesium bromide
502462-00-2

(2,4,5-trifluorophenyl)-magnesium bromide

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 2 h / 25 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 25 °C
2.2: pH 5 - 6
View Scheme
1-bromo-2,4,5-trifluorobenzene
327-52-6

1-bromo-2,4,5-trifluorobenzene

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere
2.1: 2 h / 25 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 25 °C
3.2: pH 5 - 6
View Scheme
2,4,5-trifluorobenzaldehyde
165047-24-5

2,4,5-trifluorobenzaldehyde

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium hydroxide; water / methanol; water / 0.5 h / Cooling with ice
2.1: sodium tetrahydroborate; isopropyl alcohol / chloroform / 0.5 h / 27 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C
4.1: iodine / 27 °C
5.1: basic alumina / dichloromethane / 2 h / 27 °C
6.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
6.2: polymethylhydrosiloxane (PMHS) / 17 h
6.3: 1 h
7.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydroxide; water / methanol; water / 0.5 h / Cooling with ice
2.1: sodium tetrahydroborate; isopropyl alcohol / chloroform / 0.5 h / 27 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C
4.1: iodine / 27 °C
5.1: basic alumina / dichloromethane / 2 h / 27 °C
6.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
6.2: polymethylhydrosiloxane (PMHS) / 17 h
6.3: 1 h
7.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr
8.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
3-(2,4,5-trifluorophenyl)nitroethane

3-(2,4,5-trifluorophenyl)nitroethane

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C
2.1: iodine / 27 °C
3.1: basic alumina / dichloromethane / 2 h / 27 °C
4.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
4.2: polymethylhydrosiloxane (PMHS) / 17 h
4.3: 1 h
5.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C
2.1: iodine / 27 °C
3.1: basic alumina / dichloromethane / 2 h / 27 °C
4.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
4.2: polymethylhydrosiloxane (PMHS) / 17 h
4.3: 1 h
5.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr
6.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
1,2,4-trifluoro-5-(2-nitrovinyl)-benzene
913623-45-7

1,2,4-trifluoro-5-(2-nitrovinyl)-benzene

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate; isopropyl alcohol / chloroform / 0.5 h / 27 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C
3.1: iodine / 27 °C
4.1: basic alumina / dichloromethane / 2 h / 27 °C
5.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
5.2: polymethylhydrosiloxane (PMHS) / 17 h
5.3: 1 h
6.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate; isopropyl alcohol / chloroform / 0.5 h / 27 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C
3.1: iodine / 27 °C
4.1: basic alumina / dichloromethane / 2 h / 27 °C
5.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
5.2: polymethylhydrosiloxane (PMHS) / 17 h
5.3: 1 h
6.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr
7.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
2-hydroxy-3-nitro-4-(2,4,5-trifluoro-phenyl)butyric acid ethyl ester

2-hydroxy-3-nitro-4-(2,4,5-trifluoro-phenyl)butyric acid ethyl ester

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: iodine / 27 °C
2.1: basic alumina / dichloromethane / 2 h / 27 °C
3.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
3.2: polymethylhydrosiloxane (PMHS) / 17 h
3.3: 1 h
4.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: iodine / 27 °C
2.1: basic alumina / dichloromethane / 2 h / 27 °C
3.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
3.2: polymethylhydrosiloxane (PMHS) / 17 h
3.3: 1 h
4.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr
5.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
2-acetoxy-3-nitro-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester

2-acetoxy-3-nitro-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: basic alumina / dichloromethane / 2 h / 27 °C
2.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
2.2: polymethylhydrosiloxane (PMHS) / 17 h
2.3: 1 h
3.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: basic alumina / dichloromethane / 2 h / 27 °C
2.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
2.2: polymethylhydrosiloxane (PMHS) / 17 h
2.3: 1 h
3.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr
4.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
3-nitro-4-(2,4,5-trifluorophenyl)but-2-enoic acid ethyl ester

3-nitro-4-(2,4,5-trifluorophenyl)but-2-enoic acid ethyl ester

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h
1.2: polymethylhydrosiloxane (PMHS) / 17 h
1.3: 1 h
2.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr
3.1: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
3-nitro-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester

3-nitro-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr
2: hydrogenchloride / water / 6 h / 27 °C / Reflux
View Scheme
3-oxo-4-(2,4,5-trifluorophenyl)-butyric acid ethyl ester
1151240-88-8

3-oxo-4-(2,4,5-trifluorophenyl)-butyric acid ethyl ester

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester
1151240-91-3

(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester

Conditions
ConditionsYield
With pyridoxal 5'-phosphate; recombinant aminotransferase from Arthobacter sp.; water; isopropylamine In dimethyl sulfoxide at 45℃; for 8h; pH=8.5; Catalytic behavior; Concentration; Time; Enzymatic reaction; Overall yield = 95.87 %Chromat.; enantioselective reaction;A 34.48 %Chromat.
B n/a
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid propyl ester

