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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc

High Quality BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID 486460-00-8 Manufacturer

Cas:486460-00-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hangzhou Maytime Bio-Tech Co.,Ltd.

We are Top manufacturer for below Sitagliptin intermediates with high quality and competitive price. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid CAS:486460-00-8 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

Sitagliptin intermediate CAS:486460-00-8

Cas:486460-00-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Top Quality 99.9% up Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate 486460-00-8

Cas:486460-00-8

Min.Order:2 Kilogram

FOB Price: $55.0 / 200.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid[CAS:486460-00-8] Sitagliptin Butyric Acid 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride[CAS:762240-92-6] HANGZHOU THINK CHEMICAL CO., LTD. (THINKC

High purity Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Cas:486460-00-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Manufacturer/High quality/Best price/In stock

Cas:486460-00-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid supplier in China

Cas:486460-00-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/220.html Product Name Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Cas:486460-00-8

Min.Order:1 Gram

FOB Price: $22.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid Cas 486460-00-8 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid Cas 486460-00-8

Cas:486460-00-8

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid

Cas:486460-00-8

Min.Order:10000 Gram

FOB Price: $1300.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai

486460-00-8 BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID

Cas:486460-00-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid

Cas:486460-00-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID

Cas:486460-00-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Cas:486460-00-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

tert-Butoxycarbonyl-(R)-3-amino-4-(2,4,5-trifluorophenyl)-butanoic acid

Cas:486460-00-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Cas:486460-00-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Basic information Product Name: BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Synonyms: BOC-(R)-3-AMINO-4-(2,4,5-TRI

486460-00-8

Cas:486460-00-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID

Cas:486460-00-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 486460-00-8 with competitive price

Cas:486460-00-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:25kg/drum Application:Sitagliptin intermediate Transportation:Express/Sea/Air Port:Any port in china

Sitagliptin intermediate Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Cas:486460-00-8

Min.Order:1 Kilogram

FOB Price: $330.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID CAS NO 486460-00-8

Cas:486460-00-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid 486460-00-8

Cas:486460-00-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

Sitagliptin: (R)-3-(tert-butoxycarbonyl)-4-(2,4,5-trifluorophenyl)butanoic acid

Cas:486460-00-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID CAS:486460-00-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speci

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID CAS:486460-00-8

Cas:486460-00-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID

Cas:486460-00-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Sitagliptin interMediate Boc- -3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Cas:486460-00-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid cas:486460-00-8

Cas:486460-00-8

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Cas:486460-00-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-73-9

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 3h;99%
With lithium hydroxide monohydrate; water In tetrahydrofuran for 16h;95.1%
Stage #1: 3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester With water; lithium hydroxide In methanol at 20℃; for 24h;
Stage #2: With hydrogenchloride In water; ethyl acetate
95%
C15H16F3NO4

C15H16F3NO4

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With palladium on carbon; hydrogen In methanol for 24h;99%
(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
1048703-14-5

(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With sodium hypochlorite; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In water; acetonitrile at 38℃; for 0.333333h; Solvent;98%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide In dichloromethane at 0℃; for 2h;90%
Stage #1: (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide In dichloromethane at 0℃; for 2h;
Stage #2: With hydrogenchloride In dichloromethane; water pH=2 - 3;
90%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical90%
(R)-3-tertbutoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester
1152439-74-1

(R)-3-tertbutoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With lithium hydroxide monohydrate In methanol; water at 30 - 40℃;95%
Stage #1: (R)-3-tertbutoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester With water; sodium hydroxide In methanol at 40 - 45℃; for 2h;
Stage #2: In methanol; water pH=3; Acidic conditions;
Stage #1: (R)-3-tertbutoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester With sodium hydroxide In methanol; water at 40 - 45℃; for 2h;
Stage #2: In methanol; water pH=3;
[3-diazo-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester
486460-25-7

[3-diazo-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With silver benzoate In 1,4-dioxane; water for 1.5h; Sonication;94%
With silver benzoate In 1,4-dioxane at 20℃; for 2h; sonication;401 mg
With silver benzoate In 1,4-dioxane; water for 2h; Sonographic reaction;
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
936630-57-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃;91%
Stage #1: (R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid With lithium hydroxide In 1,4-dioxane; water at 0 - 30℃;
Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 25 - 30℃;
91%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 24h;91%
(R)-cyclohexyl 3-(tert-butoxycarbonyl amino)-4-(2,4,5-trifluorophenyl)butyrate
1276113-61-1

