Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:936630-57-8
Min.Order:1 Kilogram
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inquiryCAS No.936630-57-8 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher S
Cas:936630-57-8
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:936630-57-8
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:936630-57-8
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inquiryProduct Description Product Name (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid CAS No. 936630-57-8 Appearance
Cas:936630-57-8
Min.Order:1 Gram
FOB Price: $6.0
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:936630-57-8
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:936630-57-8
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:936630-57-8
Min.Order:1 Kilogram
FOB Price: $38.0 / 42.0
Type:Trading Company
inquiry(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid CAS:936630-57-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializin
Cas:936630-57-8
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:936630-57-8
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:936630-57-8
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:936630-57-8
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:936630-57-8
Min.Order:10 Gram
FOB Price: $100.0
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inquirywe are reliable supplier for APIs and intermediates for international markets. We supply good quality with competitive price. We pursue long term business relations and win-win. Package:25kg/drum Application:Sitagliptin Phosphate in
Cas:936630-57-8
Min.Order:1 Kilogram
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai
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inquiryhighest purity most favorable priceAppearance:solid or liquid Storage:room temperature under 25℃ Package:drum or bag Application:for pharmaceutical Transportation:by sea and air
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inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
Cas:936630-57-8
Min.Order:100 Gram
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inquiryAcmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
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Min.Order:1 bottle
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Type:Lab/Research institutions
inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
Cas:936630-57-8
Min.Order:0
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Type:Manufacturers
inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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Type:Manufacturers
inquiryOur own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin
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Type:Lab/Research institutions
inquiryFactory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquiry(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acidAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
Cas:936630-57-8
Min.Order:0
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Type:Other
inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:936630-57-8
Min.Order:0
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Type:Other
inquirybulk?production Application:Pharmaceutical intermediates
Cas:936630-57-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:936630-57-8
Min.Order:0
Negotiable
Type:Trading Company
inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
Cas:936630-57-8
Min.Order:0
Negotiable
Type:Trading Company
inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:936630-57-8
Min.Order:10 Milligram
Negotiable
Type:Lab/Research institutions
inquiryA
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
B
(R)-N-(2-benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methyl]-2-pyrrolidinecarboxamide
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol at 50℃; | A 85% B 96% |
(R)-3-benzoylamino-4-(2,4,5-trifluorophenyl)butanoic acid methyl ester
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water Reflux; | 95% |
(S)-methyl 3-(dibenzylamino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Stage #1: (S)-methyl 3-(dibenzylamino)-4-oxo-4-(2,4,5-trifluorophenyl)butanoate With palladium 10% on activated carbon; hydrogen In ethanol at 25℃; for 5h; Stage #2: With hydrogenchloride; water pH=5 - 6; | 93.2% |
(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water at 27℃; for 6h; Reflux; | 92% |
With lithium hydroxide pH=> 10; |
(R)-3-((benzyloxy)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 2068.65 Torr; for 12h; | 91% |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 20℃; pH=1; | 91% |
methyl (R)-3-(benzyloxyamino)-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Stage #1: methyl N-benzyloxy-4-(2,4,5-trifluorophenyl)-3(R)-aminobutanoate With palladium on activated charcoal In chloroform for 6h; Autoclave; Stage #2: With hydrogenchloride In water for 6h; pH=4; Reflux; | 77% |
ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
B
(S)-ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate
Conditions | Yield |
---|---|
With Burkholderia cepacia lipase; water In di-isopropyl ether at 45℃; for 120h; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantioselective reaction; | A 43% B n/a |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With lithium hydroxide In tetrahydrofuran; water for 24h; |
(S)-1-(2,4,5-trifluorophenyl)pent-4-en-2-amine
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With sodium periodate; rhodium(III) chloride hydrate In acetonitrile at 12 - 20℃; for 2h; |
(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane for 6h; |
(2,4,5-trifluorophenyl)-magnesium bromide
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 2 h / 25 °C / Inert atmosphere 2.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 25 °C 2.2: pH 5 - 6 View Scheme |
1-bromo-2,4,5-trifluorobenzene
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere 2.1: 2 h / 25 °C / Inert atmosphere 3.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 25 °C 3.2: pH 5 - 6 View Scheme |
2,4,5-trifluorobenzaldehyde
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium hydroxide; water / methanol; water / 0.5 h / Cooling with ice 2.1: sodium tetrahydroborate; isopropyl alcohol / chloroform / 0.5 h / 27 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C 4.1: iodine / 27 °C 5.1: basic alumina / dichloromethane / 2 h / 27 °C 6.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 6.2: polymethylhydrosiloxane (PMHS) / 17 h 6.3: 1 h 7.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme | |
Multi-step reaction with 8 steps 1.1: sodium hydroxide; water / methanol; water / 0.5 h / Cooling with ice 2.1: sodium tetrahydroborate; isopropyl alcohol / chloroform / 0.5 h / 27 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C 4.1: iodine / 27 °C 5.1: basic alumina / dichloromethane / 2 h / 27 °C 6.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 6.2: polymethylhydrosiloxane (PMHS) / 17 h 6.3: 1 h 7.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr 8.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C 2.1: iodine / 27 °C 3.1: basic alumina / dichloromethane / 2 h / 27 °C 4.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 4.2: polymethylhydrosiloxane (PMHS) / 17 h 4.3: 1 h 5.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme | |