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid propyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C
1.2: 0.5 h / 0 °C
2.1: toluene / 3 h / 100 °C
3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction
View Scheme
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

butyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

butyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C
1.2: 0.5 h / 0 °C
2.1: toluene / 3 h / 100 °C
3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction
View Scheme
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

isopropyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

isopropyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C
1.2: 0.5 h / 0 °C
2.1: toluene / 3 h / 100 °C
3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction
View Scheme
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

benzyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

benzyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C
1.2: 0.5 h / 0 °C
2.1: toluene / 3 h / 100 °C
3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction
View Scheme
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

2-hydroxyethyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

2-hydroxyethyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C
1.2: 0.5 h / 0 °C
2.1: 3 h / 100 °C
3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction
View Scheme
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester
1151240-91-3

(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C
1.2: 0.5 h / 0 °C
2.1: toluene / 3 h / 100 °C
3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid propyl ester

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid propyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 3 h / 100 °C
2: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

A

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

B

butyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

butyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 3 h / 100 °C
2: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction
View Scheme
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride
1204818-19-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol optical yield given as %ee;100%
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

C14H13F3N2O4

C14H13F3N2O4

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 2h; Reflux;95%
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃;91%
Stage #1: (R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid With lithium hydroxide In 1,4-dioxane; water at 0 - 30℃;
Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 25 - 30℃;
91%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 24h;91%
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
486460-21-3

3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

sitagliptin
486460-32-6

sitagliptin

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol In ethanol; dichloromethane at 10 - 25℃; for 3h;86%
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

C25H26F6N2O5

C25H26F6N2O5

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 20 - 30℃; Reagent/catalyst;70%
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

sitagliptin
486460-32-6

sitagliptin

C26H23F9N6O2

C26H23F9N6O2

Conditions
ConditionsYield
With dmap; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 80 - 90℃; for 24h;65%
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C20H26F3NO6

C20H26F3NO6

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 5h;60%
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

C7H14N2O

C7H14N2O

A

C17H22F3O2N3

C17H22F3O2N3

B

C17H22F3O2N3

C17H22F3O2N3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

C15H22N2O2

C15H22N2O2

A

C25H30F3O3N3

C25H30F3O3N3

B

C25H30F3O3N3

C25H30F3O3N3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

C8H13N2OF3

C8H13N2OF3

A

C18H21F6O2N3

C18H21F6O2N3

B

C18H21F6O2N3

C18H21F6O2N3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

1-tert-butyl-1,4-diazepan-2-one

1-tert-butyl-1,4-diazepan-2-one

A

C20H28F3O2N3

C20H28F3O2N3

B

C20H28F3O2N3

C20H28F3O2N3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

C9H16N2O
842104-09-0

C9H16N2O

A

C19H24N3O2F3

C19H24N3O2F3

B

C19H24N3O2F3

C19H24N3O2F3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

C7H14N2O
842103-96-2

C7H14N2O

C17H22N3O2F3

C17H22N3O2F3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

C7H14N2O
842103-82-6

C7H14N2O

C17H22N3O2F3

C17H22N3O2F3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

C7H14N2O

C7H14N2O

C17H22N3O2F3

C17H22N3O2F3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

C9H16N2O

C9H16N2O

A

C19H24F3O2N3

C19H24F3O2N3

B

C19H24F3O2N3

C19H24F3O2N3

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

((R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)-butanoyl]-3-(t-butoxymethyl)piperazin-2-one)

((R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)-butanoyl]-3-(t-butoxymethyl)piperazin-2-one)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / methanol / 6 h / 0 - 20 °C
2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.17 h / 0 °C
2.2: 1 h / 0 °C
3.1: hydrogenchloride; sodium hydrogencarbonate / dichloromethane; isopropyl alcohol
View Scheme
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

(R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(t-butoxymethyl)piperazin-2-one L-tartrate

(R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(t-butoxymethyl)piperazin-2-one L-tartrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / methanol / 6 h / 0 - 20 °C
2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.17 h / 0 °C
2.2: 1 h / 0 °C
3.1: hydrogenchloride; sodium hydrogencarbonate / dichloromethane; isopropyl alcohol
4.1: isopropyl alcohol; ethanol; water; acetone / 0.5 h
View Scheme
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

t-butyl (R)-4-[(R)-2-(t-butoxymethyl)-3-oxopiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

t-butyl (R)-4-[(R)-2-(t-butoxymethyl)-3-oxopiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / methanol / 6 h / 0 - 20 °C
2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.17 h / 0 °C
2.2: 1 h / 0 °C
View Scheme

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