(R)-cyclohexyl 3-(tert-butoxycarbonyl amino)-4-(2,4,5-trifluorophenyl)butyrate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: (R)-cyclohexyl 3-(tert-butoxycarbonyl amino)-4-(2,4,5-trifluorophenyl)butyrate With water; potassium carbonate at 60℃; for 3h;
Stage #2: With hydrogenchloride; water at 20 - 30℃; for 2h;
90%
Stage #1: (R)-cyclohexyl 3-(tert-butoxycarbonyl amino)-4-(2,4,5-trifluorophenyl)butyrate With potassium carbonate In water at 60℃; for 3h;
Stage #2: With hydrogenchloride In water at 20 - 30℃; for 2h;
90%
C16H20F3NO2

C16H20F3NO2

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With potassium permanganate In acetone at 20℃; for 3h; Concentration;89%
With ruthenium trichloride; sodium periodate In water; acetonitrile at -10℃; for 2h;70%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(R)-3-((R)-1-phenylethylamino)-4-(2,4,5-trifluorophenyl)-N-phenyl butanamide

(R)-3-((R)-1-phenylethylamino)-4-(2,4,5-trifluorophenyl)-N-phenyl butanamide

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: (R)-3-((R)-1-phenylethylamino)-4-(2,4,5-trifluorophenyl)-N-phenyl butanamide With 5%-palladium/activated carbon; hydrogen In methanol at 70℃; under 6000.6 Torr;
Stage #2: With hydrogenchloride; water In methanol at 90℃;
Stage #3: di-tert-butyl dicarbonate In tetrahydrofuran; water at 10 - 20℃; for 20h;
88%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

diethyl 2-((R)-1-((R)-1,1-dimethylethylsulfinamido)-2-(2,4,5-trifluorophenyl)ethyl)malonate

diethyl 2-((R)-1-((R)-1,1-dimethylethylsulfinamido)-2-(2,4,5-trifluorophenyl)ethyl)malonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: diethyl 2-((R)-1-((R)-1,1-dimethylethylsulfinamido)-2-(2,4,5-trifluorophenyl)ethyl)malonate With hydrogenchloride In water for 18h; Reflux;
Stage #2: di-tert-butyl dicarbonate With sodium hydroxide In water at 20℃; pH=8;
88%
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester; di-tert-butyl dicarbonate With triethylamine In ethyl acetate at 20 - 30℃; for 7h;
Stage #2: With water; sodium hydroxide In ethanol at 20 - 30℃; for 2h;
85.5%
Stage #1: (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester With water; lithium hydroxide In tetrahydrofuran at 0 - 30℃;
Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 25 - 30℃; for 6h;
Stage #3: With sodium hydrogen sulfate In water pH=2;
80%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

di-tert-butyl 2-((R)-1-((R)-1,1-dimethylethylsulfinamido)-2-(2,4,5-trifluorophenyl)ethyl)malonate

di-tert-butyl 2-((R)-1-((R)-1,1-dimethylethylsulfinamido)-2-(2,4,5-trifluorophenyl)ethyl)malonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: di-tert-butyl 2-((R)-1-((R)-1,1-dimethylethylsulfinamido)-2-(2,4,5-trifluorophenyl)ethyl)malonate With hydrogenchloride In water for 9h; Reflux;
Stage #2: di-tert-butyl dicarbonate With sodium hydroxide In water at 20℃;
83%
(R)-tert-butyl (1-cyano-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate
1246960-23-5

(R)-tert-butyl (1-cyano-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 75 - 85℃;81%
With dihydrogen peroxide; sodium hydroxide In water at 100℃; for 3h;75%
Stage #1: (R)-tert-butyl (1-cyano-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate With potassium hydroxide In ethanol; water at 80℃; for 12h;
Stage #2: With oxalic acid In ethanol; water at 20℃;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C19H16F3NO5

C19H16F3NO5

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: C19H16F3NO5 With hydrogenchloride; palladium on activated charcoal; hydrogen In diethyl ether; ethanol at 20℃; for 10h;
Stage #2: With hydrogenchloride In diethyl ether; ethanol for 0.5h; Reflux;
Stage #3: di-tert-butyl dicarbonate With lithium hydroxide In tetrahydrofuran; diethyl ether; ethanol at 20℃; for 8h;
66%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2-hydroxyethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