Multi-step reaction with 6 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C 2.1: iodine / 27 °C 3.1: basic alumina / dichloromethane / 2 h / 27 °C 4.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 4.2: polymethylhydrosiloxane (PMHS) / 17 h 4.3: 1 h 5.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr 6.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme |
1,2,4-trifluoro-5-(2-nitrovinyl)-benzene
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium tetrahydroborate; isopropyl alcohol / chloroform / 0.5 h / 27 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C 3.1: iodine / 27 °C 4.1: basic alumina / dichloromethane / 2 h / 27 °C 5.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 5.2: polymethylhydrosiloxane (PMHS) / 17 h 5.3: 1 h 6.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium tetrahydroborate; isopropyl alcohol / chloroform / 0.5 h / 27 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 27 °C 3.1: iodine / 27 °C 4.1: basic alumina / dichloromethane / 2 h / 27 °C 5.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 5.2: polymethylhydrosiloxane (PMHS) / 17 h 5.3: 1 h 6.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr 7.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: iodine / 27 °C 2.1: basic alumina / dichloromethane / 2 h / 27 °C 3.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 3.2: polymethylhydrosiloxane (PMHS) / 17 h 3.3: 1 h 4.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme | |
Multi-step reaction with 5 steps 1.1: iodine / 27 °C 2.1: basic alumina / dichloromethane / 2 h / 27 °C 3.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 3.2: polymethylhydrosiloxane (PMHS) / 17 h 3.3: 1 h 4.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr 5.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: basic alumina / dichloromethane / 2 h / 27 °C 2.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 2.2: polymethylhydrosiloxane (PMHS) / 17 h 2.3: 1 h 3.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: basic alumina / dichloromethane / 2 h / 27 °C 2.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 2.2: polymethylhydrosiloxane (PMHS) / 17 h 2.3: 1 h 3.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr 4.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: copper (II)-fluoride; 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine / toluene / 1 h 1.2: polymethylhydrosiloxane (PMHS) / 17 h 1.3: 1 h 2.1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr 3.1: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / ethyl acetate / 5 h / 27 °C / 2585.81 Torr 2: hydrogenchloride / water / 6 h / 27 °C / Reflux View Scheme |
3-oxo-4-(2,4,5-trifluorophenyl)-butyric acid ethyl ester
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
B
(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester
Conditions | Yield |
---|---|
With pyridoxal 5'-phosphate; recombinant aminotransferase from Arthobacter sp.; water; isopropylamine In dimethyl sulfoxide at 45℃; for 8h; pH=8.5; Catalytic behavior; Concentration; Time; Enzymatic reaction; Overall yield = 95.87 %Chromat.; enantioselective reaction; | A 34.48 %Chromat. B n/a |
(2,4,5-trifluorophenyl)acetic acid
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C 1.2: 0.5 h / 0 °C 2.1: toluene / 3 h / 100 °C 3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction View Scheme |
(2,4,5-trifluorophenyl)acetic acid
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C 1.2: 0.5 h / 0 °C 2.1: toluene / 3 h / 100 °C 3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction View Scheme |
(2,4,5-trifluorophenyl)acetic acid
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C 1.2: 0.5 h / 0 °C 2.1: toluene / 3 h / 100 °C 3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction View Scheme |
(2,4,5-trifluorophenyl)acetic acid
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C 1.2: 0.5 h / 0 °C 2.1: toluene / 3 h / 100 °C 3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction View Scheme |
(2,4,5-trifluorophenyl)acetic acid
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C 1.2: 0.5 h / 0 °C 2.1: 3 h / 100 °C 3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction View Scheme |
(2,4,5-trifluorophenyl)acetic acid
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
B
(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap; N-ethyl-N,N-diisopropylamine; pivaloyl chloride / acetonitrile / 20 - 45 °C 1.2: 0.5 h / 0 °C 2.1: toluene / 3 h / 100 °C 3.1: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction View Scheme |
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene / 3 h / 100 °C 2: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction View Scheme |
A
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene / 3 h / 100 °C 2: water; recombinant aminotransferase from Arthobacter sp.; pyridoxal 5'-phosphate; isopropylamine / dimethyl sulfoxide / 8 h / 45 °C / pH 8.5 / Enzymatic reaction View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol optical yield given as %ee; | 100% |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
1-hydroxy-pyrrolidine-2,5-dione
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 2h; Reflux; | 95% |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
di-tert-butyl dicarbonate
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water at 20℃; | 91% |
Stage #1: (R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid With lithium hydroxide In 1,4-dioxane; water at 0 - 30℃; Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 25 - 30℃; | 91% |
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 24h; | 91% |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
sitagliptin
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol In ethanol; dichloromethane at 10 - 25℃; for 3h; | 86% |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 20 - 30℃; Reagent/catalyst; | 70% |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
sitagliptin
Conditions | Yield |
---|---|
With dmap; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 80 - 90℃; for 24h; | 65% |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
di-tert-butyl dicarbonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 5h; | 60% |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
C9H16N2O
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
C7H14N2O
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
C7H14N2O
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydrogencarbonate / methanol / 6 h / 0 - 20 °C 2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.17 h / 0 °C 2.2: 1 h / 0 °C 3.1: hydrogenchloride; sodium hydrogencarbonate / dichloromethane; isopropyl alcohol View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydrogencarbonate / methanol / 6 h / 0 - 20 °C 2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.17 h / 0 °C 2.2: 1 h / 0 °C 3.1: hydrogenchloride; sodium hydrogencarbonate / dichloromethane; isopropyl alcohol 4.1: isopropyl alcohol; ethanol; water; acetone / 0.5 h View Scheme |
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydrogencarbonate / methanol / 6 h / 0 - 20 °C 2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.17 h / 0 °C 2.2: 1 h / 0 °C View Scheme |
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