2-hydroxyethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: 2-hydroxyethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate With pyridoxal 5'-phosphate; recombinant aminotransferase from Arthobacter sp.; water; isopropylamine In dimethyl sulfoxide at 45℃; for 24h; Green chemistry; Enzymatic reaction;
Stage #2: With lithium hydroxide In dimethyl sulfoxide at 45℃; for 3h; Green chemistry;
Stage #3: di-tert-butyl dicarbonate In tetrahydrofuran; dimethyl sulfoxide at 35℃; Green chemistry; enantioselective reaction;
60.6%
C11H10F3NO3

C11H10F3NO3

tert-butyl alcohol
75-65-0

tert-butyl alcohol

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With bromine; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 50℃; Hofmann Rearrangement; enantioselective reaction;55%
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
769195-26-8

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / ammonium acetate / methanol / 7 h / Heating
2: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
3: 93 percent / CH2Cl2 / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: ammonium acetate / methanol / 60 - 63 °C
2.1: sulfuric acid / methanol / -10 - 0 °C
2.2: 2 h / -10 - 0 °C
2.3: pH 8 - 9
3.1: isopropyl alcohol / 3 h / 25 - 30 °C
4.1: sodium carbonate / water / pH 8 - 9
5.1: water; lithium hydroxide / tetrahydrofuran / 0 - 30 °C
6.1: water; tetrahydrofuran / 6 h / 25 - 30 °C
6.2: pH 2
View Scheme
Multi-step reaction with 4 steps
1: acetic acid / methanol / Reflux; Large scale
2: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 1.5 h / -78 - 0 °C / Large scale
3: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 25 °C
4: lithium hydroxide monohydrate / methanol; water / 30 - 40 °C
View Scheme
(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
881995-69-3

(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / CH2Cl2 / 3 h / 20 °C
2: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: water; lithium hydroxide / tetrahydrofuran / 0 - 30 °C
2.1: water; tetrahydrofuran / 6 h / 25 - 30 °C
2.2: pH 2
View Scheme
methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
2: 93 percent / CH2Cl2 / 3 h / 20 °C
3: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
(2,4,5-trifluorophenyl)acetic acid
209995-38-0

(2,4,5-trifluorophenyl)acetic acid

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / N,N-dimethylaminopyridine; N,N-diisopropylethylamine; trimethylacetylchloride / acetonitrile / 3 h / 45 °C
2: 88.7 percent / toluene / 3 h / Heating
3: 95 percent / ammonium acetate / methanol / 7 h / Heating
4: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
5: 93 percent / CH2Cl2 / 3 h / 20 °C
6: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 50 °C
2.1: ethanol / 3 h / 70 °C
3.1: formic acid / ethanol / 3 h / Reflux
3.2: 2 h / 40 °C / Reflux
4.1: methanol / Reflux
5.1: sodium carbonate / water; methanol / 3 h / 30 °C / pH 10
6.1: sodium hydroxide; water / methanol / 2 h / 40 - 45 °C
6.2: pH 3 / Acidic conditions
View Scheme
Multi-step reaction with 8 steps
1.1: 1,1'-carbonyldiimidazole
1.2: 3 h / 50 °C
2.1: 3 h / 70 °C
3.1: ethanol / 3 h / Reflux
4.1: ethanol; sodium cyanoborohydride / 2 h / 40 °C / Reflux
5.1: methanol / Reflux
6.1: Basic conditions
7.1: sodium carbonate / water; methanol / 3 h / 30 °C / pH 10
8.1: sodium hydroxide / water; methanol / 2 h / 40 - 45 °C
8.2: pH 3
View Scheme
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
764667-64-3

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 88.7 percent / toluene / 3 h / Heating
2: 95 percent / ammonium acetate / methanol / 7 h / Heating
3: 68 percent / H2; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr
4: 93 percent / CH2Cl2 / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 60 - 63 °C
2.1: ammonium acetate / methanol / 60 - 63 °C
3.1: sulfuric acid / methanol / -10 - 0 °C
3.2: 2 h / -10 - 0 °C
3.3: pH 8 - 9
4.1: isopropyl alcohol / 3 h / 25 - 30 °C
5.1: sodium carbonate / water / pH 8 - 9
6.1: water; lithium hydroxide / tetrahydrofuran / 0 - 30 °C
7.1: water; tetrahydrofuran / 6 h / 25 - 30 °C
7.2: pH 2
View Scheme
Multi-step reaction with 3 steps
1.1: acetonitrile / 24 h / 80 - 84 °C / Inert atmosphere
2.1: salicylic acid; ammonium acetate; Ru(OAc)2((R)-dm-Segphos); hydrogen / 20 h / 40 - 80 °C / Green chemistry
3.1: triethylamine / ethyl acetate / 7 h / 20 - 30 °C
3.2: 2 h / 20 - 30 °C
View Scheme
Multi-step reaction with 7 steps
1.1: toluene / Reflux
2.1: ammonium acetate / acetonitrile / Reflux
3.1: N-tert-butylaminoborane / tetrahydrofuran / 20 °C
3.2: 8 h / 0 - 20 °C
4.1: acetonitrile; water / 0.5 h / Reflux
5.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h
6.1: palladium on activated charcoal; hydrogen / methanol / 25 - 30 °C
7.1: sodium carbonate / tetrahydrofuran; water / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1: acetonitrile / 65 °C
2: sodium tetrahydroborate; ethanol / 65 °C / Cooling with ice
3: hydrogenchloride / methanol / 20 °C / pH 1
4: sodium hydrogencarbonate / tetrahydrofuran; water / 24 h / 20 °C
View Scheme
methyl (3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate (1S)-(+)-10-camphorsulfonic acid

methyl (3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate (1S)-(+)-10-camphorsulfonic acid

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiOH*H2O / tetrahydrofuran; H2O / 24 h
2: 14 g / LiOH*H2O / tetrahydrofuran; H2O / 12 h / 20 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1.) NaH; 2.) SOCl2

1.) NaH; 2.) SOCl2

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aq. HCl / acetonitrile / 72 h / 20 °C
1.2: 2.41 g / triethylamine / CH2Cl2 / 16 h / 20 °C
2.1: aq. LiOH / tetrahydrofuran / 20 °C
3.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C
3.2: 0.36 g / diethyl ether / 1 h
4.1: 401 mg / aq. silver benzoate / dioxane / 2 h / 20 °C / sonication
View Scheme
2,4,5-trifluorobenzyl bromide
157911-56-3

2,4,5-trifluorobenzyl bromide

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: n-BuLi / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / -78 °C
2.1: aq. HCl / acetonitrile / 72 h / 20 °C
2.2: 2.41 g / triethylamine / CH2Cl2 / 16 h / 20 °C
3.1: aq. LiOH / tetrahydrofuran / 20 °C
4.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C
4.2: 0.36 g / diethyl ether / 1 h
5.1: 401 mg / aq. silver benzoate / dioxane / 2 h / 20 °C / sonication
View Scheme
(R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoate
486460-08-6

(R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aq. LiOH / tetrahydrofuran / 20 °C
2.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C
2.2: 0.36 g / diethyl ether / 1 h
3.1: 401 mg / aq. silver benzoate / dioxane / 2 h / 20 °C / sonication
View Scheme
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine
486460-07-5

(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aq. HCl / acetonitrile / 72 h / 20 °C
1.2: 2.41 g / triethylamine / CH2Cl2 / 16 h / 20 °C
2.1: aq. LiOH / tetrahydrofuran / 20 °C
3.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C
3.2: 0.36 g / diethyl ether / 1 h
4.1: 401 mg / aq. silver benzoate / dioxane / 2 h / 20 °C / sonication
View Scheme
(R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid
486460-09-7

(R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C
1.2: 0.36 g / diethyl ether / 1 h
2.1: 401 mg / aq. silver benzoate / dioxane / 2 h / 20 °C / sonication
View Scheme
Multi-step reaction with 2 steps
1.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C
1.2: 1 h / -20 °C
2.1: silver benzoate / water; 1,4-dioxane / 1.5 h / Sonication
View Scheme
Multi-step reaction with 2 steps
1.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C
1.2: 1 h / -20 °C
2.1: silver benzoate / 1,4-dioxane; water / 2 h
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride
1204818-19-8

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran at 0 - 20℃;
3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyric acid ethyl ester

3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyric acid ethyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: 3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyric acid ethyl ester With water; sodium hydroxide In methanol at 40 - 45℃;
Stage #2: With hydrogenchloride In water pH=2 - 3; Cooling with ice;
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
762240-92-6

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
486460-23-5

(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In tetrahydrofuran at 55 - 60℃; for 12h;99.02%
With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In methanol at 20 - 50℃; Reagent/catalyst; Solvent;96%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 0 - 20℃; for 24h;95%
3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
486460-21-3

3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
486460-23-5

(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Conditions
ConditionsYield
With (2-iodo-5-methoxyphenyl)boronic acid; 4-(dimethylamino)pyridine N-oxide In fluorobenzene for 40h; Catalytic behavior; Reagent/catalyst;99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In water; ethyl acetate at 20℃; for 12h;91%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;88%
C11H13F5N4

C11H13F5N4

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl ((2R)-4-oxo-4-(1-(perfluoroethyl)-4,5,5a,8,9,9a-hexahydro-[1,2,4]triazolo[4,3-a][1,6]naphthyridin-7(6H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

tert-butyl ((2R)-4-oxo-4-(1-(perfluoroethyl)-4,5,5a,8,9,9a-hexahydro-[1,2,4]triazolo[4,3-a][1,6]naphthyridin-7(6H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;98%
rac-(5aS,9aR)-1-(6-ethoxypyridin-2-yl)-4,5,5a,6,7,8,9,9a-octahydro[1,2,4]triazolo[4,3-a][1,6]naphthyridine

rac-(5aS,9aR)-1-(6-ethoxypyridin-2-yl)-4,5,5a,6,7,8,9,9a-octahydro[1,2,4]triazolo[4,3-a][1,6]naphthyridine

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl ((R)-4-((5aS*,9aR*)-1-(6-ethoxypyridin-2-yl)-4,5,5a,8,9,9a-hexahydro-[1,2,4]triazolo[4,3-a][1,6]naphthyridin-7(6H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

tert-butyl ((R)-4-((5aS*,9aR*)-1-(6-ethoxypyridin-2-yl)-4,5,5a,8,9,9a-hexahydro-[1,2,4]triazolo[4,3-a][1,6]naphthyridin-7(6H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 20h; Inert atmosphere;98%
hexahydro-2-(4-cyanophenyl)-imidazo[1,5-a]pyrazin-3-one
1256815-22-1

hexahydro-2-(4-cyanophenyl)-imidazo[1,5-a]pyrazin-3-one

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl [(1R)-3-[2-(4-cyanophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate
1256815-41-4

tert-butyl [(1R)-3-[2-(4-cyanophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 12h;97%
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
762240-92-6

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Sitagliptin hydrochloride

Sitagliptin hydrochloride

Conditions
ConditionsYield
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid; 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride In N,N-dimethyl-formamide for 0.166667h;
Stage #2: With 2-chloro-1,3-dimethylimidazolinium chloride In N,N-dimethyl-formamide at 20 - 25℃; for 5h; Reagent/catalyst;
97%
1-(1-methanesulfonylpiperazin-2-yl)cyclopropylcarboxylic acid methyl ester

1-(1-methanesulfonylpiperazin-2-yl)cyclopropylcarboxylic acid methyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

1-[4-[(3R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl]-1-methanesulfonylpiperazin-2-yl]cyclopropylcarboxylic acid methyl ester

1-[4-[(3R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl]-1-methanesulfonylpiperazin-2-yl]cyclopropylcarboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0 - 30℃; for 1h; Inert atmosphere;97%
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
762240-92-6

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

sitagliptin
486460-32-6

sitagliptin

Conditions
ConditionsYield
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With triethylamine In dichloromethane for 0.166667h;
Stage #2: With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 25 - 30℃; for 4h;
Stage #3: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Further stages;
96.5%
hexahydro-2-(pyridin-2-yl)-imidazo[1,5-a]pyrazin-3(5h)-one
1256815-18-5

hexahydro-2-(pyridin-2-yl)-imidazo[1,5-a]pyrazin-3(5h)-one

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl [(1R)-3-[2-(pyridin-2-yl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate
1256815-36-7

tert-butyl [(1R)-3-[2-(pyridin-2-yl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 12h;96%
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

sitagliptin
486460-32-6

sitagliptin

Conditions
ConditionsYield
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With thionyl chloride In ethyl acetate at 26℃; for 2h;
Stage #2: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride With triethylamine In ethyl acetate at 25℃; Solvent; Temperature;
96%
Stage #1: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride; (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With 1-methyl-1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0 - 20℃; for 16h;
Stage #2: With hydrogenchloride In ethanol at 20℃; for 18h;
Stage #3: With sodium hydroxide In ethanol; water pH=10 - 12; Time; Solvent;
90%
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With pivaloyl chloride; sodium carbonate In toluene Cooling;
Stage #2: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride In toluene
Stage #3: With hydrogenchloride In water; toluene Reagent/catalyst;
4.4 g
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-3-(amino-d2)-4-(2,4,5-trifluorophenyl)-2,2-d2-butanoic acid deuterochloride
1078568-89-4

(R)-3-(amino-d2)-4-(2,4,5-trifluorophenyl)-2,2-d2-butanoic acid deuterochloride

Conditions
ConditionsYield
With water-d2; hydrogen chloride at 70 - 160℃; for 15h;95%
hexahydro-2-(3-cyanobenzyl)-imidazo[1,5-a]pyrazin-3-one
1256815-17-4

hexahydro-2-(3-cyanobenzyl)-imidazo[1,5-a]pyrazin-3-one

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl [(1R)-3-[2-(3-cyanobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate

tert-butyl [(1R)-3-[2-(3-cyanobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 12h;95%
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
486460-23-5

(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Conditions
ConditionsYield
With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0 - 20℃; for 16h;95%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 0 - 20℃; for 24h;95%
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With Triisopropyl borate; sulfuric acid In toluene at 20℃; for 2h; Reflux;
Stage #2: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride With triethylamine In toluene at 80℃; Reagent/catalyst; Temperature; Solvent; Concentration; Reflux; Dean-Stark;
92.1%
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

N-Boc-sitagliptin

N-Boc-sitagliptin

Conditions
ConditionsYield
With 4-(dimethylamino)pyridine N-oxide; sodium hydroxide; 2,6-difluorophenylboronic acid In fluorobenzene; water at 100℃; for 23h; Reagent/catalyst; Molecular sieve;95%
C14H19N3O2
1256815-14-1

C14H19N3O2

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl [(1R)-3-[2-(2-methoxybenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate
1256815-32-3

tert-butyl [(1R)-3-[2-(2-methoxybenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 12h;94%
4-[3-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl]piperidine
868669-70-9

4-[3-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl]piperidine

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl (R)-(4-(4-(3-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl)piperidin-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

tert-butyl (R)-(4-(4-(3-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl)piperidin-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;93%
bis(pentafluorophenyl)carbonate
59483-84-0

bis(pentafluorophenyl)carbonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-pentafluorophenyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

(R)-pentafluorophenyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With triethylamine In N,N-dimethyl-formamide at 25℃; for 0.333333h;
Stage #2: bis(pentafluorophenyl)carbonate In N,N-dimethyl-formamide at 25℃; for 2h;
92.3%
hexahydro-2-(4-chlorobenzyl)-imidazo[1,5-a]pyrazin-3-one
1256815-12-9

hexahydro-2-(4-chlorobenzyl)-imidazo[1,5-a]pyrazin-3-one

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl [(1R)-3-[2-(4-chlorobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate
1256815-30-1

tert-butyl [(1R)-3-[2-(4-chlorobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazin-7(8H)-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 12h;92%
7-methoxy-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-one hydrochloride
1364122-94-0

7-methoxy-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-one hydrochloride

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-[3-(7-methoxy-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-yl)-3-oxo-1-(2,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester

(R)-[3-(7-methoxy-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-yl)-3-oxo-1-(2,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole In acetonitrile at 20℃; for 0.5h;
Stage #2: 7-methoxy-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-one hydrochloride In acetonitrile at 65 - 70℃; for 22h;
92%
bis-(p-nitrophenyl) carbonate
5070-13-3

bis-(p-nitrophenyl) carbonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-4-nitrophenyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

(R)-4-nitrophenyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With triethylamine In N,N-dimethyl-formamide at 25℃; for 0.333333h;
Stage #2: bis-(p-nitrophenyl) carbonate In N,N-dimethyl-formamide at 25 - 70℃; for 4h;
91.9%
2,2'-dipyridyl carbonate
1659-31-0

2,2'-dipyridyl carbonate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-pyridin-2-yl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

(R)-pyridin-2-yl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Conditions
ConditionsYield
Stage #1: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid With triethylamine In N,N-dimethyl-formamide at 25℃; for 0.333333h;
Stage #2: 2,2'-dipyridyl carbonate In N,N-dimethyl-formamide at 25 - 70℃; for 2h;
91.4%
C10H13F3N4

C10H13F3N4

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

tert-butyl ((2R)-4-oxo-4-(1-(trifluoromethyl)-4,5,5a,8,9,9a-hexahydro-[1,2,4]triazolo[4,3-a][1,6]naphthyridin-7(6H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

tert-butyl ((2R)-4-oxo-4-(1-(trifluoromethyl)-4,5,5a,8,9,9a-hexahydro-[1,2,4]triazolo[4,3-a][1,6]naphthyridin-7(6H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;91%
1,2-diazepane dihydrochloride

1,2-diazepane dihydrochloride

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester
939964-18-8

(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 12h;90%
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